P-POD: Princeton Protein Orthology Database: GO3/Jaccard61

This family has 201 members: 35 Arabidopsis thaliana, 56 Caenorhabditis elegans, 11 Danio rerio, 5 Dictyostelium discoideum, 26 Drosophila melanogaster, 13 Gallus gallus, 13 Homo sapiens, 14 Mus musculus, 14 Rattus norvegicus, 7 Saccharomyces cerevisiae, 7 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Jaccard61
201 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_192655.2 · TAIR:locus:2141563 (AT4G09160 · T8A17_90 · T8A17.90)⌘
A. thalianaNCBI:NP_195184.2 · TAIR:locus:2139564 (COW1 · SRH1 · AT4G34580 · T4L20_160 · T4L20.160)SHORT ROOT HAIR 1 · CAN OF WORMS1⌘
A. thalianaNCBI:NP_973831.1 · TAIR:locus:2006732 (AT1G14820 · F10B6.40 · F10B6_40)⌘
A. thalianaNCBI:NP_851144.1 · TAIR:locus:2171594 (AT5G47180 · MQL5.3 · MQL5_3)⌘
A. thalianaNCBI:NP_567101.1 · TAIR:locus:2101766 ((AT)VAP · AT3G60600 · VAP27 · T4C21.10 · VAP · VAP27-1)VESICLE ASSOCIATED PROTEIN · VAMP/SYNAPTOBREVIN-ASSOCIATED PROTEIN 27-1⌘
A. thalianaNCBI:NP_175980.1 · TAIR:locus:2012040 (AT1G55840 · F14J16_8 · F14J16.8)⌘
A. thalianaNCBI:NP_199562.2 · TAIR:locus:2169038 (AT5G47510 · MNJ7.10 · MNJ7_10)⌘
A. thalianaNCBI:NP_567153.1 · TAIR:locus:2126921 (AT4G00170 · F6N15.21 · F6N15_21)⌘
A. thalianaNCBI:NP_177360.1 · TAIR:locus:2207001 (AT1G72150 · T9N14_1 · PATL1 · T9N14.1)PATELLIN 1⌘
A. thalianaNCBI:NP_177361.1 · TAIR:locus:2207016 (T9N14.8 · AT1G72160 · T9N14_8)⌘
A. thalianaNCBI:NP_564092.1 · TAIR:locus:2013134 (F14P1.2 · F14P1_2 · AT1G19650)⌘
A. thalianaNCBI:NP_201111.2 · TAIR:locus:2161942 (MDC12.2 · AT5G63060 · MDC12_2)⌘
A. thalianaNCBI:NP_200427.3 · TAIR:locus:2161765 (MDA7_22 · MDA7.22 · AT5G56160)⌘
A. thalianaNCBI:NP_195629.2 · TAIR:locus:2136303 (T22F8_80 · AT4G39180 · ATSEC14 · SEC14 · T22F8.80)⌘
A. thalianaNCBI:NP_171669.1 · TAIR:locus:2198135 (T1N6.1 · T1N6_1 · AT1G01630)⌘
A. thalianaNCBI:NP_190735.1 · TAIR:locus:2098282 (AT3G51670 · T18N14.50)⌘
A. thalianaNCBI:NP_565514.1 · TAIR:locus:2049319 (ATSFH3 · SFH3 · AT2G21540 · F3K23.30)SEC14-LIKE 3⌘
A. thalianaNCBI:NP_195382.1 · TAIR:locus:2115320 (AP22.47 · AT4G36640 · AP22_47)⌘
A. thalianaNCBI:NP_568054.1 · TAIR:locus:2136288 (AT4G39170 · T22F8_70 · T22F8.70)⌘
A. thalianaNCBI:NP_199584.1 · TAIR:locus:2160892 (MCA23.5 · MCA23_5 · AT5G47730)⌘
A. thalianaNCBI:NP_001118356.1 · TAIR:locus:2050019 (F3K23.28 · AT2G21520 · F3K23_28)⌘
A. thalianaNCBI:NP_849815.1 · TAIR:locus:2020492 (F20N2.11 · AT1G55690)⌘
A. thalianaNCBI:NP_001031598.1 · TAIR:locus:2138606 (T32A17.1 · AT4G08690)⌘
A. thalianaNCBI:NP_565387.1 · TAIR:locus:2042634 (F16F14.12 · AT2G16380 · F16F14_12)⌘
