P-POD: Princeton Protein Orthology Database: GO3/Nens210

This family has 56 members: 3 Caenorhabditis elegans, 7 Danio rerio, 1 Dictyostelium discoideum, 4 Drosophila melanogaster, 10 Gallus gallus, 9 Homo sapiens, 9 Mus musculus, 10 Rattus norvegicus, 1 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

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GO3/Nens210
56 members.
OrganismProtein (Synonyms)DescriptionAmiGO
C. elegansUniProtKB:Q09547 · WB:WBGene00009738 (F45H7.6)⌘
C. elegansWB:WBGene00022358 (Y92H12A.2) · UniProtKB:Q9BKW4⌘
C. elegansWB:WBGene00007009 (Y65B4BR.4 · wwp-1) · UniProtKB:Q9N2Z7 (Y65B4BR.4 · wwp-1)Ww domain protein (E3 ubiquitin ligase) protein 1, isoform a⌘⌘
D. rerioENSEMBL:ENSDARP00000078496
D. rerioENSEMBL:ENSDARP00000084719
D. rerioENSEMBL:ENSDARP00000055490
D. rerioENSEMBL:ENSDARG00000061345 · UniProtKB:A2VCZ7
D. rerioZFIN:ZDB-GENE-060503-2 (si:ch211-106n13.1) · UniProtKB:Q1LYI3⌘
D. rerioUniProtKB:Q3KRP0 · ZFIN:ZDB-GENE-051005-2 (nedd4a)neural precursor cell expressed, developmentally down-regulated 4a⌘
D. rerioUniProtKB:Q6PCR3 · ZFIN:ZDB-GENE-040426-2744 (wwp1)WW domain containing E3 ubiquitin protein ligase 1⌘
D. discoideumUniProtKB:Q54QF1 · dictyBase:DDB_G0283983 (DDB_G0283983)ubiquitin-protein ligase (HECT) domain-containing protein, filamin/ABP280 repeat-containing protein⌘
D. melanogasterFB:FBgn0036736 · UniProtKB:Q9VVI3
D. melanogasterUniProtKB:Q9V853 · FB:FBgn0029006 (dSmurf1 · dSmurf · d-smurf · Smurf · lack · CG4943 · Smurf1 · D-smurf · DSmurf · Dsmurf)Smurf ubiquitin ligase · lethal with a checkpoint kinase⌘
D. melanogasterUniProtKB:Q9Y0H4 · FB:FBgn0003557 (CG4244 · anon-WO0073329.1 · Su(dx) · anon-WO0073329.4 · su(dx) · Su(Dx) · anon-WO0073329.2 · Su(deltex))Suppressor of deltex · Suppressor of Deltex · suppressor of deltex⌘
D. melanogasterFB:FBgn0030145 (CG3099) · UniProtKB:Q9W325⌘
G. gallusNCBI:XP_421906 · ENTREZ:424050
G. gallusNCBI:XP_001231787 · ENTREZ:768699
G. gallusNCBI:XP_424462 · ENTREZ:374119
G. gallusNCBI:XP_413791 · ENTREZ:415406
G. gallusNCBI:XP_417330 · ENTREZ:419145
G. gallusNCBI:XP_425380 · ENTREZ:427809
G. gallusNCBI:XP_414794 · ENTREZ:416487
G. gallusNCBI:XP_418870 · ENTREZ:420774
G. gallusUniProtKB:Q5F372 (RCJMB04_30i22 · IPI00580040 · Q5F372) · ENTREZ:420212⌘
G. gallusUniProtKB:Q5F427 (RCJMB04_3l19 · IPI00822818 · Q5F427) · ENTREZ:415868⌘
H. sapiensENSEMBL:ENSG00000002746 · UniProtKB:Q76N89 (Q76N89 · HECW1_HUMAN · IPI00173347 · KIAA0322 · HECW1 · NEDL1)E3 ubiquitin-protein ligase HECW1⌘
H. sapiensENSEMBL:ENSG00000138411 · UniProtKB:Q9P2P5 (IPI00827974 · IPI00017163 · KIAA1301 · HECW2 · HECW2_HUMAN · Q9P2P5 · NEDL2)E3 ubiquitin-protein ligase HECW2⌘
H. sapiensENSEMBL:ENSG00000078747 · UniProtKB:Q96J02 (ITCH_HUMAN · IPI00061780 · IPI00176010 · Q96J02 · ITCH)E3 ubiquitin-protein ligase Itchy homolog⌘
H. sapiensENSEMBL:ENSG00000049759 · UniProtKB:Q96PU5 (IPI00640924 · IPI00166830 · NEDD4L · IPI00304945 · Q96PU5 · IPI00644256 · IPI00645053 · KIAA0439 · NED4L_HUMAN · IPI00163321 · NEDL3 · IPI00023287 · IPI00643856)E3 ubiquitin-protein ligase NEDD4-like⌘
H. sapiensENSEMBL:ENSG00000069869 · UniProtKB:P46934 (NEDD4_HUMAN · P46934 · IPI00009322 · KIAA0093 · NEDD4)E3 ubiquitin-protein ligase NEDD4⌘
H. sapiensENSEMBL:ENSG00000198742 · UniProtKB:Q9HCE7 (SMUF1_HUMAN · IPI00219332 · IPI00217054 · KIAA1625 · SMURF1 · Q9HCE7)E3 ubiquitin-protein ligase SMURF1⌘
H. sapiensENSEMBL:ENSG00000108854 · UniProtKB:Q9HAU4 (IPI00329664 · SMUF2_HUMAN · Q9HAU4 · SMURF2)E3 ubiquitin-protein ligase SMURF2⌘
