P-POD: Princeton Protein Orthology Database: GO3/Nens116

This family has 81 members: 2 Arabidopsis thaliana, 6 Caenorhabditis elegans, 17 Danio rerio, 3 Dictyostelium discoideum, 4 Drosophila melanogaster, 8 Gallus gallus, 13 Homo sapiens, 11 Mus musculus, 10 Rattus norvegicus, 5 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

• Protein Family
• Functional Conservation (5)
• Download Files (5)
• Disease References (5)

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

81 members.

Organism	Protein (Synonyms)	Description	AmiGO
A. thaliana	NCBI:NP_187484.1 · TAIR:locus:2077843 (S6K2 · ATS6K2 · F17O14.19 · ATPK19 · ATPK2 · AT3G08720)	ARABIDOPSIS THALIANA PROTEIN KINASE 2 · ARABIDOPSIS THALIANA SERINE/THREONINE PROTEIN KINASE 2 · Arabidopsis thaliana protein kinase 19
A. thaliana	NCBI:NP_187485.1 · TAIR:locus:2077873 (ATPK6 · ATS6K1 · S6K1 · PK1 · ATPK1 · F17O14.20 · PK6 · AT3G08730)	ROTEIN-SERINE KINASE 6 · ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 1 · PROTEIN-SERINE KINASE · P70 RIBOSOMAL S6 KINASE · PROTEIN-SERINE KINASE 1 · ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 6
C. elegans	WB:WBGene00000102 (C12D8.10 · akt-1) · UniProtKB:Q17941 (C12D8.10 · AKT1_CAEEL · akt-1)	Serine/threonine-protein kinase akt-1
C. elegans	WB:WBGene00000103 (F28H6.1 · akt-2) · UniProtKB:Q9XTG7 (F28H6.1 · akt-2 · AKT2_CAEEL)	Serine/threonine-protein kinase akt-2
C. elegans	WB:WBGene00002189 (kin-1 · ZK909.2) · UniProtKB:P21137
C. elegans	WB:WBGene00004789 (W10G6.2 · sgk-1) · UniProtKB:Q2PJ68 (W10G6.2 · W10G6.2B · sgk-1)	Protein W10G6.2b, partially confirmed by transcript evidence
C. elegans	WB:WBGene00018569 (F47F2.1) · UniProtKB:Q7JP68
C. elegans	WB:WBGene00012929 (rsks-1 · Y47D3A.16) · UniProtKB:Q9NAH6
D. rerio	ENSEMBL:ENSDARP00000012715
D. rerio	ENSEMBL:ENSDARP00000086932
D. rerio	ENSEMBL:ENSDARP00000087028
D. rerio	ENSEMBL:ENSDARP00000050022
D. rerio	ENSEMBL:ENSDARP00000080286
D. rerio	ENSEMBL:ENSDARP00000086600
D. rerio	UniProtKB:A3KMS9 · ZFIN:ZDB-GENE-070424-14 (zgc:158799)
D. rerio	UniProtKB:A4IG56 · ZFIN:ZDB-GENE-070424-62 (sgk3)	serum/glucocorticoid regulated kinase family, member 3
D. rerio	ZFIN:ZDB-GENE-060929-44 (zgc:154065) · UniProtKB:Q08BW4
D. rerio	UniProtKB:Q3ZB92 · ZFIN:ZDB-GENE-050904-4 (prkacb)	protein kinase, cAMP-dependent, catalytic, beta
D. rerio	ZFIN:ZDB-GENE-040801-208 (zgc:91856) · UniProtKB:Q6DBV8
D. rerio	ZFIN:ZDB-GENE-040426-1351 (zgc:64054) · UniProtKB:Q7T374
D. rerio	UniProtKB:Q7ZTW4 · ZFIN:ZDB-GENE-030131-2860 (sgk1)	serum/glucocorticoid regulated kinase 1
D. rerio	UniProtKB:Q802Y3 · ZFIN:ZDB-GENE-040121-5 (akt2l)	v-akt murine thymoma viral oncogene homolog 2, like
D. rerio	UniProtKB:Q802Y7 · ZFIN:ZDB-GENE-040426-2038 (rps6kb1)	ribosomal protein S6 kinase b, polypeptide 1
D. rerio	UniProtKB:Q8UUX0 · ZFIN:ZDB-GENE-031007-5 (akt2)	v-akt murine thymoma viral oncogene homolog 2
D. rerio	ZFIN:ZDB-GENE-030131-7626 (si:ch211-195b13.1) · UniProtKB:Q08BB4
D. discoideum	UniProtKB:P34099 · dictyBase:DDB_G0283907 (DdPK2 · pkacat · cAK · PK2 · PKA · PKA-C · DdPK3 · PK3 · pkaC)	cAMP-dependent protein kinase, protein serine/threonine kinase, protein kinase, AGC group, PKA family protein kinase, protein kinase A catalytic subunit
D. discoideum	UniProtKB:P54644 · dictyBase:DDB_G0268620 (pkfC · Akt · PKB · pkbA · AktPKB · DK1)	protein serine/threonine kinase, protein kinase, AGC group, AKT family protein kinase, AKT/PKB protein kinase
D. discoideum	UniProtKB:P28178 · dictyBase:DDB_G0290157 (DK2 · PKBR1 · pkgB · pkfA · PK2)	protein kinase 2, protein serine/threonine kinase, protein kinase, AGC group, SGK family protein kinase