A. thalianaNCBI:NP_177670.2 · TAIR:locus:2018416 (F1B16.10 · AT1G75370 · F1B16_10)⌘
A. thalianaNCBI:NP_173669.1 · TAIR:locus:2009502 (AT1G22530 · F12K8.13 · F12K8_13 · PATL2)PATELLIN 2⌘
A. thalianaNCBI:NP_564360.1 · TAIR:locus:2204594 (T5I8_14 · T5I8.14 · AT1G30690)⌘
A. thalianaNCBI:NP_179410.1 · TAIR:locus:2053114 (F8D23.4 · F8D23_4 · AT2G18180)⌘
A. thalianaNCBI:NP_189128.2 · TAIR:locus:2087293 (AT3G24840 · K7P8.31)⌘
A. thalianaNCBI:NP_173637.3 · TAIR:locus:2015066 (AT1G22180 · F16L1.9 · F16L1_9)⌘
A. thalianaNCBI:NP_179963.1 · TAIR:locus:2061461 (T29E15_3 · T29E15.3 · AT2G23830)⌘
A. thalianaNCBI:NP_568006.1 · TAIR:locus:2115265 (ATSFH12 · AT4G36490 · AP22.26 · SFH12 · AP22_26)SEC14-LIKE 12⌘
A. thalianaNCBI:NP_172359.2 · TAIR:locus:2025585 (F22O13_31 · AT1G08820 · VAP27-2 · F22O13.31)VAMP/SYNAPTOBREVIN-ASSOCIATED PROTEIN 27-2⌘
A. thalianaNCBI:NP_182039.1 · TAIR:locus:2055557 (PVA12 · T14P1.5 · AT2G45140)PLANT VAP HOMOLOG 12⌘
A. thalianaNCBI:NP_177653.1 · TAIR:locus:2025202 (F22H5_20 · F22H5.20 · AT1G75170)⌘
C. elegansWB:WBGene00003470 (ZK546.6 · msp-152) · UniProtKB:Q23519⌘
C. elegansWB:WBGene00003432 (C04G2.4 · msp-36) · UniProtKB:P05634⌘
C. elegansUniProtKB:P05634 · WB:WBGene00003463 (ZK1251.6 · msp-76)⌘
C. elegansUniProtKB:P05634 · WB:WBGene00003425 (K07F5.2 · msp-10)⌘
C. elegansUniProtKB:P05634 · WB:WBGene00003449 (msp-56 · K07F5.3)⌘
C. elegansWB:WBGene00003457 (ZK1248.6 · msp-64) · UniProtKB:P53017⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003468 (msp-113 · ZK354.4)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003429 (msp-31 · R05F9.13)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003444 (ZK354.5 · msp-51)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003458 (msp-65 · ZK354.1)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003467 (msp-81 · K07F5.1)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003435 (msp-40 · C33F10.9)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003452 (ZK354.11 · msp-59)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003443 (C34F11.4 · msp-50)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003426 (F36H12.7 · msp-19)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003446 (R13H9.4 · msp-53)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003438 (F58A6.8 · msp-45)⌘
C. elegansUniProtKB:P53017 · WB:WBGene00003469 (K05F1.2 · msp-142)⌘
C. elegansWB:WBGene00003430 (msp-32 · R05F9.3) · UniProtKB:P53018⌘
C. elegansWB:WBGene00003431 (msp-33 · R05F9.8) · UniProtKB:P53019⌘
C. elegansWB:WBGene00003434 (K08F4.8 · msp-38) · UniProtKB:P53020⌘
