P-POD: Princeton Protein Orthology Database: GO3/Nens181

This family has 61 members: 1 Arabidopsis thaliana, 9 Caenorhabditis elegans, 13 Danio rerio, 7 Dictyostelium discoideum, 3 Drosophila melanogaster, 6 Gallus gallus, 6 Homo sapiens, 6 Mus musculus, 6 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Nens181
61 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_180198.1 · TAIR:locus:2005529 (t1d16.6 · AT2G26300 · ATGPA1 · t1d16_6 · GPA1)GP ALPHA 1 · ARABIDOPSIS THALIANA G PROTEIN ALPHA SUBUNIT 1 · G PROTEIN ALPHA SUBUNIT · G PROTEIN ALPHA SUBUNIT 1⌘
C. elegansWB:WBGene00001648 (C26C6.2 · goa-1) · UniProtKB:P51875 (GNAO_CAEEL · C26C6.2 · goa-1)Guanine nucleotide-binding protein G(o) subunit alpha⌘⌘
C. elegansWB:WBGene00001677 (M04C7.1 · gpa-15) · UniProtKB:P91907⌘
C. elegansWB:WBGene00001678 (gpa-16 · Y95B8A.5) · UniProtKB:Q9N2V6 (GPA16_CAEEL · gpa-16 · spn-1 · Y95B8A.5)Guanine nucleotide-binding protein alpha-16 subunit⌘⌘
C. elegansWB:WBGene00003850 (odr-3 · C34D1.3) · UniProtKB:Q18434⌘
C. elegansWB:WBGene00001663 (T19C4.6 · gpa-1) · UniProtKB:P28051⌘
C. elegansWB:WBGene00001664 (F38E1.5 · gpa-2) · UniProtKB:P22454⌘
C. elegansWB:WBGene00001665 (gpa-3 · E02C12.5) · UniProtKB:P28052⌘
C. elegansWB:WBGene00001666 (gpa-4 · T07A9.7) · UniProtKB:Q9BIG5⌘
C. elegansWB:WBGene00001669 (gpa-7 · R10H10.5) · UniProtKB:Q21917⌘
D. rerioENSEMBL:ENSDARP00000063142
D. rerioENSEMBL:ENSDARP00000073634
D. rerioENSEMBL:ENSDARP00000047527
D. rerioZFIN:ZDB-GENE-050208-700 (si:ch211-207c7.3) · UniProtKB:Q1LW09⌘
D. rerioUniProtKB:Q6AZW4 · ZFIN:ZDB-GENE-040808-7 (gna14)guanine nucleotide binding protein (G protein), alpha 14⌘
D. rerioZFIN:ZDB-GENE-040801-146 (zgc:100942) · UniProtKB:Q6DEH5⌘
D. rerioUniProtKB:Q6P967 · ZFIN:ZDB-GENE-040426-1693 (gnao1b)guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b⌘
D. rerioUniProtKB:Q6PBP1 · ZFIN:ZDB-GENE-040426-1757 (gnao1a)guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a⌘
D. rerioUniProtKB:Q6TNT8 · ZFIN:ZDB-GENE-030131-8365 (gnai2l)guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like⌘
D. rerioUniProtKB:Q7T3D3 · ZFIN:ZDB-GENE-040426-1310 (gnai1)guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1⌘
D. rerioUniProtKB:Q7ZW82 · ZFIN:ZDB-GENE-030131-2229 (gnaia)guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a⌘
D. rerioUniProtKB:Q7ZWI5 · ZFIN:ZDB-GENE-030131-5861 (gnai2)guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2⌘
D. rerioUniProtKB:Q90WX5 · ZFIN:ZDB-GENE-011128-10 (gnat2)guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2⌘
D. discoideumUniProtKB:P16894 · dictyBase:DDB_G0283349 (gpa1 · Ga1 · gpaA · Galpha1)G-protein subunit alpha 1⌘
D. discoideumUniProtKB:P16051 · dictyBase:DDB_G0276267 (Galpha2 · gpaB · gpa2 · Ga2)G-protein subunit alpha 2⌘
D. discoideumUniProtKB:Q54KV6 · dictyBase:DDB_G0287031 (gpa3 · Ga3 · Galpha3 · gpaC)G-protein subunit alpha 3⌘
