This family has 69 members: 11 Arabidopsis thaliana, 5 Caenorhabditis elegans, 5 Danio rerio, 6 Dictyostelium discoideum, 5 Drosophila melanogaster, 2 Escherichia coli, 5 Gallus gallus, 6 Homo sapiens, 6 Mus musculus, 6 Rattus norvegicus, 6 Saccharomyces cerevisiae, 6 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_194210.2 · TAIR:locus:2121934 | ||
| A. thaliana | NCBI:NP_193617.2 · TAIR:locus:2124122 | ||
| A. thaliana | NCBI:NP_565285.1 · TAIR:locus:2065299 (T8K22_22 · T8K22.22 · STICHEL · AT2G02480 · STI) | DNA POLYMERASE III-LIKE PROTEIN, GAMMA SUBUNIT |  |
| A. thaliana | NCBI:NP_564148.1 · TAIR:locus:2036927 (emb1968 · F8K7_11 · AT1G21690 · F8K7.11) | embryo defective 1968 | |
| A. thaliana | NCBI:NP_177871.1 · TAIR:locus:2204710 (T5M16_6 · T5M16.6 · AT1G77470) | | |
| A. thaliana | NCBI:NP_176504.1 · TAIR:locus:2015233 (F16M19.6 · AT1G63160 · F16M19_6) | | |
| A. thaliana | NCBI:NP_198126.1 · TAIR:locus:2180315 | ||
| A. thaliana | NCBI:NP_172898.2 · TAIR:locus:2012497 | ||
| A. thaliana | NCBI:NP_173839.1 · TAIR:locus:2032432 (F3I6.23 · AT1G24290 · F3I6_23) | | |
| A. thaliana | NCBI:NP_199384.2 · TAIR:locus:2172013 | ||
| A. thaliana | NCBI:NP_680188.1 · TAIR:locus:504956441 (AtRFC1 · AT5G22010) | replication factor C 1 | |
| C. elegans | WB:WBGene00004340 (rfc-4 · F31E3.3) · UniProtKB:P53016 (RFC4_CAEEL · rfc-4 · F31E3.3) | Replication factor C subunit 4 | |
| C. elegans | WB:WBGene00018409 (F44B9.8) · UniProtKB:P34429 (F44B9.8 · RFC5_CAEEL) | Probable replication factor C subunit 5 | |
| C. elegans | WB:WBGene00004338 (F58F6.4 · rfc-2) · UniProtKB:O44175 (F58F6.4 · rfc-2) | Rfc (Dna replication factor) family protein 2 | |
| C. elegans | WB:WBGene00004339 (rfc-3 · C39E9.13) · UniProtKB:Q18547 (rfc-3 · C39E9.13) | Protein C39E9.13, confirmed by transcript evidence | |
| C. elegans | WB:WBGene00004337 (rfc-1 · C54G10.2) · UniProtKB:Q18841 | | |
| D. rerio | ZFIN:ZDB-GENE-050306-29 (zgc:110810) · UniProtKB:Q5CZN5 | | |
| D. rerio | UniProtKB:Q6DRF4 · ZFIN:ZDB-GENE-040824-3 (rfc4) | replication factor C (activator 1) 4 | |
| D. rerio | ZFIN:ZDB-GENE-040426-2415 (zgc:85976) · UniProtKB:Q6NW46 | | |
| D. rerio | UniProtKB:Q8AW06 · ZFIN:ZDB-GENE-020809-3 (rfc3) | replication factor C (activator 1) 3 | |
| D. rerio | UniProtKB:Q6DRK4 · ZFIN:ZDB-GENE-040907-1 (rfc5) | replication factor C (activator 1) 5 | |
| D. discoideum | UniProtKB:Q54MH9 · dictyBase:DDB_G0285961 (rfc1) | replication factor C subunit | |
| D. discoideum | UniProtKB:Q54E21 · dictyBase:DDB_G0291868 (rfc2) | replication factor C subunit | |
| D. discoideum | UniProtKB:Q54BN3 · dictyBase:DDB_G0293702 (rfc3) | replication factor C subunit | |
| D. discoideum | UniProtKB:Q54MD4 · dictyBase:DDB_G0286027 (rfc4) | replication factor C subunit | |
| D. discoideum | UniProtKB:Q54ST4 · dictyBase:DDB_G0282235 (rfc5) | replication factor C subunit | |
| D. discoideum | UniProtKB:Q75JU2 · dictyBase:DDB_G0272158 (DDB_G0272158) | PUTATIVE HELICASE RUVBL | |
