P-POD: Princeton Protein Orthology Database: GO3/Jaccard65

This family has 196 members: 11 Arabidopsis thaliana, 14 Caenorhabditis elegans, 23 Danio rerio, 15 Dictyostelium discoideum, 11 Drosophila melanogaster, 27 Gallus gallus, 35 Homo sapiens, 24 Mus musculus, 22 Rattus norvegicus, 6 Saccharomyces cerevisiae, 8 Schizosaccharomyces pombe.

• Protein Family
• Functional Conservation (4)
• Download Files (5)
• Disease References (2)

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

196 members.

Organism	Protein (Synonyms)	Description	AmiGO
A. thaliana	NCBI:NP_181460.3 · TAIR:locus:2056083
A. thaliana	NCBI:NP_181266.2 · TAIR:locus:2049776
A. thaliana	NCBI:NP_193109.1 · TAIR:locus:2119435
A. thaliana	NCBI:NP_200531.1 · TAIR:locus:2165625
A. thaliana	NCBI:NP_567014.2 · TAIR:locus:2097213 (AT3G55020 · T15C9.20)
A. thaliana	NCBI:NP_565706.1 · TAIR:locus:2054477
A. thaliana	NCBI:NP_171975.2 · TAIR:locus:2010662
A. thaliana	NCBI:NP_197097.1 · TAIR:locus:2146117
A. thaliana	NCBI:NP_567836.2 · TAIR:locus:2123859
A. thaliana	NCBI:NP_566323.1 · TAIR:locus:2077472
A. thaliana	NCBI:NP_566172.1 · TAIR:locus:2076949
C. elegans	WB:WBGene00015410 (tbc-6 · C04A2.1) · UniProtKB:Q09445
C. elegans	WB:WBGene00013016 (Y48E1C.3 · tbc-15) · UniProtKB:O18207
C. elegans	WB:WBGene00019915 (tbc-10 · R06B10.5) · UniProtKB:O44873
C. elegans	WB:WBGene00009322 (F32B6.8 · tbc-3) · UniProtKB:O45434
C. elegans	WB:WBGene00012868 (tbc-9 · Y45F10A.6) · UniProtKB:O62462
C. elegans	WB:WBGene00007167 (B0393.2 · rbg-3) · UniProtKB:Q17491 (B0393.2 · rbg-3)	Protein B0393.2, partially confirmed by transcript evidence
C. elegans	WB:WBGene00009726 (tbc-13 · F45E6.3) · UniProtKB:Q20436
C. elegans	WB:WBGene00044061 (tbc-12 · R11B5.1) · UniProtKB:Q21928
C. elegans	WB:WBGene00020770 (T24D11.1 · tbc-4) · UniProtKB:Q22729
C. elegans	WB:WBGene00022880 (tbc-2 · ZK1248.10) · UniProtKB:Q23419 (ZK1248.10)	Putative uncharacterized protein
C. elegans	WB:WBGene00007849 (tbc-19 · C31E10.8) · UniProtKB:Q93316
C. elegans	WB:WBGene00018281 (F41D9.1 · tbc-18) · UniProtKB:Q94222
C. elegans	WB:WBGene00018075 (tbc-11 · F35H12.2) · UniProtKB:Q967F6
C. elegans	WB:WBGene00012894 (tbc-17 · Y46G5A.1) · UniProtKB:Q9U2D8
D. rerio	ENSEMBL:ENSDARP00000078232
D. rerio	ENSEMBL:ENSDARP00000089416
D. rerio	ENSEMBL:ENSDARP00000067199
D. rerio	ENSEMBL:ENSDARP00000083499
D. rerio	ENSEMBL:ENSDARP00000004695
D. rerio	ENSEMBL:ENSDARP00000078788
D. rerio	ENSEMBL:ENSDARP00000055755
D. rerio	ENSEMBL:ENSDARP00000039408
D. rerio	ENSEMBL:ENSDARP00000054436
D. rerio	ENSEMBL:ENSDARP00000096116
D. rerio	ENSEMBL:ENSDARP00000040945
D. rerio	ENSEMBL:ENSDARP00000084048
D. rerio	UniProtKB:Q7T2D0 · ZFIN:ZDB-GENE-040426-2635 (sgsm3)	small G protein signaling modulator 3
D. rerio	UniProtKB:A1L201 · ZFIN:ZDB-GENE-041111-244 (evi5)	ecotropic viral integration site 5
