This family has 46 members: 24 Arabidopsis thaliana, 2 Caenorhabditis elegans, 4 Danio rerio, 5 Gallus gallus, 3 Homo sapiens, 3 Mus musculus, 3 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_199197.1 · TAIR:locus:2170832 (AT-HSFA6A · HSFA6A · MQD19.20 · MQD19_20 · AT5G43840) | HEAT SHOCK TRANSCRIPTION FACTOR A6A |  |
| A. thaliana | NCBI:NP_186949.1 · TAIR:locus:2075447 (F13E7.6 · AT3G02990 · ATHSFA1E · F13E7_6 · HSFA1E) | HEAT SHOCK TRANSCRIPTION FACTOR A1E | |
| A. thaliana | NCBI:NP_181700.1 · TAIR:locus:2062698 (AT2G41690 · T32G6.21 · T32G6_21 · HSFB3 · AT-HSFB3) | HEAT SHOCK TRANSCRIPTION FACTOR B3 | |
| A. thaliana | NCBI:NP_193622.1 · TAIR:locus:2117124 (F13C5.40 · AT4G18870 · F13C5_40) | | |
| A. thaliana | NCBI:NP_175142.1 · TAIR:locus:2825726 (AT1G46264 · F2G19.8 · F2G19_8 · AT-HSFB4 · HSFB4) | HEAT SHOCK TRANSCRIPTION FACTOR B4 | |
| A. thaliana | NCBI:NP_180184.1 · TAIR:locus:2057371 (T19L18.4 · T19L18_4 · ATHSFA2 · AT2G26150 · HSFA2) | HEAT SHOCK TRANSCRIPTION FACTOR A2 | |
| A. thaliana | NCBI:NP_197184.2 · TAIR:locus:2149050 (F5E19.160 · HSF3 · AT5G16820 · ATHSFA1B · HSFA1B · F5E19_160) | HEAT SHOCK FACTOR 3 · ARABIDOPSIS THALIANA CLASS A HEAT SHOCK FACTOR 1B · CLASS A HEAT SHOCK FACTOR 1B | |
| A. thaliana | NCBI:NP_195992.2 · TAIR:locus:2144603 (AT-HSFA3 · HSFA3 · F17C15_140 · F17C15.140 · AT5G03720) | HEAT SHOCK TRANSCRIPTION FACTOR A3 | |
| A. thaliana | NCBI:NP_189095.1 · TAIR:locus:2091762 (MOB24.9 · HSFC1 · AT-HSFC1 · AT3G24520) | HEAT SHOCK TRANSCRIPTION FACTOR C1 | |
| A. thaliana | NCBI:NP_176964.1 · TAIR:locus:2200171 (T23K23_18 · AT1G67970 · T23K23.18 · HSFA8 · AT-HSFA8) | HEAT SHOCK TRANSCRIPTION FACTOR A8 | |
| A. thaliana | NCBI:NP_193510.1 · TAIR:locus:2005495 (FCAALL.107 · ATHSFA1A · HSFA1A · DL4910C · ATHSF1 · HSF1 · AT4G17750) | ARABIDOPSIS THALIANA HEAT SHOCK FACTOR 1 · CLASS A HEAT SHOCK FACTOR 1A · HEAT SHOCK FACTOR 1 · ARABIDOPSIS THALIANA CLASS A HEAT SHOCK FACTOR 1A · HEAT SHOCK FACTOR | |
| A. thaliana | NCBI:NP_192903.1 · TAIR:locus:2139792 (AT-HSFB2B · T5C23_90 · T5C23.90 · AT4G11660 · HSFB2B) | HEAT SHOCK TRANSCRIPTION FACTOR B2B | |
| A. thaliana | NCBI:NP_200218.1 · TAIR:locus:2166562 (AT-HSFA9 · MJP23_4 · MJP23.4 · HSFA9 · AT5G54070) | HEAT SHOCK TRANSCRIPTION FACTOR A9 | |
| A. thaliana | NCBI:NP_188922.1 · TAIR:locus:2094339 (HSFA6B · MWI23.20 · AT3G22830 · AT-HSFA6B) | HEAT SHOCK TRANSCRIPTION FACTOR A6B | |
| A. thaliana | NCBI:NP_195416.1 · TAIR:locus:2115015 (AP22.9 · HSF4 · AT-HSFB1 · AT4G36990 · HSFB1 · AP22_9 · ATHSF4) | ARABIDOPSIS THALIANA HEAT SHOCK FACTOR 4 · ARABIDOPSIS THALIANA CLASS B HEAT SHOCK FACTOR B1 · CLASS B HEAT SHOCK FACTOR B1 · HEAT SHOCK FACTOR 4 | |
| A. thaliana | NCBI:NP_199383.1 · TAIR:locus:2172003 (MRA19_11 · MRA19.11 · RHA1 · AT-HSFA4C · HSFA4C · AT5G45710) | HEAT SHOCK TRANSCRIPTION FACTOR A4C · ROOT HANDEDNESS 1 | |
| A. thaliana | NCBI:NP_177880.2 · TAIR:locus:2204750 (AT1G77570 · T5M16_16 · T5M16.16) | | |
| A. thaliana | NCBI:NP_567415.1 · TAIR:locus:2129276 (AT-HSFA5 · DL3030C · FCAALL.27 · AT4G13980 · HSFA5) | HEAT SHOCK TRANSCRIPTION FACTOR A5 | |
| A. thaliana | NCBI:NP_190759.1 · TAIR:locus:2083690 (HSFA7A · AT-HSFA7A · AT3G51910 · F4F15.20) | HEAT SHOCK TRANSCRIPTION FACTOR A7A | |
| A. thaliana | NCBI:NP_191894.1 · TAIR:locus:2077249 (MAA21.4 · AT3G63350 · HSFA7B · AT-HSFA7B) | HEAT SHOCK TRANSCRIPTION FACTOR A7B | |
| A. thaliana | NCBI:NP_174511.2 · TAIR:locus:2028326 (AT1G32330 · HSFA1D · ATHSFA1D · F27G20.6) | HEAT SHOCK TRANSCRIPTION FACTOR A1D | |
