45 members.| Organism | Protein (Synonyms) | Description | AmiGO |
|---|
| A. thaliana | NCBI:NP_181400.2 · TAIR:locus:2064143 (T6A23_14 · T6A23.14 · AT2G38660) | |  |
| A. thaliana | NCBI:NP_178929.1 · TAIR:locus:2054192 (T10J7.26 · T10J7_26 · AT2G12280) | | |
| A. thaliana | NCBI:NP_187837.1 · TAIR:locus:2082254 (AT3G12290 · F28J15.8) | | |
| A. thaliana | NCBI:NP_178923.1 · TAIR:locus:2054213 (T10J7.18 · T10J7_18 · AT2G12200) | | |
| A. thaliana | NCBI:NP_191971.1 · TAIR:locus:2127113 (F6N23.26 · F6N23_26 · AT4G00620) | | |
| A. thaliana | NCBI:NP_191969.1 · TAIR:locus:2127083 (F6N23_28 · AT4G00600 · F6N23.28) | | |
| A. thaliana | NCBI:NP_564571.1 · TAIR:locus:2008101 (F11F12.17 · THFS · AT1G50480) | 10-FORMYLTETRAHYDROFOLATE SYNTHETASE | |
| C. elegans | WB:WBGene00019492 (K07E3.4) · UniProtKB:Q21284 | | |
| C. elegans | WB:WBGene00000929 (dao-3 · K07E3.3) · UniProtKB:Q21285 | | |
| D. rerio | UniProtKB:Q5PNN4 · ZFIN:ZDB-GENE-041001-134 (si:dkey-25e12.6) | | |
| D. rerio | ZFIN:ZDB-GENE-041001-127 (si:dkey-1h6.1) · UniProtKB:Q5RIH2 | | |
| D. rerio | UniProtKB:Q6GMK2 · ZFIN:ZDB-GENE-040704-20 (mthfd2) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | |
| D. rerio | ZFIN:ZDB-GENE-030131-5707 (zgc:63479) · UniProtKB:Q7SY55 | | |
| D. rerio | UniProtKB:Q7ZVV5 · ZFIN:ZDB-GENE-020905-4 (mthfd1) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) | |
| D. discoideum | UniProtKB:Q86KU6 · dictyBase:DDB_G0277725 (thfA) | methylenetetrahydrofolate dehydrogenase (NAD+) | |
| D. discoideum | UniProtKB:Q54G53 · dictyBase:DDB_G0290397 (fthS · FTHFS) | formate-dihydrofolate ligase, formyltetrahydrofolate synthetase | |
| D. discoideum | UniProtKB:Q54RI8 · dictyBase:DDB_G0283121 (DDB_G0283121) | methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase | |
| D. discoideum | UniProtKB:Q54VK0 · dictyBase:DDB_G0280291 (DDB_G0280291) | methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase, methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase, mitochondrial | |
| D. melanogaster | FB:FBgn0020385 (Pugilist · bs14h02.y1 · pugilist · pugD · MTHFD · Pug · CG4067 · pug) · UniProtKB:O96553 | | |
| D. melanogaster | UniProtKB:Q04448 · FB:FBgn0010222 (DNMDMC · CG18466 · dNMDMC · 151767_at · Nmdmc · Dnmdmc) | NAD-dependent methylenetetrahydrofolate dehydrogenase | |
| E. coli | ECOLI:FOLD-MONOMER (ads · FolD · ECK0522 · folD · b0529) · UniProtKB:P24186 | | |
| G. gallus | NCBI:XP_001233663 · ENTREZ:770327 | | |
| G. gallus | NCBI:XP_419672 · ENTREZ:421633 | | |
| G. gallus | ENTREZ:426126 · UniProtKB:Q5ZKA5 (MTDC_CHICK · MTHFD2 · RCJMB04_12b8 · Q5ZKA5 · IPI00588640) | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | |
| G. gallus | UniProtKB:Q5ZI76 (IPI00604008 · Q5ZI76 · RCJMB04_29j22) · ENTREZ:423508 | | |
| H. sapiens | ENSEMBL:ENSG00000100714 · UniProtKB:P11586 (MTHFC · MTHFD · MTHFD1 · P11586 · C1TC_HUMAN · IPI00218342) | C-1-tetrahydrofolate synthase, cytoplasmic | |
| H. sapiens | ENSEMBL:ENSG00000120254 · UniProtKB:Q6UB35 (C1TM_HUMAN · FTHFSDC1 · IPI00552054 · IPI00291646 · MTHFD1L · Q6UB35) | Monofunctional C1-tetrahydrofolate synthase, mitochondrial | |
| H. sapiens | ENSEMBL:ENSG00000163738 · UniProtKB:Q9H903 (MTHFD2L · Q9H903 · MTD2L_HUMAN · IPI00746020 · IPI00873515 · IPI00017391) | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 | |
| H. sapiens | ENSEMBL:ENSG00000065911 · UniProtKB:P13995 (MTHFD2 · MTDC_HUMAN · IPI00011307 · P13995 · NMDMC) | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | |
| M. musculus | NCBI:NP_081064 · MGI:MGI:1915871 | | |
| M. musculus | UniProtKB:Q922D8 · MGI:MGI:1342005 (DCS · Mthfd1 · NEUT2 · Mthfd) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase | |
| M. musculus | UniProtKB:Q3V3R1 · MGI:MGI:1924836 (Fthfsdc1 · Mthfd1l) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | |
| M. musculus | UniProtKB:P18155 · MGI:MGI:1338850 (Mthfd2 · NMDMC) | methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase | |
| R. norvegicus | NCBI:XP_575579 · RGD:1559929 | | |
| R. norvegicus | NCBI:XP_233236 · RGD:1564040 (RGD1564040) | similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15)/methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor | |
| R. norvegicus | NCBI:XP_223282 · RGD:1310879 (Mthfd2l) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | |
| R. norvegicus | NCBI:XP_001056213 · RGD:1593019 | | |
| R. norvegicus | UniProtKB:P27653 · RGD:708531 (Mthfd1) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | |
| R. norvegicus | NCBI:XP_341751 · RGD:1307311 (Mthfd1l) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | |
| S. cerevisiae | UniProtKB:P07245 · SGD:S000003436 (YGR204W · ADE3) | Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine | |
| S. cerevisiae | UniProtKB:P09440 · SGD:S000000288 (YBR084W · MIS1) | Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF) | |
| S. cerevisiae | UniProtKB:Q02046 · SGD:S000001788 (YKR080W · MTD1) | NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units | |
| S. pombe | GeneDB_Spombe:SPBC839.16 (C1-5,6,7,8-tetrahydrofolate · SPBC839.16) · UniProtKB:Q8WZJ7 | | |
| S. pombe | GeneDB_Spombe:SPBC2G2.08 (SPBC2G2.08 · ade9 · C-1-tetrahydrofolatesynthase/methylenetetrahydrofolatedehydrogenase/methylenetetrahydrofolatecyclohydrolase/formyltetrahydrofolatesynthetase) · UniProtKB:O43007 | | |
| S. pombe | UniProtKB:Q9P786 · GeneDB_Spombe:SPBC1711.04 (SPBC1711.04) | methylenetetrahydrofolate reductase | |
2186031 Thigpen AE, et al. Rat C1-tetrahydrofolate synthase. cDNA isolation, tissue-specific levels of the mRNA, and expression of the protein in yeast. J Biol Chem. 1990 May 15;265(14):7907-13.