D. rerio	UniProtKB:A1L201 · ENSEMBL:ENSDARG00000070839
D. rerio	ENSEMBL:ENSDARG00000059900 · UniProtKB:A2AW07
D. rerio	ENSEMBL:ENSDARG00000052766 · UniProtKB:A2AW99
D. rerio	UniProtKB:Q1LUN4 · ZFIN:ZDB-GENE-040426-1197 (tbc1d5)	TBC1 domain family, member 5
D. rerio	ENSEMBL:ENSDARG00000061757 · UniProtKB:Q1LVY2
D. rerio	ENSEMBL:ENSDARG00000011088 · UniProtKB:Q1LYR2
D. rerio	UniProtKB:Q566X0 · ZFIN:ZDB-GENE-050417-346 (grtp1b)	growth hormone regulated TBC protein 1b
D. rerio	UniProtKB:Q6PUR3 · ZFIN:ZDB-GENE-041114-144 (tbc1d22a)	TBC1 domain family, member 22a
D. rerio	ZFIN:ZDB-GENE-041210-192 (si:ch211-198d18.2) · UniProtKB:B3DLG6
D. discoideum	NCBI:EAL67019.2 · dictyBase:DDB_G0280955 (DDB_G0280955 · rabGAP)	cyclin-like F-box containing protein, RabGAP/TBC domain-containing protein, putative GTPase activating protein (GAP), disgorgin
D. discoideum	NCBI:EAL66865.2 · dictyBase:DDB_G0281137
D. discoideum	UniProtKB:O96904 · dictyBase:DDB_G0269130 (rabGAP · phgA)	drainin, RabGAP/TBC domain-containing protein, putative GTPase activating protein (GAP)
D. discoideum	dictyBase:DDB_G0289735 · UniProtKB:Q54H32
D. discoideum	dictyBase:DDB_G0284995 · UniProtKB:Q54NT3
D. discoideum	dictyBase:DDB_G0283285 · UniProtKB:Q54RA7
D. discoideum	dictyBase:DDB_G0282303 · UniProtKB:Q54SQ5
D. discoideum	dictyBase:DDB_G0279511 · UniProtKB:Q54WP7
D. discoideum	dictyBase:DDB_G0277967 · UniProtKB:Q54Z16
D. discoideum	dictyBase:DDB_G0276961 · UniProtKB:Q550W0
D. discoideum	dictyBase:DDB_G0275421 (DDB_G0275421) · UniProtKB:Q553U1
D. discoideum	dictyBase:DDB_G0269982 · UniProtKB:Q55CN5
D. discoideum	dictyBase:DDB_G0270856 · UniProtKB:Q55E78
D. discoideum	UniProtKB:Q55EP9 · dictyBase:DDB_G0268794 (bub2)	RabGAP/TBC domain-containing protein, putative GTPase activating protein (GAP), putative mitotic checkpoint protein
D. discoideum	UniProtKB:Q55F14 · dictyBase:DDB_G0269052
D. melanogaster	UniProtKB:A1Z9K4 · FB:FBgn0020620 (CG13351 · RN-tre · DRN-tre · CG8085)	tre oncogene-related protein
D. melanogaster	FB:FBgn0035879 (CG7112) · UniProtKB:Q8MT33
D. melanogaster	FB:FBgn0038855 (CG5745) · UniProtKB:Q95RC5
D. melanogaster	FB:FBgn0038401 (CG5916) · UniProtKB:Q9VEY4
D. melanogaster	FB:FBgn0038304 (CG12241) · UniProtKB:Q9VFB6
D. melanogaster	FB:FBgn0038129 (CG8449) · UniProtKB:Q9VFX6
D. melanogaster	FB:FBgn0037917 (cg5344 · wkd · CG5344 · whacked) · UniProtKB:Q9VGL8
D. melanogaster	FB:FBgn0004879 (CG1093 · plx · pollux) · UniProtKB:Q9VNG9
D. melanogaster	FB:FBgn0037074 (CG7324) · UniProtKB:Q9VP46
D. melanogaster	FB:FBgn0035916 (BEST:LD24460 · CG5978) · UniProtKB:Q9VSM8
D. melanogaster	FB:FBgn0030299 (BcDNA:LD11130 · CG11727 · BcDNA:GH08923) · UniProtKB:Q9VYY9
G. gallus	NCBI:XP_414602 · ENTREZ:416282
G. gallus	NCBI:XP_416941 · ENTREZ:418742
G. gallus	NCBI:XP_001231569 · ENTREZ:768562
