P-POD: Princeton Protein Orthology Database: GO3/Jaccard986

This family has 27 members: 5 Arabidopsis thaliana, 2 Caenorhabditis elegans, 2 Danio rerio, 2 Dictyostelium discoideum, 2 Drosophila melanogaster, 3 Gallus gallus, 2 Homo sapiens, 3 Mus musculus, 2 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

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27 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_565477.1 · TAIR:locus:2046016 (RPN1A · AT2G20580 · F23N11.10 · ATRPN1A · F23N11_10)26S PROTEASOME REGULATORY SUBUNIT S2 1A⌘
A. thalianaNCBI:NP_171973.1 · TAIR:locus:2010672 (F13M7.20 · F13M7_20 · AT1G04810)⌘
A. thalianaNCBI:NP_194576.2 · TAIR:locus:2121358 (F20O9_150 · ATRPN1B · F20O9.150 · RPN1B · AT4G28470)26S PROTEASOME REGULATORY SUBUNIT S2 1B⌘
A. thalianaNCBI:NP_180832.1 · TAIR:locus:2046402 (F24L7_13 · F24L7.13 · AT2G32730)⌘
A. thalianaNCBI:NP_192554.1 · TAIR:locus:2128823 (AT4G08140 · F9M13_6 · F9M13.6)⌘
C. elegansWB:WBGene00004459 (C23G10.4 · rpn-2) · UniProtKB:Q18115 (PSMD1_CAEEL · C23G10.4 · rpn-2)26S proteasome non-ATPase regulatory subunit 1⌘⌘
C. elegansWB:WBGene00004458 (T22D1.9 · rpn-1) · UniProtKB:Q9GZH5⌘
D. rerioUniProtKB:A3KQC7 · ZFIN:ZDB-GENE-040426-810 (psmd1)proteasome (prosome, macropain) 26S subunit, non-ATPase, 1⌘
D. rerioUniProtKB:Q6PHK7 · ZFIN:ZDB-GENE-040426-1480 (psmd2)proteasome (prosome, macropain) 26S subunit, non-ATPase, 2⌘
D. discoideumUniProtKB:Q54JM5 · dictyBase:DDB_G0287953 (psmD1)26S proteasome regulatory subunit S1, 26S proteasome non-ATPase regulatory subunit 1⌘
D. discoideumUniProtKB:Q54BC6 · dictyBase:DDB_G0293752 (psmD2)26S proteasome regulatory subunit S2, 26S proteasome non-ATPase regulatory subunit 2⌘
D. melanogasterFB:FBgn0028692 (p110 · Rpn2 · dRpn2 · CG11888) · UniProtKB:Q9V3P6⌘
D. melanogasterFB:FBgn0028695 (p97 · Rpn1 · BcDNA:LD21723 · CG7762) · UniProtKB:Q9VW54⌘
G. gallusNCBI:XP_424586 · ENTREZ:426976
G. gallusENTREZ:424926 · UniProtKB:Q5F418 (PSMD1 · PSMD1_CHICK · RCJMB04_3m24 · IPI00598268 · Q5F418)26S proteasome non-ATPase regulatory subunit 1⌘
G. gallusUniProtKB:Q5ZLU4 (Q5ZLU4 · IPI00592623 · RCJMB04_4n15) · ENTREZ:425294⌘
H. sapiensENSEMBL:ENSG00000173692 · UniProtKB:Q99460 (PSMD1_HUMAN · IPI00456695 · PSMD1 · IPI00299608 · Q99460)26S proteasome non-ATPase regulatory subunit 1⌘
H. sapiensENSEMBL:ENSG00000175166 · UniProtKB:Q13200 (PSMD2 · Q13200 · PSMD2_HUMAN · IPI00012268 · TRAP2)26S proteasome non-ATPase regulatory subunit 2⌘
M. musculusNCBI:XP_895386 · MGI:MGI:3643411
M. musculusUniProtKB:Q3TXS7 · MGI:MGI:1917497 (S1 · Psmd1 · P112)proteasome (prosome, macropain) 26S subunit, non-ATPase, 1⌘
M. musculusUniProtKB:Q8VDM4 · MGI:MGI:1096584 (TEG-190 · Tex190 · Psmd2)proteasome (prosome, macropain) 26S subunit, non-ATPase, 2⌘
R. norvegicusUniProtKB:O88761 · RGD:621669 (Psmd1)proteasome (prosome, macropain) 26S subunit, non-ATPase, 1⌘
R. norvegicusUniProtKB:Q4FZT9 · RGD:1305752 (Psmd2)proteasome (prosome, macropain) 26S subunit, non-ATPase, 2⌘
S. cerevisiaeUniProtKB:P38764 · SGD:S000001069 (NAS1 · YHR027C · RPN1 · HRD2)Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome⌘
S. cerevisiaeUniProtKB:P32565 · SGD:S000001337 (YIL075C · SEN3 · RPN2)Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p⌘
S. pombeUniProtKB:P87048 · GeneDB_Spombe:SPBP19A11.03c (SPBP19A11.03c · mts4 · rpn1)19S proteasome regulatory subunit Mts4⌘
S. pombeUniProtKB:O74762 · GeneDB_Spombe:SPBC17D11.07c (SPBC17D11.07c · rpn2)19S proteasome regulatory subunit Rpn2⌘
ProteinPublicationCurator Notes
UniProtKB:P32565 · SGD:S000001337PMID:16679556 Sharma N, et al. alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress. J Mol Neurosci. 2006;28(2):161-78.The H. sapiens protein P37840 was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P38764 · SGD:S000001069PMID:8774743 Tsurumi C, et al. cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11. Eur J Biochem. 1996 Aug 1;239(3):912-21.The H. sapiens protein Q13200 complements a homologous mutation in S. cerevisiae.
UniProtKB:P38764 · SGD:S000001069PMID:8970163 Hampton RY, et al. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell. 1996 Dec;7(12):2029-44.The H. sapiens protein Q13200 complements a homologous mutation in S. cerevisiae.
UniProtKB:P32565 · SGD:S000001337PMID:8816993 Yokota K, et al. CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p. Mol Biol Cell. 1996 Jun;7(6):853-70.The H. sapiens protein Q99460 complements a homologous mutation in S. cerevisiae. This paper shows that human p112 cDNA (Q99460) suppressed the growth defect at high temperature of an rpn2 mutant, indicating that p112 is a functional homologue of yeast Rpn2p.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
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