This family has 19 members: 3 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 2 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Escherichia coli, 2 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
Interactive Java Applets: Notung Tree Analysis · Jalview Alignment
| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_190196.1 · TAIR:locus:2075306 (AT3G46100 · ATHRS1 · F12M12.70) | HISTIDYL-TRNA SYNTHETASE 1 · HISTIDYL-TRNA SYNTHETASE |  |
| A. thaliana | NCBI:NP_001031826.1 · TAIR:locus:1009023403 | ||
| A. thaliana | NCBI:NP_186925.1 · TAIR:locus:2075472 (AT3G02760 · F13E7.30 · F13E7_30) | | |
| C. elegans | WB:WBGene00002001 (T11G6.1 · hrs-1) · UniProtKB:P34183 | | |
| D. rerio | UniProtKB:Q66HY3 · ZFIN:ZDB-GENE-040912-152 (hars) | histidyl-tRNA synthetase | |
| D. discoideum | UniProtKB:Q86AS6 · dictyBase:DDB_G0274159 (HisRS · hisS) | histidine-tRNA ligase, histidyl-tRNA synthetase | |
| D. discoideum | UniProtKB:Q55D12 · dictyBase:DDB_G0269822 (HisRS · mhisS) | histidine-tRNA ligase, histidyl-tRNA synthetase, putative mitochondrial histidyl-tRNA synthetase, putative mitochondrial histidine-tRNA ligase | |
| D. melanogaster | UniProtKB:Q8IQX8 · FB:FBgn0027087 (HisRS · l(1)G0165 · HRS · CG6335 · l(1)G0358 · Aats-his) | Histidyl-tRNA synthetase | |
| E. coli | UniProtKB:P60906 · ECOLI:HISS-MONOMER (ECK2510 · HisS · hisS · b2514) | histidyl-tRNA synthetase | |
| G. gallus | NCBI:XP_001231932 · ENTREZ:768802 | ||
| G. gallus | ENTREZ:416132 · UniProtKB:Q5ZK86 (Q5ZK86 · IPI00821125 · RCJMB04_12f15) | | |
| H. sapiens | ENSEMBL:ENSG00000170445 · UniProtKB:P12081 (SYHC_HUMAN · HRS · P12081 · IPI00021808 · HARS) | Histidyl-tRNA synthetase, cytoplasmic | |
| H. sapiens | ENSEMBL:ENSG00000112855 · UniProtKB:P49590 (IPI00027445 · HARS2 · P49590 · HO3 · HARSL · HARSR · SYHM_HUMAN) | Probable histidyl-tRNA synthetase, mitochondrial | |
| M. musculus | UniProtKB:Q61035 · MGI:MGI:108087 (MMHRS · Hars) | histidyl-tRNA synthetase | |
| M. musculus | UniProtKB:Q99KK9 · MGI:MGI:1918041 (Hars2 · HO3 · HARSR · Harsl) | histidyl-tRNA synthetase 2, mitochondrial (putative) | |
| R. norvegicus | UniProtKB:Q4QQV4 · RGD:1310695 (Hars) | histidyl-tRNA synthetase | |
| R. norvegicus | UniProtKB:Q5EB72 · RGD:1308426 (Hars2l) | histidyl-tRNA synthetase 2-like | |
| S. cerevisiae | UniProtKB:P07263 · SGD:S000006237 (HTS1 · YPR033C · TSM4572) | Cytoplasmic and mitochondrial histidine tRNA synthetase | |
| S. pombe | UniProtKB:O43011 · GeneDB_Spombe:SPBC2G2.12 (hrs1 · SPBC2G2.12) | mitochondrial and cytoplasmic histidine-tRNA ligase Hrs1 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P07263 · SGD:S000006237 |  22930593 Vester A, et al. A loss-of-function variant in the human histidyl-tRNA synthetase (HARS) gene is neurotoxic in vivo. Hum Mutat. 2013 Jan;34(1):191-9. | The H. sapiens protein HARS complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |