P-POD: Princeton Protein Orthology Database: GO3/Jaccard986

This family has 27 members: 5 Arabidopsis thaliana, 2 Caenorhabditis elegans, 2 Danio rerio, 2 Dictyostelium discoideum, 2 Drosophila melanogaster, 3 Gallus gallus, 2 Homo sapiens, 3 Mus musculus, 2 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

• Protein Family
• Functional Conservation (4)
• Download Files (5)
• Disease References (0)

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

27 members.

Organism	Protein (Synonyms)	Description	AmiGO
A. thaliana	NCBI:NP_565477.1 · TAIR:locus:2046016 (RPN1A · AT2G20580 · F23N11.10 · ATRPN1A · F23N11_10)	26S PROTEASOME REGULATORY SUBUNIT S2 1A
A. thaliana	NCBI:NP_171973.1 · TAIR:locus:2010672 (F13M7.20 · F13M7_20 · AT1G04810)
A. thaliana	NCBI:NP_194576.2 · TAIR:locus:2121358 (F20O9_150 · ATRPN1B · F20O9.150 · RPN1B · AT4G28470)	26S PROTEASOME REGULATORY SUBUNIT S2 1B
A. thaliana	NCBI:NP_180832.1 · TAIR:locus:2046402 (F24L7_13 · F24L7.13 · AT2G32730)
A. thaliana	NCBI:NP_192554.1 · TAIR:locus:2128823 (AT4G08140 · F9M13_6 · F9M13.6)
C. elegans	WB:WBGene00004459 (C23G10.4 · rpn-2) · UniProtKB:Q18115 (PSMD1_CAEEL · C23G10.4 · rpn-2)	26S proteasome non-ATPase regulatory subunit 1
C. elegans	WB:WBGene00004458 (T22D1.9 · rpn-1) · UniProtKB:Q9GZH5
D. rerio	UniProtKB:A3KQC7 · ZFIN:ZDB-GENE-040426-810 (psmd1)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
D. rerio	UniProtKB:Q6PHK7 · ZFIN:ZDB-GENE-040426-1480 (psmd2)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
D. discoideum	UniProtKB:Q54JM5 · dictyBase:DDB_G0287953 (psmD1)	26S proteasome regulatory subunit S1, 26S proteasome non-ATPase regulatory subunit 1
D. discoideum	UniProtKB:Q54BC6 · dictyBase:DDB_G0293752 (psmD2)	26S proteasome regulatory subunit S2, 26S proteasome non-ATPase regulatory subunit 2
D. melanogaster	FB:FBgn0028692 (p110 · Rpn2 · dRpn2 · CG11888) · UniProtKB:Q9V3P6
D. melanogaster	FB:FBgn0028695 (p97 · Rpn1 · BcDNA:LD21723 · CG7762) · UniProtKB:Q9VW54
G. gallus	NCBI:XP_424586 · ENTREZ:426976
G. gallus	ENTREZ:424926 · UniProtKB:Q5F418 (PSMD1 · PSMD1_CHICK · RCJMB04_3m24 · IPI00598268 · Q5F418)	26S proteasome non-ATPase regulatory subunit 1
G. gallus	UniProtKB:Q5ZLU4 (Q5ZLU4 · IPI00592623 · RCJMB04_4n15) · ENTREZ:425294
H. sapiens	ENSEMBL:ENSG00000173692 · UniProtKB:Q99460 (PSMD1_HUMAN · IPI00456695 · PSMD1 · IPI00299608 · Q99460)	26S proteasome non-ATPase regulatory subunit 1
H. sapiens	ENSEMBL:ENSG00000175166 · UniProtKB:Q13200 (PSMD2 · Q13200 · PSMD2_HUMAN · IPI00012268 · TRAP2)	26S proteasome non-ATPase regulatory subunit 2
M. musculus	NCBI:XP_895386 · MGI:MGI:3643411
M. musculus	UniProtKB:Q3TXS7 · MGI:MGI:1917497 (S1 · Psmd1 · P112)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
M. musculus	UniProtKB:Q8VDM4 · MGI:MGI:1096584 (TEG-190 · Tex190 · Psmd2)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
R. norvegicus	UniProtKB:O88761 · RGD:621669 (Psmd1)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
R. norvegicus	UniProtKB:Q4FZT9 · RGD:1305752 (Psmd2)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
S. cerevisiae	UniProtKB:P38764 · SGD:S000001069 (NAS1 · YHR027C · RPN1 · HRD2)	Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome
S. cerevisiae	UniProtKB:P32565 · SGD:S000001337 (YIL075C · SEN3 · RPN2)	Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p
S. pombe	UniProtKB:P87048 · GeneDB_Spombe:SPBP19A11.03c (SPBP19A11.03c · mts4 · rpn1)	19S proteasome regulatory subunit Mts4
S. pombe	UniProtKB:O74762 · GeneDB_Spombe:SPBC17D11.07c (SPBC17D11.07c · rpn2)	19S proteasome regulatory subunit Rpn2

Protein	Publication	Curator Notes
UniProtKB:P32565 · SGD:S000001337	16679556 Sharma N, et al. alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress. J Mol Neurosci. 2006;28(2):161-78.	The H. sapiens protein P37840 was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P38764 · SGD:S000001069	8774743 Tsurumi C, et al. cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11. Eur J Biochem. 1996 Aug 1;239(3):912-21.	The H. sapiens protein Q13200 complements a homologous mutation in S. cerevisiae.
UniProtKB:P38764 · SGD:S000001069	8970163 Hampton RY, et al. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell. 1996 Dec;7(12):2029-44.	The H. sapiens protein Q13200 complements a homologous mutation in S. cerevisiae.
UniProtKB:P32565 · SGD:S000001337	8816993 Yokota K, et al. CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p. Mol Biol Cell. 1996 Jun;7(6):853-70.	The H. sapiens protein Q99460 complements a homologous mutation in S. cerevisiae. This paper shows that human p112 cDNA (Q99460) suppressed the growth defect at high temperature of an rpn2 mutant, indicating that p112 is a functional homologue of yeast Rpn2p.

Description	Suffix
Sequences in this family	.fasta
mafft aligned Fasta file	.afasta
phyml newick file	.newick
Notung rooted & rearranged newick file	.newick.rooting.0.rearrange.0
Notung Homolog Table	.newick.rooting.0.rearrange.0.homologs.csv