This family has 46 members: 9 Arabidopsis thaliana, 3 Caenorhabditis elegans, 8 Danio rerio, 2 Dictyostelium discoideum, 2 Drosophila melanogaster, 3 Gallus gallus, 4 Homo sapiens, 3 Mus musculus, 5 Rattus norvegicus, 3 Saccharomyces cerevisiae, 4 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_186907.1 · TAIR:locus:2076884 (F16B3_21 · DWF7 · BUL1 · AT3G02580 · F16B3.21 · STE1) | STEROL 1 · BOULE 1 · DELTA7 STEROL C-5 DESATURASE · DWARF 7 |  |
| A. thaliana | NCBI:NP_565681.1 · TAIR:locus:2043132 (AT2G29390 · F16P2_23 · ATSMO2 · SMO2-2 · F16P2.23) | STEROL 4-ALPHA-METHYL-OXIDASE 2-2 · STEROL 4-ALPHA-METHYL-OXIDASE 2 | |
| A. thaliana | NCBI:NP_192948.1 · TAIR:locus:2118121 (F16J13_180 · F16J13.180 · ATSMO1 · AT4G12110 · SMO1-1 · ATSMO1-1) | STEROL-4ALPHA-METHYL OXIDASE 1-1 · STEROL 4-ALPHA-METHYL-OXIDASE 1 | |
| A. thaliana | NCBI:NP_186908.1 · TAIR:locus:2076899 (F16B3.22 · AT3G02590 · F16B3_22) | | |
| A. thaliana | NCBI:NP_567670.1 · TAIR:locus:505006515 (SMO1 · ATSMO1-2 · SMO1-2 · ATSMO1 · AT4G22756) | STEROL C4-METHYL OXIDASE 1 · STEROL 4-ALPHA-METHYL-OXIDASE 1 · STEROL C4-METHYL OXIDASE 1-2 | |
| A. thaliana | NCBI:NP_177122.2 · TAIR:locus:2026756 (SBH1 · AT1G69640 · F24J1.22) | SPHINGOID BASE HYDROXYLASE 1 | |
| A. thaliana | NCBI:NP_563789.1 · TAIR:locus:2024982 (F22G5.23 · AT1G07420 · F22G5_23 · ATSMO2 · SMO2-1) | STEROL 4-ALPHA-METHYL-OXIDASE 2-1 · STEROL 4-ALPHA-METHYL-OXIDASE 2 | |
| A. thaliana | NCBI:NP_563944.1 · TAIR:locus:2012512 (F14L17.5 · SBH2 · AT1G14290 · F14L17_5) | SPHINGOID BASE HYDROXYLASE 2 | |
| A. thaliana | NCBI:NP_567669.1 · TAIR:locus:505006514 (ATSMO1-3 · SMO1 · ATSMO1 · SMO1-3 · AT4G22753) | STEROL C4-METHYL OXIDASE 1 · STEROL 4-ALPHA METHYL OXIDASE 1-3 · STEROL 4-ALPHA-METHYL-OXIDASE 1 | |
| C. elegans | WB:WBGene00018036 (F35C8.5) · UniProtKB:Q20027 | | |
| C. elegans | WB:WBGene00009902 (F49E12.9) · UniProtKB:Q20611 | | |
| C. elegans | WB:WBGene00009903 (F49E12.10) · UniProtKB:Q20612 | | |
| D. rerio | ENSEMBL:ENSDARP00000056559 | ||
| D. rerio | ENSEMBL:ENSDARP00000051313 | ||
| D. rerio | UniProtKB:Q5PRC0 · ZFIN:ZDB-GENE-041212-81 (ch25h) | cholesterol 25-hydroxylase | |
| D. rerio | ZFIN:ZDB-GENE-030131-8617 (si:dkey-24l11.8) · UniProtKB:Q567X1 | | |
| D. rerio | UniProtKB:Q7ZW77 · ZFIN:ZDB-GENE-040426-2670 (sc4mol) | sterol-C4-methyl oxidase-like | |
| D. rerio | ZFIN:ZDB-GENE-050419-90 (si:dkey-24l11.9) · UniProtKB:Q1LX59 | | |
| D. rerio | UniProtKB:Q66ID6 · ZFIN:ZDB-GENE-040912-56 (sc5d) | sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) | |
| D. rerio | ZFIN:ZDB-GENE-040426-2907 (zgc:55420) · UniProtKB:Q803P4 | | |
| D. discoideum | UniProtKB:Q55D52 · dictyBase:DDB_G0270946 (DDB_G0270946) | Putative sterol 4-alpha-methyl-oxidase. | |
| D. discoideum | UniProtKB:Q55D54 · dictyBase:DDB_G0269788 (DDB_G0269788) | Similar to sterol-C4-methyl oxidase-like. | |
| D. melanogaster | FB:FBgn0030509 (CG11162) · UniProtKB:Q9VYA2 | | |
| D. melanogaster | FB:FBgn0030485 (CG1998) · UniProtKB:Q9VYD2 | | |
| G. gallus | NCBI:XP_421660 · ENTREZ:423788 | ||
| G. gallus | NCBI:XP_414576 · ENTREZ:416256 | ||
| G. gallus | ENTREZ:422423 · UniProtKB:Q5ZLL6 (SC4MOL · IPI00578812 · Q5ZLL6 · ERG25_CHICK · RCJMB04_5j19) | C-4 methylsterol oxidase | |
| H. sapiens | ENSEMBL:ENSG00000170271 · UniProtKB:Q96IV6 (IPI00063851 · Q96IV6 · CE004_HUMAN · C5orf4) | Uncharacterized protein C5orf4 | |
| H. sapiens | ENSEMBL:ENSG00000138135 · UniProtKB:O95992 (IPI00022560 · CH25H_HUMAN · O95992 · CH25H) | Cholesterol 25-hydroxylase | |
| H. sapiens | ENSEMBL:ENSG00000052802 · UniProtKB:Q15800 (ERG25 · SC4MOL · IPI00019899 · Q15800 · ERG25_HUMAN · DESP4) | C-4 methylsterol oxidase | |
| H. sapiens | ENSEMBL:ENSG00000109929 · UniProtKB:O75845 (O75845 · SC5D_HUMAN · SC5DL · IPI00027181) | Lathosterol oxidase | |
| M. musculus | UniProtKB:Q9Z0F5 · MGI:MGI:1333869 (Ch25h · m25OH) | cholesterol 25-hydroxylase | |