D. melanogaster	UniProtKB:Q8INB9 · FB:FBgn0010379 (RAC · pAkt · Dakt · Dakt1 · dAkt/PKB · RacPK · l(3)04226 · dAKT/dPKB · DAkt · l(3)89Bq · akt · Akt · akt1 · dAkt1 · PKB/AKT · PKB · dAkt · DPKB · PKB/Akt · Akt1 · DAKT1 · dAKT · Akt/PKB · dAKT1 · CG4006 · DRAC-PK · DAkt1 · PKB/dAKT · DAKT1/PKB · dakt · dakt1 · dPKB · D-Akt · AKT/PKB · AKT)	dAkt kinase · DRAC-PK66; DRAC-PK85 · related to the A and C kinases · Related to PKA to PKC protein kinases
D. melanogaster	UniProtKB:P12370 · FB:FBgn0000273 (pka-C1 · Cos1 · PKA · DCO · CdkA · l(2)cos[[1]] · 6353 · DC0 · pkA · pKA · Pka-C · Costal · pka-c1 · l(2)01272 · Dco · l(2)s4402 · CG4379 · Cos-1 · dPKA · PKAc · dcO · PKAcA · C · PkaC1 · pka · Dcpk · Costal-1 · PKA-C1 · Dc0 · cos1 · dco · Pka-C1 · costal-1 · Pka · Cos)	Protein Kinase A · catalytic subunit of cAMP-dependent protein kinase · PKA catalytic subunit · PKA Cl · protein kinase A · catalytic subunit of PKA · pka C1 · PKA CI · cAMP-dependent protein kinase 1 · cAMP-dependent protein kinase
D. melanogaster	UniProtKB:P16912 · FB:FBgn0000489 (Pk72A · PKA-C3 · PKA · 5-23 · DC2 · Pk?5 · Dpck · Protein-kinase-like-72A · CG6117 · PKA-C-3 · Pka-C3)	PKA C3 · cAMP-dependent protein kinase 3 · cAMP-dependent protein kinase · cAMP-activated protein kinase A · Swiss Cheese
D. melanogaster	UniProtKB:P91656 · FB:FBgn0015806 (p70[S6K] · dp70[S6k] · p70[S6k] · dps6k · dp70s6k · dS6k · s6k11 · s6k · p70S6K · Dp70S6k · l(3)07084 · 7084 · CG10539 · S6k · DS6K · Dp70[s6k] · p70[S6kinase] · Dp70s6k · S6kinase · S6-kinase · ds6k · dS6K · p70/S6K · fs(3)07084 · S6K · p70s6K)	p70 S6K · p70[S6 kinase] · RPS6-p70-protein kinase · dS6 kinase · p70 s6 kinase · S6 kinase
G. gallus	NCBI:XP_417346 · ENTREZ:419166
G. gallus	NCBI:XP_419544 · ENTREZ:421497
G. gallus	NCBI:XP_422379 · ENTREZ:424542
G. gallus	NCBI:XP_416852 · ENTREZ:418656
G. gallus	UniProtKB:O57513 (IPI00582661 · O57513 · akt1) · ENTREZ:395928
G. gallus	UniProtKB:Q5ZJQ4 (IPI00572465 · Q5ZJQ4 · RCJMB04_16g8) · ENTREZ:420167
G. gallus	UniProtKB:Q5ZLW5 (IPI00579385 · RCJMB04_4j14 · Q5ZLW5) · ENTREZ:417637
G. gallus	UniProtKB:Q6U1I9 (IPI00574209 · Q6U1I9) · ENTREZ:395133
H. sapiens	ENSEMBL:ENSG00000142208 · UniProtKB:P31749 (AKT1 · RAC · IPI00012866 · P31749 · PKB · AKT1_HUMAN)	RAC-alpha serine/threonine-protein kinase
H. sapiens	ENSEMBL:ENSG00000105221 · UniProtKB:P31751 (AKT2_HUMAN · P31751 · IPI00012870 · AKT2)	RAC-beta serine/threonine-protein kinase
H. sapiens	ENSEMBL:ENSG00000117020 · UniProtKB:Q9Y243 (IPI00219411 · AKT3 · PKBG · AKT3_HUMAN · IPI00031747 · Q9Y243)	RAC-gamma serine/threonine-protein kinase
H. sapiens	ENSEMBL:ENSG00000072062 · UniProtKB:P17612 (KAPCA_HUMAN · PRKACA · PKACA · IPI00396630 · P17612 · IPI00217960)	cAMP-dependent protein kinase catalytic subunit alpha
H. sapiens	ENSEMBL:ENSG00000142875 · UniProtKB:P22694 (IPI00739595 · IPI00738231 · P22694 · IPI00739094 · KAPCB_HUMAN · IPI00395654 · IPI00376119 · IPI00737651 · IPI00737155 · PRKACB)	cAMP-dependent protein kinase catalytic subunit beta
H. sapiens	ENSEMBL:ENSG00000165059 · UniProtKB:P22612 (PRKACG · KAPCG_HUMAN · P22612 · IPI00219592)	cAMP-dependent protein kinase catalytic subunit gamma
H. sapiens	ENSEMBL:ENSG00000108443 · UniProtKB:P23443 (IPI00216132 · STK14A · RPS6KB1 · IPI00759649 · KS6B1_HUMAN · P23443)	Ribosomal protein S6 kinase beta-1
H. sapiens	ENSEMBL:ENSG00000175634 · UniProtKB:Q9UBS0 (KS6B2_HUMAN · RPS6KB2 · Q9UBS0 · IPI00217069 · STK14B)	Ribosomal protein S6 kinase beta-2
H. sapiens	ENSEMBL:ENSG00000183943 · UniProtKB:P51817 (PRKX · PRKX_HUMAN · IPI00020904 · PKX1 · P51817)	Serine/threonine-protein kinase PRKX
H. sapiens	ENSEMBL:ENSG00000099725 · UniProtKB:O43930 (O43930 · PRKY · PRKY_HUMAN · IPI00288889)	Serine/threonine-protein kinase PRKY
H. sapiens	ENSEMBL:ENSG00000118515 · UniProtKB:O00141 (SGK · IPI00297590 · O00141 · SGK1 · SGK1_HUMAN)	Serine/threonine-protein kinase Sgk1
