P-POD: Princeton Protein Orthology Database: GO3/Nens20276

This family has 2 members: 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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2 members.
OrganismProtein (Synonyms)DescriptionAmiGO
S. cerevisiaeUniProtKB:P36012 · SGD:S000001532 (CSE4 · YKL049C · CSL2)Centromere protein that resembles histone H3, required for proper kinetochore function⌘
S. pombeUniProtKB:Q9Y812 · GeneDB_Spombe:SPBC1105.17 (cnp1 · sim2 · SPBC1105.17)histone H3 variant CENP-A⌘
ProteinPublicationCurator Notes
UniProtKB:P36012 · SGD:S000001532PMID:10639145 Henikoff S, et al. Heterochromatic deposition of centromeric histone H3-like proteins. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):716-21.The S. cerevisiae protein CSE4 was expressed in D. melanogaster, but complementation was not directly tested.
UniProtKB:P36012 · SGD:S000001532PMID:15254229 Wieland G, et al. Functional complementation of human centromere protein A (CENP-A) by Cse4p from Saccharomyces cerevisiae. Mol Cell Biol. 2004 Aug;24(15):6620-30.The S. cerevisiae protein CSE4 complements a homologous mutation in H. sapiens. CENP-A expression was ablated by RNAi.
UniProtKB:P36012 · SGD:S000001532PMID:15470243 Stoyan T, et al. Inner kinetochore of the pathogenic yeast Candida glabrata. Eukaryot Cell. 2004 Oct;3(5):1154-63.The C. glabrata protein CSE4 complements a homologous mutation in S. cerevisiae.
Sequences in this family.fasta
SGD Disease Papers (1)
UniProtKB:P36012 · SGD:S000001532PMID:15530401 Collins KA, et al. (2004) Proteolysis contributes to the exclusive centromere localization of the yeast Cse4/CENP-A histone H3 variant. Curr Biol 14(21):1968-72
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