G. gallus	NCBI:XP_423511 · ENTREZ:425799
G. gallus	NCBI:XP_413750 · ENTREZ:415364
G. gallus	NCBI:XP_415391 · ENTREZ:417106
G. gallus	NCBI:XP_425583 · ENTREZ:428012
G. gallus	NCBI:XP_001232386 · ENTREZ:422452
G. gallus	NCBI:XP_420352 · ENTREZ:422383
G. gallus	NCBI:XP_001236221 · ENTREZ:776712
G. gallus	NCBI:XP_001234776 · ENTREZ:771498
G. gallus	NCBI:XP_422340 · ENTREZ:424500
G. gallus	NCBI:XP_421043 · ENTREZ:423110
G. gallus	NCBI:XP_001232770 · ENTREZ:422862
G. gallus	NCBI:XP_423827 · ENTREZ:426162
G. gallus	NCBI:XP_424947 · ENTREZ:427374
G. gallus	NCBI:XP_415301 · ENTREZ:417011
G. gallus	NCBI:XP_416245 · ENTREZ:418008
G. gallus	NCBI:XP_420809 · ENTREZ:422863
G. gallus	NCBI:XP_001236608 · ENTREZ:777135
G. gallus	NCBI:XP_418745 · ENTREZ:420646
G. gallus	NCBI:XP_001231528 · ENTREZ:768541
G. gallus	NCBI:XP_001233464 · ENTREZ:771771
G. gallus	NCBI:XP_001236734 · ENTREZ:777266
G. gallus	ENTREZ:424438 · UniProtKB:Q5ZJ17 (RBG1L_CHICK · RCJMB04_21k9 · RABGAP1L · Q5ZJ17 · IPI00582667)	RAB GTPase-activating protein 1-like
G. gallus	UniProtKB:Q5ZIM3 · ENTREZ:419104
G. gallus	UniProtKB:Q5ZMI3 (IPI00583762 · Q5ZMI3 · RCJMB04_1p10) · ENTREZ:428128
H. sapiens	ENSEMBL:ENSG00000142459 · UniProtKB:Q96CN4 (IPI00060473 · EVI5L_HUMAN · Q96CN4 · EVI5L)	EVI5-like protein
H. sapiens	ENSEMBL:ENSG00000067208 · UniProtKB:O60447 (NB4S · O60447 · EVI5_HUMAN · IPI00029661 · EVI5)	Ecotropic viral integration site 5 protein homolog
H. sapiens	ENSEMBL:ENSG00000139835 · UniProtKB:Q5TC63 (IPI00791131 · TBC1D6 · IPI00003052 · Q5TC63 · GRTP1_HUMAN · GRTP1)	Growth hormone-regulated TBC protein 1
H. sapiens	ENSEMBL:ENSG00000152061 · UniProtKB:Q5R372 (Q5R372 · KIAA0471 · IPI00646639 · RABGAP1L · RBG1L_HUMAN · IPI00334655 · IPI00477388 · IPI00006648 · HHL · IPI00418300 · IPI00465119 · IPI00396010 · IPI00641910 · IPI00902948)	RAB GTPase-activating protein 1-like
H. sapiens	ENSEMBL:ENSG00000011454 · UniProtKB:Q9Y3P9 (IPI00016702 · Q9Y3P9 · IPI00386898 · RBGP1_HUMAN · IPI00855799 · IPI00856033 · HSPC094 · RABGAP1)	Rab GTPase-activating protein 1
H. sapiens	ENSEMBL:ENSG00000100359 · UniProtKB:Q96HU1 (RUTBC3 · SGSM3 · SGSM3_HUMAN · IPI00376350 · IPI00236852 · RABGAPLP · MAP · Q96HU1)	Small G protein signaling modulator 3
H. sapiens	ENSEMBL:ENSG00000099992 · UniProtKB:Q9BXI6 (TBC1D10A · TBC1D10 · Q9BXI6 · TB10A_HUMAN · IPI00011167 · EPI64)	TBC1 domain family member 10A
H. sapiens	ENSEMBL:ENSG00000169221 · UniProtKB:Q4KMP7 (FP2461 · IPI00878181 · IPI00465071 · TBC1D10B · Q4KMP7 · TB10B_HUMAN)	TBC1 domain family member 10B
H. sapiens	ENSEMBL:ENSG00000175463 · UniProtKB:Q8IV04 (TB10C_HUMAN · IPI00216811 · Carabin · Q8IV04 · TBC1D10C)
H. sapiens	ENSEMBL:ENSG00000054611 · UniProtKB:Q8WUA7 (Q8WUA7 · C22orf4 · IPI00445622 · TBC1D22A · IPI00011032 · TB22A_HUMAN · IPI00413005)	TBC1 domain family member 22A
