P-POD: Princeton Protein Orthology Database: GO3/Jaccard339

This family has 57 members: 7 Arabidopsis thaliana, 3 Caenorhabditis elegans, 7 Danio rerio, 3 Dictyostelium discoideum, 4 Drosophila melanogaster, 1 Escherichia coli, 6 Gallus gallus, 6 Homo sapiens, 6 Mus musculus, 6 Rattus norvegicus, 3 Saccharomyces cerevisiae, 5 Schizosaccharomyces pombe.

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GO3/Jaccard339
57 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_173431.1 · TAIR:locus:2198651 (T20H2_20 · ATLFNR2 · FNR2 · AT1G20020 · T20H2.20)FERREDOXIN:NADP(H) OXIDOREDUCTASE · LEAF FNR 2 · FERREDOXIN-NADP(+)-OXIDOREDUCTASE 2⌘
A. thalianaNCBI:NP_186877.2 · TAIR:locus:2076547 (F14P3.7 · F14P3_7 · AT3G02280)⌘
A. thalianaNCBI:NP_201420.1 · TAIR:locus:2156917 (K2A18.27 · AT5G66190 · FNR1 · ATLFNR1 · K2A18_27)FERREDOXIN:NADP(H) OXIDOREDUCTASE · FERREDOXIN-NADP(+)-OXIDOREDUCTASE 1 · LEAF FNR 1⌘
A. thalianaNCBI:NP_194183.1 · TAIR:locus:2121894 (F22K18_280 · AR1 · ATR1 · AT4G24520 · F22K18.280)ARABIDOPSIS CYTOCHROME REDUCTASE · ARABIDOPSIS P450 REDUCTASE 1⌘
A. thalianaNCBI:NP_567293.1 · TAIR:locus:2115964 (C6L9.70 · AT4G05390 · C6L9_70 · ATRFNR1)ROOT FNR 1 · FERREDOXIN:NADP(H) OXIDOREDUCTASE⌘
A. thalianaNCBI:NP_849472.2 · TAIR:locus:2128951 (AT4G30210 · F9N11.60 · F9N11_60 · ATR2 · AR2)ARABIDOPSIS P450 REDUCTASE 2⌘
A. thalianaNCBI:NP_849734.1 · TAIR:locus:2028145 (F26G16_13 · F26G16.13 · ATRFNR2 · AT1G30510)FERREDOXIN:NADP(H) OXIDOREDUCTASE · ROOT FNR 2⌘
C. elegansWB:WBGene00006510 (C01G6.6 · tag-165) · UniProtKB:Q17574⌘
C. elegansWB:WBGene00001262 (K10D2.6 · emb-8) · UniProtKB:Q09590⌘
C. elegansWB:WBGene00001485 (Y113G7A.8 · fre-1) · UniProtKB:Q9U2Y8⌘
D. rerioENSEMBL:ENSDARP00000048846
D. rerioUniProtKB:Q6PFP6 · ZFIN:ZDB-GENE-040426-1555 (ndor1)NADPH dependent diflavin oxidoreductase 1⌘
D. rerioUniProtKB:Q499B1 · ZFIN:ZDB-GENE-050809-121 (por)P450 (cytochrome) oxidoreductase⌘
D. rerioUniProtKB:Q4V8W4 · ENSEMBL:ENSDARG00000045398
D. rerioZFIN:ZDB-GENE-030131-5767 (zgc:63480) · UniProtKB:Q6PH02⌘
D. rerioUniProtKB:Q800V0 · ZFIN:ZDB-GENE-001101-1 (nos1)nitric oxide synthase 1 (neuronal)⌘
D. rerioUniProtKB:A7WK81 · ZFIN:ZDB-GENE-040305-1 (nos2a)nitric oxide synthase 2a, inducible⌘
D. discoideumUniProtKB:Q54B10 · dictyBase:DDB_G0293904 (DG1047 · redA)NADPH-cytochrome-P450 oxidoreductase⌘
D. discoideumdictyBase:DDB_G0286763 (DDB_G0286763) · UniProtKB:Q54L96⌘
D. discoideumdictyBase:DDB_G0267824 (DDB_G0267824) · UniProtKB:Q55G48⌘
D. melanogasterUniProtKB:Q27597 · FB:FBgn0015623 (P450 · Cpr · cpr · CPR · DmCPR · CG11567 · DMR · NCPR)Cytochrome P450 reductase · NADPH-cytochrome P450 oxidoreductase · P450 reductase⌘
D. melanogasterUniProtKB:Q27571 · FB:FBgn0011676 (drNOSoxy · NOS · dNOS · Nos · CG6713 · DNOS · DNOS1)Nitric oxide synthase · nitric oxide synthase · nitric oixide synthase⌘
D. melanogasterFB:FBgn0038429 (BcDNA:SD10961 · CG14882) · UniProtKB:Q9VEV2⌘
D. melanogasterFB:FBgn0035890 (CG13667) · UniProtKB:Q9VSJ5⌘
E. coliUniProtKB:P38038 · ECOLI:ALPHACOMP-MONOMER (ECK2759 · b2764 · CysJ · cysJ)sulfite reductase flavoprotein subunit⌘
G. gallusNCBI:XP_415553 · ENTREZ:417280
G. gallusNCBI:XP_001234897 · ENTREZ:771641
G. gallusNCBI:XP_415768 · ENTREZ:417520
G. gallusNCBI:XP_425296 · ENTREZ:427721
G. gallusNCBI:XP_426057 · ENTREZ:428502
G. gallusENTREZ:395807 · UniProtKB:Q90703 (Q90703 · NOS2 · NOS2_CHICK · IPI00593125)Nitric oxide synthase, inducible⌘
