P-POD: Princeton Protein Orthology Database: GO3/Jaccard459

This family has 45 members: 7 Arabidopsis thaliana, 2 Caenorhabditis elegans, 5 Danio rerio, 4 Dictyostelium discoideum, 2 Drosophila melanogaster, 1 Escherichia coli, 4 Gallus gallus, 4 Homo sapiens, 4 Mus musculus, 6 Rattus norvegicus, 3 Saccharomyces cerevisiae, 3 Schizosaccharomyces pombe.

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GO3/Jaccard459
45 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_181400.2 · TAIR:locus:2064143 (T6A23_14 · T6A23.14 · AT2G38660)⌘
A. thalianaNCBI:NP_178929.1 · TAIR:locus:2054192 (T10J7.26 · T10J7_26 · AT2G12280)⌘
A. thalianaNCBI:NP_187837.1 · TAIR:locus:2082254 (AT3G12290 · F28J15.8)⌘
A. thalianaNCBI:NP_178923.1 · TAIR:locus:2054213 (T10J7.18 · T10J7_18 · AT2G12200)⌘
A. thalianaNCBI:NP_191971.1 · TAIR:locus:2127113 (F6N23.26 · F6N23_26 · AT4G00620)⌘
A. thalianaNCBI:NP_191969.1 · TAIR:locus:2127083 (F6N23_28 · AT4G00600 · F6N23.28)⌘
A. thalianaNCBI:NP_564571.1 · TAIR:locus:2008101 (F11F12.17 · THFS · AT1G50480)10-FORMYLTETRAHYDROFOLATE SYNTHETASE⌘
C. elegansWB:WBGene00019492 (K07E3.4) · UniProtKB:Q21284⌘
C. elegansWB:WBGene00000929 (dao-3 · K07E3.3) · UniProtKB:Q21285⌘
D. rerioUniProtKB:Q5PNN4 · ZFIN:ZDB-GENE-041001-134 (si:dkey-25e12.6)⌘
D. rerioZFIN:ZDB-GENE-041001-127 (si:dkey-1h6.1) · UniProtKB:Q5RIH2⌘
D. rerioUniProtKB:Q6GMK2 · ZFIN:ZDB-GENE-040704-20 (mthfd2)methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase⌘
D. rerioZFIN:ZDB-GENE-030131-5707 (zgc:63479) · UniProtKB:Q7SY55⌘
D. rerioUniProtKB:Q7ZVV5 · ZFIN:ZDB-GENE-020905-4 (mthfd1)methylenetetrahydrofolate dehydrogenase (NADP+ dependent)⌘
D. discoideumUniProtKB:Q86KU6 · dictyBase:DDB_G0277725 (thfA)methylenetetrahydrofolate dehydrogenase (NAD+)⌘
D. discoideumUniProtKB:Q54G53 · dictyBase:DDB_G0290397 (fthS · FTHFS)formate-dihydrofolate ligase, formyltetrahydrofolate synthetase⌘
D. discoideumUniProtKB:Q54RI8 · dictyBase:DDB_G0283121 (DDB_G0283121)methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase⌘
D. discoideumUniProtKB:Q54VK0 · dictyBase:DDB_G0280291 (DDB_G0280291)methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase, methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase, mitochondrial⌘
D. melanogasterFB:FBgn0020385 (Pugilist · bs14h02.y1 · pugilist · pugD · MTHFD · Pug · CG4067 · pug) · UniProtKB:O96553⌘
D. melanogasterUniProtKB:Q04448 · FB:FBgn0010222 (DNMDMC · CG18466 · dNMDMC · 151767_at · Nmdmc · Dnmdmc)NAD-dependent methylenetetrahydrofolate dehydrogenase⌘
E. coliECOLI:FOLD-MONOMER (ads · FolD · ECK0522 · folD · b0529) · UniProtKB:P24186⌘
G. gallusNCBI:XP_001233663 · ENTREZ:770327
G. gallusNCBI:XP_419672 · ENTREZ:421633
G. gallusENTREZ:426126 · UniProtKB:Q5ZKA5 (MTDC_CHICK · MTHFD2 · RCJMB04_12b8 · Q5ZKA5 · IPI00588640)Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial⌘
G. gallusUniProtKB:Q5ZI76 (IPI00604008 · Q5ZI76 · RCJMB04_29j22) · ENTREZ:423508⌘
H. sapiensENSEMBL:ENSG00000100714 · UniProtKB:P11586 (MTHFC · MTHFD · MTHFD1 · P11586 · C1TC_HUMAN · IPI00218342)C-1-tetrahydrofolate synthase, cytoplasmic⌘
H. sapiensENSEMBL:ENSG00000120254 · UniProtKB:Q6UB35 (C1TM_HUMAN · FTHFSDC1 · IPI00552054 · IPI00291646 · MTHFD1L · Q6UB35)Monofunctional C1-tetrahydrofolate synthase, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000163738 · UniProtKB:Q9H903 (MTHFD2L · Q9H903 · MTD2L_HUMAN · IPI00746020 · IPI00873515 · IPI00017391)Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2⌘