D. discoideumUniProtKB:P34042 · dictyBase:DDB_G0285425 (Ga4 · gpaD · gpa4 · Galpha4)G-protein subunit alpha 4⌘
D. discoideumUniProtKB:P34043 · dictyBase:DDB_G0286185 (gpaE · Galpha5 · gpa5 · Ga5)G-protein subunit alpha 5⌘
D. discoideumUniProtKB:P34044 · dictyBase:DDB_G0283151 (gpa6 · Ga6 · Galpha6 · gpaF)G-protein subunit alpha 6⌘
D. discoideumUniProtKB:Q54R41 · dictyBase:DDB_G0283419 (Galpha9 · gpaI · Ga9 · gpa9)G-protein subunit alpha 9⌘
D. melanogasterUniProtKB:P20353 · FB:FBgn0001104 (G[[alphai]] · Galpha65A · DG[[alpha1]] · G-ialpha65A · G[[i]]alpha · Gi · Galpha[[i]] · CG10060 · G-oalpha65A · Galphai · Gialpha · i · G-alpha-65A · Gi-alpha · Galphaiota65A · DGalpha1 · G-ia65A · Galpha[[i65A]] · Gai)G protein I a-subunit 65A · G protein alpha-subunit · G protein alphai subunit 65A · Galpha i · G protein alpha subunit · G protein alpha o subunit 65A · G protein alphao subunit 65A⌘
D. melanogasterUniProtKB:P16378 · FB:FBgn0001122 (G[[o]]alpha · Bkh · dgoalpha · G-oalpha · Goa · Go · Galphao47A · G-alpha-47A · Galpha[[0]] · Galpha47A · Galphao · DG[[o]] · Go-alpha · n · dgo · Galpha[[047A]] · DROGPAD · Drogpad · brokenhearted · CG2204 · bkh · Goalpha · DGalpha0 · G[[oalpha]] · brokenheart · G(o)alpha47A · DGalpha[[o]] · G-oalpha47A · alpha(o) · Galpha[[o]])G protein oalpha 47A⌘
D. melanogasterFB:FBgn0033756 (BcDNA:SD21019 · CG17760) · UniProtKB:Q8MQV5⌘
G. gallusNCBI:XP_001232703 · ENTREZ:415698
G. gallusNCBI:XP_425425 · ENTREZ:427851
G. gallusENTREZ:396368 · UniProtKB:P50146 (P50146 · GNAI1_CHICK · IPI00585976 · GNAI1)Guanine nucleotide-binding protein G(i), alpha-1 subunit⌘
G. gallusENTREZ:396367 · UniProtKB:P50147 (IPI00589157 · GNAI2 · P50147 · GNAI2_CHICK)Guanine nucleotide-binding protein G(i), alpha-2 subunit⌘
G. gallusENTREZ:374097 · UniProtKB:Q90846 (Q90846 · IPI00570876)Galpa i3-o⌘
G. gallusUniProtKB:Q9DG27 (Q9DG27 · IPI00577038) · ENTREZ:395425⌘
H. sapiensENSEMBL:ENSG00000127955 · UniProtKB:P63096 (P63096 · GNAI1_HUMAN · GNAI1 · IPI00337415)Guanine nucleotide-binding protein G(i), alpha-1 subunit⌘
H. sapiensENSEMBL:ENSG00000114353 · UniProtKB:P04899 (GNAI2B · GNAI2_HUMAN · GNAI2 · P04899 · IPI00217906 · IPI00748145)Guanine nucleotide-binding protein G(i), alpha-2 subunit⌘
H. sapiensENSEMBL:ENSG00000065135 · UniProtKB:P08754 (P08754 · IPI00220578 · GNAI3_HUMAN · GNAI3)Guanine nucleotide-binding protein G(k) subunit alpha⌘
H. sapiensENSEMBL:ENSG00000087258 · UniProtKB:P09471 (IPI00220281 · P09471 · GNAO_HUMAN · GNAO1 · IPI00398700)Guanine nucleotide-binding protein G(o) subunit alpha⌘
H. sapiensENSEMBL:ENSG00000134183 · UniProtKB:P19087 (P19087 · GNATC · IPI00217269 · GNAT2 · GNAT2_HUMAN)Guanine nucleotide-binding protein G(t) subunit alpha-2⌘
H. sapiensENSEMBL:ENSG00000214415 · UniProtKB:A8MTJ3 (GNAT3_HUMAN · IPI00248911 · A8MTJ3 · GNAT3)Guanine nucleotide-binding protein G(t) subunit alpha-3⌘