C. elegansWB:WBGene00003424 (msp-3 · F26G1.7) · UniProtKB:Q19832⌘
C. elegansWB:WBGene00003442 (msp-49 · C34F11.6) · UniProtKB:Q18461⌘
C. elegansWB:WBGene00003450 (R13H9.2 · msp-57) · UniProtKB:Q17856⌘
C. elegansUniProtKB:Q17856 · WB:WBGene00003448 (msp-55 · C09B9.6)⌘
C. elegansWB:WBGene00003456 (K05F1.7 · msp-63) · UniProtKB:Q21244⌘
C. elegansWB:WBGene00003464 (F32B6.6 · msp-77) · UniProtKB:Q9TVW5⌘
C. elegansUniProtKB:Q9TVW5 · WB:WBGene00003466 (T13F2.10 · msp-79)⌘
C. elegansWB:WBGene00003465 (msp-78 · T13F2.11) · UniProtKB:Q94053⌘
C. elegansWB:WBGene00011962 (T23G5.2) · UniProtKB:Q03606⌘
C. elegansWB:WBGene00009241 · UniProtKB:Q19895
C. elegansWB:WBGene00008929 · UniProtKB:O01324
C. elegansWB:WBGene00010370 · UniProtKB:O17907
C. elegansWB:WBGene00018008 (F33D11.11 · vpr-1) · UniProtKB:O44782 (F33D11.11 · vpr-1)Major sperm protein⌘⌘
C. elegansWB:WBGene00019268 (H41C03.1) · UniProtKB:O76636⌘
C. elegansWB:WBGene00015148 (B0336.11) · UniProtKB:Q10956⌘
C. elegansWB:WBGene00007987 (C36H8.1) · UniProtKB:Q18503 (C36H8.1)Protein C36H8.1, partially confirmed by transcript evidence⌘⌘
C. elegansWB:WBGene00010985 · UniProtKB:Q21660
C. elegansWB:WBGene00011756 · UniProtKB:Q22467
C. elegansWB:WBGene00020847 (T27A10.7 · cgr-1) · UniProtKB:Q22824⌘
C. elegansWB:WBGene00022884 (ZK1248.17) · UniProtKB:Q23428⌘
C. elegansWB:WBGene00022760 (ZK546.3) · UniProtKB:Q23524⌘
C. elegansWB:WBGene00023500 · UniProtKB:Q5WRP2
C. elegansWB:WBGene00011404 · UniProtKB:Q8I4G3
C. elegansWB:WBGene00008987 · UniProtKB:Q93546
C. elegansWB:WBGene00003462 (msp-74 · F09C12.7) · UniProtKB:Q95PJ7⌘
C. elegansUniProtKB:Q95PJ7 · WB:WBGene00019026 (F58A6.9)⌘
C. elegansUniProtKB:Q95PJ7 · WB:WBGene00022875 (ZK1248.4)⌘
C. elegansWB:WBGene00022005 (Y59H11AM.1) · UniProtKB:Q95XU7⌘
C. elegansWB:WBGene00021997 (Y59E9AR.1) · UniProtKB:Q9N2M1⌘
C. elegansUniProtKB:Q9N2M1 · WB:WBGene00022002 (Y59E9AR.7)⌘
C. elegansWB:WBGene00013047 (Y50E8A.2) · UniProtKB:Q9NAF5⌘
C. elegansWB:WBGene00013658 (Y105C5B.19) · UniProtKB:Q9NAM2 (Y105C5B.19)Protein Y105C5B.19, confirmed by transcript evidence⌘⌘
C. elegansWB:WBGene00010951 (M199.2) · UniProtKB:Q9NAP2⌘
C. elegansWB:WBGene00013777 (Y116A8A.7) · UniProtKB:Q9U2V8⌘
C. elegansWB:WBGene00013773 (Y116A8A.2) · UniProtKB:Q9U2W1⌘
D. rerioENSEMBL:ENSDARP00000089486
D. rerioZFIN:ZDB-GENE-041014-313 (si:ch211-199i15.4) · UniProtKB:Q5SPP0⌘
D. rerioENSEMBL:ENSDARG00000059729 · UniProtKB:A2BIR0
D. rerioUniProtKB:Q5U377 · ZFIN:ZDB-GENE-041114-1 (mospd2)motile sperm domain containing 2⌘
D. rerioUniProtKB:Q6DGS7 · ZFIN:ZDB-GENE-040718-281 (vapal)VAMP (vesicle-associated membrane protein)-associated protein A, like⌘
