This family has 65 members: 11 Arabidopsis thaliana, 3 Caenorhabditis elegans, 7 Danio rerio, 5 Dictyostelium discoideum, 4 Drosophila melanogaster, 4 Escherichia coli, 4 Gallus gallus, 5 Homo sapiens, 7 Mus musculus, 6 Rattus norvegicus, 5 Saccharomyces cerevisiae, 4 Schizosaccharomyces pombe.
Interactive Java Applets: Notung Tree Analysis · Jalview Alignment
| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | TAIR:locus:2152916 (K16H17.13 · K16H17_13 · AT5G24420) · NCBI:NP_197830.1 |  | |
| A. thaliana | NCBI:NP_563844.1 · TAIR:locus:2012305 (F14J9_8 · F14J9.8 · G6PD4 · AT1G09420) | GLUCOSE-6-PHOSPHATE DEHYDROGENASE 4 | |
| A. thaliana | NCBI:NP_190505.1 · TAIR:locus:2082916 (F2K15.220 · AT3G49360) | | |
| A. thaliana | NCBI:NP_198892.1 · TAIR:locus:2154805 (AT5G40760 · K1B16.1 · K1B16_1 · G6PD6) | GLUCOSE-6-PHOSPHATE DEHYDROGENASE 6 | |
| A. thaliana | NCBI:NP_198428.1 · TAIR:locus:2165154 (MWP19.3 · G6PD1 · AT5G35790) | GLUCOSE-6-PHOSPHATE DEHYDROGENASE 1 | |
| A. thaliana | NCBI:NP_189366.1 · TAIR:locus:2086558 (G6PD5 · AT3G27300 · K17E12.12) | glucose-6-phosphate dehydrogenase 5 | |
| A. thaliana | NCBI:NP_196815.2 · TAIR:locus:2179887 (T19L5_70 · T19L5.70 · G6PD2 · AT5G13110) | GLUCOSE-6-PHOSPHATE DEHYDROGENASE 2 | |
| A. thaliana | NCBI:NP_172826.1 · TAIR:locus:2023842 (AT1G13700 · F21F23_14 · F21F23.14) | | |
| A. thaliana | NCBI:NP_568445.1 · TAIR:locus:2152906 (K16H17_11 · K16H17.11 · emb2024 · AT5G24400) | embryo defective 2024 | |
| A. thaliana | NCBI:NP_173838.1 · TAIR:locus:2032412 (G6PD3 · F3I6.22 · F3I6_22 · AT1G24280) | GLUCOSE-6-PHOSPHATE DEHYDROGENASE 3 | |
| A. thaliana | NCBI:NP_197829.1 · TAIR:locus:2152911 (K16H17.12 · AT5G24410 · K16H17_12) | | |
| C. elegans | WB:WBGene00013301 (Y57G11C.3) · UniProtKB:O18229 | | |
| C. elegans | WB:WBGene00007108 (gspd-1 · B0035.5) · UniProtKB:Q27464 | | |
| C. elegans | WB:WBGene00011399 (T03F6.3) · UniProtKB:Q9XVJ2 (GNPI_CAEEL · T03F6.3) | Probable glucosamine-6-phosphate isomerase | |
| D. rerio | ENSEMBL:ENSDARP00000088131 | ||
| D. rerio | ENSEMBL:ENSDARP00000095604 | ||
| D. rerio | ENSEMBL:ENSDARP00000001421 | ||
| D. rerio | ENSEMBL:ENSDARP00000039222 | ||
| D. rerio | ENSEMBL:ENSDARP00000094268 | ||
| D. rerio | UniProtKB:Q567X3 · ZFIN:ZDB-GENE-050417-417 (gnpda1) | glucosamine-6-phosphate deaminase 1 | |
| D. rerio | ZFIN:ZDB-GENE-040822-9 (6-phosphogluconolactonase · pgls) · UniProtKB:Q68EK1 | | |
| D. discoideum | dictyBase:DDB_G0292898 (6-phosphogluconolactonase · pgl · PGLS) · UniProtKB:Q54CJ3 | | |
| D. discoideum | UniProtKB:Q557D2 · dictyBase:DDB_G0273131 (G6PD · zwf · G6PDH · g6pd-1) | glucose 6-phosphate-1-dehydrogenase | |
| D. discoideum | UniProtKB:Q557D2 · dictyBase:DDB_G0273639 (g6pd-2 · G6PD · zwf · G6PDH) | glucose 6-phosphate-1-dehydrogenase | |
| D. discoideum | UniProtKB:Q54XK9 · dictyBase:DDB_G0278873 (nagB2 · GNPDA1 · gnpda1 · gniA) | glucosamine-6-phosphate isomerase, glucosamine-6-phosphate deaminase | |
| D. discoideum | UniProtKB:Q54M58 · dictyBase:DDB_G0286195 (GPI · nagB1) | PIG-L family protein, glucosamine-6-phosphate isomerase, glucosamine-6-phosphate deaminase | |