H. sapiensENSEMBL:ENSG00000124275 · UniProtKB:Q9UBK8 (IPI00307334 · Q9UBK8 · MTRR_HUMAN · IPI00221302 · MTRR · IPI00221303)Methionine synthase reductase, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000127948 · UniProtKB:P16435 (P16435 · POR · NCPR_HUMAN · IPI00470467 · CYPOR)NADPH--cytochrome P450 reductase⌘
H. sapiensENSEMBL:ENSG00000188566 · UniProtKB:Q9UHB4 (NR1 · Q9UHB4 · IPI00791177 · NDOR1_HUMAN · IPI00748284 · NDOR1)NADPH-dependent diflavin oxidoreductase 1⌘
H. sapiensENSEMBL:ENSG00000089250 · UniProtKB:P29475 (IPI00216232 · NOS1_HUMAN · IPI00746356 · IPI00217225 · P29475 · NOS1 · IPI00472618)Nitric oxide synthase, brain⌘
H. sapiensENSEMBL:ENSG00000007171 · UniProtKB:P35228 (IPI00220339 · NOS2_HUMAN · NOS2A · IPI00017304 · NOS2 · P35228)Nitric oxide synthase, inducible⌘
H. sapiensENSEMBL:ENSG00000164867 · UniProtKB:P29474 (NOS3_HUMAN · IPI00218845 · NOS3 · P29474)Nitric oxide synthase, endothelial⌘
M. musculusNCBI:NP_766068 · MGI:MGI:1891037 (Mtrr)5-methyltetrahydrofolate-homocysteine methyltransferase reductase⌘
M. musculusUniProtKB:P37040 · MGI:MGI:97744 (Por · CPR · CYPOR)NADH cytochrome P450 oxydoreductase · P450 (cytochrome) oxidoreductase⌘
M. musculusUniProtKB:A2AI05 · MGI:MGI:1926047 (NR1 · Ndor1)NADPH dependent diflavin oxidoreductase 1⌘
M. musculusUniProtKB:Q9Z0J4 · MGI:MGI:97360 (NO · bNOS · nNOS · Nos1 · Nos-1)nitric oxide synthase 1, neuronal⌘
M. musculusUniProtKB:P29477 · MGI:MGI:97361 (Nos2a · Nos-2 · NOS-II · iNOS · Nos2)nitric oxide synthase 2, inducible⌘
M. musculusUniProtKB:P70313 · MGI:MGI:97362 (Nos-3 · eNOS · ecNOS · Nos3)nitric oxide synthase 3, endothelial cell⌘
R. norvegicusNCBI:XP_001072474 · RGD:1308479 (Ndor1)NADPH dependent diflavin oxidoreductase 1⌘
R. norvegicusUniProtKB:P00388 · RGD:68335 (Por)P450 (cytochrome) oxidoreductase⌘
R. norvegicusRGD:3184 (Nos1) · UniProtKB:P29476 (NOS1_RAT · IPI00231079 · IPI00324698 · Bnos · IPI00204773 · Nos1 · P29476)nitric oxide synthase 1, neuronal · Nitric oxide synthase, brain⌘⌘
R. norvegicusUniProtKB:Q06518 · RGD:3185 (Nos2)nitric oxide synthase 2, inducible⌘
R. norvegicusUniProtKB:Q62600 · RGD:3186 (Nos3)nitric oxide synthase 3, endothelial cell⌘
R. norvegicusUniProtKB:Q498R1 · RGD:1308671 (Mtrr)5-methyltetrahydrofolate-homocysteine methyltransferase reductase⌘
S. cerevisiaeUniProtKB:P39692 · SGD:S000001926 (YFR030W · MET10)Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide⌘
S. cerevisiaeUniProtKB:P16603 · SGD:S000001084 (YHR042W · CPR1 · NCP1)NADP-cytochrome P450 reductase⌘
S. cerevisiaeUniProtKB:Q12181 · SGD:S000006252 (YPR048W · TAH18)Protein of unknown function that plays a pro-death role in response to oxidative stress⌘
S. pombeUniProtKB:Q09878 · GeneDB_Spombe:SPCC584.01c (SPCC584.01c)sulfite reductase NADPH flavoprotein subunit⌘
S. pombeUniProtKB:P36587 · GeneDB_Spombe:SPBC29A10.01 (ccr1 · SPBC29A10.01 · SPBC365.17)NADPH-cytochrome p450 reductase⌘
S. pombeUniProtKB:O94613 · GeneDB_Spombe:SPAC1296.06 (SPAC1296.06)NADPH-dependent diflavin oxidoreductase (predicted) · NADPH-dependent diflavin oxidoreductase⌘
S. pombeUniProtKB:Q09744 · GeneDB_Spombe:SPBC12C2.03c (SPBC12C2.03c)FAD binding protein · FAD binding protein (predicted)⌘
S. pombeUniProtKB:Q9US28 · GeneDB_Spombe:SPAC1783.01 (SPAC1783.01)FAD binding protein · FAD binding protein (predicted)⌘
ProteinPublicationCurator Notes
UniProtKB:P16603 · SGD:S000001084PMID:15849785 He F, et al. Cloning and heterologous expression of the NADPH cytochrome P450 oxidoreductase genes from an industrial dicarboxylic acid-producing Candida tropicalis. Yeast. 2005 Apr 30;22(6):481-91.The C. tropicalis protein CPR-a complements a homologous mutation in S. cerevisiae.