H. sapiens	ENSEMBL:ENSG00000065491 · UniProtKB:Q9NU19 (TB22B_HUMAN · C6orf197 · TBC1D22B · Q9NU19 · IPI00002515)	TBC1 domain family member 22B
H. sapiens	ENSEMBL:ENSG00000205019 · UniProtKB:A6NI40 (IPI00735340 · A6NI40 · TB3L2_HUMAN)	TBC1 domain family member 3C-like protein ENSP00000341742
H. sapiens	ENSEMBL:ENSG00000108239 · UniProtKB:O60347 (IPI00847137 · TBC1D12 · O60347 · TBC12_HUMAN · KIAA0608)	TBC1 domain family member 12
H. sapiens	ENSEMBL:ENSG00000107021 · UniProtKB:Q9NVG8 (IPI00301216 · TBC1D13 · TBC13_HUMAN · Q9NVG8)	TBC1 domain family member 13
H. sapiens	ENSEMBL:ENSG00000132405 · UniProtKB:Q9P2M4 (TBC14_HUMAN · TBC1D14 · KIAA1322 · Q9P2M4 · IPI00002347)	TBC1 domain family member 14
H. sapiens	ENSEMBL:ENSG00000214946 · UniProtKB:Q86UD7 (IPI00641942 · IPI00893820 · TBC1D26 · Q86UD7 · IPI00478049 · TBC26_HUMAN)	TBC1 domain family member 26
H. sapiens	ENSEMBL:ENSG00000189375 · UniProtKB:Q2M2D7 (IPI00556226 · TBC28_HUMAN · Q2M2D7 · TBC1D28)	TBC1 domain family member 28
H. sapiens	ENSEMBL:ENSG00000174115 · UniProtKB:Q8IZP1 (TBC3A_HUMAN · TBC1D3A · PRC17 · TBC1D3 · IPI00895782 · Q8IZP1)	TBC1 domain family member 3
H. sapiens	ENSEMBL:ENSG00000189309 · UniProtKB:A6NDS4 (TBC1D3I · A6NDS4 · TBC3B_HUMAN · IPI00748211 · TBC1D3B)	TBC1 domain family member 3B/I
H. sapiens	ENSEMBL:ENSG00000215748 · UniProtKB:Q6IPX1 (Q6IPX1 · TBC3C_HUMAN · TBC1D3C · IPI00412620 · TBC1D3D)	TBC1 domain family member 3C/3D
H. sapiens	ENSEMBL:ENSG00000161583 · UniProtKB:Q6IPX1 (Q6IPX1 · TBC3C_HUMAN · TBC1D3C · IPI00412620 · TBC1D3D)	TBC1 domain family member 3C/3D
H. sapiens	ENSEMBL:ENSG00000197681 · UniProtKB:A6NER0 (A6NER0 · TBC1D3F · TBC1D3E · IPI00472526 · TBC3E_HUMAN)	TBC1 domain family member 3E/3F
H. sapiens	ENSEMBL:ENSG00000185128 · UniProtKB:A6NER0 (A6NER0 · TBC1D3F · TBC1D3E · IPI00472526 · TBC3E_HUMAN)	TBC1 domain family member 3E/3F
H. sapiens	ENSEMBL:ENSG00000188849 · UniProtKB:A6NH17 (TBC3L_HUMAN · IPI00409701 · A6NH17)	TBC1 domain family member 3-like protein LOC729837
H. sapiens	ENSEMBL:ENSG00000133138 · UniProtKB:Q0IIM8 (IPI00419174 · TBC1D8B · Q0IIM8 · TBC8B_HUMAN · IPI00394744)	TBC1 domain family member 8B
H. sapiens	ENSEMBL:ENSG00000197226 · UniProtKB:Q66K14 (Q66K14 · IPI00640908 · IPI00307257 · KIAA0676 · TBC1D9B · TBC9B_HUMAN)	TBC1 domain family member 9B
H. sapiens	ENSEMBL:ENSG00000065882 · UniProtKB:Q86TI0 (Q86TI0 · TBCD1_HUMAN · IPI00164610 · KIAA1108 · TBC1D1)	TBC1 domain family member 1
H. sapiens	ENSEMBL:ENSG00000136111 · UniProtKB:O60343 (TBCD4_HUMAN · O60343 · TBC1D4 · IPI00220901 · KIAA0603)	TBC1 domain family member 4
H. sapiens	ENSEMBL:ENSG00000131374 · UniProtKB:Q92609 (Q92609 · TBCD5_HUMAN · KIAA0210 · TBC1D5 · IPI00022450)	TBC1 domain family member 5
H. sapiens	ENSEMBL:ENSG00000204634 · UniProtKB:O95759 (VRP · O95759 · TBCD8_HUMAN · TBC1D8 · IPI00855843)	TBC1 domain family member 8
