P-POD: Princeton Protein Orthology Database: GO3/Nens217

This family has 54 members: 18 Arabidopsis thaliana, 2 Caenorhabditis elegans, 2 Danio rerio, 3 Dictyostelium discoideum, 1 Drosophila melanogaster, 4 Gallus gallus, 5 Homo sapiens, 5 Mus musculus, 5 Rattus norvegicus, 7 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Nens217
54 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_171665.1 · TAIR:locus:2025366 (FRO1 · ATFRO1 · F22L4_13 · AT1G01590 · F22L4.13)FERRIC REDUCTION OXIDASE 1⌘
A. thalianaNCBI:NP_194239.2 · TAIR:locus:2117258
A. thalianaNCBI:NP_973799.1 · TAIR:locus:2036104 (F7G19_4 · AT1G09090 · ATRBOHB · F7G19.4)respiratory burst oxidase homolog B⌘
A. thalianaNCBI:NP_199785.2 · TAIR:locus:2157032 (AT5G49740 · K2I5_10 · K2I5.10 · ATFRO7 · FRO7)FERRIC REDUCTION OXIDASE 7⌘
A. thalianaNCBI:NP_171664.1 · TAIR:locus:2025351 (ATFRO2 · F22L4.12 · AT1G01580 · F22L4_12 · FRD1 · FRO2)FERRIC REDUCTION OXIDASE 2 · FERRIC CHELATE REDUCTASE DEFECTIVE 1⌘
A. thalianaNCBI:NP_192862.2 · TAIR:locus:2128248
A. thalianaNCBI:NP_199919.1 · TAIR:locus:2157348 (ATRBOHC · RHD2 · K3K7.25 · RBOHC · AT5G51060 · K3K7_25)ROOT HAIR DEFECTIVE 2 · RESPIRATORY BURST OXIDASE HOMOLOG C · A. THALIANA RESPIRATORY BURST OXIDASE HOMOLOG C⌘
A. thalianaNCBI:NP_196356.1 · TAIR:locus:2183309 (T2I1_100 · T2I1.100 · AT5G07390 · ATRBOHA)respiratory burst oxidase homolog A⌘
A. thalianaNCBI:NP_199784.2 · TAIR:locus:2157027 (ATFRO6 · K2I5_9 · FRO6 · AT5G49730 · K2I5.9)FERRIC REDUCTION OXIDASE 6⌘
A. thalianaNCBI:NP_197786.2 · TAIR:locus:2178677 (FRO4 · AT5G23980 · MZF18_14 · MZF18.14 · ATFRO4)FERRIC REDUCTION OXIDASE 4⌘
A. thalianaNCBI:NP_199602.1 · TAIR:locus:2160917 (RBOHD · MCA23_25 · AT5G47910 · ATRBOHD · MCA23.25)RESPIRATORY BURST OXIDASE · RESPIRATORY BURST OXIDASE HOMOLOGUE D⌘
A. thalianaNCBI:NP_200809.1 · TAIR:locus:2168113 (MMN10_18 · MMN10.18 · AT5G60010)⌘
A. thalianaNCBI:NP_173357.1 · TAIR:locus:2202210 (T29M8.10 · T29M8_10 · AT1G19230)⌘
A. thalianaNCBI:NP_564821.1 · TAIR:locus:2024603 (RBOHF · F22C12_18 · AT1G64060 · RBOHAP108 · F22C12.18 · ATRBOHF)ARABIDOPSIS THALIANA RESPIRATORY BURST OXIDASE PROTEIN F · ATRBOH F · ARABIDOPSIS THALIANA RESPIRATORY BURST OXIDASE HOMOLOG F · CYTOCHROME B245 BETA CHAIN HOMOLOG RBOHAP108 · RESPIRATORY BURST OXIDASE PROTEIN F⌘
A. thalianaNCBI:NP_173715.1 · TAIR:locus:2017789 (F19G10.4 · FRO3 · F19G10_4 · AT1G23020 · ATFRO3)FERRIC REDUCTION OXIDASE 3⌘
A. thalianaNCBI:NP_197787.1 · TAIR:locus:2178687 (AT5G23990 · ATFRO5 · FRO5 · MZF18.13 · MZF18_13)FERRIC REDUCTION OXIDASE 5⌘
A. thalianaNCBI:NP_199827.2 · TAIR:locus:2157697 (ATFRO8 · K6A12.2 · FRO8 · AT5G50160 · K6A12_2)FERRIC REDUCTION OXIDASE 8⌘
A. thalianaTAIR:locus:2077192 (F16L2.20 · AT3G45810) · NCBI:NP_190167.2⌘
C. elegansWB:WBGene00000253 (bli-3 · F56C11.1) · UniProtKB:O61213⌘
C. elegansWB:WBGene00018771 (F53G12.3) · UniProtKB:O01795⌘
D. rerioENSEMBL:ENSDARG00000062632 · UniProtKB:Q08JS2
D. rerioUniProtKB:Q7T2A7 · ZFIN:ZDB-GENE-040426-1380 (cybb)cytochrome b-245, beta polypeptide (chronic granulomatous disease)⌘
D. discoideumUniProtKB:Q9XYS3 · dictyBase:DDB_G0289653 (noxA · gp91phox)superoxide-generating NADPH oxidase flavocytochrome, flavocytochrome b large subunit⌘
