P-POD: Princeton Protein Orthology Database: GO3/Jaccard1223

This family has 22 members: 2 Arabidopsis thaliana, 2 Caenorhabditis elegans, 2 Danio rerio, 2 Dictyostelium discoideum, 2 Drosophila melanogaster, 2 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

• Protein Family
• Functional Conservation (1)
• Download Files (5)
• Disease References (7)

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

22 members.

Organism	Protein (Synonyms)	Description	AmiGO
A. thaliana	TAIR:locus:2177431 (MXI10.19 · AT5G38460 · MXI10_19) · NCBI:NP_198662.1
A. thaliana	NCBI:NP_181994.2 · TAIR:locus:2042411 (F16B22.15 · AT2G44660)
C. elegans	WB:WBGene00007435 (C08B11.8) · UniProtKB:Q09226
C. elegans	WB:WBGene00007464 (C08H9.3) · UniProtKB:P52887
D. rerio	UniProtKB:Q6AXK8 · ZFIN:ZDB-GENE-040808-45 (alg6)	asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)
D. rerio	UniProtKB:Q6ZM97 · ZFIN:ZDB-GENE-030131-5812 (alg8)	asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)
D. discoideum	UniProtKB:Q54QG6 · dictyBase:DDB_G0283841 (alg6)	dolichyl-phosphate-glucose alpha-1,3-glucosyltransferase, glycosyltransferase
D. discoideum	UniProtKB:Q554E2 · dictyBase:DDB_G0275261 (alg8)	dolichyl-phosphate-glucose alpha-1,3-glucosyltransferase, glycosyltransferase
D. melanogaster	FB:FBgn0032234 (CG5091) · UniProtKB:Q9VKX7
D. melanogaster	FB:FBgn0029906 (CG4542) · UniProtKB:Q9W3V8
G. gallus	NCBI:XP_425656 · ENTREZ:428097
G. gallus	ENTREZ:395078 · UniProtKB:Q802T2 (IPI00822734 · ALG6_CHICK · RCJMB04_6f21 · ALG6 · Q802T2)	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
H. sapiens	ENSEMBL:ENSG00000088035 · UniProtKB:Q9Y672 (ALG6_HUMAN · ALG6 · My046 · Q9Y672 · IPI00797222)	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
H. sapiens	ENSEMBL:ENSG00000159063 · UniProtKB:Q9BVK2 (IPI00032370 · HUSSY-02 · ALG8 · Q9BVK2 · ALG8_HUMAN)	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
M. musculus	UniProtKB:Q3TAE8 · MGI:MGI:2444031 (Alg6)	asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase)
M. musculus	UniProtKB:Q6P8H8 · MGI:MGI:2141959 (LOC381903 · Alg8)	asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)
R. norvegicus	UniProtKB:Q3T1L5 · RGD:1308815 (Alg6)	asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
R. norvegicus	UniProtKB:Q497D1 · RGD:1305468 (Alg8)	asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
S. cerevisiae	UniProtKB:Q12001 · SGD:S000005528 (YOR002W · ALG6)	Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation
S. cerevisiae	UniProtKB:P40351 · SGD:S000005593 (YOR067C · ALG8 · YOR29-18)	Glucosyl transferase, involved in N-linked glycosylation
S. pombe	UniProtKB:O43053 · GeneDB_Spombe:SPBC342.01c (SPBC342.01c · alg6 · SPBC3F6.06c)	glucosyltransferase Alg6
S. pombe	UniProtKB:Q10479 · GeneDB_Spombe:SPAC17C9.07 (alg8 · SPAC17C9.07)	glucosyltransferase Alg8

Protein	Publication	Curator Notes
UniProtKB:P40351 · SGD:S000005593	15235028 Schollen E, et al. Clinical and molecular features of three patients with congenital disorders of glycosylation type Ih (CDG-Ih) (ALG8 deficiency). J Med Genet. 2004 Jul;41(7):550-6.	The H. sapiens protein Q9BVK2 complements a homologous mutation in S. cerevisiae. Human ALG8 cmplements a yeast alg8 deletion in a wbp1-1 background.

Description	Suffix
Sequences in this family	.fasta
mafft aligned Fasta file	.afasta
phyml newick file	.newick
Notung rooted & rearranged newick file	.newick.rooting.0.rearrange.0
Notung Homolog Table	.newick.rooting.0.rearrange.0.homologs.csv

OMIM (2)
ENSEMBL:ENSG00000159063 · UniProtKB:Q9BVK2	#603147 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ic; CDG1C;;CDG Ic; CDGIc;;CARBOHYDRATE-DEFICIENT GLYCOPROTEIN SYNDROME, TYPE I, WITH DEFICIENTGLYCOSYLATION OF DOLICHOL-LINKED OLIGOSACCHARIDE, FORMERLY;;CARBOHYDRATE-DEFICIENT GLYCOPROTEIN SYNDROME, TYPE V, FORMERLY; CDGS5,FORMERLY
UniProtKB:Q12001 · SGD:S000005528	#608104 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ih; CDG1H;;CDG Ih; CDGIh
SGD Disease Papers (5)
UniProtKB:P40351 · SGD:S000005593	11106564 Westphal V, et al. (2000) Reduced heparan sulfate accumulation in enterocytes contributes to protein-losing enteropathy in a congenital disorder of glycosylation. Am J Pathol 157(6):1917-25
	10924277 Westphal V, et al. (2000) Analysis of multiple mutations in the hALG6 gene in a patient with congenital disorder of glycosylation Ic. Mol Genet Metab 70(3):219-23
	10914684 Imbach T, et al. (2000) Multi-allelic origin of congenital disorder of glycosylation (CDG)-Ic. Hum Genet 106(5):538-45
	10359825 Imbach T, et al. (1999) A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic. Proc Natl Acad Sci U S A 96(12):6982-7
UniProtKB:P40351 · SGD:S000005593	15235028 Schollen E, et al. (2004) Clinical and molecular features of three patients with congenital disorders of glycosylation type Ih (CDG-Ih) (ALG8 deficiency). J Med Genet 41(7):550-6