H. sapiens	ENSEMBL:ENSG00000101049 · UniProtKB:Q9HBY8 (IPI00217154 · SGK2 · IPI00853438 · IPI00009887 · Q9HBY8 · SGK2_HUMAN)	Serine/threonine-protein kinase Sgk2
H. sapiens	ENSEMBL:ENSG00000104205 · UniProtKB:Q96BR1 (IPI00655852 · SGK2 · SGK3_HUMAN · Q96BR1 · SGKL · SGK3)	Serine/threonine-protein kinase Sgk3
M. musculus	UniProtKB:P31750 · MGI:MGI:87986 (Akt1 · Akt · PKBalpha · PKB · PKB/Akt)	thymoma viral proto-oncogene 1
M. musculus	UniProtKB:Q60823 · MGI:MGI:104874 (PKBbeta · PKB · Akt2)	thymoma viral proto-oncogene 2
M. musculus	UniProtKB:Q9WUA6 · MGI:MGI:1345147 (Akt3)	PKB gamma · thymoma viral proto-oncogene 3
M. musculus	UniProtKB:P05132 · MGI:MGI:97592 (Pkaca · Prkaca · PKA · Cs)	protein kinase, cAMP dependent, catalytic, alpha · C alpha
M. musculus	UniProtKB:P68181 · MGI:MGI:97594 (Prkacb · Pkacb)	protein kinase, cAMP dependent, catalytic, beta · cAMP-dependent protein kinase C beta
M. musculus	UniProtKB:Q8BSK8 · MGI:MGI:1270849 (Rps6kb1 · p70s6k · S6K1 · p70/85s6k)	ribosomal protein S6 kinase, polypeptide 1
M. musculus	UniProtKB:Q9Z1M4 · MGI:MGI:1927343 (S6K2 · Rps6kb2)	ribosomal protein S6 kinase, polypeptide 2
M. musculus	UniProtKB:Q922R0 · MGI:MGI:1309999 (Prkx · Pkare)	protein kinase, X-linked
M. musculus	UniProtKB:Q9WVC6 · MGI:MGI:1340062 (Sgk · Sgk1)	serum/glucocorticoid regulated kinase 1
M. musculus	UniProtKB:Q9QZS5 · MGI:MGI:1351318 (Sgk2)	serum/glucocorticoid regulated kinase 2
M. musculus	UniProtKB:Q9ERE3 · MGI:MGI:2182368 (Sgk3 · Cisk · fy)	cytokine-independent survival kinase · serum/glucocorticoid regulated kinase 3
R. norvegicus	UniProtKB:P47196 · RGD:2081 (Akt1)	v-akt murine thymoma viral oncogene homolog 1
R. norvegicus	UniProtKB:P47197 · RGD:2082 (Akt2)	v-akt murine thymoma viral oncogene homolog 2
R. norvegicus	UniProtKB:Q63484 · RGD:62390 (Akt3)	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
R. norvegicus	RGD:3389 (Prkaca) · UniProtKB:P27791 (Prkaca · P27791 · IPI00555215 · KAPCA_RAT · IPI00200013)	protein kinase, cAMP-dependent, catalytic, alpha · cAMP-dependent protein kinase catalytic subunit alpha
R. norvegicus	UniProtKB:P68182 · RGD:1310574 (Prkacb)	protein kinase, cAMP dependent, catalytic, beta
R. norvegicus	RGD:620683 (Rps6kb1) · UniProtKB:P67999 (Rps6kb1 · IPI00760127 · P67999 · KS6B1_RAT · IPI00471630)	ribosomal protein S6 kinase, 70kDa, polypeptide 1 · Ribosomal protein S6 kinase beta-1
R. norvegicus	UniProtKB:Q06226 · RGD:3668 (Sgk1)	serum/glucocorticoid regulated kinase 1
R. norvegicus	UniProtKB:Q8R4U9 · RGD:620232 (Sgk2)	serum/glucocorticoid regulated kinase 2
R. norvegicus	UniProtKB:Q8R4V0 · RGD:620242 (Sgk3)	serum/glucocorticoid regulated kinase 3
R. norvegicus	UniProtKB:Q5BK52 · RGD:1564076 (Prkx)	protein kinase, X-linked
S. cerevisiae	UniProtKB:P06244 · SGD:S000003700 (SRA3 · TPK1 · YJL164C · PKA1)	cAMP-dependent protein kinase catalytic subunit
S. cerevisiae	UniProtKB:P06245 · SGD:S000006124 (PKA2 · TPK2 · PKA3 · YPL203W · YKR1)	cAMP-dependent protein kinase catalytic subunit
S. cerevisiae	UniProtKB:P05986 · SGD:S000001649 (YKL166C · TPK3)	cAMP-dependent protein kinase catalytic subunit
S. cerevisiae	UniProtKB:P12688 · SGD:S000001609 (SLI2 · YPK1 · YKL126W)	Serine/threonine protein kinase required for receptor-mediated endocytosis
S. cerevisiae	UniProtKB:P18961 · SGD:S000004710 (YPK2 · YMR104C · YKR2)	Protein kinase with similarity to serine/threonine protein kinase Ypk1p
S. pombe	UniProtKB:Q9P7J8 · GeneDB_Spombe:SPCC24B10.07 (gad8 · SPCC24B10.07)	serine/threonine protein kinase Gad8
S. pombe	UniProtKB:P40376 · GeneDB_Spombe:SPBC106.10 (git6 · pka1 · tpk · SPBC106.10)	cAMP-dependent protein kinase catalytic subunit Pka1

