P-POD: Princeton Protein Orthology Database: GO3/Jaccard243

This family has 70 members: 5 Arabidopsis thaliana, 7 Caenorhabditis elegans, 10 Danio rerio, 5 Dictyostelium discoideum, 4 Drosophila melanogaster, 2 Escherichia coli, 9 Gallus gallus, 7 Homo sapiens, 7 Mus musculus, 8 Rattus norvegicus, 4 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

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GO3/Jaccard243
70 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_198386.1 · TAIR:locus:2182658 (T26D22_8 · T26D22.8 · AT5G35360 · CAC2)ACETYL-COA CARBOXYLASE⌘
A. thalianaNCBI:NP_567950.1 · TAIR:locus:2124256 (F28A23_210 · AT4G34030 · F28A23.210 · MCCB)3-METHYLCROTONYL-COA CARBOXYLASE⌘
A. thalianaNCBI:NP_849583.1 · TAIR:locus:2007559 (MCCA · AT1G03090)⌘
A. thalianaNCBI:NP_174849.2 · TAIR:locus:2034310 (GURKE · GK · EMB22 · ACC1 · AT1G36160 · PAS3 · AT-ACC1 · F15C21.1)PASTICCINO 3 · EMBRYO DEFECTIVE 22 · ACETYL-COENZYME A CARBOXYLASE 1⌘
A. thalianaNCBI:NP_174850.3 · TAIR:locus:2013190 (F15C21.2 · AT1G36180 · ACC2 · F15C21_2)ACETYL-COA CARBOXYLASE 2⌘
C. elegansWB:WBGene00008514 (F02A9.4) · UniProtKB:P34385⌘
C. elegansWB:WBGene00017864 (F27D9.5 · pcca-1) · UniProtKB:Q19842⌘
C. elegansWB:WBGene00004258 (D2023.2 · pyc-1) · UniProtKB:O17732⌘
C. elegansWB:WBGene00009319 (F32B6.2) · UniProtKB:O45430⌘
C. elegansWB:WBGene00018701 (F52E4.1 · pccb-1) · UniProtKB:Q20676 (F52E4.1 · pccb-1)Putative uncharacterized protein⌘⌘
C. elegansWB:WBGene00004076 (pod-2 · W09B6.1) · UniProtKB:Q9GZI3⌘
C. elegansWB:WBGene00012131 (T28F3.5) · UniProtKB:Q9XUC3⌘
D. rerioENSEMBL:ENSDARP00000071058
D. rerioENSEMBL:ENSDARP00000077514
D. rerioENSEMBL:ENSDARP00000083485
D. rerioENSEMBL:ENSDARG00000061994 · UniProtKB:A2BGP4
D. rerioUniProtKB:Q6DGE2 · ZFIN:ZDB-GENE-040718-246 (pcca)propionyl-Coenzyme A carboxylase, alpha polypeptide⌘
D. rerioUniProtKB:Q6NWC8 · ZFIN:ZDB-GENE-040426-2467 (pccb)propionyl Coenzyme A carboxylase, beta polypeptide⌘
D. rerioUniProtKB:Q6NWI5 · ZFIN:ZDB-GENE-040426-2493 (mccc2)methylcrotonoyl-Coenzyme A carboxylase 2 (beta)⌘
D. rerioUniProtKB:A0JMP7 · ZFIN:ZDB-GENE-061103-95 (zgc:154106)⌘
D. rerioUniProtKB:B3DGZ9 · ZFIN:ZDB-GENE-000831-1 (pc)pyruvate carboxylase⌘
D. rerioZFIN:ZDB-GENE-051120-144 (zgc:123047) · UniProtKB:Q5PR38⌘
D. discoideumUniProtKB:Q54J08 · dictyBase:DDB_G0288387 (accA)acetyl-CoA carboxylase, biotin carboxylase⌘
D. discoideumUniProtKB:Q54KE6 · dictyBase:DDB_G0287377 (mccA · MCCC1)methylcrotonyl-CoA carboxylase, 3-methylcrotonyl-CoA:carbon dioxide ligase alpha subunit⌘
D. discoideumUniProtKB:Q8T2J9 · dictyBase:DDB_G0271960 (MCCC2 · mccB)3-methylcrotonyl-CoA:carbon dioxide ligase beta subunit, methylcrotonyl-CoA carboxylase⌘