D. rerioUniProtKB:Q6P027 · ZFIN:ZDB-GENE-040426-1870 (rlbp1b)retinaldehyde binding protein 1b⌘
D. rerioUniProtKB:Q6P2B0 · ZFIN:ZDB-GENE-030131-2348 (vapb)vesicle-associated membrane protein, associated protein B and C⌘
D. rerioUniProtKB:Q6PC74 · ZFIN:ZDB-GENE-040426-1662 (rlbp1a)retinaldehyde binding protein 1a⌘
D. rerioUniProtKB:Q7SXS4 · ZFIN:ZDB-GENE-030131-296 (ttpal)tocopherol (alpha) transfer protein-like⌘
D. rerioUniProtKB:Q6P0D4 · ZFIN:ZDB-GENE-030131-6540 (vapa)VAMP (vesicle-associated membrane protein)-associated protein A⌘
D. rerioUniProtKB:Q803G8 · ZFIN:ZDB-GENE-040426-801 (sec14l1)SEC14-like 1 (S. cerevisiae)⌘
D. discoideumNCBI:EAL60615.1 · dictyBase:DDB_G0293606 (DDB_G0293606)cellular retinaldehyde-binding/triple function domain-containing protein, cellular retinaldehyde binding/alpha-tocopherol transport family protein⌘
D. discoideumNCBI:EAL67988.1 · dictyBase:DDB_G0278773 (DDB_G0278773)major sperm protein (MSP) domain-containing protein, vesicle-associated membrane protein-associated (VAP) related protein⌘
D. discoideumNCBI:EAL69436.1 · dictyBase:DDB_G0275959 (DDB_G0275959)cellular retinaldehyde-binding/triple function domain-containing protein⌘
D. discoideumNCBI:EAL72361.1 · dictyBase:DDB_G0270022 (DDB_G0270022)cellular retinaldehyde-binding/triple function domain-containing protein⌘
D. discoideumUniProtKB:Q55CU8 · dictyBase:DDB_G0269182 (rsc5)cellular retinaldehyde-binding/triple function domain-containing protein⌘
D. melanogasterFB:FBgn0031814 (real-time · CG9528 · retm) · UniProtKB:Q9VMD6⌘
D. melanogasterFB:FBgn0033434 · UniProtKB:Q7K1M4
D. melanogasterUniProtKB:Q8I099 · FB:FBgn0037323 (CG2663)alpha tocopherol transfer protein⌘
D. melanogasterUniProtKB:Q8I935 · FB:FBgn0053523 (BcDNA:GH09028 · CG33523 · CG32410 · CG10727 · CG10977)MSP protein⌘
D. melanogasterFB:FBgn0052485 · UniProtKB:Q8I941
D. melanogasterFB:FBgn0051636 (CG31636 · CG13770) · UniProtKB:Q8IPJ5⌘
D. melanogasterFB:FBgn0050339 (CG30339 · BcDNA:RE54230) · UniProtKB:Q8SXR4⌘
D. melanogasterFB:FBgn0033437 (CG12926) · UniProtKB:Q8SXZ7⌘
D. melanogasterFB:FBgn0035146 (CG13893) · UniProtKB:Q8SYC4⌘
D. melanogasterFB:FBgn0039107 (CG10300) · UniProtKB:Q8SYC9⌘
D. melanogasterFB:FBgn0031913 (CG5958) · UniProtKB:Q8SYZ8⌘
D. melanogasterFB:FBgn0051826 (CG13241 · CG31826 · BG:DS09217.6) · UniProtKB:Q8T413⌘
D. melanogasterFB:FBgn0052407 · UniProtKB:Q8T8U3
D. melanogasterFB:FBgn0032785 (CG10026) · UniProtKB:Q8T9G7⌘
D. melanogasterFB:FBgn0023525 (62D9.a · CG18842 · BEST:GM01072 · EG:30B8.3 · CG3191) · UniProtKB:Q95R34⌘
D. melanogasterFB:FBgn0039864 · UniProtKB:Q9V9V4
