P-POD: Princeton Protein Orthology Database: GO3/Jaccard710

This family has 33 members: 6 Arabidopsis thaliana, 2 Caenorhabditis elegans, 3 Danio rerio, 1 Dictyostelium discoideum, 2 Drosophila melanogaster, 3 Gallus gallus, 3 Homo sapiens, 3 Mus musculus, 3 Rattus norvegicus, 5 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

33 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_851069.1 · TAIR:locus:2153914 (TTG · K18P6.4 · TTG1 · AT5G24520 · URM23 · K18P6_4)UNARMED 23 · TRANSPARENT TESTA GLABRA 1⌘
A. thalianaNCBI:NP_173317.2 · TAIR:locus:2034990 (F6A14.8 · F6A14_8 · AT1G18830)⌘
A. thalianaNCBI:NP_179544.1 · TAIR:locus:2050388 (F3P11_14 · AT2G19540 · F3P11.14)⌘
A. thalianaNCBI:NP_851024.1 · TAIR:locus:2087433 (MAA21.90 · AT3G63460)⌘
A. thalianaNCBI:NP_172751.1 · TAIR:locus:2010356 (F13K23.16 · LWD1 · ANTHOCYANIN11 · ATAN11 · F13K23_16 · AT1G12910)LIGHT-REGULATED WD 1⌘
A. thalianaNCBI:NP_189298.1 · TAIR:locus:2090792 (MLJ15.4 · AT3G26640 · LWD2)LIGHT-REGULATED WD 2⌘
C. elegansWB:WBGene00009977 (swan-1) · UniProtKB:Q93758⌘
C. elegansWB:WBGene00009976 · UniProtKB:Q93759
D. rerioENSEMBL:ENSDARP00000008006
D. rerioUniProtKB:Q7SYD5 · ZFIN:ZDB-GENE-020919-2 (sec31a)sec31 homolog A (S. cerevisiae)⌘
D. rerioUniProtKB:Q7T3E0 · ZFIN:ZDB-GENE-030131-9511 (wdr68)WD repeat domain 68⌘
D. discoideumUniProtKB:Q55CT5 · dictyBase:DDB_G0270992 (sec31)putative transport protein, WD40 repeat-containing protein⌘
D. melanogasterFB:FBgn0033339 (Sec31 · CG8266 · sec31 · dSec31p · SEC31) · UniProtKB:A1Z7J6⌘
D. melanogasterFB:FBgn0031186 · UniProtKB:Q9VR53
G. gallusNCBI:XP_001232876 · ENTREZ:423764
G. gallusENTREZ:422597 · UniProtKB:Q5F3X8 (RCJMB04_4i13 · SC31A_CHICK · SEC31A · Q5F3X8 · IPI00571140 · SEC31L1)Protein transport protein Sec31A⌘
G. gallusUniProtKB:Q5ZIT1 (RCJMB04_23l24 · Q5ZIT1 · IPI00594361) · ENTREZ:771554⌘
H. sapiensENSEMBL:ENSG00000138674 · UniProtKB:O94979 (KIAA0905 · HSPC334 · IPI00445429 · IPI00746182 · O94979 · IPI00305152 · SEC31L1 · IPI00852741 · IPI00853220 · HSPC275 · SEC31A · IPI00795507 · SC31A_HUMAN · IPI00853290 · IPI00515103)Protein transport protein Sec31A⌘
H. sapiensENSEMBL:ENSG00000075826 · UniProtKB:Q9NQW1 (IPI00023442 · IPI00853302 · Q9NQW1 · IPI00853086 · IPI00426029 · SEC31L2 · SEC31B · SC31B_HUMAN)Protein transport protein Sec31B⌘
H. sapiensENSEMBL:ENSG00000136485 · UniProtKB:P61962 (IPI00006754 · WDR68_HUMAN · P61962 · HAN11 · WDR68)WD repeat-containing protein 68⌘
M. musculusUniProtKB:Q3UPL0 · MGI:MGI:1916412 (HSPC275 · Sec31l1 · ABP125 · Sec31a · ABP130)Sec31 homolog A (S. cerevisiae)⌘
M. musculusUniProtKB:Q3TZ89 · MGI:MGI:2685187 (Sec31b · Sec31l2 · LOC240667)Sec31 homolog B (S. cerevisiae)⌘
M. musculusUniProtKB:P61963 · MGI:MGI:1919083 (Wdr68)WD repeat domain 68⌘
R. norvegicusNCBI:XP_001057433 · RGD:1598329
R. norvegicusNCBI:XP_221032 · RGD:1305140 (Wdr68)WD repeat domain 68⌘
R. norvegicusRGD:620233 (Sec31a) · UniProtKB:Q9Z2Q1 (SC31A_RAT · Sec31l1 · Vap1 · Sec31a · IPI00515833 · IPI00210147 · Q9Z2Q1)SEC31 homolog A (S. cerevisiae) · Protein transport protein Sec31A⌘⌘