D. discoideumUniProtKB:Q553S7 · dictyBase:DDB_G0275355 (pccA)propionyl-CoA carboxylase, propanoyl-CoA:carbon dioxide ligase alpha subunit⌘
D. discoideumUniProtKB:Q8T131 · dictyBase:DDB_G0276341 (pccB)propanoyl-CoA:carbon dioxide ligase beta subunit, propionyl-CoA carboxylase⌘
D. melanogasterFB:FBgn0042083 (l(2)4524 · CG3267 · FBgn0042083) · UniProtKB:Q9V9A7⌘
D. melanogasterUniProtKB:A1Z784 · FB:FBgn0033246 (CG8723 · FBgn0043811 · ACC · CG11198 · DmACC)Acetyl CoA carboxylase · Acetyl-CoA carboxylase · acetyl-coenzyme A carboxylase⌘
D. melanogasterUniProtKB:Q0E9E2 · FB:FBgn0027580 (BcDNA · BcDNA:GH06348 · CG1516 · GH06348 · PC)pyruvate carboxylase⌘
D. melanogasterUniProtKB:Q9V9T5 · FB:FBgn0039877 (CG2118 · MCC · mcc)3-methyl-crotonyl-CoA carboxylase⌘
E. coliUniProtKB:P24182 · ECOLI:BIOTIN-CARBOXYL-MONOMER (fabG · accC · AccC · ECK3243 · b3256)⌘
E. coliUniProtKB:P0A9Q5 · ECOLI:CARBOXYL-TRANSFERASE-BETA-MONOMER (ECK2310 · dedB · b2316 · usg · accD · AccD)⌘
G. gallusNCBI:XP_416970 · ENTREZ:418774
G. gallusNCBI:XP_424967 · ENTREZ:427395
G. gallusNCBI:XP_428114 · ENTREZ:430557
G. gallusNCBI:XP_001231794 · ENTREZ:768706
G. gallusNCBI:XP_001233303 · ENTREZ:769988
G. gallusENTREZ:396504 · UniProtKB:P11029 (ACAC · IPI00583030 · P11029 · ACAC_CHICK)Acetyl-CoA carboxylase⌘
G. gallusUniProtKB:Q5ZK45 (RCJMB04_13e11 · IPI00583497 · Q5ZK45) · ENTREZ:424962⌘
G. gallusUniProtKB:Q5ZMS5 (IPI00571238 · Q5ZMS5 · RCJMB04_1f4) · ENTREZ:429115⌘
G. gallusUniProtKB:Q8JHF6 (PYC · Q8JHF6 · IPI00580024) · ENTREZ:374263⌘
H. sapiensENSEMBL:ENSG00000132142 · UniProtKB:Q13085 (ACC1 · ACACA · ACAC · IPI00396018 · ACACA_HUMAN · ACCA · Q13085 · IPI00396015 · IPI00847501 · IPI00011569)Acetyl-CoA carboxylase 1⌘
H. sapiensENSEMBL:ENSG00000076555 · UniProtKB:O00763 (IPI00013003 · ACCB · ACACB_HUMAN · ACACB · O00763 · IPI00157056 · ACC2)Acetyl-CoA carboxylase 2⌘
H. sapiensENSEMBL:ENSG00000078070 · UniProtKB:Q96RQ3 (MCCA_HUMAN · IPI00024580 · MCCA · Q96RQ3 · MCCC1)Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000131844 · UniProtKB:Q9HCC0 (MCCB_HUMAN · MCCC2 · IPI00784044 · IPI00789428 · Q9HCC0 · MCCB)Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000175198 · UniProtKB:P05165 (PCCA_HUMAN · PCCA · IPI00744115 · P05165)Propionyl-CoA carboxylase alpha chain, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000114054 · UniProtKB:P05166 (IPI00007247 · PCCB · PCCB_HUMAN · P05166)Propionyl-CoA carboxylase beta chain, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000173599 · UniProtKB:P11498 (P11498 · PYC_HUMAN · IPI00299402 · PC)Pyruvate carboxylase, mitochondrial⌘