D. melanogasterFB:FBgn0039106 · UniProtKB:Q9VCJ3
D. melanogasterUniProtKB:Q9VD09 · FB:FBgn0038966 (CT33362 · pinta · CG13848)prolonged depolarization afterpotential (PDA) is not apparent⌘
D. melanogasterFB:FBgn0032783 (CG10237) · UniProtKB:Q9VIW5⌘
D. melanogasterFB:FBgn0031914 (CG5973) · UniProtKB:Q9VM11⌘
D. melanogasterUniProtKB:Q9VRP8 · FB:FBgn0035636 (CG10546 · Cralbp · CRALBP)Cellular retinaldehyde binding protein⌘
D. melanogasterFB:FBgn0028379 (fan · CG7919 · farinelli) · UniProtKB:Q9VSD3⌘
D. melanogasterUniProtKB:Q9VTY1 · FB:FBgn0036289 (CG10657 · BEST:LD32330)retinaldehyde-binding related protein⌘
D. melanogasterFB:FBgn0029863 (CG3823) · UniProtKB:Q9W408⌘
D. melanogasterUniProtKB:Q9W4N8 · FB:FBgn0029687 (l(1)G0231 · VAP33-A · vap-33A · dVAP33A · VAPB · anon-WO03040301.124 · BcDNA:GM03307 · CG5014 · anon-EST:Liang-2.42 · dVAP · DVAP-33A · VAP-33-1 · VAP-33 · Vap-33-1)clone 2.42⌘
D. melanogasterFB:FBgn0029608 (CG3091) · UniProtKB:Q9W503⌘
G. gallusNCBI:XP_416825 · ENTREZ:418627
G. gallusNCBI:XP_415614 · ENTREZ:417350
G. gallusNCBI:XP_419223 · ENTREZ:421141
G. gallusNCBI:XP_426173 · ENTREZ:428616
G. gallusNCBI:XP_414710 · ENTREZ:416396
G. gallusNCBI:XP_001234376 · ENTREZ:771074
G. gallusNCBI:XP_001236132 · ENTREZ:776618
G. gallusNCBI:XP_415298 · ENTREZ:417008
G. gallusNCBI:XP_001235701 · ENTREZ:776156
G. gallusNCBI:NP_001019865 · ENTREZ:415492
G. gallusUniProtKB:Q5F355 (IPI00651591 · Q5F355 · RCJMB04_34d4) · ENTREZ:419197⌘
G. gallusUniProtKB:Q5F419 (RCJMB04_3m23 · Q5F419 · IPI00583274) · ENTREZ:768928⌘
G. gallusUniProtKB:Q5ZJJ3 (RCJMB04_17k23 · IPI00603449 · Q5ZJJ3) · ENTREZ:419317⌘
H. sapiensENSEMBL:ENSG00000130150 · UniProtKB:Q8NHP6 (IPI00169283 · MOSPD2 · MSPD2_HUMAN · IPI00604606 · Q8NHP6)Motile sperm domain-containing protein 2⌘
H. sapiensENSEMBL:ENSG00000177182 · UniProtKB:Q8IUQ0 (RLBP1L1 · CRALBPL · RLBL1_HUMAN · IPI00385813 · IPI00292661 · Q8IUQ0)Retinaldehyde-binding protein 1-like protein 1⌘
H. sapiensENSEMBL:ENSG00000146352 · UniProtKB:Q5SYC1 (C6orf212 · IPI00646640 · IPI00646147 · RLBL2_HUMAN · C6orf213 · RLBP1L2 · Q5SYC1)Retinaldehyde-binding protein 1-like protein 2⌘
H. sapiensENSEMBL:ENSG00000140522 · UniProtKB:P12271 (P12271 · RLBP1_HUMAN · IPI00218633 · RLBP1 · CRALBP)Retinaldehyde-binding protein 1⌘
H. sapiensENSEMBL:ENSG00000129657 · UniProtKB:Q92503 (Q92503 · SEC14L1 · S14L1_HUMAN · IPI00021887 · SEC14L)SEC14-like protein 1⌘
H. sapiensENSEMBL:ENSG00000100003 · UniProtKB:O76054 (S14L2_HUMAN · KIAA1658 · C22orf6 · SEC14L2 · IPI00018314 · KIAA1186 · O76054)SEC14-like protein 2⌘