S. cerevisiaeUniProtKB:P13712 · SGD:S000000399 (CAC3 · YBR195C · MSI1)Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase⌘
S. cerevisiaeUniProtKB:P39108 · SGD:S000002549 (PEB1 · YDR142C · PEX7 · PAS7)Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins⌘
S. cerevisiaeUniProtKB:Q04225 · SGD:S000004738 (YMR131C · RRB1)Essential nuclear protein involved in early steps of ribosome biogenesis⌘
S. cerevisiaeUniProtKB:P38968 · SGD:S000002354 (WEB1 · YDL195W · SEC31)Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p⌘
S. cerevisiaeUniProtKB:Q12523 · SGD:S000006168 (YPL247C)Putative protein of unknown function⌘
S. pombeUniProtKB:Q9P783 · GeneDB_Spombe:SPBC1711.07 (SPBC1711.07)WD repeat protein Rrb1 · WD repeat protein Rrb1 (predicted)⌘
S. pombeUniProtKB:O13637 · GeneDB_Spombe:SPBC8D2.20c (sec31 · SPBC8D2.20c)COPII-coated vesicle component Sec31 (predicted) · COPII-coated vesicle component Sec31⌘
ProteinPublicationCurator Notes
UniProtKB:P38968 · SGD:S000002354PMID:7760818 Zieler HA, et al. Suppression of mutations in two Saccharomyces cerevisiae genes by the adenovirus E1A protein. Mol Cell Biol. 1995 Jun;15(6):3227-37.The ADENOVIRUS protein E1A was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows suppression of a yeast sec31 null mutant by the adenovirus E1A protein.
UniProtKB:P13712 · SGD:S000000399PMID:8350924 Qian YW, et al. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature. 1993 Aug 12;364(6438):648-52.The H. sapiens protein Q09028 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows that human RbAp48 (Q09028) shows homology to yeast MSI1. However, the authors did not use human RbAp48 to complement a yeast msi1 strain, instead they showed that human RbAp48 mimics the function of yeast Msi1p by suppressing the heat-shock sensitivity of a yeast ira1 strain and RAS2(Val19) strain.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (7)
UniProtKB:P39108 · SGD:S000002549PMID:10212151 Chang CC, et al. (1999) Metabolic control of peroxisome abundance. J Cell Sci 112 ( Pt 10):1579-90
UniProtKB:P39108 · SGD:S000002549PMID:9480815 Shimozawa N, et al. (1998) Peroxisome biogenesis disorders: identification of a new complementation group distinct from peroxisome-deficient CHO mutants and not complemented by human PEX 13. Biochem Biophys Res Commun 243(2):368-71
PMID:9090383 Purdue PE, et al. (1997) Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor. Nat Genet 15(4):381-4
PMID:9090382 Motley AM, et al. (1997) Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor. Nat Genet 15(4):377-80
PMID:9090381 Braverman N, et al. (1997) Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata. Nat Genet 15(4):369-76
PMID:7544797 Slawecki ML, et al. (1995) Identification of three distinct peroxisomal protein import defects in patients with peroxisome biogenesis disorders. J Cell Sci 108 ( Pt 5):1817-29
PMID:10904262 Gould SJ and Valle D (2000) Peroxisome biogenesis disorders: genetics and cell biology. Trends Genet 16(8):340-5
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