P-POD: Princeton Protein Orthology Database: GO3/Jaccard318

This family has 59 members: 10 Arabidopsis thaliana, 1 Caenorhabditis elegans, 7 Danio rerio, 5 Dictyostelium discoideum, 3 Drosophila melanogaster, 1 Escherichia coli, 6 Gallus gallus, 7 Homo sapiens, 7 Mus musculus, 6 Rattus norvegicus, 3 Saccharomyces cerevisiae, 3 Schizosaccharomyces pombe.

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GO3/Jaccard318
59 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_188928.2 · TAIR:locus:2084558 (DMC1 · AT3G22880 · ATDMC1 · F5N5.6 · ARLIM15)DISRUPTION OF MEIOTIC CONTROL 1 · ARABIDOPSIS HOMOLOG OF LILY MESSAGES INDUCED AT MEIOSIS 15 · ARABIDOPSIS THALIANA DISRUPTION OF MEIOTIC CONTROL 1⌘
A. thalianaNCBI:NP_189781.1 · TAIR:locus:2103131 (T7B9.20 · AT3G32920)⌘
A. thalianaNCBI:NP_851202.1 · TAIR:locus:2174577 (ATXRCC3 · MUA2.3 · MUA2_3 · AT5G57450 · XRCC3)⌘
A. thalianaNCBI:NP_566040.1 · TAIR:locus:2050852 (AT2G45280 · ATRAD51C · F4L23.21 · RAD51C)⌘
A. thalianaNCBI:NP_172254.2 · TAIR:locus:2825233 (F24B9_14 · RAD51D · ATRAD51D · F24B9.14 · SSN1 · AT1G07745)ARABIDOPSIS HOMOLOG OF RAD51 D · SUPPRESOR OF SNI1⌘
A. thalianaNCBI:NP_187625.2 · TAIR:locus:2100038 (T22K18.3 · RECA3 · AT3G10140)recA homolog 3⌘
A. thalianaNCBI:NP_179539.2 · TAIR:locus:2050439 (F3P11_9 · F3P11.9 · AT2G19490)⌘
A. thalianaNCBI:NP_568402.1 · TAIR:locus:2147092 (RAD51 · ATRAD51 · AT5G20850 · F22D1_20 · F22D1.20)⌘
A. thalianaNCBI:NP_565198.1 · TAIR:locus:2207445 (YUP8H12R_33 · YUP8H12R.33 · AT1G79050)⌘
A. thalianaNCBI:NP_180423.3 · TAIR:locus:2056583 (RAD51B · AT2G28560 · ATRAD51B · T17D12_12 · T17D12.12)⌘
C. elegansWB:WBGene00004297 (rad-51 · Y43C5A.6) · UniProtKB:Q95Q25 (Y43C5A.6a · rad-51 · Y43C5A.6)Protein Y43C5A.6a, confirmed by transcript evidence⌘⌘
D. rerioUniProtKB:Q50LF4 · ZFIN:ZDB-GENE-060331-93 (dmc1)DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)⌘
D. rerioENSEMBL:ENSDARG00000013933 · UniProtKB:Q566S1
D. rerioUniProtKB:Q5TYR1 · ZFIN:ZDB-GENE-040426-2286 (rad51)RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)⌘
D. rerioUniProtKB:Q5XJT2 · ZFIN:ZDB-GENE-041010-204 (rad51c)rad51 homolog C (S. cerevisiae)⌘
D. rerioZFIN:ZDB-GENE-040426-2490 (zgc:77165) · UniProtKB:Q6NYZ3⌘
D. rerioENSEMBL:ENSDARG00000037046 · UniProtKB:Q7ZTX4
D. rerioUniProtKB:Q5TZD9 · ZFIN:ZDB-GENE-050320-116 (xrcc3)X-ray repair complementing defective repair in Chinese hamster cells 3⌘
D. discoideumNCBI:EAL70787.1 · dictyBase:DDB_G0273139 (DDB_G0273139)putative DNA repair protein, putative Rad51 protein⌘
D. discoideumUniProtKB:Q75JL2 · dictyBase:DDB_G0276073 (recA)recombinase A, DNA recombination protein⌘
D. discoideumUniProtKB:Q54PJ7 · dictyBase:DDB_G0284507 (DDB_G0284507)putative DNA repair protein, putative Rad51C protein⌘
D. discoideumUniProtKB:Q54QU4 · dictyBase:DDB_G0283637 (xrcc3)AAA ATPase domain-containing protein, putative DNA repair protein XRCC3⌘
D. discoideumUniProtKB:Q557E6 · dictyBase:DDB_G0273611 (DDB_G0273611)Similar to dna repair protein rad51 homolog.⌘
D. melanogasterUniProtKB:Q27297 · FB:FBgn0003479 (spn-A · Rad51 · DMR1 · rad51 · CG7948 · DMR/DroRAD51 · Spindle-A · DmRAD51 · RA51 · D37788 · DMR · Rad51-like · spindle-A · dmRAD51 · Rad51dm · spnA · RAD51 · DmRad51 · Dmrad51)spindle A · Dm Rad51⌘