H. sapiensENSEMBL:ENSG00000100012 · UniProtKB:Q9UDX4 (S14L3_HUMAN · TAP2 · SEC14L3 · IPI00894186 · Q9UDX4)SEC14-like protein 3⌘
H. sapiensENSEMBL:ENSG00000133488 · UniProtKB:Q9UDX3 (IPI00004815 · Q9UDX3 · S14L4_HUMAN · SEC14L4 · TAP3)SEC14-like protein 4⌘
H. sapiensENSEMBL:ENSG00000103184 · UniProtKB:O43304 (KIAA0420 · SEC14L5 · O43304 · S14L5_HUMAN · IPI00853360)SEC14-like protein 5⌘
H. sapiensENSEMBL:ENSG00000124120 · UniProtKB:Q9BTX7 (TTPAL · TTPAL_HUMAN · C20orf121 · Q9BTX7 · IPI00013624)Alpha-tocopherol transfer protein-like⌘
H. sapiensENSEMBL:ENSG00000137561 · UniProtKB:P49638 (TPP1 · P49638 · TTPA_HUMAN · IPI00027692 · TTPA)Alpha-tocopherol transfer protein⌘
H. sapiensENSEMBL:ENSG00000101558 · UniProtKB:Q9P0L0 (Q9P0L0 · IPI00170692 · VAPA_HUMAN · VAP33 · VAPA)Vesicle-associated membrane protein-associated protein A⌘
H. sapiensENSEMBL:ENSG00000124164 · UniProtKB:O95292 (O95292 · VAPB_HUMAN · IPI00748221 · IPI00006211 · VAPB · UNQ484/PRO983)Vesicle-associated membrane protein-associated protein B/C⌘
M. musculusNCBI:NP_001121197 · MGI:MGI:3616084
M. musculusNCBI:NP_083053 · MGI:MGI:1921386
M. musculusNCBI:NP_001025108 · MGI:MGI:3617848
M. musculusUniProtKB:Q9CWP6 · MGI:MGI:1924013 (Mospd2)motile sperm domain containing 2⌘
M. musculusUniProtKB:Q9D4C9 · MGI:MGI:1921688 (Rlbp1l1)retinaldehyde binding protein 1-like 1⌘
M. musculusUniProtKB:Q8BG92 · MGI:MGI:2443223 (Rlbp1l2)retinaldehyde binding protein 1-like 2⌘
M. musculusUniProtKB:Q9Z275 · MGI:MGI:97930 (Rlbp1 · CRALBP)retinaldehyde binding protein 1⌘
M. musculusUniProtKB:Q99J08 · MGI:MGI:1915065 (tap · Spf · Sec14l2)SEC14-like 2 (S. cerevisiae)⌘
M. musculusUniProtKB:Q8R0F9 · MGI:MGI:2144095 (Sec14l4)SEC14-like 4 (S. cerevisiae)⌘
M. musculusUniProtKB:Q9D3D0 · MGI:MGI:1923330 (Ttpal)tocopherol (alpha) transfer protein-like⌘
M. musculusUniProtKB:Q8BWP5 · MGI:MGI:1354168 (alpha-TTP · Ttpa)alpha TTP · tocopherol (alpha) transfer protein⌘
M. musculusUniProtKB:Q9WV55 · MGI:MGI:1353561 (VAP33 · Vapa)vesicle-associated membrane protein, associated protein A · synaptobrevin-associated protein of 33kDa⌘
M. musculusUniProtKB:Q9QY76 · MGI:MGI:1928744 (VAP33b · D2Abb2e · Vapb)vesicle-associated membrane protein, associated protein B and C · VAMP-associated protein 33b⌘
M. musculusMGI:MGI:1919326 · UniProtKB:Q9D8A4
R. norvegicusNCBI:XP_343783 · RGD:1563952
R. norvegicusNCBI:XP_001063324 · RGD:1564200 (RGD1564200)similar to hypothetical protein MGC34646⌘
R. norvegicusNCBI:XP_220173 · RGD:1564638 (RGD1564638)similar to KIAA0420⌘
R. norvegicusNCBI:XP_001057142 · RGD:1306801
R. norvegicusNCBI:XP_573640 · RGD:1565810 (Sec14l4)SEC14-like 4 (S. cerevisiae)⌘
