This family has 64 members: 4 Arabidopsis thaliana, 3 Caenorhabditis elegans, 6 Danio rerio, 13 Dictyostelium discoideum, 8 Drosophila melanogaster, 2 Escherichia coli, 4 Gallus gallus, 5 Homo sapiens, 7 Mus musculus, 6 Rattus norvegicus, 4 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.
Interactive Java Applets: Notung Tree Analysis · Jalview Alignment
| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_175247.1 · TAIR:locus:2023772 (AT1G48130 · F21D18.15 · ATPER1 · F21D18_15) | 1-Cys peroxiredoxin |  |
| A. thaliana | NCBI:NP_568166.1 · TAIR:locus:2164265 (MHF15_19 · AT5G06290 · MHF15.19) | 2-Cysteine peroxiredoxin B · 2-Cys Prx B | |
| A. thaliana | NCBI:NP_187769.1 · TAIR:locus:2080707 (AT3G11630 · F24K9.28 · T19F11.3 · F24K9_28) | | |
| A. thaliana | NCBI:NP_189235.1 · TAIR:locus:2092135 (AT3G26060 · MPE11.21) | ATPRX Q | |
| C. elegans | WB:WBGene00011110 (R07E5.2 · prdx-3) · UniProtKB:Q21824 | | |
| C. elegans | WB:WBGene00006434 (prdx-2 · F09E5.15) · UniProtKB:A8DYR6 | | |
| C. elegans | WB:WBGene00021401 (Y38C1AA.11 · prdx-6) · UniProtKB:Q8MXT1 | | |
| D. rerio | ENSEMBL:ENSDARP00000063907 | ||
| D. rerio | ENSEMBL:ENSDARG00000069013 · UniProtKB:A3KP44 | ||
| D. rerio | UniProtKB:Q5BJB9 · ZFIN:ZDB-GENE-030826-18 (prdx3) | peroxiredoxin 3 | |
| D. rerio | UniProtKB:Q5TZD2 · ZFIN:ZDB-GENE-040426-1778 (prdx6) | peroxiredoxin 6 | |
| D. rerio | UniProtKB:Q6DGJ6 · ZFIN:ZDB-GENE-030326-2 (prdx2) | peroxiredoxin 2 | |
| D. rerio | ZFIN:ZDB-GENE-050320-35 (zgc:110343) · UniProtKB:A7MCD6 | | |
| D. discoideum | NCBI:EAL71985.1 · dictyBase:DDB_G0269270 (DDB_G0269270) | AhpC/TSA family protein | |
| D. discoideum | NCBI:EAL71292.1 · dictyBase:DDB_G0272280 (DDB_G0272280) | AhpC/TSA family protein | |
| D. discoideum | NCBI:EDR41074.1 · dictyBase:DDB_G0279949 (DDB_G0279949) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q54SE2 · dictyBase:DDB_G0282517 (DDB_G0282517) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q54NG4 · dictyBase:DDB_G0285273 (DDB_G0285273) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q54W09 · dictyBase:DDB_G0279973 (DDB_G0279973) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q54W30 · dictyBase:DDB_G0279951 (DDB_G0279951) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q552Z0 · dictyBase:DDB_G0275755 (DDB_G0275755) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q55E48 · dictyBase:DDB_G0269392 (DDB_G0269392) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q55EE4 · dictyBase:DDB_G0269256 (DDB_G0269256) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q55EF1 · dictyBase:DDB_G0269260 (DDB_G0269260) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q55FA7 · dictyBase:DDB_G0268192 (DDB_G0268192) | AhpC/TSA family protein | |
| D. discoideum | UniProtKB:Q8MP16 · dictyBase:DDB_G0274859 (prdx4) | peroxiredoxin, thioredoxin peroxidase | |
