This family has 19 members: 3 Arabidopsis thaliana, 2 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 2 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_198760.1 · TAIR:locus:2175663 (SnRK1.3 · AT5G39440 · MUL8_120 · MUL8.120) | SNF1-RELATED PROTEIN KINASE 1.3 |  |
| A. thaliana | NCBI:NP_566843.1 · TAIR:locus:2094672 (SnRK1.2 · AKIN11 · MXE2.18 · AT3G29160) | Arabidopsis SNF1 kinase homolog 11 · SNF1-RELATED PROTEIN KINASE · SNF1-RELATED PROTEIN KINASE 1.2 | |
| A. thaliana | NCBI:NP_850488.1 · TAIR:locus:2102132 (AT3G01090 · T4P13_22 · SnRK1.1 · AKIN10 · T4P13.22) | Arabidopsis SNF1 kinase homolog 10 · SNF1-RELATED PROTEIN KINASE 1.1 · SNF1-RELATED PROTEIN KINASE | |
| C. elegans | WB:WBGene00019801 (PAR2.3 · aak-1) · UniProtKB:P45894 | | |
| C. elegans | WB:WBGene00020142 (aak-2 · T01C8.1) · UniProtKB:Q95ZQ4 (aak-2 · T01C8.1 · AAPK2_CAEEL) | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | |
| D. rerio | ENSEMBL:ENSDARP00000079966 | ||
| D. rerio | ENSEMBL:ENSDARP00000080103 | ||
| D. discoideum | UniProtKB:Q54YF2 · dictyBase:DDB_G0277905 (AMPKα · SNF1 · pkraa · snfA) | AMP-activated protein kinase alpha subunit, AMPK complex alpha subunit, putative protein serine/threonine kinase, SNF/AMP-activated kinase (AMPK), protein kinase, CAMK group, CAMKL family protein kinase, putative CAM kinase | |
| D. melanogaster | UniProtKB:O18645 · FB:FBgn0023169 (EG:132E8.2 · snf1a · Gprk4 · FBgn0023169 · Gprk-4 · AMPK · AMPKalpha · ampkalpha · dAMPKa · CG3051 · SNF1A) | DmAMPK alpha · AMP-activated protein kinase · 5'monophosphate-activated kinase · SNF1A/AMP-activated protein kinase · SNF/AMP-activated protein S/T kinase gamma subunit · G protein-coupled receptor kinase 4 · AMP-dependent kinase | |
| G. gallus | UniProtKB:Q2LAI0 (Q2LAI0 · PRKAA2 · IPI00590626) · ENTREZ:429110 | | |
| G. gallus | UniProtKB:Q2PUH1 (PRKAA1 · Q2PUH1 · IPI00579930) · ENTREZ:427185 | | |
| H. sapiens | ENSEMBL:ENSG00000132356 · UniProtKB:Q13131 (IPI00872459 · PRKAA1 · IPI00872804 · AMPK1 · Q13131 · AAPK1_HUMAN) | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | |
| H. sapiens | ENSEMBL:ENSG00000162409 · UniProtKB:P54646 (IPI00307755 · AAPK2_HUMAN · PRKAA2 · AMPK · AMPK2 · P54646) | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | |
| M. musculus | UniProtKB:Q5EG47 · MGI:MGI:2145955 (Prkaa1) | protein kinase, AMP-activated, alpha 1 catalytic subunit | |
| M. musculus | UniProtKB:Q8BRK8 · MGI:MGI:1336173 (Prkaa2 · AMPKalpha2) | protein kinase, AMP-activated, alpha 2 catalytic subunit | |
| R. norvegicus | UniProtKB:P54645 · RGD:3387 (Prkaa1) | protein kinase, AMP-activated, alpha 1 catalytic subunit | |
| R. norvegicus | RGD:620893 (Prkaa2) · UniProtKB:Q09137 (Prkaa2 · Q09137 · IPI00231190 · Ampk2 · AAPK2_RAT · IPI00201424 · Ampk) | protein kinase, AMP-activated, alpha 2 catalytic subunit · 5'-AMP-activated protein kinase catalytic subunit alpha-2 | |
| S. cerevisiae | UniProtKB:P06782 · SGD:S000002885 (CAT1 · SNF1 · HAF3 · YDR477W · PAS14 · GLC2 · CCR1) | AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family | |
| S. pombe | UniProtKB:O74536 · GeneDB_Spombe:SPCC74.03c (ucp9 · ssp2 · SPCC74.03c) | serine/threonine protein kinase Ssp2 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P06782 · SGD:S000002885 |  11252725 Lumbreras V, et al. Domain fusion between SNF1-related kinase subunits during plant evolution. EMBO Rep. 2001 Jan;2(1):55-60. | The A. thaliana protein AT3G29160.1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows functional expression of A. thaliana AT3G29160.1 (AKIN11) in yeast, but not complementation. | |
