P-POD: Princeton Protein Orthology Database: GO3/Jaccard3164

This family has 11 members: 1 Arabidopsis thaliana, 1 Escherichia coli, 6 Saccharomyces cerevisiae, 3 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

11 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:505006580 (AT5G03555) · NCBI:NP_568122.2⌘
E. coliUniProtKB:P75712 · ECOLI:B0511-MONOMER (YbbW · glxB2 · ECK0504 · ybbW · allP · b0511)YbbW NCS1 Transporter⌘
S. cerevisiaeUniProtKB:Q04895 · SGD:S000001467 (YIR028W · DAL4)Allantoin permease⌘
S. cerevisiaeUniProtKB:P38196 · SGD:S000000138 (FUI1 · YBL042C)High affinity uridine permease, localizes to the plasma membrane⌘
S. cerevisiaeUniProtKB:P05316 · SGD:S000000225 (FUR4 · YBR021W)Uracil permease, localized to the plasma membrane⌘
S. cerevisiaeUniProtKB:Q05998 · SGD:S000004227 (THI10 · YLR237W · THI7)Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters⌘
S. cerevisiaeUniProtKB:Q08485 · SGD:S000005597 (YOR29-22 · NRT1 · YOR071C · THI71)High-affinity nicotinamide riboside transporter⌘
S. cerevisiaeUniProtKB:Q08579 · SGD:S000005718 (YOR192C · THI72)Transporter of thiamine or related compound⌘
S. pombeUniProtKB:Q10279 · GeneDB_Spombe:SPAC1399.03 (SPAC1399.03 · fur4)uracil permease⌘
S. pombeUniProtKB:O14035 · GeneDB_Spombe:SPAC29B12.14c (SPAC29B12.14c)purine transporter⌘
S. pombeUniProtKB:Q9P6J5 · GeneDB_Spombe:SPBC1683.05 (SPBC1683.05)membrane transporter⌘
ProteinPublicationCurator Notes
UniProtKB:Q05998 · SGD:S000004227PMID:10074490 Stagg AR, et al. Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts. J Clin Invest. 1999 Mar;103(5):723-9.The S. cerevisiae protein THI7 complements a homologous mutation in H. sapiens. This paper shows that the yeast thiamine transporter THI10 (alias for THI7) rescues thiamine-responsive megaloblastic anemia (TRMA) fibroblasts indicating an apparent deficiency of a thiamine transporter in the TRMA cells. Although this paper did not identify the human thiamine transporter, two separate publications (PubMed ids: 10391221, 10391223) identified mutations in the human SLC19A2 gene (O60779) encoding a thiamine transporter that were found to cause thiamine-responsive megaloblastic anaemia syndrome.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
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