H. sapiensENSEMBL:ENSG00000065911 · UniProtKB:P13995 (MTHFD2 · MTDC_HUMAN · IPI00011307 · P13995 · NMDMC)Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial⌘
M. musculusNCBI:NP_081064 · MGI:MGI:1915871
M. musculusUniProtKB:Q922D8 · MGI:MGI:1342005 (DCS · Mthfd1 · NEUT2 · Mthfd)methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase⌘
M. musculusUniProtKB:Q3V3R1 · MGI:MGI:1924836 (Fthfsdc1 · Mthfd1l)methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like⌘
M. musculusUniProtKB:P18155 · MGI:MGI:1338850 (Mthfd2 · NMDMC)methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase⌘
R. norvegicusNCBI:XP_575579 · RGD:1559929
R. norvegicusNCBI:XP_233236 · RGD:1564040 (RGD1564040)similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15)/methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor⌘
R. norvegicusNCBI:XP_223282 · RGD:1310879 (Mthfd2l)methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like⌘
R. norvegicusNCBI:XP_001056213 · RGD:1593019
R. norvegicusUniProtKB:P27653 · RGD:708531 (Mthfd1)methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase⌘
R. norvegicusNCBI:XP_341751 · RGD:1307311 (Mthfd1l)methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like⌘
S. cerevisiaeUniProtKB:P07245 · SGD:S000003436 (YGR204W · ADE3)Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine⌘
S. cerevisiaeUniProtKB:P09440 · SGD:S000000288 (YBR084W · MIS1)Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF)⌘
S. cerevisiaeUniProtKB:Q02046 · SGD:S000001788 (YKR080W · MTD1)NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units⌘
S. pombeGeneDB_Spombe:SPBC839.16 (C1-5,6,7,8-tetrahydrofolate · SPBC839.16) · UniProtKB:Q8WZJ7⌘
S. pombeGeneDB_Spombe:SPBC2G2.08 (SPBC2G2.08 · ade9 · C-1-tetrahydrofolatesynthase/methylenetetrahydrofolatedehydrogenase/methylenetetrahydrofolatecyclohydrolase/formyltetrahydrofolatesynthetase) · UniProtKB:O43007⌘
S. pombeUniProtKB:Q9P786 · GeneDB_Spombe:SPBC1711.04 (SPBC1711.04)methylenetetrahydrofolate reductase⌘
ProteinPublicationCurator Notes
UniProtKB:P07245 · SGD:S000003436PMID:2186031 Thigpen AE, et al. Rat C1-tetrahydrofolate synthase. cDNA isolation, tissue-specific levels of the mRNA, and expression of the protein in yeast. J Biol Chem. 1990 May 15;265(14):7907-13.The R. norvegicus protein Mthfd1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P07245 · SGD:S000003436PMID:2186031 Thigpen AE, et al. Rat C1-tetrahydrofolate synthase. cDNA isolation, tissue-specific levels of the mRNA, and expression of the protein in yeast. J Biol Chem. 1990 May 15;265(14):7907-13.The R. norvegicus protein Mthfd1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (3)
ENSEMBL:ENSG00000100714 · UniProtKB:P11586#114500 COLORECTAL CANCER; CRC;;COLON CANCER
UniProtKB:P09440 · SGD:S000000288#601634 NEURAL TUBE DEFECTS, FOLATE-SENSITIVE;;NTD, FOLATE-SENSITIVESPINA BIFIDA, FOLATE-SENSITIVE, INCLUDED
+172460 METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1; MTHFD1;;METHYLENETETRAHYDROFOLATE DEHYDROGENASE/METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE/FORMYLTETRAHYDROFOLATESYNTHETASE, NADP(+)-DEPENDENT;;CYCLOHYDROLASE/FORMYLTETRAHYDROFOLATE SYNTHETASE, NADP(+)-DEPENDENT;;C1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC;;C1-THF-SYNTHASEABRUPTIO PLACENTAE, SUSCEPTIBILITY TO, INCLUDED
SGD Disease Papers (1)
UniProtKB:P09440 · SGD:S000000288PMID:12134146 Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
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