This family has 77 members: 12 Arabidopsis thaliana, 4 Caenorhabditis elegans, 9 Danio rerio, 2 Dictyostelium discoideum, 4 Drosophila melanogaster, 10 Gallus gallus, 10 Homo sapiens, 10 Mus musculus, 11 Rattus norvegicus, 2 Saccharomyces cerevisiae, 3 Schizosaccharomyces pombe.
Interactive Java Applets: Notung Tree Analysis · Jalview Alignment
| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_973743.1 · TAIR:locus:2196140 (IMPA-6 · T14P4.3 · AT1G02690 · T14P4_3) | IMPORTIN ALPHA ISOFORM 6 |  |
| A. thaliana | NCBI:NP_200013.1 · TAIR:locus:2173123 (MSG15.24 · MSG15_24 · IMPA-8 · AT5G52000) | IMPORTIN ALPHA ISOFORM 8 | |
| A. thaliana | NCBI:NP_174565.1 · TAIR:locus:2037900 (AT1G32880 · F9L11.34 · F9L11_34) | | |
| A. thaliana | NCBI:NP_850852.1 · TAIR:locus:2150295 (F7K24.80 · F7K24_80 · AT5G19330) | | |
| A. thaliana | NCBI:NP_567485.1 · TAIR:locus:505006475 (IMPA-2 · AT4G16143) | IMPORTIN ALPHA ISOFORM 2 | |
| A. thaliana | NCBI:NP_199742.1 · TAIR:locus:2155929 (K21P3_21 · K21P3.21 · AT5G49310 · IMPA-5) | IMPORTIN ALPHA ISOFORM 5 | |
| A. thaliana | NCBI:NP_187328.1 · TAIR:locus:2083313 (IMPA1 · F3E22.14 · IMPA-1 · AT-IMP · AT3G06720) | IMPORTIN ALPHA · AIMP ALPHA · ATKAP ALPHA · IMPORTIN ALPHA ISOFORM 1 | |
| A. thaliana | NCBI:NP_195927.2 · TAIR:locus:2143423 (F15A17_100 · IMPA-9 · AT5G03070 · F15A17.100) | IMPORTIN ALPHA ISOFORM 9 | |
| A. thaliana | NCBI:NP_196810.2 · TAIR:locus:2179842 (AT5G13060 · T19L5_20 · T19L5.20 · ABAP1) | ARMADILLO BTB ARABIDOPSIS PROTEIN 1 | |
| A. thaliana | NCBI:NP_187223.1 · TAIR:locus:2078122 (F18C1.1 · F18C1_1 · IMPA-7 · AT3G05720) | IMPORTIN ALPHA ISOFORM 7 | |
| A. thaliana | NCBI:NP_172398.1 · TAIR:locus:2195351 (AT1G09270 · T12M4_2 · T12M4.2 · IMPA-4) | IMPORTIN ALPHA ISOFORM 4 | |
| A. thaliana | NCBI:NP_192124.1 · TAIR:locus:2132238 (T10M13_16 · AT4G02150 · T10M13.16 · MOS6 · IMPA-3 · ATIMPALPHA3) | IMPORTIN ALPHA ISOFORM 3 · MODIFIER OF SNC1, 6 · IMPORTIN ALPHA 3 | |
| C. elegans | WB:WBGene00002072 (ima-1 · T19B10.7) · UniProtKB:Q22560 (ima-1 · IMA1_CAEEL · T19B10.7) | Importin subunit alpha-1 | |
| C. elegans | WB:WBGene00002073 (F26B1.3 · ima-2) · UniProtKB:P91276 (IMA2_CAEEL · F26B1.3 · ima-2) | Importin subunit alpha-2 | |
| C. elegans | WB:WBGene00002074 (F32E10.4 · ima-3) · UniProtKB:Q19969 (IMA3_CAEEL · F32E10.4 · ima-3) | Importin subunit alpha-3 | |
| C. elegans | WB:WBGene00009956 (F53B2.5) · UniProtKB:Q20703 | | |
| D. rerio | ENSEMBL:ENSDARP00000010856 | ||
| D. rerio | ENSEMBL:ENSDARP00000066122 | ||
| D. rerio | ZFIN:ZDB-GENE-070410-47 (zgc:162240) · UniProtKB:A4QNX0 | | |
| D. rerio | ZFIN:ZDB-GENE-050522-22 (zgc:110662) · UniProtKB:Q503E9 | | |
| D. rerio | UniProtKB:Q6DI01 · ZFIN:ZDB-GENE-040718-22 (kpna2) | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | |
| D. rerio | UniProtKB:Q6GMH8 · ZFIN:ZDB-GENE-040704-53 (spag6) | sperm associated antigen 6 | |
| D. rerio | UniProtKB:Q6PUQ6 · ZFIN:ZDB-GENE-030131-5584 (kpna4) | karyopherin alpha 4 (importin alpha 3) | |
| D. rerio | ZFIN:ZDB-GENE-040426-2023 (zgc:55877) · UniProtKB:Q803D8 | | |
| D. rerio | UniProtKB:Q8JFT7 · ZFIN:ZDB-GENE-030616-541 (kpna3) | karyopherin (importin) alpha 3 | |
| D. discoideum | NCBI:EAL71085.1 · dictyBase:DDB_G0272895 | ||
