This family has 13 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.
Interactive Java Applets: Notung Tree Analysis · Jalview Alignment
| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_564557.1 · TAIR:locus:2007283 | ||
| C. elegans | WB:WBGene00018955 (F56C11.3) · UniProtKB:O44975 |  | |
| D. rerio | UniProtKB:A4QNU9 · ZFIN:ZDB-GENE-060810-186 (gfer) | growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) | |
| D. discoideum | UniProtKB:Q75JQ5 · dictyBase:DDB_G0272230 | ||
| D. melanogaster | UniProtKB:Q8SX43 · FB:FBgn0031068 (alr · CG12534) | augmenter of liver regeneration | |
| G. gallus | NCBI:XP_414848 · ENTREZ:416547 | ||
| H. sapiens | ENSEMBL:ENSG00000127554 · UniProtKB:P55789 (ALR_HUMAN · HPO · ALR · HERV1 · IPI00902969 · GFER · P55789) | FAD-linked sulfhydryl oxidase ALR | |
| M. musculus | UniProtKB:P56213 · MGI:MGI:107757 (Alr · Gfer · ERV1) | growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration) | |
| R. norvegicus | UniProtKB:Q63042 · RGD:61845 (Gfer) | growth factor, augmenter of liver regeneration | |
| S. cerevisiae | UniProtKB:P27882 · SGD:S000003261 (YGR029W · ERV1) | Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins | |
| S. cerevisiae | UniProtKB:Q12284 · SGD:S000006241 (ERV2 · YPR037C) | Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER | |
| S. pombe | UniProtKB:O14144 · GeneDB_Spombe:SPAC3G6.08 (erv1 · SPAC3G6.08) | sulfhydryl oxidase | |
| S. pombe | UniProtKB:Q9Y806 · GeneDB_Spombe:SPBC146.04 (SPBC146.04) | sulfhydryl oxidase | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P27882 · SGD:S000003261 |  10384986 Hofhaus G, et al. Highly divergent amino termini of the homologous human ALR and yeast scERV1 gene products define species specific differences in cellular localization. Eur J Cell Biol. 1999 May;78(5):349-56. | The H. sapiens protein GFER does not complement a homologous mutation in S. cerevisiae. | |
| UniProtKB:P27882 · SGD:S000003261 | 23186364 Sztolsztener ME, et al. Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40. Traffic. 2013 Mar;14(3):309-20. | The H. sapiens protein GFER complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| SGD Disease Papers (1) | |
|---|---|
| UniProtKB:P27882 · SGD:S000003261 | 19409522 Di Fonzo A, et al. (2009) The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency. Am J Hum Genet 84(5):594-604 |