D. discoideumUniProtKB:Q86GL4 · dictyBase:DDB_G0287101 (noxB · gp91phox)superoxide-generating NADPH oxidase flavocytochrome, flavocytochrome b large subunit⌘
D. discoideumUniProtKB:Q54F44 · dictyBase:DDB_G0291117 (gp91phox · noxC)superoxide-generating NADPH oxidase flavocytochrome, flavocytochrome b large subunit⌘
D. melanogasterUniProtKB:Q9VQH2 · FB:FBgn0031464 (CG3131 · dDuox · Duox)Dual oxidase⌘
G. gallusNCBI:XP_425053 · ENTREZ:427482
G. gallusNCBI:XP_426166 · ENTREZ:428609
G. gallusUniProtKB:A7E3K3 (A7E3K3 · IPI00572292 · Nox1) · ENTREZ:422257⌘
G. gallusUniProtKB:A7E3K8 (IPI00866799 · Nox2 · A7E3K8) · ENTREZ:418581⌘
H. sapiensENSEMBL:ENSG00000165168 · UniProtKB:P04839 (CYBB · P04839 · IPI00218646 · NOX2 · CY24B_HUMAN)Cytochrome b-245 heavy chain⌘
H. sapiensENSEMBL:ENSG00000137857 · UniProtKB:Q9NRD9 (LNOX1 · Q9NRD9 · IPI00185038 · DUOX1_HUMAN · THOX1 · IPI00719817 · DUOX1 · DUOX)Dual oxidase 1⌘
H. sapiensENSEMBL:ENSG00000140279 · UniProtKB:Q9NRD8 (DUOX2_HUMAN · IPI00299627 · LNOX2 · THOX2 · Q9NRD8 · DUOX2)Dual oxidase 2⌘
H. sapiensENSEMBL:ENSG00000007952 · UniProtKB:Q9Y5S8 (IPI00336126 · NOX1 · IPI00216593 · Q9Y5S8 · NOH1 · NOX1_HUMAN · IPI00292186)NADPH oxidase 1⌘
H. sapiensENSEMBL:ENSG00000074771 · UniProtKB:Q9HBY0 (NOX3 · Q9HBY0 · NOX3_HUMAN · IPI00024581 · MOX2)NADPH oxidase 3⌘
M. musculusNCBI:NP_808278 · MGI:MGI:3036280 (NOXEF2 · LNOX2 · THOX2 · P138-TOX · Duox2)dual oxidase 2⌘
M. musculusNCBI:NP_001092767 · MGI:MGI:2139422 (LNOX1 · Duox1 · NOXEF1 · THOX1)dual oxidase 1⌘
M. musculusUniProtKB:Q61093 · MGI:MGI:88574 (Nox2 · Cgd · Cybb · gp91 · gp91phox)cytochrome b-245, beta polypeptide⌘
M. musculusUniProtKB:Q8CIZ9 · MGI:MGI:2450016 (Nox-1 · Nox1)GP91 phox homolog · NADPH oxidase 1⌘
M. musculusUniProtKB:Q672J9 · MGI:MGI:2681162 (het · nmf250 · Nox3)NADPH oxidase 3⌘
R. norvegicusUniProtKB:Q8CIY2 · RGD:628760 (Duox1)dual oxidase 1⌘
R. norvegicusRGD:628761 (Duox2) · UniProtKB:Q9ES45 (IPI00734574 · Lnox2 · Q9ES45 · Thox2 · IPI00191453 · DUOX2_RAT · Duox2)dual oxidase 2 · Dual oxidase 2⌘⌘
R. norvegicusUniProtKB:Q9WV87 · RGD:620598 (Nox1)NADPH oxidase 1⌘
R. norvegicusUniProtKB:Q672K1 · RGD:1303190 (Nox3)NADPH oxidase 3⌘
R. norvegicusUniProtKB:Q9ERL1 · RGD:620574 (Cybb)cytochrome b-245, beta polypeptide⌘
S. cerevisiaeUniProtKB:P32791 · SGD:S000004204 (FRE1 · YLR214W)Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters⌘
S. cerevisiaeUniProtKB:P36033 · SGD:S000001703 (YKL220C · FRE2)Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters⌘
S. cerevisiaeUniProtKB:Q08905 · SGD:S000005908 (YOR381W · FRE3)Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters⌘
S. cerevisiaeUniProtKB:P53746 · SGD:S000005343 (YNR060W · FRE4)Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters⌘
S. cerevisiaeUniProtKB:Q08908 · SGD:S000005911 (YOR384W · FRE5)Putative ferric reductase with similarity to Fre2p⌘
S. cerevisiaeUniProtKB:Q12473 · SGD:S000003974 (YLL051C · FRE6)Putative ferric reductase with similarity to Fre2p⌘
S. cerevisiaeUniProtKB:Q12333 · SGD:S000005512 (FRE7 · YOL152W)Putative ferric reductase with similarity to Fre2p⌘
S. pombeUniProtKB:Q04800 · GeneDB_Spombe:SPBC1683.09c (SPBC1683.09c · frp1)ferric-chelate reductase Frp1⌘