| D. melanogaster | FB:FBgn0030239 (CG17333) · UniProtKB:Q9VZ64 | | |
| D. melanogaster | UniProtKB:P12646 · FB:FBgn0004057 (CG12529 · G6PDH · G6PD · G-6pd · G-6-PD · Zw · G-6PD · G-6-pdh · g6pd · G6pdh · G6pd · G6-pd · Zwischenferment · G6-PD) | glucose-6-phosphate dehydrogenase · Glucose-6-phosphate DH · Glucose-6-phosphate dehydrogenase · glucose-6-phosphate 1dehydrogenase | |
| D. melanogaster | FB:FBgn0031717 (Oscillin · CG6957) · UniProtKB:Q9VMP9 | | |
| D. melanogaster | FB:FBgn0037147 (CG7140) · UniProtKB:Q9VNW4 | | |
| E. coli | UniProtKB:P42912 · ECOLI:G7636-MONOMER (ECK3129 · agaI · AgaI · b3141 · yraG) | predicted galactosamine-6-phosphate isomerase | |
| E. coli | UniProtKB:P0AC53 · ECOLI:GLU6PDEHYDROG-MONOMER (ECK1853 · G6PDH · b1852 · zwf · Zwf · B1852 · GLU6PDEHYDROG) | glucose-6-phosphate dehydrogenase · glucose 6-phosphate-1-dehydrogenase | |
| E. coli | UniProtKB:P0A759 · ECOLI:GLUCOSAMINE-6-P-DEAMIN-MONOMER (glmD · b0678 · NagB · ECK0666 · nagB) | | |
| E. coli | UniProtKB:P31470 · ECOLI:EG11728-MONOMER (ECK3711 · YieK · b3718 · yieK) | predicted 6-phosphogluconolactonase | |
| G. gallus | NCBI:XP_425746 · ENTREZ:428188 | ||
| G. gallus | NCBI:XP_420726 · ENTREZ:422772 | ||
| G. gallus | UniProtKB:Q5ZJY1 (Q5ZJY1 · RCJMB04_14h20 · IPI00600301) · ENTREZ:430442 | | |
| G. gallus | UniProtKB:Q5ZLA0 (IPI00572218 · Q5ZLA0 · RCJMB04_7a23) · ENTREZ:416341 | | |
| H. sapiens | ENSEMBL:ENSG00000130313 · UniProtKB:O95336 (6PGL_HUMAN · IPI00029997 · 6-phosphogluconolactonase · PGLS · O95336) | | |
| H. sapiens | ENSEMBL:ENSG00000160211 · UniProtKB:P11413 (IPI00289800 · G6PD_HUMAN · G6PD · IPI00216008 · P11413) | Glucose-6-phosphate 1-dehydrogenase | |
| H. sapiens | ENSEMBL:ENSG00000049239 · UniProtKB:O95479 (G6PE_HUMAN · GDH · H6PD · IPI00607861 · O95479) | GDH/6PGL endoplasmic bifunctional protein | |
| H. sapiens | ENSEMBL:ENSG00000113552 · UniProtKB:P46926 (IPI00009305 · KIAA0060 · GNPI · GNPDA1 · GNPI1_HUMAN · P46926 · HLN) | Glucosamine-6-phosphate isomerase 1 | |
| H. sapiens | ENSEMBL:ENSG00000163281 · UniProtKB:Q8TDQ7 (Q8TDQ7 · IPI00550894 · GNPDA2 · GNPI2_HUMAN · IPI00896510 · IPI00896466) | Glucosamine-6-phosphate isomerase 2 | |
| M. musculus | NCBI:XP_995500 · MGI:MGI:3647532 | ||
| M. musculus | MGI:MGI:1913421 (Pgls · 6-phosphogluconolactonase) · UniProtKB:Q9CQ60 | | |
| M. musculus | UniProtKB:Q00612 · MGI:MGI:105979 (G6pd · G28A · Gpdx · G6pdx) | glucose-6-phosphate dehydrogenase X-linked | |
| M. musculus | UniProtKB:P97324 · MGI:MGI:105977 (Gpd2 · G6pd2 · G6pdx-ps1 · Gpd-2) | glucose-6-phosphate dehydrogenase 2 | |
| M. musculus | UniProtKB:Q8CFX1 · MGI:MGI:2140356 (Gpd-1 · G6pd1 · H6pd · Gpd1) | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | |
| M. musculus | UniProtKB:O88958 · MGI:MGI:1347054 (Gnpi · Gnp1 · Gnpda1 · oscillin) | glucose-6-phosphate isomerase · glucosamine-6-phosphate deaminase 1 | |
| M. musculus | UniProtKB:Q9CRC9 · MGI:MGI:1915230 (Gnp2 · Gnpda2) | glucosamine-6-phosphate deaminase 2 | |
| R. norvegicus | NCBI:XP_001077409 · RGD:1305521 (Gnpda2) | glucosamine-6-phosphate deaminase 2 | |
