P-POD: Princeton Protein Orthology Database: GO3/Jaccard1539

This family has 19 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 2 Drosophila melanogaster, 4 Escherichia coli, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

19 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2040771 (F13M22.19 · AT2G37690 · F13M22_19) · NCBI:NP_181305.2⌘
A. thalianaNCBI:NP_178587.1 · TAIR:locus:2051314 (F5G3.4 · F5G3_4 · AT2G05140)⌘
C. elegansWB:WBGene00015116 (B0286.3) · UniProtKB:Q10457 (B0286.3 · PUR6_CAEEL)Probable multifunctional protein ADE2⌘⌘
D. rerioUniProtKB:Q5RG55 · ZFIN:ZDB-GENE-030131-9762 (paics)phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase⌘
D. discoideumUniProtKB:Q54QE4 · dictyBase:DDB_G0283987 (purC · purC/E · purE)PAICS, phosphoribosylaminoimidazole carboxylase (AIR carboxylase), phosphoribosylaminoimidazolesuccinocarboxamide synthase (SAICAR synthase)⌘
D. melanogasterUniProtKB:Q9I7S8 · FB:FBgn0020513 (CG3989 · AIRc-SAICARs · ade5 · Ade5)AIR-carboxylase-SAICAR synthetase⌘
D. melanogasterUniProtKB:Q9VK80 · FB:FBgn0032437 (CG17024)⌘
E. coliUniProtKB:P0AG18 · ECOLI:PURE-MONOMER (ECK0516 · PurE · ade3 · b0523 · ade(f) · Pur2 · purE · ade)⌘
E. coliUniProtKB:P0A7D7 · ECOLI:SAICARSYN-MONOMER (ade(g) · b2476 · ECK2472 · purC · ade · PurC)⌘
E. coliUniProtKB:P09029 · ECOLI:PURK-MONOMER (b0522 · ECK0515 · purE2 · purK · PurK)N5-carboxyaminoimidazole ribonucleotide synthase monomer⌘
E. coliUniProtKB:P33221 · ECOLI:GARTRANSFORMYL2-MONOMER (purT · ECK1850 · PurT · b1849)GAR transformylase 2⌘
G. gallusENTREZ:396534 · UniProtKB:P38024 (P38024 · IPI00602224 · PUR6_CHICK · AIRC)Multifunctional protein ADE2⌘
H. sapiensENSEMBL:ENSG00000128050 · UniProtKB:P22234 (PUR6_HUMAN · PAIS · ADE2 · PAICS · IPI00217223 · P22234 · AIRC)Multifunctional protein ADE2⌘
M. musculusUniProtKB:Q9DCL9 · MGI:MGI:1914304 (PAIS · Paics · AIRC · ADE2H1)phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase⌘
R. norvegicusUniProtKB:P51583 · RGD:620066 (Paics)phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase⌘
S. cerevisiaeUniProtKB:P21264 · SGD:S000005654 (YOR128C · ADE2)Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway⌘
S. cerevisiaeUniProtKB:P27616 · SGD:S000000070 (YAR015W · ADE1)N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis⌘
S. pombeUniProtKB:P15567 · GeneDB_Spombe:SPCC1322.13 (min1 · SPCC1322.13 · ade6)phosphoribosylaminoimidazole carboxylase Ade6⌘
S. pombeUniProtKB:Q9UUB4 · GeneDB_Spombe:SPBC409.10 (SPBC409.10 · ade7)phosphoribosylamidoimidazolesuccinocarboxamide synthase Ade7⌘
ProteinPublicationCurator Notes
UniProtKB:P27616 · SGD:S000000070PMID:1368674 Kawai S, et al. Isolation and sequencing of a gene, C-ADE1, and its use for a host-vector system in Candida maltosa with two genetic markers. Agric Biol Chem. 1991 Jan;55(1):59-65.The C. maltosa protein C-ADE1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P21264 · SGD:S000005654PMID:17698621 Lüscher A, et al. Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites. Antimicrob Agents Chemother. 2007 Nov;51(11):3895-901.The T. brucei protein TbAT1 was expressed in S. cerevisiae, but complementation was not directly tested. Heterologous expression of T. brucei adenosine transporter allowed a yeast ade2 mutant to bypass adenosine synthesis by importing adenosine from the medium.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (1)
UniProtKB:P27616 · SGD:S000000070PMID:17360454 Yuen KW, et al. (2007) Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci U S A 104(10):3925-30
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