H. sapiensENSEMBL:ENSG00000123124 · UniProtKB:Q9H0M0 (WWP1_HUMAN · IPI00328376 · IPI00328378 · IPI00013009 · Q9H0M0 · IPI00328377 · WWP1)NEDD4-like E3 ubiquitin-protein ligase WWP1⌘
H. sapiensENSEMBL:ENSG00000198373 · UniProtKB:O00308 (IPI00013010 · WWP2 · O00308 · WWP2_HUMAN)NEDD4-like E3 ubiquitin-protein ligase WWP2⌘
M. musculusUniProtKB:Q8K4P8 · MGI:MGI:2444115 (NEDL1 · Hecw1)HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1⌘
M. musculusUniProtKB:Q6I6G8 · MGI:MGI:2685817 (Hecw2 · Nedl2)HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2⌘
M. musculusUniProtKB:Q8C863 · MGI:MGI:1202301 (Itch)itchy, E3 ubiquitin protein ligase⌘
M. musculusUniProtKB:Q8CFI0 · MGI:MGI:1933754 (Nedd4b · Nedd4l · Nedd4-2)neural precursor cell expressed, developmentally down-regulated gene 4-like⌘
M. musculusUniProtKB:P46935 · MGI:MGI:97297 (Nedd4a · Nedd4 · Nedd4-1)neural precursor cell expressed, developmentally down-regulated 4⌘
M. musculusUniProtKB:Q9CUN6 · MGI:MGI:1923038 (Smurf1)SMAD specific E3 ubiquitin protein ligase 1⌘
M. musculusUniProtKB:A2A5Z6 · MGI:MGI:1913563 (Smurf2)SMAD specific E3 ubiquitin protein ligase 2⌘
M. musculusUniProtKB:Q8BZZ3 · MGI:MGI:1861728 (Tiul1 · AIP5 · SDRP1 · Wwp1)WW domain containing E3 ubiquitin protein ligase 1⌘
M. musculusUniProtKB:Q9DBH0 · MGI:MGI:1914144 (Wwp2)WW domain containing E3 ubiquitin protein ligase 2⌘
R. norvegicusNCBI:XP_225450 · RGD:1561038 (RGD1561038)similar to HECT type E3 ubiquitin ligase⌘
R. norvegicusNCBI:XP_001081579 · RGD:1310067 (Smurf2)SMAD specific E3 ubiquitin protein ligase 2⌘
R. norvegicusNCBI:XP_001071299 · RGD:1309707
R. norvegicusNCBI:XP_214669 · RGD:1310091 (Wwp2)WW domain containing E3 ubiquitin protein ligase 2⌘
R. norvegicusNCBI:XP_237139 · RGD:1593244
R. norvegicusNCBI:XP_001074660 · RGD:1594738 (LOC690516)similar to Smad ubiquitination regulatory factor 1 isoform 2⌘
R. norvegicusUniProtKB:Q62940 · RGD:3157 (Nedd4)neural precursor cell expressed, developmentally down-regulated gene 4⌘
R. norvegicusUniProtKB:Q4V8H7 · RGD:1311734 (Wwp1)WW domain containing E3 ubiquitin protein ligase 1⌘
R. norvegicusUniProtKB:Q5U1Z5 · RGD:735047 (Nedd4l)neural precursor cell expressed, developmentally down-regulated 4-like⌘
R. norvegicusUniProtKB:Q5YB86 · RGD:1359556 (Itch)itchy E3 ubiquitin protein ligase homolog (mouse)⌘
S. cerevisiaeUniProtKB:P39940 · SGD:S000000927 (NPI1 · UBY1 · SMM1 · YER125W · RSP5 · MUT2 · MDP1)Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation⌘
S. pombeUniProtKB:Q92462 · GeneDB_Spombe:SPAC11G7.02 (SPAC11G7.02 · pub1)HECT-type ubiquitin-protein ligase Pub1⌘
S. pombeUniProtKB:O14326 · GeneDB_Spombe:SPBC16E9.11c (SPBC16E9.11c · pub3)HECT-type ubiquitin-protein ligase Pub3⌘
ProteinPublicationCurator Notes
UniProtKB:P39940 · SGD:S000000927PMID:12684839 Gajewska B, et al. Functional analysis of the human orthologue of the RSP5-encoded ubiquitin protein ligase, hNedd4, in yeast. Curr Genet. 2003 Apr;43(1):1-10.The H. sapiens protein P46934 does not complement a homologous mutation in S. cerevisiae. This paper shows that hNedd4 (P46934) improved the growth and partially suppressed the endocytosis defect of yeast rsp5-w1 mutant cells, but it did not restore the viability of the yeast rsp5 null mutant.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (1)
UniProtKB:P39940 · SGD:S000000927PMID:12709439 Welsch CA, et al. (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82
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