P-POD: Princeton Protein Orthology Database: GO3/Nens1488

This family has 17 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Dictyostelium discoideum, 2 Drosophila melanogaster, 2 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

17 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_565767.1 · TAIR:locus:2050977 (F4P9_33 · F4P9.33 · AT2G33560)⌘
C. elegansWB:WBGene00004721 (ZC328.4 · san-1) · UniProtKB:O02053 (ZC328.4 · san-1)Suspended animation (Anoxia-induced) defective protein 1⌘⌘
D. discoideumUniProtKB:Q54CV5 · dictyBase:DDB_G0292676 (bub1)putative protein serine/threonine kinase, putative mitotic checkpoint protein, BUB family protein kinase⌘
D. melanogasterUniProtKB:Q7KN56 · FB:FBgn0025458 (l(2)k06109 · BUB1 · CG7838 · bub1 · l(2)k03113 · 31/13 · BubR1 · Bub1 · dBUB1 · Dmbub1 · BUBR1 · bubR1 · BcDNA:LD23835 · bubr1 · Mad3 · DmBUB1)bub related one · CG 7838 · Bub1-related kinase⌘
D. melanogasterUniProtKB:Q9VMS5 · FB:FBgn0031696 (BUB1-like · CG14030/Bub1 · CG14030 · Bub1 · BUB1 · bub1 · BubR1)Bub1 homologue⌘
G. gallusUniProtKB:Q5ZLQ8 (IPI00600012 · RCJMB04_5c21 · Q5ZLQ8) · ENTREZ:421226⌘
G. gallusENTREZ:378922 · UniProtKB:Q800D4 (Q800D4 · IPI00819314 · BubR1)⌘
H. sapiensENSEMBL:ENSG00000156970 · UniProtKB:O60566 (BUB1B_HUMAN · BUB1B · MAD3L · O60566 · SSK1 · IPI00141933 · BUBR1)Mitotic checkpoint serine/threonine-protein kinase BUB1 beta⌘
H. sapiensENSEMBL:ENSG00000169679 · UniProtKB:O43683 (O43683 · BUB1_HUMAN · BUB1 · BUB1L · IPI00783305)Mitotic checkpoint serine/threonine-protein kinase BUB1⌘
M. musculusUniProtKB:Q9Z1S0 · MGI:MGI:1333889 (Bub1b · BUBR1)budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)⌘
M. musculusUniProtKB:O08901 · MGI:MGI:1100510 (Bub1 · D2Xrf87 · Bub1a)budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)⌘
R. norvegicusNCBI:XP_215849 · RGD:1311707 (Bub1)budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)⌘
R. norvegicusUniProtKB:O35822 · RGD:619791 (Bub1b)budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)⌘
S. cerevisiaeUniProtKB:P41695 · SGD:S000003420 (BUB1 · YGR188C)Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p⌘
S. cerevisiaeUniProtKB:P47074 · SGD:S000003550 (YJL013C · MAD3)Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly⌘
S. pombeUniProtKB:O94751 · GeneDB_Spombe:SPCC1322.12c (SPCC1322.12c · bub1)serine/threonine protein kinase Bub1⌘
S. pombeUniProtKB:O59767 · GeneDB_Spombe:SPCC1795.01c (SPCC1795.01c · SPCC895.02 · mad3)mitotic spindle checkpoint protein Mad3⌘

No functional conservation results.

Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (2)
SGD Disease Papers (10)
UniProtKB:P41695 · SGD:S000003420PMID:9521327 Cahill DP, et al. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature 392(6673):300-3
PMID:17360454 Yuen KW, et al. (2007) Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci U S A 104(10):3925-30
PMID:12096343 Ru HY, et al. (2002) hBUB1 defects in leukemia and lymphoma cells. Oncogene 21(30):4673-9
PMID:11932908 Saeki A, et al. (2002) Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma. Cancer 94(7):2047-54
PMID:11905802 Jallepalli PV and Lengauer C (2001) Chromosome segregation and cancer: cutting through the mystery. Nat Rev Cancer 1(2):109-17
PMID:11400114 Hernando E, et al. (2001) Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer. Int J Cancer 95(4):223-7
PMID:11355300 Reis RM, et al. (2001) Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas. Acta Neuropathol 101(4):297-304
PMID:11283619 Kaplan KB, et al. (2001) A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol 3(4):429-32
PMID:11146226 Haruki N, et al. (2001) Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers. Cancer Lett 162(2):201-5
PMID:10395177 Yamaguchi K, et al. (1999) Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines. Cancer Lett 139(2):183-7
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