D. melanogasterUniProtKB:Q8SZ30 · FB:FBgn0003482 (spn-D · spnD · BcDNA:RE19845 · CG31069 · spndD · rad51C · Spn-D)spindle D⌘
D. melanogasterUniProtKB:Q8SZF1 · FB:FBgn0003480 (Rad51 · CG3325 · spnB · spn-B · rad51-like · Spindle-B · xrcc3 · XRCC3 · spindle-B · SpnB)spindle B⌘
E. coliUniProtKB:P0A7G6 · ECOLI:EG10823-MONOMER (srf · zab · RecA · rnmB · tif · lexB · recA · ECK2694 · umuB · recH · b2699)DNA strand exchange and recombination protein with protease and nuclease activity⌘
G. gallusNCBI:XP_001232262 · ENTREZ:769071
G. gallusNCBI:XP_415870 · ENTREZ:417626
G. gallusNCBI:XP_425477 · ENTREZ:427903
G. gallusNCBI:XP_415775 · ENTREZ:417528
G. gallusENTREZ:396086 · UniProtKB:P37383 (RAD51 · P37383 · RAD51A · RAD51_CHICK · IPI00593131)DNA repair protein RAD51 homolog 1⌘
G. gallusUniProtKB:Q5ZM26 (IPI00684938 · RCJMB04_3f19 · Q5ZM26) · ENTREZ:423485⌘
H. sapiensENSEMBL:ENSG00000100206 · UniProtKB:Q14565 (DMC1 · Q14565 · DMC1H · DMC1_HUMAN · IPI00031512 · LIM15)Meiotic recombination protein DMC1/LIM15 homolog⌘
H. sapiensENSEMBL:ENSG00000182185 · UniProtKB:O15315 (RA51B_HUMAN · IPI00386489 · IPI00006105 · IPI00386490 · RAD51L1 · IPI00220523 · O15315 · RAD51B · IPI00395987 · REC2)DNA repair protein RAD51 homolog 2⌘
H. sapiensENSEMBL:ENSG00000108384 · UniProtKB:O43502 (IPI00012829 · RAD51C · O43502 · RA51C_HUMAN · RAD51L2)DNA repair protein RAD51 homolog 3⌘
H. sapiensENSEMBL:ENSG00000185379 · UniProtKB:O75771 (RAD51L3 · IPI00216386 · IPI00216383 · IPI00216382 · IPI00291454 · RA51D_HUMAN · IPI00411326 · IPI00216381 · IPI00216384 · O75771 · RAD51D)DNA repair protein RAD51 homolog 4⌘
H. sapiensENSEMBL:ENSG00000051180 · UniProtKB:Q06609 (IPI00032201 · RECA · RAD51 · IPI00220649 · RAD51_HUMAN · RAD51A · Q06609)DNA repair protein RAD51 homolog 1⌘
H. sapiensENSEMBL:ENSG00000196584 · UniProtKB:O43543 (XRCC2_HUMAN · IPI00306229 · O43543 · XRCC2)DNA repair protein XRCC2⌘
H. sapiensENSEMBL:ENSG00000126215 · UniProtKB:O43542 (IPI00023073 · O43542 · XRCC3_HUMAN · XRCC3)DNA repair protein XRCC3⌘
M. musculusNCBI:NP_444499 · MGI:MGI:2150020 (Rad51c · Rad51l2)RAD51 homolog c (S. cerevisiae)⌘
M. musculusUniProtKB:Q61880 · MGI:MGI:105393 (Mei11 · sgdp · Dmc1 · Dmc1h)DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)⌘
M. musculusUniProtKB:O35719 · MGI:MGI:1099436 (mREC2 · Rad51l1 · R51H2 · Rad51b)RAD51-like 1 (S. cerevisiae)⌘
M. musculusUniProtKB:O55230 · MGI:MGI:1261809 (R51H3 · Rad51l3 · Rad51d)RAD51-like 3 (S. cerevisiae)⌘
M. musculusUniProtKB:Q08297 · MGI:MGI:97890 (Reca · Rad51 · Rad51a)RAD51 homolog (S. cerevisiae)⌘
M. musculusUniProtKB:Q9CX47 · MGI:MGI:1927345 (RecA · Xrcc2)X-ray repair complementing defective repair in Chinese hamster cells 2⌘
M. musculusUniProtKB:Q9CXE6 · MGI:MGI:1921585 (Xrcc3)X-ray repair complementing defective repair in Chinese hamster cells 3⌘
R. norvegicusNCBI:XP_576058 · RGD:1560681 (Rad51l1)RAD51-like 1 (S. cerevisiae)⌘
R. norvegicusNCBI:XP_001075521 · RGD:1307611 (Dmc1)DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)⌘
R. norvegicusNCBI:XP_575211 · RGD:1563603 (Rad51)RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)⌘