S. pombeUniProtKB:O94727 · GeneDB_Spombe:SPBC947.05c (SPBC947.05c)ferric-chelate reductase⌘
ProteinPublicationCurator Notes
UniProtKB:P32791 · SGD:S000004204PMID:10024528 Bagnaresi P, et al. Cloning and characterization of a maize cytochrome-b5 reductase with Fe3+-chelate reduction capability. Biochem J. 1999 Mar 1;338 ( Pt 2):499-505.The Z. mays protein NFCTR was expressed in S. cerevisiae, but complementation was not directly tested. Maize NADH:Fe3+-citrate reductase was expressed in yeast, but orthology was not directly tested.
UniProtKB:P36033 · SGD:S000001703PMID:16911521 Su D, et al. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. FEBS J. 2006 Aug;273(16):3722-34.The M. musculus protein Q60720 complements a homologous mutation in S. cerevisiae. Mouse chromaffin granule cytochrome b 561 rescued the iron-deficient growth defect of fre1 fre2 yeast.
UniProtKB:P32791 · SGD:S000004204PMID:16911521 Su D, et al. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. FEBS J. 2006 Aug;273(16):3722-34.The M. musculus protein Q60720 complements a homologous mutation in S. cerevisiae. Mouse chromaffin granule cytochrome b 561 rescued the iron-deficient growth defect of fre1 fre2 yeast.
UniProtKB:P36033 · SGD:S000001703PMID:16911521 Su D, et al. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. FEBS J. 2006 Aug;273(16):3722-34.The M. musculus protein DCytb (protein ID unknown) complements a homologous mutation in S. cerevisiae. Mouse duodenal cytochrome b 561 rescued the iron-deficient growth defect of fre1 fre2 yeast.
UniProtKB:P32791 · SGD:S000004204PMID:16911521 Su D, et al. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. FEBS J. 2006 Aug;273(16):3722-34.The M. musculus protein DCytb (protein ID unknown) complements a homologous mutation in S. cerevisiae. Mouse duodenal cytochrome b 561 rescued the iron-deficient growth defect of fre1 fre2 yeast.
UniProtKB:P36033 · SGD:S000001703PMID:16911521 Su D, et al. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. FEBS J. 2006 Aug;273(16):3722-34.The M. musculus protein LCytb (protein ID unknown) complements a homologous mutation in S. cerevisiae. Mouse lysosomal cytochrome b 561 rescued the iron-deficient growth defect of fre1 fre2 yeast.
UniProtKB:P32791 · SGD:S000004204PMID:16911521 Su D, et al. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. FEBS J. 2006 Aug;273(16):3722-34.The M. musculus protein LCytb (protein ID unknown) complements a homologous mutation in S. cerevisiae. Mouse lysosomal cytochrome b 561 rescued the iron-deficient growth defect of fre1 fre2 yeast.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (2)
ENSEMBL:ENSG00000140279 · UniProtKB:Q9NRD8#306400 GRANULOMATOUS DISEASE, CHRONIC, X-LINKED; CGD;;CYTOCHROME b-NEGATIVE GRANULOMATOUS DISEASE, CHRONIC, X-LINKED;;CHRONIC GRANULOMATOUS DISEASE, X-LINKEDCYTOCHROME b-POSITIVE GRANULOMATOUS DISEASE, CHRONIC, X-LINKED, INCLUDED;;GRANULOMATOUS DISEASE, CHRONIC, X-LINKED, VARIANT, INCLUDED;;CHRONIC GRANULOMATOUS DISEASE, ATYPICAL, INCLUDED
ENSEMBL:ENSG00000140279 · UniProtKB:Q9NRD8#607200 THYROID HORMONOGENESIS, GENETIC DEFECT IN, 6;;HYPOTHYROIDISM, CONGENITAL, DUE TO DYSHORMONOGENESIS, 6
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