P-POD: Princeton Protein Orthology Database: GO3/Jaccard380

This family has 52 members: 6 Arabidopsis thaliana, 5 Caenorhabditis elegans, 3 Danio rerio, 6 Dictyostelium discoideum, 2 Drosophila melanogaster, 1 Escherichia coli, 3 Gallus gallus, 6 Homo sapiens, 5 Mus musculus, 5 Rattus norvegicus, 6 Saccharomyces cerevisiae, 4 Schizosaccharomyces pombe.

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GO3/Jaccard380
52 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_194284.2 · TAIR:locus:2131829 (M7J2_90 · ATMSH3 · M7J2.90 · AT4G25540 · MSH3)Arabidopsis homolog of DNA mismatch repair protein MSH3⌘
A. thalianaNCBI:NP_850630.1 · TAIR:locus:1005716529 (MSH7 · AT3G24495 · ATMSH7 · MSH6-2)ARABIDOPSIS THALIANA MUTS HOMOLOG 7 · MUTS HOMOLOG 7 · MUTS HOMOLOG 6-2⌘
A. thalianaNCBI:NP_193469.2 · TAIR:locus:2130913 (DL4725W · MSH4 · FCAALL.423 · AT4G17380)MUTS-LIKE PROTEIN 4 · MUTS HOMOLOG 4⌘
A. thalianaNCBI:NP_566804.3 · TAIR:locus:2095097 (AT3G18524 · MSH2 · MOJ10.1 · ATMSH2)MUTS HOMOLOG 2⌘
A. thalianaNCBI:NP_188683.3 · TAIR:locus:2092404 (MQC12.27 · MSH5 · ATMSH5 · AT3G20475)MUTS-HOMOLOGUE 5⌘
A. thalianaNCBI:NP_192116.1 · TAIR:locus:2132233 (T10M13.8 · ATMSH6 · T10M13_8 · MSH6 · MSH6-1 · AT4G02070)MUTS HOMOLOG 6-1 · ARABIDOPSIS THALIANA MUTS HOMOLOG 6 · MUTS HOMOLOG 6⌘
C. elegansWB:WBGene00001872 (him-14 · ZK1127.11) · UniProtKB:Q23405 (him-14 · msh-4 · HIM14_CAEEL · ZK1127.11)MutS protein homolog him-14⌘⌘
C. elegansWB:WBGene00003421 (F09E8.3 · msh-5) · UniProtKB:Q19272 (MSH5_CAEEL · F09E8.3 · msh-5)MutS protein homolog 5⌘⌘
C. elegansWB:WBGene00003420 (T02G5.6 · msh-4) · UniProtKB:Q22103⌘
C. elegansWB:WBGene00003422 (msh-6 · Y47G6A.11) · UniProtKB:Q9N3T8⌘
C. elegansWB:WBGene00003418 (msh-2 · H26D21.2) · UniProtKB:Q9TXR4⌘
D. rerioENSEMBL:ENSDARG00000063276 · UniProtKB:A2CE81
D. rerioUniProtKB:Q90XA7 · ZFIN:ZDB-GENE-040426-2932 (msh2)mutS homolog 2 (E. coli)⌘
D. rerioUniProtKB:Q90XA6 · ZFIN:ZDB-GENE-020905-3 (msh6)mutS homolog 6 (E. coli)⌘
D. discoideumUniProtKB:Q553L4 · dictyBase:DDB_G0275809 (msh2)mutS homolog, DNA mismatch repair protein⌘
D. discoideumUniProtKB:Q1ZXH0 · dictyBase:DDB_G0281683 (msh3)mutS homolog, DNA mismatch repair protein⌘
D. discoideumUniProtKB:Q55GU9 · dictyBase:DDB_G0268614 (msh6)mutS homolog, DNA mismatch repair protein⌘
D. discoideumUniProtKB:Q54P75 · dictyBase:DDB_G0284747 (msh5)mutS homolog, DNA mismatch repair protein⌘
D. discoideumUniProtKB:Q54QB8 · dictyBase:DDB_G0283957 (msh4)mutS homolog, DNA mismatch repair protein⌘
D. discoideumUniProtKB:Q552L1 · dictyBase:DDB_G0275999 (msh1)mutS homolog, DNA mismatch repair protein⌘
D. melanogasterFB:FBgn0015546 (spellchecker1 · spellchecker · CG4215 · BG:DS01068.9 · Msh2 · spel · spel-1 · SPEL1 · spel1) · UniProtKB:P43248⌘
D. melanogasterFB:FBgn0036486 (CG7003 · Msh6) · UniProtKB:Q9VUM0⌘
E. coliUniProtKB:P23909 · ECOLI:EG10625-MONOMER (Fdv · fdv · ant · mutS · B2733 · Ant · MutS · ECK2728 · plm · Plm · b2733)methyl-directed mismatch repair protein⌘
G. gallusNCBI:XP_422549 · ENTREZ:424725
G. gallusNCBI:XP_419359 · ENTREZ:421291
G. gallusNCBI:XP_426110 · ENTREZ:378799
H. sapiensENSEMBL:ENSG00000095002 · UniProtKB:P43246 (IPI00017303 · MSH2 · MSH2_HUMAN · P43246)DNA mismatch repair protein Msh2⌘