R. norvegicusNCBI:XP_001064754 · RGD:1309649 (Rlbp1)retinaldehyde binding protein 1⌘
R. norvegicusNCBI:XP_001081756 · RGD:1563123
R. norvegicusNCBI:XP_001069672 · RGD:1305754
R. norvegicusRGD:621779 (Sec14l2) · UniProtKB:Q99MS0 (Sec14l2 · Q99MS0 · IPI00777782 · S14L2_RAT)SEC14-like 2 (S. cerevisiae) · SEC14-like protein 2⌘⌘
R. norvegicusUniProtKB:Q9Z1J8 · RGD:620812 (Sec14l3)SEC14-like 3 (S. cerevisiae)⌘
R. norvegicusUniProtKB:P41034 · RGD:3915 (Ttpa)tocopherol (alpha) transfer protein⌘
R. norvegicusUniProtKB:Q9Z270 · RGD:61803 (Vapa)VAMP (vesicle-associated membrane protein)-associated protein A⌘
R. norvegicusUniProtKB:Q9Z269 · RGD:68326 (Vapb)VAMP (vesicle-associated membrane protein)-associated protein B and C⌘
R. norvegicusNCBI:XP_001054144 · RGD:1304785
S. cerevisiaeUniProtKB:Q06705 · SGD:S000004372 (YLR380W · CSR1 · SFH2)Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions⌘
S. cerevisiaeUniProtKB:P53860 · SGD:S000005175 (YNL231C · SFH3 · PDR16)Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p⌘
S. cerevisiaeUniProtKB:P53844 · SGD:S000005208 (YNL264C · PDR17 · ISS1 · SFH4)Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition⌘
S. cerevisiaeUniProtKB:Q6Q595 · SGD:S000007228 (YBL091C-A · SCS22)Protein involved in regulation of phospholipid metabolism⌘
S. cerevisiaeUniProtKB:P40075 · SGD:S000000922 (SCS2 · YER120W)Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog⌘
S. cerevisiaeUniProtKB:P24280 · SGD:S000004684 (PIT1 · YMR079W · SEC14)Phosphatidylinositol/phosphatidylcholine transfer protein⌘
S. cerevisiaeUniProtKB:P33324 · SGD:S000001574 (SFH1 · YKL091C)Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism⌘
S. pombeUniProtKB:Q10137 · GeneDB_Spombe:SPAC3H8.10 (sec14 · SPAC3H8.10 · spo20)sec14 cytosolic factor family Sec14⌘
S. pombeUniProtKB:Q10138 · GeneDB_Spombe:SPAC3H8.02 (SPAC3H8.02)sec14 cytosolic factor family⌘
S. pombeUniProtKB:Q10484 · GeneDB_Spombe:SPAC17C9.12 (SPAC17C9.12)MSP domain⌘
S. pombeUniProtKB:Q9UUC2 · GeneDB_Spombe:SPBC365.01 (SPBC365.01)sec14 cytosolic factor family⌘
S. pombeUniProtKB:O60119 · GeneDB_Spombe:SPBC16G5.05c (SPBC16G5.05c)MSP domain⌘
S. pombeUniProtKB:Q9UU99 · GeneDB_Spombe:SPCC23B6.04c (SPCC23B6.04c)sec14 cytosolic factor family⌘
S. pombeUniProtKB:Q9HDZ5 · GeneDB_Spombe:SPAC589.09 (SPAC589.09)sec14 cytosolic factor family⌘
ProteinPublicationCurator Notes
UniProtKB:P40075 · SGD:S000000922PMID:15668246 Loewen CJ, et al. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem. 2005 Apr 8;280(14):14097-104.The H. sapiens protein VAPA complements a homologous mutation in S. cerevisiae.