Protein	Publication	Curator Notes
UniProtKB:P12688 · SGD:S000001609	10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.	The H. sapiens protein Q9HBY8 complements a homologous mutation in S. cerevisiae. A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant.
UniProtKB:P18961 · SGD:S000004710	10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.	The H. sapiens protein Q9HBY8 complements a homologous mutation in S. cerevisiae. A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant.
UniProtKB:P12688 · SGD:S000001609	20516150 Jacquier N, et al. Ypk1, the yeast orthologue of the human serum- and glucocorticoid-induced kinase, is required for efficient uptake of fatty acids. J Cell Sci. 2010 Jul 1;123(Pt 13):2218-27.	The H. sapiens protein SGK1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P12688 · SGD:S000001609	10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.	The R. norvegicus protein Sgk1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P18961 · SGD:S000004710	10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.	The R. norvegicus protein Sgk1 complements a homologous mutation in S. cerevisiae.

Description	Suffix
Sequences in this family	.fasta
mafft aligned Fasta file	.afasta
phyml newick file	.newick
Notung rooted & rearranged newick file	.newick.rooting.0.rearrange.0
Notung Homolog Table	.newick.rooting.0.rearrange.0.homologs.csv

OMIM (3)
ENSEMBL:ENSG00000142208 · UniProtKB:P31749	#114480 BREAST CANCER;;BREAST CANCER, FAMILIALBREAST CANCER, FAMILIAL MALE, INCLUDED
UniProtKB:P12688 · SGD:S000001609	#604370 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1, INCLUDED;;OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1, INCLUDED
	#114500 COLORECTAL CANCER; CRC;;COLON CANCER
SGD Disease Papers (2)
UniProtKB:P18961 · SGD:S000004710	18634833 Zabrocki P, et al. (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80
UniProtKB:P18961 · SGD:S000004710	18634833 Zabrocki P, et al. (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80