P-POD: Princeton Protein Orthology Database: GO3/Jaccard422

This family has 47 members: 8 Arabidopsis thaliana, 4 Caenorhabditis elegans, 4 Danio rerio, 4 Dictyostelium discoideum, 3 Drosophila melanogaster, 2 Escherichia coli, 6 Gallus gallus, 4 Homo sapiens, 4 Mus musculus, 4 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

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GO3/Jaccard422
47 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_190788.1 · TAIR:locus:2083745 (AT3G52200 · LTA3 · T25B15.141)DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE⌘
A. thalianaNCBI:NP_189215.1 · TAIR:locus:2092070 (PLE2 · MPE11.6 · AT3G25860 · LTA2)DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE · PLASTID E2 SUBUNIT OF PYRUVATE DECARBOXYLASE⌘
A. thalianaNCBI:NP_200318.1 · TAIR:locus:2161670 (MCO15_2 · MCO15.2 · AT5G55070)⌘
A. thalianaNCBI:NP_566470.1 · TAIR:locus:2088247 (MDC16.18 · AT3G13930)⌘
A. thalianaNCBI:NP_187341.1 · TAIR:locus:2083358 (F3E22.1 · BCE2 · AT3G06850 · LTA1 · DIN3)DARK INDUCIBLE 3⌘
A. thalianaNCBI:NP_564654.1 · TAIR:locus:2020173 (AT1G54220 · F20D21.4 · F20D21_4)⌘
A. thalianaNCBI:NP_567761.1 · TAIR:locus:2116432 (F10M23.250 · F10M23_250 · AT4G26910)⌘
A. thalianaNCBI:NP_174703.1 · TAIR:locus:2009273 (F12K21.24 · AT1G34430 · F12K21_24 · EMB3003)embryo defective 3003⌘
C. elegansWB:WBGene00009082 (F23B12.5) · UniProtKB:Q19749 (F23B12.5 · ODP2_CAEEL)Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial⌘⌘
C. elegansWB:WBGene00020950 (W02F12.5) · UniProtKB:O45148⌘
C. elegansWB:WBGene00007824 (C30H6.7) · UniProtKB:O45279⌘
C. elegansWB:WBGene00014054 (ZK669.4) · UniProtKB:Q23571 (ZK669.4)Protein ZK669.4, confirmed by transcript evidence⌘⌘
D. rerioENSEMBL:ENSDARP00000067926
D. rerioUniProtKB:Q5BKV3 · ZFIN:ZDB-GENE-050320-85 (dbt)dihydrolipoamide branched chain transacylase E2⌘
D. rerioUniProtKB:Q7ZVL3 · ZFIN:ZDB-GENE-030326-1 (dlst)dihydrolipoamide S-succinyltransferase⌘
D. rerioUniProtKB:Q804C3 · ZFIN:ZDB-GENE-030131-2921 (dlat)dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)⌘
D. discoideumUniProtKB:Q869Y7 · dictyBase:DDB_G0275029 (DLST · odhB)dihydrolipoamide S-succinyltransferase, 2-oxoglutarate dehydrogenase E2 component, dihydrolipoyllysine-residue succinyltransferase⌘
D. discoideumUniProtKB:P36413 · dictyBase:DDB_G0277847 (pdhC · dlaA)dihydrolipoamide acetyltransferase, dihydrolipoyllysine-residue acetyltransferase, pyruvate dehydrogenase E2 component⌘
D. discoideumUniProtKB:Q54TR7 · dictyBase:DDB_G0281797 (bkdC)lipoamide acyltransferase, dihydrolipoyllysine-residue (2-methylpropanoyl) transferase, dihydrolipoyl transacylase, branched-chain alpha-keto acid dehydrogenase E2 component⌘
D. discoideumUniProtKB:Q86AD5 · dictyBase:DDB_G0271564 (pdhX)pyruvate dehydrogenase complex, component X, E3-binding protein⌘
D. melanogasterFB:FBgn0037891 (CG5214) · UniProtKB:Q9VGQ1⌘
D. melanogasterFB:FBgn0031912 (anon-WO0118547.121 · EP(2)0816 · EP816 · CG5261) · UniProtKB:Q9VM14⌘
D. melanogasterFB:FBgn0030612 (CG5599) · UniProtKB:Q9VXY3⌘
E. coliUniProtKB:P0AFG6 · ECOLI:SUCB-LIPOATE (SucB · B0727 · SucB-lipoate)⌘
E. coliUniProtKB:P06959 · ECOLI:ACEF-LIPOATE (AceF-lipoate · ECK0114 · aceF · b0115)⌘
G. gallusNCBI:XP_417933 · ENTREZ:419796
G. gallusNCBI:XP_001234595 · ENTREZ:771302
G. gallusNCBI:XP_001232403 · ENTREZ:769870
G. gallusUniProtKB:Q5F326 (RCJMB04_39i8 · IPI00592325 · Q5F326) · ENTREZ:423357⌘
G. gallusUniProtKB:Q5F3G9 (RCJMB04_17g4 · Q5F3G9 · IPI00572355) · ENTREZ:423154⌘
G. gallusUniProtKB:Q98UJ6 (Q98UJ6 · IPI00570647) · ENTREZ:395374⌘
H. sapiensENSEMBL:ENSG00000137992 · UniProtKB:P11182 (P11182 · DBT · ODB2_HUMAN · BCATE2 · IPI00003944)Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000119689 · UniProtKB:P36957 (DLST · P36957 · DLTS · ODO2_HUMAN · IPI00420108)Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000150768 · UniProtKB:P10515 (ODP2_HUMAN · DLAT · DLTA · P10515 · IPI00021338)Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000110435 · UniProtKB:O00330 (PDHX · IPI00298423 · ODPX_HUMAN · PDX1 · O00330)Pyruvate dehydrogenase protein X component, mitochondrial⌘
M. musculusUniProtKB:P53395 · MGI:MGI:105386 (Dbt · D3Wsu60e)dihydrolipoyl transacylase · dihydrolipoyllysine-residue (2-methylpropanoyl)transferase · dihydrolipoamide branched chain transacylase E2 · BCKAD E2⌘
M. musculusUniProtKB:Q9D2G2 · MGI:MGI:1926170 (Dlst)dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)⌘
M. musculusUniProtKB:Q8BMF4 · MGI:MGI:2385311 (PDC-E2 · Dlat)dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)⌘
M. musculusUniProtKB:Q8BKZ9 · MGI:MGI:1351627 (Pdhx · Pdx1)pyruvate dehydrogenase complex, component X⌘
R. norvegicusUniProtKB:Q01205 · RGD:1359615 (Dlst)dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)⌘
R. norvegicusRGD:619859 (Dlat) · UniProtKB:P08461 (P08461 · ODP2_RAT · IPI00231714 · Dlat)dihydrolipoamide S-acetyltransferase · Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial⌘⌘
R. norvegicusUniProtKB:Q7TQ85 · RGD:1566332 (Pdhx)pyruvate dehydrogenase complex, component X⌘
R. norvegicusUniProtKB:Q99PU6 · RGD:68403 (Dbt)dihydrolipoamide branched chain transacylase E2⌘
S. cerevisiaeUniProtKB:P19262 · SGD:S000002555 (YDR148C · KGD2)Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle⌘
S. cerevisiaeUniProtKB:P12695 · SGD:S000005015 (ODP2 · PDA2 · YNL071W · LAT1)Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA⌘
S. pombeUniProtKB:O94681 · GeneDB_Spombe:SPBC776.15c (SPBC776.15c)dihydrolipoamide S-succinyltransferase, e2 component of oxoglutarate dehydrogenase complex⌘
S. pombeUniProtKB:O59816 · GeneDB_Spombe:SPCC794.07 (SPCC794.07)dihydrolipoamide S-acetyltransferase E2⌘

