P-POD: Princeton Protein Orthology Database: GO3/Jaccard353

This family has 56 members: 6 Arabidopsis thaliana, 2 Caenorhabditis elegans, 5 Danio rerio, 5 Dictyostelium discoideum, 3 Drosophila melanogaster, 1 Escherichia coli, 7 Gallus gallus, 5 Homo sapiens, 5 Mus musculus, 11 Rattus norvegicus, 3 Saccharomyces cerevisiae, 3 Schizosaccharomyces pombe.

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GO3/Jaccard353
56 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2102554 (T5P19.140 · AT3G56490) · NCBI:NP_567038.1⌘
A. thalianaNCBI:NP_195751.1 · TAIR:locus:2179122 (AT5G01310 · T10O8_20 · T10O8.20)⌘
A. thalianaNCBI:NP_567507.1 · TAIR:locus:505006484 (AT4G16566)⌘
A. thalianaNCBI:NP_974907.1 · TAIR:locus:1006230576 (AT5G48545)⌘
A. thalianaNCBI:NP_200632.2 · TAIR:locus:2161313 (AT5G58240 · MCK7.11 · MCK7_11)⌘
A. thalianaNCBI:NP_174401.1 · TAIR:locus:2029559 (F28K20_9 · AT1G31160 · F28K20.9)⌘
C. elegansWB:WBGene00009002 (F21C3.3 · hint-1) · UniProtKB:P53795⌘
C. elegansWB:WBGene00016150 (C26F1.7 · hint-3) · UniProtKB:Q18227⌘
D. rerioZFIN:ZDB-GENE-040628-2 (aprataxin · aptx) · UniProtKB:P61799⌘
D. rerioZFIN:ZDB-GENE-041001-132 (si:dkey-25e12.3) · UniProtKB:Q5PNN8⌘
D. rerioUniProtKB:A3KP93 · ZFIN:ZDB-GENE-070410-139 (hint2)histidine triad nucleotide binding protein 2⌘
D. rerioZFIN:ZDB-GENE-040927-8 (zgc:103764) · UniProtKB:Q642J0⌘
D. rerioUniProtKB:Q6PBZ7 · ZFIN:ZDB-GENE-040426-1703 (fhit)fragile histidine triad gene⌘
D. discoideumdictyBase:DDB_G0274257 · UniProtKB:Q86KK2
D. discoideumUniProtKB:Q23921 · dictyBase:DDB_G0289391 (DD-1 · veg104 · rcdFF · pkiA)putative protein kinase C inhibitor, histidine triad (HIT) family protein⌘
D. discoideumdictyBase:DDB_G0292298 · UniProtKB:Q54DF5
D. discoideumUniProtKB:Q54HJ0 · dictyBase:DDB_G0289439 (DDB_G0289439)putative protein kinase C inhibitor, histidine triad (HIT) family protein⌘
D. discoideumUniProtKB:Q558W0 · dictyBase:DDB_G0272839 (DDB_G0272839)histidine triad (HIT) family protein⌘
D. melanogasterFB:FBgn0038704 (CG5316) · UniProtKB:Q8MSG8⌘
D. melanogasterFB:FBgn0031459 (CG2862) · UniProtKB:Q8STA5⌘
D. melanogasterFB:FBgn0031378 (CG15362) · UniProtKB:Q9VQ59⌘
E. coliUniProtKB:P0ACE7 · ECOLI:EG12172-MONOMER (b1103 · ECK1089 · ycfF · hinT · HinT)purine nucleoside phosphoramidase⌘
G. gallusNCBI:XP_429199 · ENTREZ:395173
G. gallusNCBI:XP_001231942 · ENTREZ:768814
G. gallusNCBI:XP_001232866 · ENTREZ:769579
G. gallusNCBI:XP_414409 · ENTREZ:416071
G. gallusNCBI:XP_001232145 · ENTREZ:771438
G. gallusUniProtKB:Q9I870 (Wpkci-8 · ASW · IPI00581713 · Q9I870) · ENTREZ:395423⌘
G. gallusUniProtKB:Q9I882 (chPKCI · IPI00578591 · Q9I882) · ENTREZ:395424⌘
H. sapiensENSEMBL:ENSG00000137074 · UniProtKB:Q7Z2E3 (IPI00180685 · IPI00411460 · IPI00420033 · IPI00420030 · Aprataxin · IPI00420031 · APTX_HUMAN · AXA1 · IPI00554783 · IPI00414767 · APTX · Q7Z2E3 · IPI00420029 · IPI00375305 · IPI00420032)⌘
H. sapiensENSEMBL:ENSG00000189283 · UniProtKB:P49789 (Bis(5'-adenosyl)-triphosphatase · P49789 · FHIT_HUMAN · IPI00028095 · FHIT)⌘
H. sapiensENSEMBL:ENSG00000169567 · UniProtKB:P49773 (HINT1_HUMAN · PRKCNH1 · HINT · PKCI1 · HINT1 · IPI00239077 · P49773)Histidine triad nucleotide-binding protein 1⌘
H. sapiensENSEMBL:ENSG00000137133 · UniProtKB:Q9BX68 (HINT2_HUMAN · IPI00000335 · HINT2 · Q9BX68)Histidine triad nucleotide-binding protein 2⌘
H. sapiensENSEMBL:ENSG00000111911 · UniProtKB:Q9NQE9 (HINT3 · Q9NQE9 · IPI00170924 · HINT3_HUMAN)Histidine triad nucleotide-binding protein 3⌘
M. musculusMGI:MGI:1913658 (aprataxin · Aptx) · UniProtKB:Q7TQC5⌘
M. musculusUniProtKB:O89106 · MGI:MGI:1277947 (Fra14A2 · Fhit)fragile histidine triad gene⌘
