This family has 16 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 4 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 2 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
Interactive Java Applets: Notung Tree Analysis · Jalview Alignment
| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_197058.2 · TAIR:locus:2180942 (AT5G15540 · T20K14.150 · SCC2 · EMB2773 · T20K14_150 · ATSCC2) | SISTER-CHROMATID COHESION 2 · ARABIDOPSIS THALIANA SISTER-CHROMATID COHESION 2 · EMBRYO DEFECTIVE 2773 |  |
| C. elegans | WB:WBGene00004166 (Y43H11AL.3 · pqn-85) · UniProtKB:Q95XZ5 | | |
| D. rerio | ENSEMBL:ENSDARP00000081088 | ||
| D. rerio | UniProtKB:A2BGN3 · ENSEMBL:ENSDARG00000061074 | ||
| D. discoideum | UniProtKB:Q54RK7 · dictyBase:DDB_G0283099 (DDB_G0283099) | nipped-B protein, HEAT repeat-containing protein, armadillo-like helical domain-containing protein | |
| D. melanogaster | UniProtKB:Q7PLI2 · FB:FBgn0026401 (Nipped · CG17704 · Nipped-B · l(2)02047 · CG40281) | Nipped B | |
| G. gallus | NCBI:XP_424627 · ENTREZ:427025 | ||
| G. gallus | NCBI:XP_001234650 · ENTREZ:771363 | ||
| G. gallus | NCBI:XP_423708 · ENTREZ:426031 | ||
| G. gallus | NCBI:XP_425012 · ENTREZ:427439 | ||
| H. sapiens | ENSEMBL:ENSG00000164190 · UniProtKB:Q6KC79 (IPI00436632 · IPI00436634 · NIPBL · IPI00026466 · IDN3 · NIPBL_HUMAN · Q6KC79) | Nipped-B-like protein | |
| M. musculus | UniProtKB:Q6KCD5 · MGI:MGI:1913976 (Nipbl) | Nipped-B homolog (Drosophila) | |
| R. norvegicus | NCBI:XP_001056725 · RGD:1595401 (LOC681423) | similar to delangin isoform A | |
| R. norvegicus | NCBI:XP_238213 · RGD:1306393 (NIPBL) | Nipped-B homolog (Drosophila) | |
| S. cerevisiae | UniProtKB:Q04002 · SGD:S000002588 (SCC2 · YDR180W) | Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes | |
| S. pombe | UniProtKB:Q09725 · GeneDB_Spombe:SPAC31A2.05c (SPAC31A2.05c · mis4) | cohesin loading factor Mis4 | |
No functional conservation results.
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (1) | |
|---|---|
| UniProtKB:Q04002 · SGD:S000002588 | #122470 CORNELIA DE LANGE SYNDROME 1; CDLS1;;CDLS;;CDL;;TYPUS DEGENERATIVUS AMSTELODAMENSIS;;DE LANGE SYNDROME;;BRACHMANN-DE LANGE SYNDROME; BDLS |
| SGD Disease Papers (3) | |
| UniProtKB:Q04002 · SGD:S000002588 |  16682347 Watrin E, et al. (2006) Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol 16(9):863-74 |
| 16100726 Kaur M, et al. (2005) Precocious sister chromatid separation (PSCS) in Cornelia de Lange syndrome. Am J Med Genet A 138(1):27-31 | |
| 15146185 Tonkin ET, et al. (2004) NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome. Nat Genet 36(6):636-41 | |