M. musculusNCBI:NP_598665 · MGI:MGI:2140940 (Acc2 · Acacb · Accb)acetyl-Coenzyme A carboxylase beta⌘
M. musculusUniProtKB:Q5SWU9 · MGI:MGI:108451 (LOC327983 · Acaca · Acc1 · Acac)acetyl-Coenzyme A carboxylase alpha · acetyl-CoA carboxylase⌘
M. musculusUniProtKB:Q99MR8 · MGI:MGI:1919289 (MCCalpha · Mccc1 · MCCA)methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)⌘
M. musculusUniProtKB:Q3ULD5 · MGI:MGI:1925288 (Mccc2)methylcrotonoyl-Coenzyme A carboxylase 2 (beta)⌘
M. musculusUniProtKB:Q91ZA3 · MGI:MGI:97499 (C79630 · Pcca)propionyl-Coenzyme A carboxylase, alpha polypeptide⌘
M. musculusUniProtKB:Q99MN9 · MGI:MGI:1914154 (Pccb)propionyl Coenzyme A carboxylase, beta polypeptide⌘
M. musculusUniProtKB:Q05920 · MGI:MGI:97520 (Pcx · Pc)pyruvate carboxylase⌘
R. norvegicusNCBI:XP_001075496 · RGD:1590160
R. norvegicusUniProtKB:P11497 (P11497 · Acaca · ACACA_RAT · IPI00567332 · IPI00194102 · Acac) · RGD:621248 (Acaca)Acetyl-CoA carboxylase 1 · acetyl-coenzyme A carboxylase alpha⌘⌘
R. norvegicusUniProtKB:Q5XIT9 · RGD:1310279 (Mccc2)methylcrotonoyl-Coenzyme A carboxylase 2 (beta)⌘
R. norvegicusUniProtKB:P14882 · RGD:3264 (Pcca)propionyl-coenzyme A carboxylase, alpha polypeptide⌘
R. norvegicusUniProtKB:P07633 · RGD:3265 (Pccb)propionyl coenzyme A carboxylase, beta polypeptide⌘
R. norvegicusUniProtKB:P52873 · RGD:3262 (Pc)pyruvate carboxylase⌘
R. norvegicusUniProtKB:O70151 · RGD:620500 (Acacb)acetyl-Coenzyme A carboxylase beta⌘
R. norvegicusUniProtKB:Q5I0C3 · RGD:1310615 (Mccc1)methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)⌘
S. cerevisiaeUniProtKB:Q00955 · SGD:S000005299 (MTR7 · ACC1 · FAS3 · ABP2 · YNR016C)Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA⌘
S. cerevisiaeUniProtKB:P32874 · SGD:S000004820 (YMR207C · HFA1)Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis⌘
S. cerevisiaeUniProtKB:P11154 · SGD:S000003030 (YGL062W · PYC1)Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate⌘
S. cerevisiaeUniProtKB:P32327 · SGD:S000000422 (YBR218C · PYC2)Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate⌘
S. pombeUniProtKB:P78820 · GeneDB_Spombe:SPAC56E4.04c (SPAC56E4.04c · cut6)acetyl-CoA/biotin carboxylase⌘
S. pombeUniProtKB:Q9UUE1 · GeneDB_Spombe:SPBC17G9.11c (pyr1 · SPBC17G9.11c)pyruvate carboxylase⌘
ProteinPublicationCurator Notes
UniProtKB:P32327 · SGD:S000000422PMID:10481094 Bauer J, et al. By-product formation during exposure of respiring Saccharomyces cerevisiae cultures to excess glucose is not caused by a limited capacity of pyruvate carboxylase. FEMS Microbiol Lett. 1999 Oct 1;179(1):107-13.The E. coli protein Phosphoenolpyruvate carboxylase complements a homologous mutation in S. cerevisiae.