| D. melanogaster | UniProtKB:Q9V3P0 · FB:FBgn0040309 (jafrac1 · CG1633 · T20 · Prx4783 · Jafrac1 · DPx4783 · DPx-4783 · SSP5111 · DmTPx-1) | Thioredoxin peroxidase 1 · dPrx I · thioredoxin peroxidase 1 · Peroxiredoxin I · Peroxiredoxin 4783 · thioredoxin peroxidase | |
| D. melanogaster | UniProtKB:A1Z892 · FB:FBgn0033520 (Prx2540-1 · BEST:LD11278 · AOP2-related · CG12405 · DPx-2540-1 · DPx2540 · Prx2540 · CG11765) | peroxiredoxin 2540 · Peroxiredoxin 2540 | |
| D. melanogaster | FB:FBgn0033521 (AOP2-related · CG12896 · BEST:LD11278) · UniProtKB:A1Z893 | | |
| D. melanogaster | UniProtKB:Q7JX87 · FB:FBgn0033518 (Prx2540-2 · Prx2540 · DPx2540 · DPx-2540-2 · CG11765) | Peroxiredoxin 2540 | |
| D. melanogaster | UniProtKB:Q9V3Q4 · FB:FBgn0040308 (CG1274 · DPx4156 · jafrac2 · Prx4156 · DPx-4156 · Jafrac2 · Jafrac-2) | Peroxiredoxin 4156 · thioredoxin peroxidase 2 · thioredoxin peroxidase | |
| D. melanogaster | UniProtKB:Q9VEJ0 · FB:FBgn0038519 (mTPx · DPx5037 · DPx-5037 · CG5826 · Prx5037 · thioredoxin-peroxidase-3) | mitochondrial peroxiredoxin · Peroxiredoxin 5037 · Thioredoxin peroxidase 3 | |
| D. melanogaster | UniProtKB:Q9VQI7 · FB:FBgn0031479 (CG3083 · DPx-6005 · DPx6005 · 153181_at · Prx6005) | Peroxiredoxin 6005 | |
| D. melanogaster | FB:FBgn0036490 (BcDNA:AT16346 · CG6888) · UniProtKB:Q9VUM4 | | |
| E. coli | UniProtKB:P0AE08 · ECOLI:EG11384-MONOMER (b0605 · ssi8 · ahpC · tpx · ECK0599 · AhpC · B0605 · Ssi8) | C22 subunit · AhpC component · alkyl hydroperoxide reductase | |
| E. coli | UniProtKB:P0AE52 · ECOLI:EG10108-MONOMER (ECK2476 · Bcp · bcp · b2480) | thiol peroxidase | |
| G. gallus | NCBI:XP_426543 · ENTREZ:428986 | ||
| G. gallus | NCBI:XP_416800 · ENTREZ:418601 | ||
| G. gallus | NCBI:XP_001233893 · ENTREZ:424598 | ||
| G. gallus | UniProtKB:Q5ZJF4 (PRDX6 · Peroxiredoxin-6 · IPI00577013 · RCJMB04_18k11 · Q5ZJF4 · PRDX6_CHICK) · ENTREZ:429062 | | |
| H. sapiens | ENSEMBL:ENSG00000117450 · UniProtKB:Q06830 (PAGA · Q06830 · PRDX1_HUMAN · IPI00000874 · PRDX1 · PAGB · TDPX2 · Peroxiredoxin-1) | | |
| H. sapiens | ENSEMBL:ENSG00000167815 · UniProtKB:P32119 (P32119 · NKEFB · IPI00027350 · PRDX2_HUMAN · TDPX1 · PRDX2 · Peroxiredoxin-2) | | |
| H. sapiens | ENSEMBL:ENSG00000165672 · UniProtKB:P30048 (PRDX3_HUMAN · PRDX3 · AOP1 · IPI00024919 · P30048) | Thioredoxin-dependent peroxide reductase, mitochondrial | |
| H. sapiens | ENSEMBL:ENSG00000123131 · UniProtKB:Q13162 (Peroxiredoxin-4 · PRDX4_HUMAN · PRDX4 · IPI00011937 · Q13162) | | |
| H. sapiens | ENSEMBL:ENSG00000117592 · UniProtKB:P30041 (PRDX6 · PRDX6_HUMAN · Peroxiredoxin-6 · P30041 · AOP2 · KIAA0106 · IPI00220301) | | |
| M. musculus | NCBI:XP_922530 · MGI:MGI:3645884 | ||
| M. musculus | NCBI:NP_796230 · MGI:MGI:1336888 (1-cysPrx-P1 · Prdx6-rs1 · Aop2-rs1) | peroxiredoxin 6, related sequence 1 | |
| M. musculus | UniProtKB:P35700 · MGI:MGI:99523 (Paga · PrxI · MSP23 · prx1 · TDX2 · Prdx1 · PAG · Tdpx2 · OSF-3) | macrophage 23kDa stress protein · Trx dependent peroxide reductase 2 · peroxiredoxin 1 · osteoblast specific factor 3 · macrophase stress protein 22kDa · thioredoxin dependent peroxide reductase 2 · Prx I | |