M. musculusNCBI:NP_034435 · MGI:MGI:95771 (Gnai1 · Gialpha1)guanine nucleotide binding protein (G protein), alpha inhibiting 1⌘
M. musculusUniProtKB:P08752 · MGI:MGI:95772 (Galphai2 · Gnai-2 · Gnai2 · Gia)guanine nucleotide binding protein (G protein), alpha inhibiting 2⌘
M. musculusUniProtKB:Q9DC51 · MGI:MGI:95773 (Galphai3 · Gnai3)guanine nucleotide binding protein (G protein), alpha inhibiting 3⌘
M. musculusUniProtKB:P18872 · MGI:MGI:95775 (alphaO · Gnao1)Go alpha · guanine nucleotide binding protein, alpha O⌘
M. musculusUniProtKB:P50149 · MGI:MGI:95779 (Gnat2 · Gt-2 · Gnat-2 · Tcalpha)guanine nucleotide binding protein, alpha transducing 2⌘
M. musculusUniProtKB:Q3V3I2 · MGI:MGI:3588268 (Ggust · alpha-gustducin · Gnat3 · Gtn)guanine nucleotide binding protein, alpha transducing 3⌘
R. norvegicusNCBI:XP_345272 · RGD:1309514 (Gnat2)guanine nucleotide binding protein, alpha transducing 2⌘
R. norvegicusUniProtKB:P10824 · RGD:2713 (Gnai1)guanine nucleotide binding protein (G protein), alpha inhibiting 1⌘
R. norvegicusUniProtKB:P04897 · RGD:620243 (Gnai2)guanine nucleotide binding protein (G protein), alpha inhibiting 2⌘
R. norvegicusUniProtKB:P08753 · RGD:2714 (Gnai3)guanine nucleotide binding protein (G protein), alpha inhibiting 3⌘
R. norvegicusRGD:628732 (Gnao1) · UniProtKB:P59215 (Gnao · IPI00231505 · Gna0 · GNAO_RAT · IPI00204843 · Gnao1 · P59215)guanine nucleotide binding protein, alpha O polypeptide 1 · Guanine nucleotide-binding protein G(o) subunit alpha⌘⌘
R. norvegicusUniProtKB:P29348 · RGD:727817 (Gnat3)guanine nucleotide binding protein, alpha transducing 3⌘
S. cerevisiaeUniProtKB:P08539 · SGD:S000001047 (DAC1 · SCG1 · YHR005C · CDC70 · GPA1)GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors⌘
S. cerevisiaeUniProtKB:P10823 · SGD:S000000822 (YER020W · GPA2 · SSP101)Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients⌘
S. pombeUniProtKB:P27584 · GeneDB_Spombe:SPBC24C6.06 (gpa1 · SPBC24C6.06)G-protein alpha subunit⌘
S. pombeUniProtKB:Q04665 · GeneDB_Spombe:SPAC23H3.13c (SPAC23H3.13c · gpa2 · git8)heterotrimeric G protein alpha-2 subunit Gpa2⌘
ProteinPublicationCurator Notes
UniProtKB:P08539 · SGD:S000001047PMID:2111439 Kang YS, et al. Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway. Mol Cell Biol. 1990 Jun;10(6):2582-90.The R. norvegicus protein Galphas complements a homologous mutation in S. cerevisiae. Partially complements the growth and morphological phenotypes, but cells are still sterile.
UniProtKB:P08539 · SGD:S000001047PMID:3113738 Dietzel C, et al. The yeast SCG1 gene: a G alpha-like protein implicated in the a- and alpha-factor response pathway. Cell. 1987 Sep 25;50(7):1001-10.The R. norvegicus protein Galphas complements a homologous mutation in S. cerevisiae.