UniProtKB:P40075 · SGD:S000000922PMID:15668246 Loewen CJ, et al. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem. 2005 Apr 8;280(14):14097-104.The H. sapiens protein Q9P0L0 complements a homologous mutation in S. cerevisiae. This paper shows partial complementation of a yeast scs2 null mutant by H. sapiens VAP-A (Q9P0L0).
UniProtKB:P24280 · SGD:S000004684PMID:8255295 Hay JC, et al. Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)-activated secretion. Nature. 1993 Dec 9;366(6455):572-5.The S. cerevisiae protein SEC14 was expressed in H. sapiens, but complementation was not directly tested. This paper shows that yeast Sec14p can substitute biochemically for the non-homologous human gene PITP.
UniProtKB:P24280 · SGD:S000004684PMID:15546352 Böhme K, et al. The Arabidopsis COW1 gene encodes a phosphatidylinositol transfer protein essential for root hair tip growth. Plant J. 2004 Dec;40(5):686-98.The A. thaliana protein AT4G34580.1 complements a homologous mutation in S. cerevisiae. This paper shows that a truncated form of A. thaliana COW1 complements a yeast sec14 mutant, but the full-length protein does not.
UniProtKB:P24280 · SGD:S000004684PMID:9874205 Jouannic N, et al. Isolation of a cDNA from Arabidopsis thaliana that complements the sec14 mutant of yeast. Eur J Biochem. 1998 Dec 1;258(2):402-10.The A. thaliana protein AT4G39180.1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (7)
ENSEMBL:ENSG00000140522 · UniProtKB:P12271#136880 FUNDUS ALBIPUNCTATUSRETINITIS PUNCTATA ALBESCENS, INCLUDED
ENSEMBL:ENSG00000137561 · UniProtKB:P49638#607476 NEWFOUNDLAND ROD-CONE DYSTROPHY; NFRCD
#607475 BOTHNIA RETINAL DYSTROPHY;;VASTERBOTTEN DYSTROPHY
#268000 RETINITIS PIGMENTOSA; RP
ENSEMBL:ENSG00000124164 · UniProtKB:O95292#277460 VITAMIN E, FAMILIAL ISOLATED DEFICIENCY OF; VED;;ATAXIA, FRIEDREICH-LIKE, WITH SELECTIVE VITAMIN E DEFICIENCY; AVED;;FRIEDREICH-LIKE ATAXIA
UniProtKB:P40075 · SGD:S000000922#608627 AMYOTROPHIC LATERAL SCLEROSIS 8; ALS8
#182980 SPINAL MUSCULAR ATROPHY, PROXIMAL, ADULT, AUTOSOMAL DOMINANTSPINAL MUSCULAR ATROPHY, LATE-ONSET, FINKEL TYPE, INCLUDED;;FINKEL LATE-ADULT TYPE SMA, INCLUDED
SGD Disease Papers (3)
UniProtKB:P24280 · SGD:S000004684PMID:18468439 Lev S, et al. (2008) The VAP protein family: from cellular functions to motor neuron disease. Trends Cell Biol 18(6):282-90
PMID:15372378 Nishimura AL, et al. (2004) A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Am J Hum Genet 75(5):822-31
UniProtKB:P24280 · SGD:S000004684PMID:17344474 Ryan MM, et al. (2007) Conformational dynamics of the major yeast phosphatidylinositol transfer protein sec14p: insight into the mechanisms of phospholipid exchange and diseases of sec14p-like protein deficiencies. Mol Biol Cell 18(5):1928-42
Send questions, suggestions, and comments to: yfgdb@genomics.princeton.edu