H. sapiens	ENSEMBL:ENSG00000109436 · UniProtKB:Q6ZT07 (IPI00848032 · KIAA0882 · IPI00169407 · TBCD9_HUMAN · TBC1D9 · Q6ZT07)	TBC1 domain family member 9
H. sapiens	ENSEMBL:ENSG00000095383 · UniProtKB:Q9BYX2 (TBC1D2 · Q9BYX2 · TBD2A_HUMAN · PARIS1 · TBC1D2A · IPI00097495)	TBC1 domain family member 2A
H. sapiens	ENSEMBL:ENSG00000167202 · UniProtKB:Q9UPU7 (Q9UPU7 · IPI00879627 · TBC1D2B · KIAA1055 · TBD2B_HUMAN · IPI00879800 · IPI00550733)	TBC1 domain family member 2B
H. sapiens	ENSEMBL:ENSG00000129204 · UniProtKB:P35125 (IPI00423565 · HRP1 · UBP6_HUMAN · IPI00423563 · P35125 · IPI00423562 · TRE2 · USP6)	Ubiquitin carboxyl-terminal hydrolase 6
H. sapiens	ENSEMBL:ENSG00000148429 · UniProtKB:Q92738 (KIAA0019 · USP6NL · IPI00921527 · Q92738 · US6NL_HUMAN)	USP6 N-terminal-like protein
M. musculus	NCBI:NP_941066 · MGI:MGI:2652885
M. musculus	NCBI:NP_001034667 · MGI:MGI:2442167 (Evi5l)	ecotropic viral integration site 5 like
M. musculus	NCBI:NP_941049 · MGI:MGI:2681867
M. musculus	UniProtKB:P97366 · MGI:MGI:104736 (Evi5 · NB4S)	ecotropic viral integration site 5
M. musculus	UniProtKB:Q9D3N8 · MGI:MGI:1914040 (Grtp1 · Tbc1d6)	GH regulated TBC protein 1
M. musculus	UniProtKB:A6H6A9 · MGI:MGI:1352507 (Rabgap1l · Hh1)	RAB GTPase activating protein 1-like
M. musculus	UniProtKB:A2AWA9 · MGI:MGI:2385139 (Gapcena · Rabgap1)	RAB GTPase activating protein 1
M. musculus	UniProtKB:Q8VCZ6 · MGI:MGI:1916329 (Rutbc3 · CIP85 · Sgsm3)	small G protein signaling modulator 3
M. musculus	UniProtKB:P58802 · MGI:MGI:2144164 (Tbc1d10 · Tbc1d10a · EPI64)	TBC1 domain family, member 10a
M. musculus	UniProtKB:Q8BHL3 · MGI:MGI:1915699 (Tbc1d10b)	TBC1 domain family, member 10b
M. musculus	UniProtKB:Q8C9V1 · MGI:MGI:1922072 (Tbc1d10c)	TBC1 domain family, member 10c
M. musculus	UniProtKB:Q8R5A6 · MGI:MGI:1289265 (D15Ertd781e · Tbc1d22a)	TBC1 domain family, member 22a
M. musculus	UniProtKB:Q6A039 · MGI:MGI:2384803 (Tbc1d12)	TBC1D12: TBC1 domain family, member 12
M. musculus	UniProtKB:Q8R3D1 · MGI:MGI:2385326 (Tbc1d13)	TBC1 domain family, member 13
M. musculus	UniProtKB:Q8CGA2 · MGI:MGI:1098708 (D5Ertd110e · Tbc1d14)	TBC1 domain family, member 14
M. musculus	UniProtKB:A3KGB4 · MGI:MGI:1918101 (Tbc1d8b)	TBC1 domain family, member 8B
M. musculus	UniProtKB:Q5SVR0 · MGI:MGI:1924045 (Tbc1d9b)	TBC1 domain family, member 9B
M. musculus	UniProtKB:Q60949 · MGI:MGI:1889508 (Tbc1d1)	TBC1 domain family, member 1
M. musculus	UniProtKB:Q8BYJ6 · MGI:MGI:2429660 (Tbc1d4 · KIAA0603 · AS160)	TBC1 domain family, member 4
M. musculus	UniProtKB:Q80XQ2 · MGI:MGI:1919488 (Tbc1d5)	TBC1 domain family, member 5
M. musculus	UniProtKB:Q9Z1A9 · MGI:MGI:1927225 (AD3 · HBLP1 · Tbc1d8)	GRAM domain · BUB2-like protein 1 · TBC1 domain family, member 8
M. musculus	UniProtKB:Q3UYK3 · MGI:MGI:1918560 (Tbc1d9 · C76116)	TBC1 domain family, member 9