UniProtKB:P16603 · SGD:S000001084PMID:1544575 Bligh HF, et al. Production of cytochrome P450 reductase yeast-rat hybrid proteins in Saccharomyces cerevisiae. Gene. 1992 Jan 2;110(1):33-9.The R. norvegicus protein cytochrome c P450 reductase was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P16603 · SGD:S000001084PMID:9468503 Venkateswarlu K, et al. The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity. J Biol Chem. 1998 Feb 20;273(8):4492-6.The H. sapiens protein CYP51 (protein ID unknown) was expressed in S. cerevisiae, but complementation was not directly tested. This paper describes the biochemical characterization of human CYP51 expressed in and NCP1 strain.
UniProtKB:P16603 · SGD:S000001084PMID:15849785 He F, et al. Cloning and heterologous expression of the NADPH cytochrome P450 oxidoreductase genes from an industrial dicarboxylic acid-producing Candida tropicalis. Yeast. 2005 Apr 30;22(6):481-91.The C. tropicalis protein CPR-b complements a homologous mutation in S. cerevisiae.
UniProtKB:Q12181 · SGD:S000006252PMID:20802492 Netz DJ, et al. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol. 2010 Oct;6(10):758-65.The H. sapiens protein NDOR1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (5)
ENSEMBL:ENSG00000124275 · UniProtKB:Q9UBK8#236270 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM,cblE COMPLEMENTATION TYPE;;VITAMIN B12-RESPONSIVE HOMOCYSTINURIA, cblE TYPE;;METHYLCOBALAMIN DEFICIENCY, cblE TYPE
ENSEMBL:ENSG00000127948 · UniProtKB:P16435#601634 NEURAL TUBE DEFECTS, FOLATE-SENSITIVE;;NTD, FOLATE-SENSITIVESPINA BIFIDA, FOLATE-SENSITIVE, INCLUDED
ENSEMBL:ENSG00000089250 · UniProtKB:P29475#201750 POR DEFICIENCY;;CYTOCHROME P450 OXIDOREDUCTASE DEFICIENCY;;ANTLEY-BIXLER SYNDROME-LIKE PHENOTYPE WITH DISORDERED STEROIDOGENESISDISORDERED STEROIDOGENESIS DUE TO CYTOCHROME P450 OXIDOREDUCTASE DEFICIENCY,INCLUDED;;ADRENAL HYPERPLASIA, CONGENITAL, DUE TO CYTOCHROME P450 OXIDOREDUCTASEDEFICIENCY, INCLUDED
ENSEMBL:ENSG00000164867 · UniProtKB:P29474#179010 PYLORIC STENOSIS, INFANTILE HYPERTROPHIC 1; IHPS1;;PYLORIC STENOSIS, INFANTILE;;PYLORIC STENOSIS, INFANTILE HYPERTROPHIC; IHPS
ENSEMBL:ENSG00000164867 · UniProtKB:P29474+163729 NITRIC OXIDE SYNTHASE 3; NOS3;;NITRIC OXIDE SYNTHASE, ENDOTHELIAL; ENOSCORONARY SPASM, SUSCEPTIBILITY TO, INCLUDED;;ALZHEIMER DISEASE, LATE-ONSET, SUSCEPTIBILITY TO, INCLUDED;;HYPERTENSION, PREGNANCY-INDUCED, SUSCEPTIBILITY TO, INCLUDED;;HYPERTENSION, RESISTANT TO CONVENTIONAL THERAPY, INCLUDED
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