P-POD: Princeton Protein Orthology Database: GO3/Jaccard1011

This family has 26 members: 4 Arabidopsis thaliana, 1 Caenorhabditis elegans, 3 Danio rerio, 2 Dictyostelium discoideum, 2 Drosophila melanogaster, 1 Escherichia coli, 2 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 3 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

26 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_174157.3 · TAIR:locus:2032164 (F3M18.22 · F3M18_22 · AT1G28350)⌘
A. thalianaNCBI:NP_191557.1 · TAIR:locus:2080492 (AT3G59980 · F24G16.250)⌘
A. thalianaNCBI:NP_850222.1 · TAIR:locus:2057599 (AT2G33840 · T1B8.14 · T1B8_14)⌘
A. thalianaNCBI:NP_565938.1 · TAIR:locus:2064801 (T7D17.16 · AT2G40660 · T7D17_16)⌘
C. elegansWB:WBGene00013677 (Y105E8A.19) · UniProtKB:Q8WQA5⌘
D. rerioUniProtKB:Q6TGS6 · ZFIN:ZDB-GENE-030425-2 (yars)tyrosyl-tRNA synthetase⌘
D. rerioZFIN:ZDB-GENE-060825-144 (zgc:154081) · UniProtKB:Q0P3U2⌘
D. rerioZFIN:ZDB-GENE-041212-13 (zgc:101853) · UniProtKB:Q5PR96⌘
D. discoideumUniProtKB:Q54DX3 · dictyBase:DDB_G0291926 (DDB_G0291926)endothelial monocyte-activating polypeptide II precursor pro-EMAP II family protein⌘
D. discoideumUniProtKB:Q551A1 · dictyBase:DDB_G0276721 (tyrS · TyrRS)tyrosine-tRNA ligase, tyrosyl-tRNA synthetase⌘
D. melanogasterFB:FBgn0033351 (CG8235) · UniProtKB:A1Z7K8⌘
D. melanogasterUniProtKB:Q9VV60 · FB:FBgn0027080 (TyrRS · CG4561 · Aats-tyr · anon-EST:Posey261 · YRS)Tyrosyl-tRNA synthetase⌘
E. coliUniProtKB:P42589 · ECOLI:G7597-MONOMER (ygjH · b3074 · YgjH · ECK3064)putative tRNA synthetase⌘
G. gallusNCBI:XP_420496 · ENTREZ:422533
G. gallusENTREZ:419666 · UniProtKB:Q5ZJ08 (IPI00583766 · RCJMB04_21p3 · YARS · Q5ZJ08 · SYYC_CHICK)Tyrosyl-tRNA synthetase, cytoplasmic⌘
H. sapiensENSEMBL:ENSG00000164022 · UniProtKB:Q12904 (EMAP2 · MCA1_HUMAN · Q12904 · SCYE1 · IPI00006252)Multisynthetase complex auxiliary component p43⌘
H. sapiensENSEMBL:ENSG00000134684 · UniProtKB:P54577 (IPI00007074 · YARS · P54577 · SYYC_HUMAN)Tyrosyl-tRNA synthetase, cytoplasmic⌘
M. musculusUniProtKB:P31230 · MGI:MGI:102774 (Emap2 · p43 · Scye1 · AIMP1)small inducible cytokine subfamily E, member 1⌘
M. musculusUniProtKB:Q91WQ3 · MGI:MGI:2147627 (Yars)tyrosyl-tRNA synthetase⌘
R. norvegicusNCBI:XP_001081511 · RGD:1591213 (LOC688209)similar to small inducible cytokine subfamily E, member 1⌘
R. norvegicusUniProtKB:Q4KM49 · RGD:1307616 (Yars)tyrosyl-tRNA synthetase⌘
R. norvegicusUniProtKB:Q4G079 · RGD:620466 (Scye1)small inducible cytokine subfamily E, member 1⌘
S. cerevisiaeUniProtKB:P46672 · SGD:S000003073 (YGL105W · ARC1)Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm⌘
S. cerevisiaeUniProtKB:P36421 · SGD:S000003417 (TTS1 · TyrRS · YGR185C · TYS1)Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis⌘
S. pombeUniProtKB:O14055 · GeneDB_Spombe:SPCC1672.05c (SPCC1672.05c · yrs1)cytoplasmic tyrosine-tRNA ligase Yrs1⌘
S. pombeUniProtKB:Q9P6K7 · GeneDB_Spombe:SPAC30C2.04 (SPAC30C2.04)cofactor for methionyl-and glutamyl-tRNA synthetases⌘
ProteinPublicationCurator Notes
UniProtKB:P46672 · SGD:S000003073PMID:15184019 Golinelli-Cohen MP, et al. Complementation of yeast Arc1p by the p43 component of the human multisynthetase complex does not require its association with yeast MetRS and GluRS. J Mol Biol. 2004 Jun 25;340(1):15-27.The O. sativa protein OsMetRS was expressed in S. cerevisiae, but complementation was not directly tested. Rice MetRS complements a yeast arc1 mes1 double mutant, but is only homologous to MES1.
UniProtKB:P36421 · SGD:S000003417PMID:9427763 Wakasugi K, et al. Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant. EMBO J. 1998 Jan 2;17(1):297-305.The H. sapiens protein YARS complements a homologous mutation in S. cerevisiae.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
SGD Disease Papers (1)
UniProtKB:P36421 · SGD:S000003417PMID:16429158 Jordanova A, et al. (2006) Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet 38(2):197-202
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