| D. discoideum | dictyBase:DDB_G0273971 · UniProtKB:Q556L4 | ||
| D. melanogaster | UniProtKB:P52295 · FB:FBgn0011823 (alpha2A-Kap · Pen · Dalpha2 · Importin-alpha2 · l(2)k14401 · bs29g06.y1 · oho-31 · Kap-alpha2 · Pendulin · Rch1 · pen-2 · CG4799 · IMPalpha2 · Importin-a2 · OHO31 · alpha2 · Oho31 · alpha-importin · pen · anon-WO0140519.258 · Pendulum · pendulin · oho31 · Imp-alpha2 · l(2)144/1 · importin-alpha2 · Dimp-alpha2 · DPend · 2.1 · Kpna2 · imp-alpha2) | importin alpha2/pendulin · imp alpha2 · importin alpha2 · Kap alpha2 · Importin alpha · Importin alpha2 | |
| D. melanogaster | UniProtKB:O76521 · FB:FBgn0024889 (Kpna1 · CG8548 · karyopherin-alpha1 · Kap-alpha1 · impalpha1 · Importin-alpha1 · Dalpha1 · IMPalpha1 · anon-WO0118547.276) | Kap alpha1 · karyopherin alpha1 · imp alpha1 · importin alpha1 | |
| D. melanogaster | UniProtKB:Q9UB78 · FB:FBgn0027338 (IMPalpha3 · Importin-alpha3 · dKap-alpha3 · karyopherin-alpha4 · imp-a3 · Dalpha3 · l(3)S033513 · Kpna3 · 0335/13 · Kap-alpha3 · imp-alpha3 · karyopherin-alpha3 · importin-alpha3 · CG9423) | importin alpha-3 · karyopherin alpha3 · importin alpha · karyopherin alpha4 · importin alpha3 · imp alpha3 · Imp alpha-3 · Importin alpha-3 · Kap alpha3 · importin a3 · karyopherin a3 | |
| D. melanogaster | FB:FBgn0035657 (CG11040 · g7295403 · CG10478) · UniProtKB:Q9VRS0 | | |
| G. gallus | NCBI:XP_418607 · ENTREZ:420505 | ||
| G. gallus | NCBI:XP_414468 · ENTREZ:416135 | ||
| G. gallus | NCBI:XP_419770 · ENTREZ:421738 | ||
| G. gallus | NCBI:XP_414795 · ENTREZ:416488 | ||
| G. gallus | NCBI:XP_001236620 · ENTREZ:777147 | ||
| G. gallus | NCBI:XP_417065 · ENTREZ:418870 | ||
| G. gallus | ENTREZ:418271 · UniProtKB:Q5ZML1 (IMA1_CHICK · IPI00583750 · RCJMB04_1l14 · Q5ZML1 · KPNA1) | Importin subunit alpha-1 | |
| G. gallus | UniProtKB:Q5ZJZ0 (IPI00602141 · RCJMB04_14f8 · Q5ZJZ0) · ENTREZ:419656 | | |
| G. gallus | UniProtKB:Q5ZLF7 (Q5ZLF7 · RCJMB04_6g17 · IPI00583236) · ENTREZ:425012 | | |
| G. gallus | UniProtKB:Q5ZMA9 (Q5ZMA9 · IPI00571040 · RCJMB04_2k18) · ENTREZ:417420 | | |
| H. sapiens | ENSEMBL:ENSG00000114030 · UniProtKB:P52294 (IPI00303292 · RCH2 · P52294 · IMA1_HUMAN · KPNA1) | Importin subunit alpha-1 | |
| H. sapiens | ENSEMBL:ENSG00000214180 · UniProtKB:A8MYJ9 (IMA2L_HUMAN · IPI00873236 · A8MYJ9) | Importin subunit alpha-2-like protein | |
| H. sapiens | ENSEMBL:ENSG00000182481 · UniProtKB:P52292 (P52292 · IMA2_HUMAN · IPI00002214 · RCH1 · KPNA2 · SRP1) | Importin subunit alpha-2 | |
| H. sapiens | ENSEMBL:ENSG00000215769 · UniProtKB:P52292 (P52292 · IMA2_HUMAN · IPI00002214 · RCH1 · KPNA2 · SRP1) | Importin subunit alpha-2 | |
| H. sapiens | ENSEMBL:ENSG00000102753 · UniProtKB:O00505 (KPNA3 · O00505 · IMA3_HUMAN · QIP2 · IPI00299033) | Importin subunit alpha-3 | |
| H. sapiens | ENSEMBL:ENSG00000186432 · UniProtKB:O00629 (IPI00012578 · O00629 · IMA4_HUMAN · QIP1 · KPNA4) | Importin subunit alpha-4 | |
| H. sapiens | ENSEMBL:ENSG00000196911 · UniProtKB:O15131 (KPNA5 · IMA5_HUMAN · O15131 · IPI00413214) | Importin subunit alpha-6 | |
| H. sapiens | ENSEMBL:ENSG00000025800 · UniProtKB:O60684 (IPI00747764 · IMA7_HUMAN · IPOA7 · O60684 · KPNA6) | Importin subunit alpha-7 | |
