P-POD: Princeton Protein Orthology Database: GO3/Nens2227

This family has 13 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

13 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_564557.1 · TAIR:locus:2007283
C. elegansWB:WBGene00018955 (F56C11.3) · UniProtKB:O44975⌘
D. rerioUniProtKB:A4QNU9 · ZFIN:ZDB-GENE-060810-186 (gfer)growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)⌘
D. discoideumUniProtKB:Q75JQ5 · dictyBase:DDB_G0272230
D. melanogasterUniProtKB:Q8SX43 · FB:FBgn0031068 (alr · CG12534)augmenter of liver regeneration⌘
G. gallusNCBI:XP_414848 · ENTREZ:416547
H. sapiensENSEMBL:ENSG00000127554 · UniProtKB:P55789 (ALR_HUMAN · HPO · ALR · HERV1 · IPI00902969 · GFER · P55789)FAD-linked sulfhydryl oxidase ALR⌘
M. musculusUniProtKB:P56213 · MGI:MGI:107757 (Alr · Gfer · ERV1)growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)⌘
R. norvegicusUniProtKB:Q63042 · RGD:61845 (Gfer)growth factor, augmenter of liver regeneration⌘
S. cerevisiaeUniProtKB:P27882 · SGD:S000003261 (YGR029W · ERV1)Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins⌘
S. cerevisiaeUniProtKB:Q12284 · SGD:S000006241 (ERV2 · YPR037C)Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER⌘
S. pombeUniProtKB:O14144 · GeneDB_Spombe:SPAC3G6.08 (erv1 · SPAC3G6.08)sulfhydryl oxidase⌘
S. pombeUniProtKB:Q9Y806 · GeneDB_Spombe:SPBC146.04 (SPBC146.04)sulfhydryl oxidase⌘
ProteinPublicationCurator Notes
UniProtKB:P27882 · SGD:S000003261PMID:10384986 Hofhaus G, et al. Highly divergent amino termini of the homologous human ALR and yeast scERV1 gene products define species specific differences in cellular localization. Eur J Cell Biol. 1999 May;78(5):349-56.The H. sapiens protein GFER does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P27882 · SGD:S000003261PMID:23186364 Sztolsztener ME, et al. Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40. Traffic. 2013 Mar;14(3):309-20.The H. sapiens protein GFER complements a homologous mutation in S. cerevisiae.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (1)
UniProtKB:P27882 · SGD:S000003261PMID:19409522 Di Fonzo A, et al. (2009) The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency. Am J Hum Genet 84(5):594-604
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