| R. norvegicus | NCBI:XP_001053009 · RGD:1596984 | ||
| R. norvegicus | NCBI:XP_001075788 · RGD:1306562 (H6pd) | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | |
| R. norvegicus | NCBI:XP_214296 · RGD:1307001 (Pgls · 6-phosphogluconolactonase) | | |
| R. norvegicus | NCBI:XP_001066558 · RGD:1585624 (Gnpda1) | glucosamine-6-phosphate deaminase 1 | |
| R. norvegicus | UniProtKB:P05370 · RGD:2645 (G6pd) | glucose-6-phosphate dehydrogenase | |
| S. cerevisiae | UniProtKB:P11412 · SGD:S000005185 (YNL241C · ZWF1 · POS10 · MET19) | Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway | |
| S. cerevisiae | UniProtKB:P50278 · SGD:S000005317 (SOL1 · YNR034W) | Protein with a possible role in tRNA export | |
| S. cerevisiae | UniProtKB:P37262 · SGD:S000000718 (YCRX13W · SOL2 · YCR073W-A) | Protein with a possible role in tRNA export | |
| S. cerevisiae | UniProtKB:P38858 · SGD:S000001206 (SOL3 · YHR163W) | 6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway | |
| S. cerevisiae | UniProtKB:P53315 · SGD:S000003480 (SOL4 · YGR248W) | 6-phosphogluconolactonase with similarity to Sol3p | |
| S. pombe | GeneDB_Spombe:SPCC16C4.10 (SPCC16C4.10 · 6-phosphogluconolactonase) · UniProtKB:O74455 | | |
| S. pombe | UniProtKB:O59812 · GeneDB_Spombe:SPCC794.01c (SPCC794.01c) | glucose-6-phosphate 1-dehydrogenase | |
| S. pombe | UniProtKB:O14137 · GeneDB_Spombe:SPAC3C7.13c (SPAC3C7.13c) | glucose-6-phosphate 1-dehydrogenase | |
| S. pombe | UniProtKB:O00091 · GeneDB_Spombe:SPAC3A12.18 (zwf1 · SPAC9.01 · SPAC3A12.18) | glucose-6-phosphate 1-dehydrogenase | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P11412 · SGD:S000005185 |  16193512 Merritt J, et al. Parallel analysis of mutant human glucose 6-phosphate dehydrogenase in yeast using PCR colonies. Biotechnol Bioeng. 2005 Dec 5;92(5):519-31. | The H. sapiens protein P11413 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P11412 · SGD:S000005185 | 14757426 Grabowska D, et al. A novel mutation in the glucose-6-phosphate dehydrogenase gene in a subject with chronic nonspherocytic hemolytic anemia--characterization of enzyme using yeast expression system and molecular modeling. Blood Cells Mol Dis. 2004 Jan-Feb;32(1):124-30. | The H. sapiens protein P11413 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P11412 · SGD:S000005185 | 14757426 Grabowska D, et al. A novel mutation in the glucose-6-phosphate dehydrogenase gene in a subject with chronic nonspherocytic hemolytic anemia--characterization of enzyme using yeast expression system and molecular modeling. Blood Cells Mol Dis. 2004 Jan-Feb;32(1):124-30. | The H. sapiens protein G6PD complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (2) | |
|---|---|
| ENSEMBL:ENSG00000049239 · UniProtKB:O95479 | +305900 GLUCOSE-6-PHOSPHATE DEHYDROGENASE; G6PDANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY, INCLUDED |
| ENSEMBL:ENSG00000049239 · UniProtKB:O95479 | #604931 CORTISONE REDUCTASE DEFICIENCY;;11-@BETA-HYDROXYSTEROID DEHYDROGENASE, TYPE I, DEFICIENCY OF;;HSD11B1 DEFICIENCY |