| A. thaliana | NCBI:NP_201008.2 · TAIR:locus:2174043 (HSFB2A · MTG10_7 · AT-HSFB2A · AT5G62020 · MTG10.7) | HEAT SHOCK TRANSCRIPTION FACTOR B2A | |
| A. thaliana | NCBI:NP_193623.1 · TAIR:locus:2117139 (F13C5.50 · AT4G18880 · AT-HSFA4A · F13C5_50) | HEAT SHOCK TRANSCRIPTION FACTOR A4A · HSF A4A | |
| A. thaliana | NCBI:NP_193698.2 · TAIR:locus:2123005 (AT4G19630 · F24J7_180 · F24J7.180) | | |
| C. elegans | WB:WBGene00002004 (hsf-1 · Y53C10A.12) · UniProtKB:Q9XW45 | | |
| C. elegans | WB:WBGene00013134 (Y53C10A.3) · UniProtKB:Q9XW54 | | |
| D. rerio | ENSEMBL:ENSDARP00000072537 | ||
| D. rerio | UniProtKB:Q5CZP2 · ZFIN:ZDB-GENE-050306-18 (hsf4) | heat shock transcription factor 4 | |
| D. rerio | UniProtKB:Q90XA8 · ZFIN:ZDB-GENE-011128-1 (hsf2) | heat shock factor 2 | |
| D. rerio | UniProtKB:Q9IAS0 · ZFIN:ZDB-GENE-000616-16 (hsf1) | heat shock transcription factor 1 | |
| G. gallus | NCBI:XP_418467 · ENTREZ:420362 | ||
| G. gallus | NCBI:XP_419760 · ENTREZ:421724 | ||
| G. gallus | NCBI:XP_001236044 · ENTREZ:776528 | ||
| G. gallus | NCBI:XP_425114 · ENTREZ:427540 | ||
| G. gallus | ENTREZ:422169 · UniProtKB:P38531 (HSF3_CHICK · HSF3 · P38531 · IPI00582276) | Heat shock factor protein 3 | |
| H. sapiens | ENSEMBL:ENSG00000185122 · UniProtKB:Q00613 (IPI00024071 · IPI00218507 · HSF1 · HSF1_HUMAN · Q00613 · HSTF1) | Heat shock factor protein 1 | |
| H. sapiens | ENSEMBL:ENSG00000025156 · UniProtKB:Q03933 (IPI00012878 · Q03933 · HSF2 · HSTF2 · HSF2_HUMAN) | Heat shock factor protein 2 | |
| H. sapiens | ENSEMBL:ENSG00000102878 · UniProtKB:Q9ULV5 (HSF4 · IPI00220197 · HSF4_HUMAN · IPI00008456 · Q9ULV5) | Heat shock factor protein 4 | |
| M. musculus | UniProtKB:P38532 · MGI:MGI:96238 (Hsf1) | heat shock transcription factor 1 · heat shock factor 1 | |
| M. musculus | UniProtKB:P38533 · MGI:MGI:96239 (Hsf2) | heat shock factor 2 | |
| M. musculus | UniProtKB:Q9R0L1 · MGI:MGI:1347058 (Hsf4 · ldis1) | heat shock transcription factor 4 | |
| R. norvegicus | NCBI:XP_001075468 · RGD:1310808 (Hsf4) | heat shock transcription factor 4 | |
| R. norvegicus | UniProtKB:Q63717 · RGD:620913 (Hsf1) | heat shock transcription factor 1 | |
| R. norvegicus | UniProtKB:Q9R120 · RGD:68395 (Hsf2) | heat shock factor 2 | |
| S. cerevisiae | UniProtKB:P10961 · SGD:S000003041 (YGL073W · EXA3 · HSF1 · MAS3) | Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia | |
| S. pombe | UniProtKB:Q02953 · GeneDB_Spombe:SPAC2E12.02 (hstf · hsf1 · hsf · SPAC2E12.02) | transcription factor Hsf1 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P10961 · SGD:S000003041 |  10358080 Liu PC, et al. Modulation of human heat shock factor trimerization by the linker domain. J Biol Chem. 1999 Jun 11;274(24):17219-25. | The H. sapiens protein Q00613 complements a homologous mutation in S. cerevisiae. Although human HSF1 is an inactive monomer in yeast that is unable to substitute for the essential yeast HSF protein, mutations in the linker region between the DNA binding domain and the first coiled-coil allow human HSF1 to homotrimerize and rescue the viability defect of a hsf yeast strain. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (1) | |
|---|---|
| UniProtKB:P10961 · SGD:S000003041 | #116800 CATARACT, LAMELLAR;;CATARACT, ZONULAR;;PERINUCLEAR CATARACTCATARACT, MARNER TYPE, INCLUDED;;CAM, INCLUDED;;CTM, INCLUDED |
| SGD Disease Papers (1) | |
| UniProtKB:P10961 · SGD:S000003041 | 18199679 Trott A, et al. (2008) Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule. Mol Biol Cell 19(3):1104-12 |