M. musculusUniProtKB:P70349 · MGI:MGI:1321133 (PRKCNH1 · Ipk1 · PKCI-1 · Hint1)protein kinase C inhibitor 1 · PKC inhibitor/ interacting protein · histidine triad nucleotide binding protein 1⌘
M. musculusUniProtKB:Q9D0S9 · MGI:MGI:1916167 (Hint2)histidine triad nucleotide binding protein 2⌘
M. musculusUniProtKB:Q9CPS6 · MGI:MGI:1914097 (HINT4 · Hint3)histidine triad nucleotide binding protein 3⌘
R. norvegicusNCBI:XP_001073678 · RGD:1593411 (Hint1)histidine triad nucleotide binding protein 1⌘
R. norvegicusNCBI:XP_576909 · RGD:1563672
R. norvegicusNCBI:XP_345534 · RGD:1562730
R. norvegicusNCBI:XP_575507 · RGD:1564065
R. norvegicusNCBI:XP_001074494 · RGD:1307818
R. norvegicusNCBI:XP_233377 · RGD:1308910 (Hint2)histidine triad nucleotide binding protein 2⌘
R. norvegicusNCBI:XP_001078746 · RGD:1560164 (RGD1560164)similar to hypothetical protein⌘
R. norvegicusRGD:628740 (aprataxin · Aptx) · UniProtKB:Q8K4H4⌘
R. norvegicusUniProtKB:Q9JIX3 · RGD:620448 (Fhit)fragile histidine triad gene⌘
R. norvegicusUniProtKB:P62959 · RGD:620960 (Hint1l)histidine triad nucleotide binding protein 1-like⌘
R. norvegicusUniProtKB:Q8K3P7 · RGD:621603 (Hint3)histidine triad nucleotide binding protein 3⌘
S. cerevisiaeUniProtKB:Q08702 · SGD:S000005784 (HNT3 · YOR258W)Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins⌘
S. cerevisiaeUniProtKB:Q04344 · SGD:S000002283 (YDL125C · HNT1)Adenosine 5'-monophosphoramidase⌘
S. cerevisiaeUniProtKB:P49775 · SGD:S000002713 (YDR305C · APH1 · HNT2)Dinucleoside triphosphate hydrolase⌘
S. pombeGeneDB_Spombe:SPCC4G3.02 (aph1 · bis · SPCC4G3.02) · UniProtKB:P49776⌘
S. pombeUniProtKB:O74859 · GeneDB_Spombe:SPCC18.09c (SPCC18.09c)human aprataxin homolog⌘
S. pombeUniProtKB:O94586 · GeneDB_Spombe:SPCC1442.14c (SPCC1442.14c)adenosine 5'-monophosphoramidase⌘
ProteinPublicationCurator Notes
UniProtKB:Q04344 · SGD:S000002283PMID:11805111 Bieganowski P, et al. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. J Biol Chem. 2002 Mar 29;277(13):10852-60.The O. cuniculus protein Hint complements a homologous mutation in S. cerevisiae.
UniProtKB:Q04344 · SGD:S000002283PMID:22961002 Zimoń M, et al. Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia. Nat Genet. 2012 Oct;44(10):1080-3.The H. sapiens protein HINT1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (3)
ENSEMBL:ENSG00000137074 · UniProtKB:Q7Z2E3#208920 ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA;EAOH;;ATAXIA-OCULOMOTOR APRAXIA SYNDROME; AOA;;ATAXIA-OCULOMOTOR APRAXIA 1; AOA1;;ATAXIA-TELANGIECTASIA-LIKE SYNDROME;;CEREBELLAR ATAXIA, EARLY-ONSET, WITH HYPOALBUMINEMIA; EOCA-HAATAXIA, ADULT-ONSET, WITH OCULOMOTOR APRAXIA, INCLUDED
ENSEMBL:ENSG00000189283 · UniProtKB:P49789#607426 COENZYME Q10 DEFICIENCY;;CoQ10 DEFICIENCY, PRIMARY;;UBIQUINONE DEFICIENCY;;COENZYME Q DEFICIENCY;;CoQ DEFICIENCY
UniProtKB:Q08702 · SGD:S000005784#144700 RENAL CELL CARCINOMA 1; RCC1;;HYPERNEPHROMA;;ADENOCARCINOMA OF KIDNEYHEREDITARY RENAL CANCER ASSOCIATED 1, INCLUDED; HRCA1, INCLUDED;;RENAL CARCINOMA, FAMILIAL, ASSOCIATED 1, INCLUDED; RCA1, INCLUDED
SGD Disease Papers (4)
UniProtKB:Q04344 · SGD:S000002283PMID:16964241 Ahel I, et al. (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 443(7112):713-6
PMID:11805111 Bieganowski P, et al. (2002) Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. J Biol Chem 277(13):10852-60
UniProtKB:P49775 · SGD:S000002713PMID:16964241 Ahel I, et al. (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 443(7112):713-6
UniProtKB:P49775 · SGD:S000002713PMID:16964241 Ahel I, et al. (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 443(7112):713-6
Send questions, suggestions, and comments to: yfgdb@genomics.princeton.edu