| UniProtKB:P06782 · SGD:S000002885 | 8164654 Muranaka T, et al. Characterization of tobacco protein kinase NPK5, a homolog of Saccharomyces cerevisiae SNF1 that constitutively activates expression of the glucose-repressible SUC2 gene for a secreted invertase of S. cerevisiae. Mol Cell Biol. 1994 May;14(5):2958-65. | The N. tabacum protein NPK5 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P06782 · SGD:S000002885 | 14636999 Lovas A, et al. Functional diversity of potato SNF1-related kinases tested in Saccharomyces cerevisiae. Gene. 2003 Dec 4;321:123-9. | The S. tuberosum protein PKIN1 does not complement a homologous mutation in S. cerevisiae. | |
| UniProtKB:P06782 · SGD:S000002885 | 17533513 Thelander M, et al. The moss genes PpSKI1 and PpSKI2 encode nuclear SnRK1 interacting proteins with homologues in vascular plants. Plant Mol Biol. 2007 Jul;64(5):559-73. | The P. patens protein PpSNF1a complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P06782 · SGD:S000002885 | 15831494 Hong SP, et al. Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast. J Biol Chem. 2005 Jun 10;280(23):21804-9. | The M. musculus protein Q9WTK7 was expressed in S. cerevisiae, but complementation was not directly tested. Mouse LKB1 (Q9WTK7) was expressed in a yeast snf1 null mutant to exclude the possibility that LKB1 simply bypasses the requirement for Snf1. | |
| UniProtKB:P06782 · SGD:S000002885 | 1924320 Alderson A, et al. Complementation of snf1, a mutation affecting global regulation of carbon metabolism in yeast, by a plant protein kinase cDNA. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8602-5. | The S. cereale protein RKIN1 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P06782 · SGD:S000002885 | 9484448 Annen F, et al. Characterization of a Sorghum bicolor gene family encoding putative protein kinases with a high similarity to the yeast SNF1 protein kinase. Plant Mol Biol. 1998 Mar;36(4):529-39. | The S. bicolor protein SNFL1 does not complement a homologous mutation in S. cerevisiae. | |
| UniProtKB:P06782 · SGD:S000002885 | 14636999 Lovas A, et al. Functional diversity of potato SNF1-related kinases tested in Saccharomyces cerevisiae. Gene. 2003 Dec 4;321:123-9. | The S. tuberosum protein StubSNF1 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P06782 · SGD:S000002885 | 17533513 Thelander M, et al. The moss genes PpSKI1 and PpSKI2 encode nuclear SnRK1 interacting proteins with homologues in vascular plants. Plant Mol Biol. 2007 Jul;64(5):559-73. | The P. patens protein PpSKI1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows that co-expression of P. patens PpSKI1 and PpSnf1a inhibits the ability of PpSnf1a to complement a yeast snf1 mutant. | |
| UniProtKB:P06782 · SGD:S000002885 | 17533513 Thelander M, et al. The moss genes PpSKI1 and PpSKI2 encode nuclear SnRK1 interacting proteins with homologues in vascular plants. Plant Mol Biol. 2007 Jul;64(5):559-73. | The P. patens protein PpSKI2 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows that co-expression of P. patens PpSKI2 and PpSnf1a inhibits the ability of PpSnf1a to complement a yeast snf1 mutant. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| SGD Disease Papers (3) | |
|---|---|
| UniProtKB:P06782 · SGD:S000002885 | 12397075 Daniel T and Carling D (2002) Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome. J Biol Chem 277(52):51017-24 |
| UniProtKB:P06782 · SGD:S000002885 | 18611432 Rutter GA and Leclerc I (2009) The AMP-regulated kinase family: Enigmatic targets for diabetes therapy. Mol Cell Endocrinol 297(1-2):41-9 |
| 16236260 Rudolph MJ, et al. (2005) Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1. Biochem Biophys Res Commun 337(4):1224-8 | |