UniProtKB:P08539 · SGD:S000001047PMID:8943324 Spain BH, et al. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Mol Cell Biol. 1996 Dec;16(12):6698-706.The H. sapiens protein Gsalpha (protein ID unknown) was expressed in S. cerevisiae, but complementation was not directly tested. Human Gsalpha suppresses a yeast gpa1 mutant.
UniProtKB:P08539 · SGD:S000001047PMID:2111439 Kang YS, et al. Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway. Mol Cell Biol. 1990 Jun;10(6):2582-90.The R. norvegicus protein Galphai complements a homologous mutation in S. cerevisiae.
UniProtKB:P08539 · SGD:S000001047PMID:2111439 Kang YS, et al. Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway. Mol Cell Biol. 1990 Jun;10(6):2582-90.The R. norvegicus protein Galphao complements a homologous mutation in S. cerevisiae.
UniProtKB:P08539 · SGD:S000001047PMID:8943324 Spain BH, et al. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Mol Cell Biol. 1996 Dec;16(12):6698-706.The H. sapiens protein Q13098 was expressed in S. cerevisiae, but complementation was not directly tested. Expression of the carboxy terminal half of human gps1 suppresses a yeast gpa1 mutant.
UniProtKB:P08539 · SGD:S000001047PMID:8943324 Spain BH, et al. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Mol Cell Biol. 1996 Dec;16(12):6698-706.The H. sapiens protein Q13227 was expressed in S. cerevisiae, but complementation was not directly tested. Human gps2 suppresses a yeast gpa1 mutant.
UniProtKB:P08539 · SGD:S000001047PMID:2111439 Kang YS, et al. Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway. Mol Cell Biol. 1990 Jun;10(6):2582-90.The R. norvegicus protein Gnao does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P08539 · SGD:S000001047PMID:2111439 Kang YS, et al. Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway. Mol Cell Biol. 1990 Jun;10(6):2582-90.The R. norvegicus protein Gnas complements a homologous mutation in S. cerevisiae.
UniProtKB:P08539 · SGD:S000001047PMID:2111439 Kang YS, et al. Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway. Mol Cell Biol. 1990 Jun;10(6):2582-90.The R. norvegicus protein Gnai2 complements a homologous mutation in S. cerevisiae.
UniProtKB:P08539 · SGD:S000001047PMID:3113738 Dietzel C, et al. The yeast SCG1 gene: a G alpha-like protein implicated in the a- and alpha-factor response pathway. Cell. 1987 Sep 25;50(7):1001-10.The R. norvegicus protein Gnas complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:P08539 · SGD:S000001047+139340 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-TRANSDUCING ACTIVITY POLYPEPTIDE2; GNAT2;;G PROTEIN, ALPHA-TRANSDUCING 2;;TRANSDUCIN, CONE-SPECIFIC, ALPHA POLYPEPTIDEACHROMATOPSIA 4, INCLUDED; ACHM4, INCLUDED
SGD Disease Papers (8)
UniProtKB:P08539 · SGD:S000001047PMID:9786851 Apanovitch DM, et al. (1998) Second site suppressor mutations of a GTPase-deficient G-protein alpha-subunit. Selective inhibition of Gbeta gamma-mediated signaling. J Biol Chem 273(44):28597-602
PMID:2829196 Levine MA, et al. (1988) Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy. Proc Natl Acad Sci U S A 85(2):617-21
PMID:2122458 Weinstein LS, et al. (1990) Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. Proc Natl Acad Sci U S A 87(21):8287-90
PMID:2116665 Lyons J, et al. (1990) Two G protein oncogenes in human endocrine tumors. Science 249(4969):655-9
PMID:17132542 Ooms LS, et al. (2006) Identification of a second-site suppressor mutation of the GTPase defect associated with McCune - Albright syndrome: A model using the yeast heterotrimeric G protein, GPA1. Arch Physiol Biochem 112(3):166-73
PMID:11853883 Kong JL, et al. (2002) Inhibition of somatostatin receptor 5-signaling by mammalian regulators of G-protein signaling (RGS) in yeast. Biochim Biophys Acta 1542(1-3):95-105
PMID:11389184 Erlenbach I, et al. (2001) Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast. J Neurochem 77(5):1327-37
PMID:10620771 Brown AJ, et al. (2000) Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein alpha-subunit chimeras. Yeast 16(1):11-22
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