H. sapiensENSEMBL:ENSG00000113318 · UniProtKB:P20585 (MSH3_HUMAN · IPI00329605 · DUG · DUC1 · MSH3 · P20585)DNA mismatch repair protein Msh3⌘
H. sapiensENSEMBL:ENSG00000057468 · UniProtKB:O15457 (MSH4 · O15457 · MSH4_HUMAN · IPI00289914)MutS protein homolog 4⌘
H. sapiensENSEMBL:ENSG00000204410 · UniProtKB:O43196 (IPI00219362 · MSH5 · MSH5_HUMAN · IPI00647584 · O43196 · IPI00297780 · IPI00172593)MutS protein homolog 5⌘
H. sapiensENSEMBL:ENSG00000096474 · UniProtKB:O43196 (IPI00219362 · MSH5 · MSH5_HUMAN · IPI00647584 · O43196 · IPI00297780 · IPI00172593)MutS protein homolog 5⌘
H. sapiensENSEMBL:ENSG00000116062 · UniProtKB:P52701 (P52701 · MSH6 · MSH6_HUMAN · GTBP · IPI00106847 · IPI00384456)DNA mismatch repair protein Msh6⌘
M. musculusUniProtKB:P43247 · MGI:MGI:101816 (Msh2)mutS homolog 2 (E. coli)⌘
M. musculusUniProtKB:P13705 · MGI:MGI:109519 (Rep-3 · D13Em1 · Msh3 · Rep3)mutS homolog 3 (E. coli)⌘
M. musculusUniProtKB:Q99MT2 · MGI:MGI:1860077 (Msh4 · mMsh4)mutS homolog 4 (E. coli)⌘
M. musculusUniProtKB:Q9QUM7 · MGI:MGI:1329021 (G7 · Mut5 · Msh5)mutS homolog 5 (E. coli)⌘
M. musculusUniProtKB:P54276 · MGI:MGI:1343961 (Msh6 · Gtmbp · GTBP)mutS homolog 6 (E. coli)⌘
R. norvegicusNCBI:XP_345634 · RGD:1310689
R. norvegicusNCBI:NP_001099947 · RGD:1309190 (Msh4)mutS homolog 4 (E. coli)⌘
R. norvegicusUniProtKB:P54275 · RGD:620786 (Msh2)mutS homolog 2 (E. coli)⌘
R. norvegicusUniProtKB:Q6MG62 · RGD:1303008 (Msh5)mutS homolog 5 (E. coli)⌘
R. norvegicusUniProtKB:Q5BJY1 · RGD:1563954 (Msh3)mutS homolog 3 (E. coli)⌘
S. cerevisiaeUniProtKB:P25846 · SGD:S000001162 (MSH1 · YHR120W)DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches⌘
S. cerevisiaeUniProtKB:P25847 · SGD:S000005450 (YOL090W · MSH2 · PMS5)Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process⌘
S. cerevisiaeUniProtKB:P25336 · SGD:S000000688 (YCR092C · MSH3)Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability⌘
S. cerevisiaeUniProtKB:P40965 · SGD:S000001891 (MSH4 · YFL003C)Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein⌘
S. cerevisiaeUniProtKB:Q12175 · SGD:S000002313 (MSH5 · YDL154W)Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis⌘
S. cerevisiaeUniProtKB:Q03834 · SGD:S000002504 (MSH6 · YDR097C · PMS3)Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs⌘
S. pombeUniProtKB:O13921 · GeneDB_Spombe:SPAC13F5.01c (SPAC13F5.01c · msh1 · SPAC23C11.18c)MutS protein homolog 1⌘
S. pombeUniProtKB:O74773 · GeneDB_Spombe:SPBC19G7.01c (msh2 · mut3 · SPBC19G7.01c · SPBC24C6.12c · swi8)MutS protein homolog 2⌘
S. pombeUniProtKB:P26359 · GeneDB_Spombe:SPAC8F11.03 (swi4 · msh3 · SPAC8F11.03)MutS protein homolog 3⌘
S. pombeUniProtKB:O74502 · GeneDB_Spombe:SPCC285.16c (SPCC285.16c · msh6)MutS protein homolog⌘
ProteinPublicationCurator Notes
UniProtKB:P25847 · SGD:S000005450PMID:9889267 Clark AB, et al. Functional analysis of human MutSalpha and MutSbeta complexes in yeast. Nucleic Acids Res. 1999 Feb 1;27(3):736-42.The H. sapiens protein P20585 does not complement a homologous mutation in S. cerevisiae. Introduction of human MSH2 (P43246), MSH3 (P20585) or MSH6 (P52701), either alone or in combination, does not decrease the high reversion rate of a yeast msh2 mutant.