| M. musculus | UniProtKB:Q9CRA4 · MGI:MGI:1913484 (C78600 · ERG25 · Sc4mol · DESP4) | sterol-C4-methyl oxidase-like | |
| M. musculus | UniProtKB:O88822 · MGI:MGI:1353611 (Sc5d) | sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) | |
| R. norvegicus | NCBI:XP_001075174 · RGD:1594987 (LOC686661) | similar to CG1998-PA | |
| R. norvegicus | UniProtKB:Q4QQV7 · RGD:1310575 (Ch25h) | cholesterol 25-hydroxylase | |
| R. norvegicus | UniProtKB:O35532 · RGD:620281 (Sc4mol) | sterol-C4-methyl oxidase-like | |
| R. norvegicus | UniProtKB:Q9EQS5 · RGD:620775 (Sc5dl) | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like | |
| R. norvegicus | NCBI:XP_001077260 · RGD:1586284 (LOC691221) | similar to CG1998-PA | |
| S. cerevisiae | UniProtKB:P53045 · SGD:S000003292 (YGR060W · ERG25) | C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis | |
| S. cerevisiae | UniProtKB:P32353 · SGD:S000004046 (ERG3 · PSO6 · SYR1 · YLR056W) | C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis | |
| S. cerevisiae | UniProtKB:P38992 · SGD:S000002705 (SUR2 · YDR297W · SYR2) | Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis | |
| S. pombe | UniProtKB:Q9UUH4 · GeneDB_Spombe:SPAC630.08c (erg25 · SPAC630.08c) | C-4 methylsterol oxidase | |
| S. pombe | UniProtKB:O94457 · GeneDB_Spombe:SPAC1687.16c (erg3 · SPAC1687.16c) | C-5 sterol desaturase Erg3 | |
| S. pombe | UniProtKB:O13666 · GeneDB_Spombe:SPBC27B12.03c (SPBC27B12.03c) | lathosterol oxidase | |
| S. pombe | UniProtKB:O94298 · GeneDB_Spombe:SPBC887.15c (SPBC887.15c) | sphingosine hydroxylase | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P32353 · SGD:S000004046 |  12878500 Pinjon E, et al. Molecular mechanisms of itraconazole resistance in Candida dubliniensis. Antimicrob Agents Chemother. 2003 Aug;47(8):2424-37. | The C. dubliniensis protein CdERG3 does not complement a homologous mutation in S. cerevisiae. | |
| UniProtKB:P38992 · SGD:S000002705 | 12956060 Beckmann C, et al. Stereochemistry of a bifunctional dihydroceramide delta 4-desaturase/hydroxylase from Candida albicans; a key enzyme of sphingolipid metabolism. Org Biomol Chem. 2003 Jul 21;1(14):2448-54. | The C. albicans protein DES1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper describes the biochemical characterization of C. albicans DES1 expressed in an S. cerevisiae sur2 null mutant. | |
| UniProtKB:P38992 · SGD:S000002705 | 16339149 Ternes P, et al. Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. J Biol Chem. 2006 Mar 3;281(9):5582-92. | The P. pastoris protein Q2QJ12_PICPA was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows functional expression of P. pastoris sphingolipid C9-methyltransferase in an S. cerevisiae sur2 null mutant. | |
| UniProtKB:P38992 · SGD:S000002705 | 16339149 Ternes P, et al. Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. J Biol Chem. 2006 Mar 3;281(9):5582-92. | The P. pastoris protein Q66VZ4_PICPA was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows functional expression of P. pastoris delta 4-(E)-sphingolipid desaturase in an S. cerevisiae sur2 null mutant. | |
| UniProtKB:P38992 · SGD:S000002705 | 16339149 Ternes P, et al. Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. J Biol Chem. 2006 Mar 3;281(9):5582-92. | The P. pastoris protein Q66VZ5_PICPA was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows functional expression of P. pastoris delta 8-(E)-sphingolipid desaturase in an S. cerevisiae sur2 null mutant. | |
| UniProtKB:P32353 · SGD:S000004046 | 10786622 Nishi S, et al. cDNA cloning of the mammalian sterol C5-desaturase and the expression in yeast mutant. Biochim Biophys Acta. 2000 Jan 31;1490(1-2):106-8. | The H. sapiens protein SC5D complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (1) | |
|---|---|
| ENSEMBL:ENSG00000109929 · UniProtKB:O75845 | #607330 LATHOSTEROLOSIS;;STEROL C5-DESATURASE DEFICIENCY;;SC5D DEFICIENCY |