| H. sapiens | ENSEMBL:ENSG00000185467 · UniProtKB:A9QM74 (KPNA7 · A9QM74 · IMA8_HUMAN · IPI00374362) | Importin subunit alpha-8 | |
| H. sapiens | ENSEMBL:ENSG00000077327 · UniProtKB:O75602 (SPAG6_HUMAN · IPI00479710 · SPAG6 · IPI00335443 · O75602 · IPI00220580 · PF16 · IPI00479375) | Sperm-associated antigen 6 | |
| M. musculus | NCBI:NP_001013796 · MGI:MGI:2141165 | ||
| M. musculus | NCBI:NP_001001334 · MGI:MGI:3040687 | ||
| M. musculus | NCBI:XP_001481264 · MGI:MGI:3704480 | ||
| M. musculus | UniProtKB:Q60960 · MGI:MGI:103560 (NPI1 · Kpna1 · Rch2 · m-importin-alpha-S1 · mSRP1) | karyopherin (importin) alpha 1 | |
| M. musculus | UniProtKB:P52293 · MGI:MGI:103561 (Rch1 · pendulin · m-importin · m-importin-alpha-P1 · Kpna2) | Importin alpha · karyopherin (importin) alpha 2 | |
| M. musculus | UniProtKB:O35344 · MGI:MGI:1100863 (IPOA4 · Kpna3) | karyopherin (importin) alpha 3 | |
| M. musculus | UniProtKB:O35343 · MGI:MGI:1100848 (IPOA3 · Kpna4) | karyopherin (importin) alpha 4 | |
| M. musculus | UniProtKB:O35345 · MGI:MGI:1100836 (NPI-2 · IPOA7 · Kpna6) | karyopherin (importin) alpha 6 | |
| M. musculus | UniProtKB:Q9JLI7 · MGI:MGI:1354388 (Spag6) | sperm associated antigen 6 | |
| M. musculus | NCBI:XP_001473221 · MGI:MGI:3704211 | ||
| R. norvegicus | NCBI:XP_225607 · RGD:1305616 | ||
| R. norvegicus | NCBI:XP_001071265 · RGD:1587952 (LOC684620) | similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) | |
| R. norvegicus | NCBI:XP_001079511 · RGD:1583798 (LOC365232) | similar to karyopherin (importin) alpha 4 | |
| R. norvegicus | NCBI:XP_001074637 · RGD:1594749 | ||
| R. norvegicus | UniProtKB:P83953 · RGD:735064 (Kpna1) | karyopherin (importin) alpha 1 | |
| R. norvegicus | UniProtKB:Q56R16 · RGD:1561324 (Kpna5) | karyopherin alpha 5 (importin alpha 6) | |
| R. norvegicus | UniProtKB:Q3KR98 (Q3KR98 · IPI00359040 · Kpna6) · RGD:1306570 (Kpna6) | karyopherin alpha 6 (importin alpha 7) | |
| R. norvegicus | UniProtKB:Q3MHU1 · RGD:1310892 (Spag6) | sperm associated antigen 6 | |
| R. norvegicus | UniProtKB:Q56R17 · RGD:1311483 (Kpna4) | karyopherin alpha 4 (importin alpha 3) | |
| R. norvegicus | UniProtKB:Q56R18 · RGD:1311339 (Kpna3) | karyopherin (importin) alpha 3 | |
| R. norvegicus | UniProtKB:Q9Z0N9 · RGD:621419 (Kpna2) | karyopherin (importin) alpha 2 | |
| S. cerevisiae | UniProtKB:Q02821 · SGD:S000005133 (SCM1 · KAP60 · SRP1 · YNL189W) | Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import | |
| S. cerevisiae | UniProtKB:P39968 · SGD:S000000739 (VAC8 · YEL013W · YEB3) | Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway | |
| S. pombe | UniProtKB:O14063 · GeneDB_Spombe:SPCC962.03c (SPCC962.03c · cut15) | karyopherin Cut15 | |
| S. pombe | UniProtKB:O94374 · GeneDB_Spombe:SPBC1604.08c (SPBC1604.08c · imp1) | importin alpha | |
| S. pombe | UniProtKB:O43028 · GeneDB_Spombe:SPBC354.14c (SPBC354.14c · vac8) | vacuolar protein Vac8 | |
No functional conservation results.
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| SGD Disease Papers (1) | |
|---|---|
| UniProtKB:Q02821 · SGD:S000005133 |  9436978 Vodicka MA, et al. (1998) HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes Dev 12(2):175-85 |