| D. melanogaster | UniProtKB:P35600 · FB:FBgn0004913 (ONF-CAACAA · Gnf1 · RFC · CG1119 · gtf1 · gnf1 · GTF-1 · RfC · Gnf-1 · RfC140 · dRF-Cp140 · Gtf1) | Germ line transcription factor 1 · RF-C 140 · Replication-factor-C 140kD subunit · germline transcription factor | |
| D. melanogaster | UniProtKB:P53034 · FB:FBgn0015287 (l(3)64Ai · rfc4 · RfC40 · rfc · l(3)rfc40 · rfc[40] · 154910_at · BEST:GH24992 · CG14999 · l(3)SH17 · rfc40 · Rfc40) | Replication-factor-C 40kD subunit | |
| D. melanogaster | UniProtKB:Q7KLW6 · FB:FBgn0028700 (n(2)k13807 · CG6258 · l(2)rfc38 · l(2)k13807 · BcDNA:LD06837 · Rfc38 · RfC38) | DNA replication factor, 38k subunit · Replication factor C 38kD subunit | |
| D. melanogaster | UniProtKB:Q9VKW3 · FB:FBgn0032244 (Rfc3 · DRFC · CG5313 · RfC3) | Drosophila replication factor C | |
| D. melanogaster | FB:FBgn0030871 (CG8142 · RfC) · UniProtKB:Q9VX15 | | |
| E. coli | UniProtKB:P06710 · ECOLI:MONOMER0-2383 (b0470 · ECK0464 · dnaX · dnaZ · DnaX) | DNA polymerase III, gamma subunit | |
| E. coli | UniProtKB:P0AAZ4 · ECOLI:EG12690-MONOMER (ECK0883 · b0892 · rarA · mgsA · ycaJ · RarA) | recombination factor | |
| G. gallus | NCBI:XP_418979 · ENTREZ:395089 | ||
| G. gallus | ENTREZ:396542 · UniProtKB:P53033 (RFC2_CHICK · IPI00586061 · RFC2 · P53033) | Replication factor C subunit 2 | |
| G. gallus | UniProtKB:Q5ZHL1 (Q5ZHL1 · RCJMB04_37a17 · IPI00574772) · ENTREZ:424958 | | |
| G. gallus | UniProtKB:Q5ZJP0 (RCJMB04_16m20 · Q5ZJP0 · IPI00593478) · ENTREZ:418907 | | |
| G. gallus | UniProtKB:Q5ZKU2 (IPI00574416 · RCJMB04_9c6 · Q5ZKU2) · ENTREZ:422788 | | |
| H. sapiens | ENSEMBL:ENSG00000035928 · UniProtKB:P35251 (IPI00375358 · RFC140 · IPI00375359 · RFC1 · P35251 · RFC1_HUMAN) | Replication factor C subunit 1 | |
| H. sapiens | ENSEMBL:ENSG00000049541 · UniProtKB:P35250 (IPI00218280 · IPI00017412 · RFC2 · RFC2_HUMAN · P35250) | Replication factor C subunit 2 | |
| H. sapiens | ENSEMBL:ENSG00000133119 · UniProtKB:P40938 (RFC3 · P40938 · RFC3_HUMAN · IPI00031521) | Replication factor C subunit 3 | |
| H. sapiens | ENSEMBL:ENSG00000163918 · UniProtKB:P35249 (IPI00017381 · P35249 · RFC4_HUMAN · RFC4) | Replication factor C subunit 4 | |
| H. sapiens | ENSEMBL:ENSG00000111445 · UniProtKB:P40937 (P40937 · RFC5_HUMAN · IPI00031514 · RFC5) | Replication factor C subunit 5 | |
| H. sapiens | ENSEMBL:ENSG00000124535 · UniProtKB:Q96S55 (WRNIP1 · IPI00102997 · Q96S55 · IPI00290314 · WRIP1_HUMAN · WHIP · IPI00645459 · IPI00642533) | ATPase WRNIP1 | |
| M. musculus | UniProtKB:P35601 · MGI:MGI:97891 (RFC140 · Recc1 · Alp145 · 140kDa · Rfc1) | replication factor C (activator 1) 1 | |
| M. musculus | UniProtKB:Q9WUK4 · MGI:MGI:1341868 (Recc2 · 40kDa · Rfc2) | replication factor C (activator 1) 2 | |
| M. musculus | UniProtKB:Q8R323 · MGI:MGI:1916513 (38kDa · Rfc3 · Recc3) | replication factor C (activator 1) 3 | |
| M. musculus | UniProtKB:Q99J62 · MGI:MGI:2146571 (A1 · Rfc4 · RFC37) | replication factor C (activator 1) 4 | |
| M. musculus | UniProtKB:Q9D0F6 · MGI:MGI:1919401 (36.5kDa · Rfc5 · Recc5 · 36kDa) | replication factor C (activator 1) 5 | |