UniProtKB:P25847 · SGD:S000005450PMID:9889267 Clark AB, et al. Functional analysis of human MutSalpha and MutSbeta complexes in yeast. Nucleic Acids Res. 1999 Feb 1;27(3):736-42.The H. sapiens protein P52701 does not complement a homologous mutation in S. cerevisiae. Introduction of human MSH2 (P43246), MSH3 (P20585) or MSH6 (P52701), either alone or in combination, does not decrease the high reversion rate of a yeast msh2 mutant.
UniProtKB:P25847 · SGD:S000005450PMID:9889267 Clark AB, et al. Functional analysis of human MutSalpha and MutSbeta complexes in yeast. Nucleic Acids Res. 1999 Feb 1;27(3):736-42.The H. sapiens protein P43246 does not complement a homologous mutation in S. cerevisiae. Introduction of human MSH2 (P43246), MSH3 (P20585) or MSH6 (P52701), either alone or in combination, does not decrease the high reversion rate of a yeast msh2 mutant.
UniProtKB:P25847 · SGD:S000005450PMID:9889267 Clark AB, et al. Functional analysis of human MutSalpha and MutSbeta complexes in yeast. Nucleic Acids Res. 1999 Feb 1;27(3):736-42.The H. sapiens protein MSH6 does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P25847 · SGD:S000005450PMID:9889267 Clark AB, et al. Functional analysis of human MutSalpha and MutSbeta complexes in yeast. Nucleic Acids Res. 1999 Feb 1;27(3):736-42.The H. sapiens protein MSH2 does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P25847 · SGD:S000005450PMID:9889267 Clark AB, et al. Functional analysis of human MutSalpha and MutSbeta complexes in yeast. Nucleic Acids Res. 1999 Feb 1;27(3):736-42.The H. sapiens protein MSH3 does not complement a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (6)
ENSEMBL:ENSG00000095002 · UniProtKB:P43246#120435 LYNCH SYNDROME I;;COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1; HNPCC1;;COLON CANCER, FAMILIAL NONPOLYPOSIS, TYPE 1; FCC1;;COCA1LYNCH SYNDROME II, INCLUDED
ENSEMBL:ENSG00000113318 · UniProtKB:P20585#608089 ENDOMETRIAL CANCER
#158320 MUIR-TORRE SYNDROME; MTS;;CUTANEOUS SEBACEOUS NEOPLASMS AND KERATOACANTHOMAS, MULTIPLE, WITHGASTROINTESTINAL AND OTHER CARCINOMAS
ENSEMBL:ENSG00000116062 · UniProtKB:P52701#608089 ENDOMETRIAL CANCER
UniProtKB:P25846 · SGD:S000001162#608089 ENDOMETRIAL CANCER
+600678 MutS, E. COLI, HOMOLOG OF, 6; MSH6;;G/T MISMATCH-BINDING PROTEIN; GTBPCOLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5, INCLUDED; HNPCC5,INCLUDED
SGD Disease Papers (36)
UniProtKB:P25847 · SGD:S000005450PMID:15558210 Foury F, et al. (2004) Mitochondrial DNA mutators. Cell Mol Life Sci 61(22):2799-811
UniProtKB:P25336 · SGD:S000000688PMID:9740671 Her C and Doggett NA (1998) Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene. Genomics 52(1):50-61
PMID:9147637 Schweitzer JK and Livingston DM (1997) Destabilization of CAG trinucleotide repeat tracts by mismatch repair mutations in yeast. Hum Mol Genet 6(3):349-55
PMID:8942985 Acharya S, et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc Natl Acad Sci U S A 93(24):13629-34
PMID:8769132 Whitehouse A, et al. (1996) A carboxy terminal domain of the hMSH-2 gene product is sufficient for binding specific mismatched oligonucleotides. Biochem Biophys Res Commun 225(1):289-95
PMID:8371783 Strand M, et al. (1993) Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365(6443):274-6
PMID:8261515 Leach FS, et al. (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75(6):1215-25
PMID:8252616 Fishel R, et al. (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75(5):1027-38
PMID:8145827 Bronner CE, et al. (1994) Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368(6468):258-61
PMID:8128251 Papadopoulos N, et al. (1994) Mutation of a mutL homolog in hereditary colon cancer. Science 263(5153):1625-9
PMID:8066446 Prolla TA, et al. (1994) MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science 265(5175):1091-3