UniProtKB:P11154 · SGD:S000003030PMID:10481094 Bauer J, et al. By-product formation during exposure of respiring Saccharomyces cerevisiae cultures to excess glucose is not caused by a limited capacity of pyruvate carboxylase. FEMS Microbiol Lett. 1999 Oct 1;179(1):107-13.The E. coli protein Phosphoenolpyruvate carboxylase complements a homologous mutation in S. cerevisiae.
UniProtKB:P32327 · SGD:S000000422PMID:15701798 Flores CL, et al. Yarrowia lipolytica mutants devoid of pyruvate carboxylase activity show an unusual growth phenotype. Eukaryot Cell. 2005 Feb;4(2):356-64.The Y. lipolytica protein PYC1 complements a homologous mutation in S. cerevisiae. The Y. lipolytica PYC1 gene complemented the growth defect of a Saccharomyces cerevisiae pyc1 pyc2 mutant.
UniProtKB:P11154 · SGD:S000003030PMID:15701798 Flores CL, et al. Yarrowia lipolytica mutants devoid of pyruvate carboxylase activity show an unusual growth phenotype. Eukaryot Cell. 2005 Feb;4(2):356-64.The Y. lipolytica protein PYC1 complements a homologous mutation in S. cerevisiae. The Y. lipolytica PYC1 gene complemented the growth defect of a Saccharomyces cerevisiae pyc1 pyc2 mutant.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (6)
ENSEMBL:ENSG00000078070 · UniProtKB:Q96RQ3+200350 ACETYL-CoA CARBOXYLASE-ALPHA; ACACA;;ACCA;;ACETYL-CoA CARBOXYLASE 1; ACC1ACETYL-CoA CARBOXYLASE DEFICIENCY, INCLUDED;;ACACA DEFICIENCY, INCLUDED;;ACAC DEFICIENCY, INCLUDED;;ACC DEFICIENCY, INCLUDED;;ACC1 DEFICIENCY, INCLUDED
ENSEMBL:ENSG00000131844 · UniProtKB:Q9HCC0#210200 3-@METHYLCROTONYL-CoA CARBOXYLASE 1 DEFICIENCY;;MCCD TYPE 1;;MCC1 DEFICIENCY;;3-@METHYLCROTONYLGLYCINURIA I;;METHYLCROTONYLGLYCINURIA TYPE I
ENSEMBL:ENSG00000175198 · UniProtKB:P05165#210210 3-@METHYLCROTONYL-CoA CARBOXYLASE 2 DEFICIENCY;;MCC2 DEFICIENCY;;3-@METHYLCROTONYLGLYCINURIA II;;METHYLCROTONYLGLYCINURIA, TYPE II
ENSEMBL:ENSG00000114054 · UniProtKB:P05166#606054 PROPIONIC ACIDEMIA;;PROPIONYL-CoA CARBOXYLASE DEFICIENCY;;PCC DEFICIENCY;;GLYCINEMIA, KETOTIC;;HYPERGLYCINEMIA WITH KETOACIDOSIS AND LEUKOPENIA;;KETOTIC HYPERGLYCINEMIA
ENSEMBL:ENSG00000173599 · UniProtKB:P11498#606054 PROPIONIC ACIDEMIA;;PROPIONYL-CoA CARBOXYLASE DEFICIENCY;;PCC DEFICIENCY;;GLYCINEMIA, KETOTIC;;HYPERGLYCINEMIA WITH KETOACIDOSIS AND LEUKOPENIA;;KETOTIC HYPERGLYCINEMIA
UniProtKB:Q00955 · SGD:S000005299#266150 PYRUVATE CARBOXYLASE DEFICIENCY;;PC DEFICIENCY;;ATAXIA WITH LACTIC ACIDOSIS II;;LEIGH NECROTIZING ENCEPHALOPATHY DUE TO PYRUVATE CARBOXYLASE DEFICIENCY;;LEIGH SYNDROME DUE TO PYRUVATE CARBOXYLASE DEFICIENCY
SGD Disease Papers (2)
UniProtKB:P11154 · SGD:S000003030PMID:19390150 Madauss KP, et al. (2009) The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. Acta Crystallogr D Biol Crystallogr 65(Pt 5):449-61
UniProtKB:P11154 · SGD:S000003030PMID:9300813 Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10
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