M. musculus	UniProtKB:Q3U0J8 · MGI:MGI:1914266 (Tbc1d2b)	TBC1 domain family, member 2B
M. musculus	UniProtKB:Q80XC3 · MGI:MGI:2138893 (TRE2NL · Usp6nl)	USP6 N-terminal like
R. norvegicus	NCBI:XP_574893 · RGD:1564143
R. norvegicus	NCBI:XP_341216 · RGD:1304562 (Tbc1d1)	TBC1 domain family, member 1
R. norvegicus	NCBI:XP_001056443 · RGD:1561626 (Tbc1d5)	TBC1 domain family, member 5
R. norvegicus	NCBI:NP_001075449 · RGD:1311490 (Tbc1d10c)	TBC1 domain family, member 10C
R. norvegicus	NCBI:XP_001070738 · RGD:1310147 (Tbc1d9b)	TBC1 domain family, member 9B
R. norvegicus	NCBI:XP_001069627 · RGD:1304620
R. norvegicus	NCBI:XP_001074235 · RGD:1596351 (LOC686547)	similar to TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)
R. norvegicus	NCBI:XP_231251 · RGD:1304691
R. norvegicus	NCBI:XP_001073298 · RGD:1308221
R. norvegicus	NCBI:XP_001053106 · RGD:1596910 (LOC678774)	similar to TBC1 domain family member 22A
R. norvegicus	NCBI:XP_001077153 · RGD:1591937 (Tbc1d13)	TBC1 domain family, member 13
R. norvegicus	NCBI:XP_001070809 · RGD:1592319 (LOC689443)	similar to TBC1 domain family member 22A
R. norvegicus	NCBI:XP_001078492 · RGD:1306588
R. norvegicus	NCBI:XP_001070749 · RGD:1311786
R. norvegicus	NCBI:XP_001066843 · RGD:1307436
R. norvegicus	NCBI:XP_001055799 · RGD:1595491 (LOC680133)	similar to TBC1 domain family, member 8
R. norvegicus	NCBI:XP_001078373 · RGD:1309191
R. norvegicus	RGD:1309210 (Grtp1) · UniProtKB:Q4QQU7 (IPI00476205 · GRTP1_RAT · Grtp1 · Q4QQU7)	growth hormone regulated TBC protein 1 · Growth hormone-regulated TBC protein 1
R. norvegicus	UniProtKB:Q6P6R7 · RGD:735113 (Sgsm3)	small G protein signaling modulator 3
R. norvegicus	RGD:1309993 (Tbc1d14) · UniProtKB:Q5CD77 (IPI00454404 · Q5CD77 · Tbc1d14 · TBC14_RAT · UR-NR#2)	TBC1 domain family, member 14 · TBC1 domain family member 14
R. norvegicus	UniProtKB:Q587K3 · RGD:1311641 (Tbc1d10a)	TBC1 domain family, member 10a
R. norvegicus	UniProtKB:Q6U1J1 · RGD:1564987 (Tbc1d22b)	TBC1 domain family, member 22B
S. cerevisiae	UniProtKB:Q08484 · SGD:S000005596 (GYP1 · YOR29-21 · YOR070C)	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro)
S. cerevisiae	UniProtKB:P53258 · SGD:S000003332 (YGR100W · MIC1 · MDR1 · GYP2)	Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p
S. cerevisiae	UniProtKB:P48566 · SGD:S000005237 (GYP3 · YNL293W · MSB3)	GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization
S. cerevisiae	UniProtKB:Q12344 · SGD:S000006170 (GYP5 · YPL249C)	GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking
S. cerevisiae	UniProtKB:Q12317 · SGD:S000005472 (MSB4 · YOL112W)	GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p
S. cerevisiae	UniProtKB:Q04322 · SGD:S000004804 (YMR192W · APP2 · GYL1)	Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis
S. pombe	UniProtKB:O59737 · GeneDB_Spombe:SPBC530.01 (gyp1 · SPBC530.01)	GTPase activating protein Gyp1
S. pombe	UniProtKB:O94711 · GeneDB_Spombe:SPCC1259.11c (gyp2 · SPCC1259.11c)	GTPase activating protein Gyp2
S. pombe	UniProtKB:P87234 · GeneDB_Spombe:SPCC4G3.09c (SPCC4G3.09c · gyp3)	GTPase activating protein Gyp3
S. pombe	UniProtKB:Q09830 · GeneDB_Spombe:SPAC4G8.04 (SPAC4G8.04)	GTPase activating protein (predicted) · GTPase activating protein
S. pombe	UniProtKB:Q09844 · GeneDB_Spombe:SPAC23D3.03c (SPAC23D3.03c)	GTPase activating protein
S. pombe	UniProtKB:O43048 · GeneDB_Spombe:SPBC215.01 (SPBC3B9.20 · SPBC215.01)	GTPase activating protein
S. pombe	UniProtKB:Q9URY3 · GeneDB_Spombe:SPAC1952.17c (SPAC1952.17c · SPAC890.01c)	GTPase activating protein
S. pombe	UniProtKB:Q9Y7J5 · GeneDB_Spombe:SPBC1778.09 (SPBC1778.09)	GTPase activating protein

Protein	Publication	Curator Notes
UniProtKB:Q12317 · SGD:S000005472	14521938 Bizimungu C, et al. Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene. Biochem Biophys Res Commun. 2003 Oct 17;310(2):498-504.	The H. sapiens protein Q92738 complements a homologous mutation in S. cerevisiae. Human RN-tre complments a yeast msb3 msb4 double mutant.
UniProtKB:P48566 · SGD:S000005237	14521938 Bizimungu C, et al. Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene. Biochem Biophys Res Commun. 2003 Oct 17;310(2):498-504.	The H. sapiens protein Q92738 complements a homologous mutation in S. cerevisiae. Human RN-tre complments a yeast msb3 msb4 double mutant.
UniProtKB:Q12317 · SGD:S000005472	14521938 Bizimungu C, et al. Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene. Biochem Biophys Res Commun. 2003 Oct 17;310(2):498-504.	The H. sapiens protein P35125 does not complement a homologous mutation in S. cerevisiae. Human Tre2 does not compleent a yeast msb3 msb4 double mutant.
UniProtKB:P48566 · SGD:S000005237	14521938 Bizimungu C, et al. Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene. Biochem Biophys Res Commun. 2003 Oct 17;310(2):498-504.	The H. sapiens protein P35125 does not complement a homologous mutation in S. cerevisiae. Human Tre2 does not compleent a yeast msb3 msb4 double mutant.

Description	Suffix
Sequences in this family	.fasta
mafft aligned Fasta file	.afasta
phyml newick file	.newick
Notung rooted & rearranged newick file	.newick.rooting.0.rearrange.0
Notung Homolog Table	.newick.rooting.0.rearrange.0.homologs.csv

SGD Disease Papers (2)
UniProtKB:Q12317 · SGD:S000005472	16099424 Bizimungu C and Vandenbol M (2005) At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity. Biochem Biophys Res Commun 335(3):883-90
UniProtKB:Q12317 · SGD:S000005472	16099424 Bizimungu C and Vandenbol M (2005) At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity. Biochem Biophys Res Commun 335(3):883-90