| M. musculus | UniProtKB:Q61171 · MGI:MGI:109486 (Calpromotin · Band-8 · TPx-B · TDX1 · Tdpx1 · PrxII · Torin · TR · TSA · Prdx2 · PRP · TPx) | thioredoxin reductase · Prx II-1 · peroxiredoxin 2 · protector protein · Trx dependent peroxide reductase 1 · thioredoxin dependent peroxide reductase 1 · thioredoxin peroxidase · thiol specific antioxidant protein | |
| M. musculus | UniProtKB:P20108 · MGI:MGI:88034 (Mer5 · Aop1 · SP22 · Prdx3 · TDXM · Ef2l · D0Tohi1) | Prx III · peroxiredoxin 3 | |
| M. musculus | UniProtKB:O08807 · MGI:MGI:1859815 (Prdx4 · Prx-iv · AOE372) | Prx IV · peroxiredoxin 4 | |
| M. musculus | UniProtKB:O08709 · MGI:MGI:894320 (Brp-12 · Ltw-4 · Prdx6 · Aop2 · Lvtw-4 · CP-3 · 1-cysPrx · Ltw4 · aiPLA2 · GPx) | acidic calcium-independent phospholipase A2 · peroxiredoxin 6 · 1-Cys Prx | |
| R. norvegicus | UniProtKB:Q63716 · RGD:620039 (Prdx1) | peroxiredoxin 1 | |
| R. norvegicus | UniProtKB:P35704 · RGD:3838 (Prdx2) | peroxiredoxin 2 | |
| R. norvegicus | UniProtKB:Q9Z0V6 · RGD:620040 (Prdx3) | peroxiredoxin 3 | |
| R. norvegicus | UniProtKB:O35244 · RGD:71005 (Prdx6) | peroxiredoxin 6 | |
| R. norvegicus | RGD:727854 · UniProtKB:O88433 | ||
| R. norvegicus | UniProtKB:Q9Z0V5 · RGD:620043 (Prdx4) | peroxiredoxin 4 | |
| S. cerevisiae | UniProtKB:P40553 · SGD:S000001272 (YIL010W · DOT5) | Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth | |
| S. cerevisiae | UniProtKB:P34227 · SGD:S000000160 (PRX1 · YBL064C) | Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides | |
| S. cerevisiae | UniProtKB:P34760 · SGD:S000004490 (YML028W · ZRG14 · TPX1 · TSA1) | Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant | |
| S. cerevisiae | UniProtKB:Q04120 · SGD:S000002861 (YDR453C · TSA2) | Stress inducible cytoplasmic thioredoxin peroxidase | |
| S. pombe | UniProtKB:O94561 · GeneDB_Spombe:SPBC1773.02c (SPBC1773.02c) | thioredoxin peroxidase | |
| S. pombe | UniProtKB:O74887 · GeneDB_Spombe:SPCC576.03c (SPCC576.03c · tpx1) | thioredoxin peroxidase Tpx1 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:Q04120 · SGD:S000002861 |  12609026 Sakamoto A, et al. Functional complementation in yeast reveals a protective role of chloroplast 2-Cys peroxiredoxin against reactive nitrogen species. Plant J. 2003 Mar;33(5):841-51. | The A. thaliana protein AT3G11630.1 complements a homologous mutation in S. cerevisiae. Arabidopsis 2CPRX complements a yeast tsa1 tsa2 double mutant. | |
| UniProtKB:P34760 · SGD:S000004490 | 12609026 Sakamoto A, et al. Functional complementation in yeast reveals a protective role of chloroplast 2-Cys peroxiredoxin against reactive nitrogen species. Plant J. 2003 Mar;33(5):841-51. | The A. thaliana protein AT3G11630.1 complements a homologous mutation in S. cerevisiae. Arabidopsis 2CPRX complements a yeast tsa1 tsa2 double mutant. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |