P-POD: Princeton Protein Orthology Database: GO3/Jaccard213

This family has 78 members: 11 Arabidopsis thaliana, 6 Caenorhabditis elegans, 11 Danio rerio, 3 Dictyostelium discoideum, 5 Drosophila melanogaster, 1 Escherichia coli, 8 Gallus gallus, 9 Homo sapiens, 7 Mus musculus, 12 Rattus norvegicus, 3 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

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GO3/Jaccard213
78 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_850867.1 · TAIR:locus:1005716878 (AT5G26667 · PYR6)CMP/UMP KINASE⌘
A. thalianaNCBI:NP_001118870.1 · TAIR:locus:4515103290 (AT3G60961)⌘
A. thalianaNCBI:NP_850726.1 · TAIR:locus:2101472 (AT3G60180 · F27H5.2)⌘
A. thalianaNCBI:NP_198367.2 · TAIR:locus:2182407 (T25C13_50 · AT5G35170 · T25C13.50)⌘
A. thalianaNCBI:NP_194258.2 · TAIR:locus:2122644 (F24A6.120 · AT4G25280 · F24A6_120)⌘
A. thalianaNCBI:NP_201145.1 · TAIR:locus:2167316 (ADK1 · MLE2_3 · MLE2.3 · AT5G63400)ADENYLATE KINASE 1⌘
A. thalianaNCBI:NP_186831.2 · TAIR:locus:2082329 (F28J7_15 · AT3G01820 · F28J7.15)⌘
A. thalianaNCBI:NP_199595.1 · TAIR:locus:2160942 (AMK2 · AT5G47840 · MCA23.18 · MCA23_18)Adenosine monophosphate kinase⌘
A. thalianaNCBI:NP_850314.1 · TAIR:locus:2056098 (AT2G39270)⌘
A. thalianaNCBI:NP_181262.1 · TAIR:locus:2049842 (F3G5.4 · AT2G37250 · ADK · F3G5_4 · ATPADK1)ADENOSINE KINASE⌘
A. thalianaNCBI:NP_199848.1 · TAIR:locus:2177527 (MXI22_8 · MXI22.8 · AT5G50370)⌘
C. elegansWB:WBGene00009531 (F38B2.4) · UniProtKB:Q20140⌘
C. elegansWB:WBGene00002879 (C29E4.8 · let-754) · UniProtKB:P34346⌘
C. elegansWB:WBGene00014058 (ZK673.2) · UniProtKB:Q09629⌘
C. elegansWB:WBGene00007812 (C29F7.3) · UniProtKB:O17622⌘
C. elegansWB:WBGene00008746 (F13E6.2) · UniProtKB:O17803⌘
C. elegansWB:WBGene00009575 (F40F8.1) · UniProtKB:Q20230⌘
D. rerioENSEMBL:ENSDARP00000033729
D. rerioENSEMBL:ENSDARP00000027924
D. rerioZFIN:ZDB-GENE-050522-275 (zgc:112030) · UniProtKB:Q502L7⌘
D. rerioUniProtKB:Q7ZWE9 · ZFIN:ZDB-GENE-040426-2113 (cmpk)cytidylate kinase⌘
D. rerioUniProtKB:Q56A38 · ZFIN:ZDB-GENE-050410-2 (ak5l)adenylate kinase 5, like⌘
D. rerioZFIN:ZDB-GENE-041014-334 (si:ch211-199m3.4) · UniProtKB:Q5RH81⌘
D. rerioENSEMBL:ENSDARG00000017975 · UniProtKB:Q5RH83
D. rerioZFIN:ZDB-GENE-040822-37 (zgc:91930) · UniProtKB:Q68EH2⌘
D. rerioUniProtKB:Q6NUY0 · ZFIN:ZDB-GENE-040426-2505 (ak3l1)adenylate kinase 3-like 1⌘
D. rerioUniProtKB:Q7T333 · ZFIN:ZDB-GENE-040426-2142 (ak3)adenylate kinase 3⌘
D. rerioUniProtKB:Q7T3D7 · ZFIN:ZDB-GENE-030131-512 (ak2)adenylate kinase 2⌘
D. discoideumUniProtKB:Q54QJ9 · dictyBase:DDB_G0283805 (adkA · ADK)adenylate kinase⌘
D. discoideumUniProtKB:Q54CT8 · dictyBase:DDB_G0292730 (adkB · ADK)adenylate kinase⌘
D. discoideumUniProtKB:P20425 · dictyBase:DDB_G0287495 (umpk · cmpk · pyrK)UMP-CMP kinase, uridine monophosphate/cytidine monophosphate kinase, cytidylate kinase, uridylate kinase⌘
D. melanogasterUniProtKB:Q8IGD0 · FB:FBgn0028833 (Dak1 · CG6092 · dak1 · anon-WO0118547.320 · Dak1L)Dm.UMP-CMP kinase⌘
D. melanogasterUniProtKB:Q8IQG9 · FB:FBgn0022709 (AK1 · CG17146 · Adk1 · ADK-1 · bs34e10.y1 · DAK1 · adk1)Adenylate kinase-1⌘
D. melanogasterUniProtKB:Q9U915 · FB:FBgn0022708 (Adk2 · anon-Dak2 · BcDNA:SD09634 · Dak2 · CG3140 · ADK-2)Adenylate kinase-2⌘
D. melanogasterUniProtKB:Q9VGU6 · FB:FBgn0042094 (CG6612 · AK3 · bs12h03.y1 · DAK3 · Adk3)Adenylate kinase-3⌘
D. melanogasterFB:FBgn0032083 (CG9541) · UniProtKB:Q9VLG2⌘
E. coliUniProtKB:P69441 · ECOLI:ADENYL-KIN-MONOMER (ECK0468 · Adk · plsA · b0474 · dnaW · adk)adenylate kinase⌘
G. gallusNCBI:XP_424173 · ENTREZ:426534
G. gallusNCBI:XP_428077 · ENTREZ:430522
G. gallusNCBI:XP_425786 · ENTREZ:428227
G. gallusNCBI:XP_001234353 · ENTREZ:771047
G. gallusNCBI:XP_422391 · ENTREZ:424555
G. gallusNCBI:XP_422526 · ENTREZ:424697
G. gallusENTREZ:396002 · UniProtKB:P05081 (AK1 · KAD1_CHICK · IPI00571711 · P05081)Adenylate kinase isoenzyme 1⌘
G. gallusENTREZ:429100 · UniProtKB:Q5ZKE7 (Q5ZKE7 · IPI00651398 · KCY_CHICK · RCJMB04_11f2 · CMPK · CMPK1)UMP-CMP kinase⌘
H. sapiensENSEMBL:ENSG00000155085 · UniProtKB:Q5TCS8 (Q5TCS8 · IPI00641136 · CF199_HUMAN · IPI00856053 · IPI00556253 · C6orf199)Coiled-coil domain-containing protein C6orf199⌘
H. sapiensENSEMBL:ENSG00000177214 · UniProtKB:Q3MIS4 (IPI00401138 · Q3MIS4 · CF224_HUMAN · C6orf224)Uncharacterized protein C6orf224⌘
H. sapiensENSEMBL:ENSG00000165695 · UniProtKB:Q96MA6 (IPI00830061 · Q96MA6 · C9orf98 · CI098_HUMAN · IPI00065450)Putative adenylate kinase-like protein C9orf98⌘
H. sapiensENSEMBL:ENSG00000106992 · UniProtKB:P00568 (AK1 · IPI00018342 · P00568 · KAD1_HUMAN)Adenylate kinase isoenzyme 1⌘
H. sapiensENSEMBL:ENSG00000004455 · UniProtKB:P54819 (IPI00218989 · IPI00172460 · IPI00218988 · KAD2_HUMAN · IPI00215901 · P54819 · AK2 · ADK2)Adenylate kinase 2, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000147853 · UniProtKB:Q9UIJ7 (IPI00465256 · AKL3L · Q9UIJ7 · AK3 · KAD3_HUMAN · AK3L1 · AK6)GTP:AMP phosphotransferase mitochondrial⌘
H. sapiensENSEMBL:ENSG00000162433 · UniProtKB:P27144 (AK3 · AK3L2 · IPI00016568 · AK4 · AK3L1 · P27144 · KAD4_HUMAN)Adenylate kinase isoenzyme 4, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000154027 · UniProtKB:Q9Y6K8 (AK5 · KAD5_HUMAN · IPI00844054 · Q9Y6K8)Adenylate kinase isoenzyme 5⌘
H. sapiensENSEMBL:ENSG00000162368 · UniProtKB:P30085 (UCK · KCY_HUMAN · CMPK · IPI00219953 · CMPK1 · UMK · P30085 · CMK · UMPK)UMP-CMP kinase⌘
M. musculusUniProtKB:Q32M07 · MGI:MGI:1916120 (1190002A17Rik)RIKEN cDNA 1190002A17 gene⌘
M. musculusUniProtKB:Q9R0Y5 · MGI:MGI:87977 (Ak-1 · Ak1)adenylate kinase 1⌘
M. musculusUniProtKB:Q9WTP6 · MGI:MGI:87978 (Ak2 · D4Ertd220e · Ak-2)adenylate kinase 2⌘
M. musculusUniProtKB:Q9WTP7 · MGI:MGI:1860835 (AK-3 · Ak3)adenylate kinase 3⌘
M. musculusUniProtKB:Q9WUR9 · MGI:MGI:87979 (Ak-3 · D4Ertd274e · Ak3l1 · Ak4 · Ak-4)adenylate kinase 3-like 1⌘
M. musculusUniProtKB:Q920P5 · MGI:MGI:2677491 (Ak5)adenylate kinase 5⌘
M. musculusUniProtKB:Q9DBP5 · MGI:MGI:1913838 (Cmpk · Cmpk1)cytidine monophosphate (UMP-CMP) kinase 1⌘
R. norvegicusNCBI:XP_573491 · RGD:1563845
R. norvegicusNCBI:XP_236788 · RGD:1588584 (LOC301115)similar to adenylate kinase 1⌘
R. norvegicusNCBI:XP_001069736 · RGD:1560386 (RGD1560386)similar to novel protein⌘
R. norvegicusNCBI:XP_001064488 · RGD:1559879 (RGD1559879)similar to chromosome 6 open reading frame 199⌘
R. norvegicusNCBI:XP_575395 · RGD:1562178
R. norvegicusNCBI:XP_001080050 · RGD:1590818 (LOC365985)similar to adenylate kinase 5 isoform 1⌘
R. norvegicusUniProtKB:Q68FP8 · RGD:1303144 (RGD1303144)HypB, AroK, ADK and rho factor domain containing protein RGD1303144⌘
R. norvegicusUniProtKB:P39069 · RGD:2076 (Ak1)adenylate kinase 1⌘
R. norvegicusRGD:2077 (Ak2) · UniProtKB:P29410 (KAD2_RAT · IPI00230857 · Ak2 · IPI00923141 · P29410)adenylate kinase 2 · Adenylate kinase 2, mitochondrial⌘⌘
R. norvegicusUniProtKB:P29411 · RGD:619885 (Ak3)adenylate kinase 3⌘
R. norvegicusUniProtKB:Q9WUS0 · RGD:2078 (Ak3l1)adenylate kinase 3-like 1⌘
R. norvegicusUniProtKB:Q4KM73 · RGD:1310116 (Cmpk1)cytidine monophosphate (UMP-CMP) kinase 1, cytosolic⌘
S. cerevisiaeUniProtKB:P07170 · SGD:S000002634 (ADK1 · AKY1 · AKY2 · YDR226W)Adenylate kinase, required for purine metabolism⌘
S. cerevisiaeUniProtKB:P26364 · SGD:S000000972 (AKY3 · YER170W · PAK3 · ADK2)Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP⌘
S. cerevisiaeUniProtKB:P15700 · SGD:S000001507 (URA6 · SOC8 · YKL024C)Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)⌘
S. pombeUniProtKB:P33075 · GeneDB_Spombe:SPAC4G9.03 (SPAC4G9.03 · adk1)adenylate kinase Adk1⌘
S. pombeUniProtKB:O59771 · GeneDB_Spombe:SPCC1795.05c (SPCC1795.05c)uridylate kinase⌘
ProteinPublicationCurator Notes
UniProtKB:P15700 · SGD:S000001507PMID:9576794 Zhou L, et al. Cloning, expression in Escherichia coli, and characterization of Arabidopsis thaliana UMP/CMP kinase. Plant Physiol. 1998 May;117(1):245-54.The A. thaliana protein AT5G26667.2 complements a homologous mutation in S. cerevisiae. A nearly identical peptide, AT5G26667.1, is also in the same OrthoMCL family.
UniProtKB:P07170 · SGD:S000002634PMID:8439550 Konrad M. Identification and characterization of a yeast gene encoding an adenylate kinase homolog. Biochim Biophys Acta. 1993 Feb 20;1172(1-2):12-6.The S. cerevisiae protein ADK1 was expressed in E. coli, but complementation was not directly tested.
UniProtKB:P07170 · SGD:S000002634PMID:18433446 Gauthier S, et al. Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations. Mol Microbiol. 2008 Jun;68(6):1583-94.The H. sapiens protein AK1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (2)
ENSEMBL:ENSG00000004455 · UniProtKB:P54819#612631 ADENYLATE KINASE DEFICIENCY, HEMOLYTIC ANEMIA DUE TO
ENSEMBL:ENSG00000004455 · UniProtKB:P54819%267500 RETICULAR DYSGENESIA;;RETICULAR DYSGENESIS;;CONGENITAL ALEUKIA;;SEVERE COMBINED IMMUNODEFICIENCY WITH LEUKOPENIA;;DE VAAL DISEASE;;HEMATOPOIETIC HYPOPLASIA, GENERALIZED
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