No functional conservation results.

DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (3)
ENSEMBL:ENSG00000150768 · UniProtKB:P10515#248600 MAPLE SYRUP URINE DISEASE;;MSUD;;BRANCHED-CHAIN KETOACIDURIA;;BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE DEFICIENCY;;BCKD DEFICIENCY;;KETO ACID DECARBOXYLASE DEFICIENCYMAPLE SYRUP URINE DISEASE, CLASSIC, INCLUDED;;MAPLE SYRUP URINE DISEASE, INTERMEDIATE, INCLUDED;;MAPLE SYRUP URINE DISEASE, INTERMITTENT, INCLUDED;;MAPLE SYRUP URINE DISEASE, THIAMINE-RESPONSIVE, INCLUDED;;MAPLE SYRUP URINE DISEASE, E3-DEFICIENT, WITH LACTIC ACIDOSIS, INCLUDED;;MAPLE SYRUP URINE DISEASE, TYPE IA, INCLUDED; MSUD1A, INCLUDED;;MAPLE SYRUP URINE DISEASE, TYPE IB, INCLUDED; MSUD1B, INCLUDED;;MAPLE SYRUP URINE DISEASE, TYPE II, INCLUDED; MSUD2, INCLUDED; MAPLESYRUP URINE DISEASE, TYPE III, INCLUDED; MSUD3, INCLUDED;;LIPOAMIDE DEHYDROGENASE DEFICIENCY, LACTIC ACIDOSIS DUE TO;;LACTIC ACIDOSIS, CONGENITAL INFANTILE, DUE TO LAD DEFICIENCY, INCLUDED;;DIHYDROLIPOAMIDE DEHYDROGENASE DEFICIENCY, INCLUDED;;DLD DEFICIENCY, INCLUDED
ENSEMBL:ENSG00000110435 · UniProtKB:O00330#245348 PYRUVATE DEHYDROGENASE E2 DEFICIENCY;;LACTIC ACIDEMIA DUE TO DEFECT OF E2 LIPOYL TRANSACETYLASE OF THE PYRUVATEDEHYDROGENASE COMPLEX
UniProtKB:P19262 · SGD:S000002555#245349 PYRUVATE DEHYDROGENASE E3-BINDING PROTEIN DEFICIENCY;;LACTIC ACIDEMIA DUE TO DEFECT IN LIPOYL-CONTAINING COMPONENT X OFTHE PYRUVATE DEHYDROGENASE COMPLEX
SGD Disease Papers (3)
UniProtKB:P12695 · SGD:S000005015PMID:12134146 Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
UniProtKB:P12695 · SGD:S000005015PMID:9300813 Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10
PMID:12134146 Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
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