PMID:7980603 Horii A, et al. (1994) Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes. Biochem Biophys Res Commun 204(3):1257-64
PMID:18031259 Aldred PM and Borts RH (2007) Humanizing mismatch repair in yeast: towards effective identification of hereditary non-polyposis colorectal cancer alleles. Biochem Soc Trans 35(Pt 6):1525-8
PMID:17720936 Gammie AE, et al. (2007) Functional Characterization of Pathogenic Human MSH2 Missense Mutations in Saccharomyces cerevisiae. Genetics 177(2):707-21
PMID:15947132 Clodfelter JE, et al. (2005) MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability. Nucleic Acids Res 33(10):3323-30
PMID:15177182 Drotschmann K, et al. (2004) Mutations in the nucleotide-binding domain of MutS homologs uncouple cell death from cell survival. DNA Repair (Amst) 3(7):729-42
PMID:11555625 Ellison AR, et al. (2001) Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. Hum Mol Genet 10(18):1889-900
PMID:11133819 Campbell MR, et al. (2000) Candidate mutator genes in mismatch repair-deficient thymic lymphomas: no evidence of mutations in the DNA polymerase delta gene. Carcinogenesis 21(12):2281-5
PMID:10720737 Drotschmann K, et al. (2000) Mutator phenotype due to loss of heterozygosity in diploid yeast strains with mutations in MSH2 and MLH1. Toxicol Lett 112-113:239-44
PMID:10615127 Das Gupta R and Kolodner RD (2000) Novel dominant mutations in Saccharomyces cerevisiae MSH6. Nat Genet 24(1):53-6
PMID:10523644 Studamire B, et al. (1999) Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination. Mol Cell Biol 19(11):7558-67
PMID:10469597 Drotschmann K, et al. (1999) Mutator phenotypes of common polymorphisms and missense mutations in MSH2. Curr Biol 9(16):907-10
PMID:10077621 Drotschmann K, et al. (1999) Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene. Proc Natl Acad Sci U S A 96(6):2970-5
UniProtKB:P40965 · SGD:S000001891PMID:9740671 Her C and Doggett NA (1998) Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene. Genomics 52(1):50-61
PMID:9024626 Fishel R and Wilson T (1997) MutS homologs in mammalian cells. Curr Opin Genet Dev 7(1):105-13
PMID:8782829 Risinger JI, et al. (1996) Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat Genet 14(1):102-5
PMID:8600025 Marsischky GT, et al. (1996) Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev 10(4):407-20
UniProtKB:Q12175 · SGD:S000002313PMID:18166824 Mandon-Pepin B, et al. (2008) Genetic investigation of four meiotic genes in women with premature ovarian failure. Eur J Endocrinol 158(1):107-15
UniProtKB:Q03834 · SGD:S000002504PMID:9740671 Her C and Doggett NA (1998) Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene. Genomics 52(1):50-61
PMID:18166824 Mandon-Pepin B, et al. (2008) Genetic investigation of four meiotic genes in women with premature ovarian failure. Eur J Endocrinol 158(1):107-15
UniProtKB:Q03834 · SGD:S000002504PMID:9740671 Her C and Doggett NA (1998) Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene. Genomics 52(1):50-61
PMID:9024626 Fishel R and Wilson T (1997) MutS homologs in mammalian cells. Curr Opin Genet Dev 7(1):105-13
PMID:8805366 Habraken Y, et al. (1996) Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3. Curr Biol 6(9):1185-7
PMID:8782829 Risinger JI, et al. (1996) Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat Genet 14(1):102-5
PMID:17440981 Poley JW, et al. (2007) Biallelic germline mutations of mismatch-repair genes: a possible cause for multiple pediatric malignancies. Cancer 109(11):2349-56
PMID:15177182 Drotschmann K, et al. (2004) Mutations in the nucleotide-binding domain of MutS homologs uncouple cell death from cell survival. DNA Repair (Amst) 3(7):729-42
Send questions, suggestions, and comments to: yfgdb@genomics.princeton.edu