P-POD: Princeton Protein Orthology Database: GO3/Jaccard915

This family has 28 members: 4 Arabidopsis thaliana, 3 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 2 Escherichia coli, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 8 Saccharomyces cerevisiae, 4 Schizosaccharomyces pombe.

Interactive Java Applets: · Jalview Alignment

GO3/Jaccard915
28 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2006887 (F10C21.1 · AT1G33320) · NCBI:NP_174600.1⌘
A. thalianaNCBI:NP_176647.1 · TAIR:locus:2019449 (F1N19.23 · F1N19_23 · AT1G64660 · ATMGL)ARABIDOPSIS THALIANA METHIONINE GAMMA-LYASE⌘
A. thalianaNCBI:NP_186761.1 · TAIR:locus:2102072 (T4P13_19 · T4P13.19 · CGS · MTO1 · AT3G01120 · CGS1 · ATCYS1 · CYSTATHIONINE-GAMMA-SYNTHASE)CYSTATHIONINE GAMMA-SYNTHASE 1 · A. THALIANA CYSTATHIONINE GAMMA-SYNTHASE 1 · CYSTATHIONINE GAMMA-SYNTHASE · METHIONINE OVERACCUMULATION 1⌘
A. thalianaNCBI:NP_191264.1 · TAIR:locus:2080605 (F24I3.130 · AT3G57050 · F24I3_130 · CBL)cystathionine beta-lyase⌘
C. elegansWB:WBGene00022856 (ZK1127.10 · cth-2) · UniProtKB:P55216⌘
C. elegansWB:WBGene00007533 (C12C8.2) · UniProtKB:O02215⌘
C. elegansWB:WBGene00009048 (F22B8.6 · cth-1) · UniProtKB:O45391⌘
D. rerioUniProtKB:Q6PHI6 · ZFIN:ZDB-GENE-030131-774 (cth)cystathionase (cystathionine gamma-lyase)⌘
D. discoideumUniProtKB:Q55DV9 · dictyBase:DDB_G0269122 (cysA)cystathionine gamma-lyase⌘
D. melanogasterUniProtKB:O97121 · FB:FBgn0000566 (EIP40 · Eip55E · Eip55BD · CG5345 · Eip40)Ecdysone-induced protein 40kD · Ecdysone-induced polypeptide 40kD⌘
E. coliUniProtKB:P00935 · ECOLI:O-SUCCHOMOSERLYASE-MONOMER (b3939 · ECK3931 · metB · MetB · met-1)⌘
E. coliUniProtKB:P06721 · ECOLI:CYSTATHIONINE-BETA-LYASE-MONOMER (ECK3000 · b3008 · metC · MetC)⌘
G. gallusNCBI:XP_422542 · ENTREZ:424716
H. sapiensENSEMBL:ENSG00000116761 · UniProtKB:P32929 (IPI00221301 · CTH · P32929 · CGL_HUMAN · IPI00031557)Cystathionine gamma-lyase⌘
M. musculusUniProtKB:Q8VCN5 · MGI:MGI:1339968 (Cth)cystathionase (cystathionine gamma-lyase)⌘
R. norvegicusUniProtKB:P18757 · RGD:2443 (Cth)cystathionase (cystathionine gamma-lyase)⌘
S. cerevisiaeUniProtKB:P31373 · SGD:S000000010 (STR1 · FUN35 · YAL012W · CYI1 · CYS3)Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine⌘
S. cerevisiaeUniProtKB:P06106 · SGD:S000004294 (MET25 · MET15 · MET17 · YLR303W)Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis⌘
S. cerevisiaeUniProtKB:P47164 · SGD:S000003891 (YJR130C · STR2)Cystathionine gamma-synthase, converts cysteine into cystathionine⌘
S. cerevisiaeUniProtKB:P43623 · SGD:S000001952 (YFR055W · IRC7)Putative cystathionine beta-lyase⌘
S. cerevisiaeUniProtKB:Q12198 · SGD:S000003981 (YLL058W)Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism⌘
S. cerevisiaeUniProtKB:Q04533 · SGD:S000004547 (YML082W)Putative protein predicted to have carbon-sulfur lyase activity⌘
S. cerevisiaeUniProtKB:P53101 · SGD:S000003152 (STR3 · YGL184C)Cystathionine beta-lyase, converts cystathionine into homocysteine⌘
S. cerevisiaeUniProtKB:P38716 · SGD:S000001154 (YHR112C)Putative protein of unknown function⌘
S. pombeUniProtKB:O94350 · GeneDB_Spombe:SPCC11E10.01 (SPCC11E10.01 · SPCC61.06)cystathionine beta-lyase⌘
S. pombeUniProtKB:O13326 · GeneDB_Spombe:SPBC428.11 (SPBC428.11 · met17)homocysteine synthase Met17⌘
S. pombeUniProtKB:O74314 · GeneDB_Spombe:SPBC15D4.09c (SPBC15D4.09c)cystathionine gamma-synthase⌘
S. pombeUniProtKB:O42851 · GeneDB_Spombe:SPAC23A1.14c (SPAC23A1.14c)uncharacterised trans-sulfuration enzyme (predicted) · uncharacterised trans-sulfuration enzyme⌘
ProteinPublicationCurator Notes
UniProtKB:P06106 · SGD:S000004294PMID:12586406 Takagi H, et al. Role of Saccharomyces cerevisiae serine O-acetyltransferase in cysteine biosynthesis. FEMS Microbiol Lett. 2003 Jan 28;218(2):291-7.The E. coli protein cysK does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P06106 · SGD:S000004294PMID:16193226 Matityahu I, et al. Transgenic tobacco plants overexpressing the Met25 gene of Saccharomyces cerevisiae exhibit enhanced levels of cysteine and glutathione and increased tolerance to oxidative stress. Amino Acids. 2006 Mar;30(2):185-94.The S. cerevisiae protein MET17 was expressed in N. tabacum, but complementation was not directly tested. This paper describes overexpression of MET17 in tobacco.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
ENSEMBL:ENSG00000116761 · UniProtKB:P32929#219500 CYSTATHIONINURIA;;CYSTATHIONASE DEFICIENCY
Send questions, suggestions, and comments to: yfgdb@genomics.princeton.edu