This family has 30 members: 3 Arabidopsis thaliana, 2 Caenorhabditis elegans, 3 Danio rerio, 1 Dictyostelium discoideum, 2 Drosophila melanogaster, 2 Escherichia coli, 4 Gallus gallus, 3 Homo sapiens, 3 Mus musculus, 3 Rattus norvegicus, 3 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_191884.1 · TAIR:locus:2077234 (AT3G63250 · HMT2 · ATHMT-2 · HMT-2 · F16M2.100) | HOMOCYSTEINE METHYLTRANSFERASE 2 · HOMOCYSTEINE METHYLTRANSFERASE-2 |  |
| A. thaliana | NCBI:NP_566715.1 · TAIR:locus:2094419 (HMT3 · MWI23.11 · AT3G22740) | | |
| A. thaliana | NCBI:NP_189219.1 · TAIR:locus:2092120 (AT3G25900 · MPE11.15 · ATHMT-1 · HMT-1) | | |
| C. elegans | WB:WBGene00010988 (R03D7.1) · UniProtKB:Q09582 (nos-1 · R03D7.1 · METH_CAEEL) | Probable methionine synthase | |
| C. elegans | WB:WBGene00020491 (T13G4.4) · UniProtKB:Q966F6 | | |
| D. rerio | ENSEMBL:ENSDARP00000057160 | ||
| D. rerio | UniProtKB:Q32LQ4 · ZFIN:ZDB-GENE-030131-947 (bhmt) | betaine-homocysteine methyltransferase | |
| D. rerio | ENSEMBL:ENSDARG00000034430 · UniProtKB:Q5PNQ3 | ||
| D. discoideum | UniProtKB:Q54P92 · dictyBase:DDB_G0284699 (mtr) | cobalamin-dependent methionine synthase, methionine synthase, 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase, dihydropteroate synthase | |
| D. melanogaster | UniProtKB:Q9VJ31 · FB:FBgn0032727 (CG10623) | selenocysteine methyltransferase | |
| D. melanogaster | UniProtKB:Q9VJ32 · FB:FBgn0032726 (BEST:LD26123 · anon-WO0140519.13 · CG10621) | selenocysteine methyltransferase | |
| E. coli | UniProtKB:P13009 · ECOLI:HOMOCYSMETB12-MONOMER (B4019 · HOMOCYSMETB12 · B12-dependent · b4019 · metH · ECK4011 · MetH) | cobalamin-dependent homocysteine transmethylase · homocysteine-N5-methyltetrahydrofolate transmethylase | |
| E. coli | UniProtKB:Q47690 · ECOLI:MMUM-MONOMER (ECK0263 · mmuM · MmuM · yagD · b0261) | homocysteine methyltransferase | |
| G. gallus | NCBI:XP_422936 · ENTREZ:425145 | ||
| G. gallus | NCBI:XP_001235997 · ENTREZ:776478 | ||
| G. gallus | NCBI:XP_414685 · ENTREZ:416371 | ||
| G. gallus | UniProtKB:Q5ZIC7 (RCJMB04_27p10 · IPI00596325 · Q5ZIC7) · ENTREZ:422069 | | |
| H. sapiens | ENSEMBL:ENSG00000145692 · UniProtKB:Q93088 (BHMT1_HUMAN · BHMT · Q93088 · IPI00004101) | Betaine--homocysteine S-methyltransferase 1 | |
| H. sapiens | ENSEMBL:ENSG00000132840 · UniProtKB:Q9H2M3 (IPI00014363 · Q9H2M3 · BHMT2 · BHMT2_HUMAN) | Betaine--homocysteine S-methyltransferase 2 | |
| H. sapiens | ENSEMBL:ENSG00000116984 · UniProtKB:Q99707 (Q99707 · IPI00743284 · METH_HUMAN · MTR) | Methionine synthase | |
| M. musculus | UniProtKB:O35490 · MGI:MGI:1339972 (Bhmt) | betaine-homocysteine methyltransferase | |
| M. musculus | UniProtKB:Q91WS4 · MGI:MGI:1891379 (D13Ucla2 · Bhmt2 · C81077) | betaine-homocysteine methyltransferase 2 | |
| M. musculus | UniProtKB:A6H5Y3 · MGI:MGI:894292 (Mtr · MS) | Methionine synthase · 5-methyltetrahydrofolate-homocysteine methyltransferase | |
| R. norvegicus | UniProtKB:O09171 · RGD:621496 (Bhmt) | betaine-homocysteine methyltransferase | |
| R. norvegicus | UniProtKB:Q68FT5 · RGD:1359418 (Bhmt2) | betaine-homocysteine methyltransferase 2 | |
| R. norvegicus | UniProtKB:Q9Z2Q4 · RGD:621283 (Mtr) | 5-methyltetrahydrofolate-homocysteine methyltransferase | |
| S. cerevisiae | UniProtKB:Q12525 · SGD:S000003985 (YLL062C · MHT1) | S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio | |
| S. cerevisiae | UniProtKB:Q08985 · SGD:S000006194 (YPL273W · SAM4) | S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio | |
| S. cerevisiae | UniProtKB:Q04898 · SGD:S000004940 (YMR321C) | Putative protein of unknown function | |
| S. pombe | UniProtKB:P87138 · GeneDB_Spombe:SPAC57A7.07c (SPAC57A7.07c) | homocysteine methyltransferase | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:Q12525 · SGD:S000003985 |  10747987 Ranocha P, et al. Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis. J Biol Chem. 2000 May 26;275(21):15962-8. | The A. thaliana proteins AT3G25900.1 and AT3G25900.2 complement a homologous mutation in S. cerevisiae. A. thaliana HMT-1 complements a yeast mht1 sam4 double mutant. | |
| UniProtKB:Q08985 · SGD:S000006194 | 10747987 Ranocha P, et al. Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis. J Biol Chem. 2000 May 26;275(21):15962-8. | The A. thaliana proteins AT3G25900.1 and AT3G25900.2 complement a homologous mutation in S. cerevisiae. A. thaliana HMT-1 complements a yeast mht1 sam4 double mutant. | |
| UniProtKB:Q12525 · SGD:S000003985 | 10747987 Ranocha P, et al. Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis. J Biol Chem. 2000 May 26;275(21):15962-8. | The A. thaliana proteins AT3G63250.1 and AT3G63250.2 complement a homologous mutation in S. cerevisiae. A. thaliana HMT-2 complements a yeast mht1 sam4 double mutant. | |
| UniProtKB:Q08985 · SGD:S000006194 | 10747987 Ranocha P, et al. Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis. J Biol Chem. 2000 May 26;275(21):15962-8. | The A. thaliana proteins AT3G63250.1 and AT3G63250.2 complement a homologous mutation in S. cerevisiae. A. thaliana HMT-2 complements a yeast mht1 sam4 double mutant. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (3) | |
|---|---|
| ENSEMBL:ENSG00000116984 · UniProtKB:Q99707 | #250940 METHYLCOBALAMIN DEFICIENCY, cblG TYPE;;HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM,cblG COMPLEMENTATION TYPE |
| ENSEMBL:ENSG00000116984 · UniProtKB:Q99707 | #603174 HOMOCYSTEINEMIA |
| #601634 NEURAL TUBE DEFECTS, FOLATE-SENSITIVE;;NTD, FOLATE-SENSITIVESPINA BIFIDA, FOLATE-SENSITIVE, INCLUDED | |