R. norvegicusNCBI:XP_001080997 · RGD:1306944 (Rad51l3)RAD51-like 3 (S. cerevisiae)⌘
R. norvegicusNCBI:XP_573171 · RGD:1563765 (Rad51c)Rad51 homolog c (S. cerevisiae)⌘
R. norvegicusNCBI:XP_575317 · RGD:1564823 (Xrcc2)X-ray repair complementing defective repair in Chinese hamster cells 2⌘
S. cerevisiaeUniProtKB:P25453 · SGD:S000000981 (DMC1 · ISC2 · YER179W)Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes⌘
S. cerevisiaeUniProtKB:P25454 · SGD:S000000897 (RAD51 · MUT5 · YER095W)Strand exchange protein, forms a helical filament with DNA that searches for homology⌘
S. cerevisiaeUniProtKB:P25301 · SGD:S000002411 (YDR004W · RAD57)Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA⌘
S. pombeUniProtKB:O42634 · GeneDB_Spombe:SPAC8E11.03c (dmc1 · dmp1 · SPAC8E11.03c)RecA family ATPase Dmc1⌘
S. pombeUniProtKB:P36601 · GeneDB_Spombe:SPAC644.14c (SPAC644.14c · rad51 · rhp51)recombinase Rhp51⌘
S. pombeUniProtKB:Q9UUL2 · GeneDB_Spombe:SPAC20H4.07 (SPAC20H4.07 · rhp57)RecA family ATPase Rhp57⌘
ProteinPublicationCurator Notes
UniProtKB:P25454 · SGD:S000000897PMID:8341671 Morita T, et al. A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6577-80.The M. musculus protein Q08297 complements a homologous mutation in S. cerevisiae.
UniProtKB:P25454 · SGD:S000000897PMID:15590830 Shalguev VI, et al. Rad51 protein from the thermotolerant yeast Pichia angusta as a typical but thermodependent member of the Rad51 family. Eukaryot Cell. 2004 Dec;3(6):1567-73.The P. angusta protein Rad51PA complements a homologous mutation in S. cerevisiae. Rad51PA parttially complements an S. cerevisiae mutant.
UniProtKB:P25454 · SGD:S000000897PMID:8341671 Morita T, et al. A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6577-80.The M. musculus protein Rad51 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (2)
ENSEMBL:ENSG00000051180 · UniProtKB:Q06609#150699 LEIOMYOMA, UTERINE; UL
UniProtKB:P25453 · SGD:S000000981#114480 BREAST CANCER;;BREAST CANCER, FAMILIALBREAST CANCER, FAMILIAL MALE, INCLUDED
SGD Disease Papers (7)
UniProtKB:P25454 · SGD:S000000897PMID:18166824 Mandon-Pepin B, et al. (2008) Genetic investigation of four meiotic genes in women with premature ovarian failure. Eur J Endocrinol 158(1):107-15
UniProtKB:P25454 · SGD:S000000897PMID:9192668 Mizuta R, et al. (1997) RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc Natl Acad Sci U S A 94(13):6927-32
PMID:9126738 Sharan SK, et al. (1997) Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386(6627):804-10
PMID:7531413 Abe H, et al. (1994) Altered drug sensitivities to anticancer agents in radiation-sensitive DNA repair deficient yeast mutants. Anticancer Res 14(5A):1807-10
PMID:17360454 Yuen KW, et al. (2007) Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci U S A 104(10):3925-30
PMID:17090598 Desfarges S, et al. (2006) Chromosomal integration of LTR-flanked DNA in yeast expressing HIV-1 integrase: down regulation by RAD51. Nucleic Acids Res 34(21):6215-24
PMID:11231130 Huang P, et al. (2001) SGS1 is required for telomere elongation in the absence of telomerase. Curr Biol 11(2):125-9
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