| M. musculus | UniProtKB:Q91XU0 · MGI:MGI:1926153 (WHIP · Wrnip1) | Werner helicase interacting protein 1 | |
| R. norvegicus | NCBI:XP_222214 · RGD:1309280 (Rfc5) | replication factor C (activator 1) 5 | |
| R. norvegicus | NCBI:XP_001056509 · RGD:1310142 (Rfc4) | replication factor C (activator 1) 4 | |
| R. norvegicus | UniProtKB:Q641W4 · RGD:621198 (Rfc2) | replication factor C (activator 1) 2 | |
| R. norvegicus | UniProtKB:Q8CG07 · RGD:628836 (Wrnip1) | Werner helicase interacting protein 1 | |
| R. norvegicus | UniProtKB:Q5M830 · RGD:1306832 (Rfc3) | replication factor C (activator 1) 3 | |
| R. norvegicus | UniProtKB:Q9Z2R7 · RGD:620619 (Rfc1) | replication factor C (activator 1) 1 | |
| S. cerevisiae | UniProtKB:P40151 · SGD:S000005162 (YNL218W · MGS1) | Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome | |
| S. cerevisiae | UniProtKB:P38630 · SGD:S000005743 (CDC44 · YOR217W · RFC1) | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon | |
| S. cerevisiae | UniProtKB:P40348 · SGD:S000003829 (RFC2 · YJR068W) | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon | |
| S. cerevisiae | UniProtKB:P38629 · SGD:S000005234 (RFC3 · YNL290W) | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon | |
| S. cerevisiae | UniProtKB:P40339 · SGD:S000005454 (YOL094C · RFC4) | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon | |
| S. cerevisiae | UniProtKB:P38251 · SGD:S000000291 (YBR087W · RFC5) | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon | |
| S. pombe | UniProtKB:O60182 · GeneDB_Spombe:SPBC23E6.07c (rfc1 · SPBC23E6.07c) | DNA replication factor C complex subunit Rfc1 | |
| S. pombe | UniProtKB:Q09843 · GeneDB_Spombe:SPAC23D3.02 (rfc2 · SPAC23D3.02) | DNA replication factor C complex subunit Rfc2 | |
| S. pombe | UniProtKB:O14003 · GeneDB_Spombe:SPAC27E2.10c (SPAC27E2.10c · SPAPJ698.01c · rfc3) | DNA replication factor C complex subunit Rfc3 | |
| S. pombe | UniProtKB:O94449 · GeneDB_Spombe:SPAC1687.03c (SPAC1687.03c · rfc4) | DNA replication factor C complex subunit Rfc4 | |
| S. pombe | UniProtKB:O94697 · GeneDB_Spombe:SPBC83.14c (SPBC83.14c · rfc5) | DNA replication factor C complex subunit Rfc5 | |
| S. pombe | UniProtKB:O13984 · GeneDB_Spombe:SPAC26H5.02c (SPAC26H5.02c) | DNA replication ATPase | |
No functional conservation results.
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (1) | |
|---|---|
| UniProtKB:P40151 · SGD:S000005162 | #194050 WILLIAMS-BEUREN SYNDROME; WBS;;CHROMOSOME 7q11.23 DELETION SYNDROME;;WILLIAMS SYNDROME; WMS; WSHYPERCALCEMIA, INFANTILE, INCLUDED;;SUPRAVALVAR AORTIC STENOSIS, INCLUDED;;ELFIN FACIES WITH HYPERCALCEMIA |
| SGD Disease Papers (2) | |
| UniProtKB:P40151 · SGD:S000005162 |  18842586 Crosetto N, et al. (2008) Human Wrnip1 Is Localized in Replication Factories in a Ubiquitin-binding Zinc Finger-dependent Manner. J Biol Chem 283(50):35173-35185 |
| 12509289 Branzei D, et al. (2002) Characterization of the slow-growth phenotype of S. cerevisiae Whip/Mgs1 Sgs1 double deletion mutants. DNA Repair (Amst) 1(8):671-82 | |