This family has 21 members: 5 Arabidopsis thaliana, 3 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Escherichia coli, 1 Gallus gallus, 2 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 2 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
| Protein | Publication | Curator Notes |
|---|
| SGD:S000000058 | ![[PubMed]](http://yfgdb.princeton.edu/PubMed.gif) 15756621: Guerrero CA, et al. Salt-dependent expression of ammonium assimilation genes in the halotolerant yeast, Debaryomyces hansenii. Curr Genet. 2005 Mar;47(3):163-71. Epub 2005 Jan 27. | The D. hansenii protein DhGDH1 complements the orthologous mutation in S. cerevisiae. DhGDH1 complements an S. cerevisiae gdh1 gdh3 double mutant. |
| SGD:S000005902 | 15756621: Guerrero CA, et al. Salt-dependent expression of ammonium assimilation genes in the halotolerant yeast, Debaryomyces hansenii. Curr Genet. 2005 Mar;47(3):163-71. Epub 2005 Jan 27. | The D. hansenii protein DhGDH1 complements the orthologous mutation in S. cerevisiae. DhGDH1 complements an S. cerevisiae gdh1 gdh3 double mutant. |
CLUSTAL W (1.83.1) multiple sequence alignment # P-POD
H.sapiens|UniProtKB:P00367 ------------------------------------------------------------
H.sapiens|UniProtKB:P49448 ------------------------------------------------------------
R.norvegicus|RGD:2708 ------------------------------------------------------------
M.musculus|MGI:95753 ------------------------------------------------------------
G.gallus|UniProtKB:P00368 ------------------------------------------------------------
D.rerio|ZFIN:ZDB-GENE-030114-2 ------------------------------------------------------------
D.rerio|ZFIN:ZDB-GENE-030828-1 ------------------------------------------------------------
D.melanogaster|FB:FBgn0001098 ------------------------------------------------------------
C.elegans|WP:WB:CE06652 ------------------------------------------------------------
C.elegans|WB:WBGene00014095 ------------------------------------------------------------
C.elegans|UniProtKB:Q23621 ------------------------------------------------------------
D.discoideum|dictyBase:DDB0231438 ------------------------------------------------------------
A.thaliana|TAIR:gene:1944559 ------------------------------------------------------------
A.thaliana|TAIR:gene:2172308 ------------------------------------------------------------
A.thaliana|TAIR:gene:2183378 ------------------------------------------------------------
A.thaliana|TAIR:gene:3355773 ------------------------------------------------------------
S.cerevisiae|SGD:S000005902 ------------------------------------------------------------
S.cerevisiae|SGD:S000000058 ------------------------------------------------------------
S.pombe|SPCC622.12c ------------------------------------------------------------
E.coli|P00370 ------------------------------------------------------------
A.thaliana|TAIR:gene:2017541 MFGPTGGLGMNPSMDDMNLIQQAQRHQLVVSNLGEEIDLEIGPGEDDAAFANNSLIGGPP
H.sapiens|UniProtKB:P00367 ------------------------------------------------------------
H.sapiens|UniProtKB:P49448 ------------------------------------------------------------
R.norvegicus|RGD:2708 ------------------------------------------------------------
M.musculus|MGI:95753 ------------------------------------------------------------
G.gallus|UniProtKB:P00368 ------------------------------------------------------------
D.rerio|ZFIN:ZDB-GENE-030114-2 ------------------------------------------------------------
D.rerio|ZFIN:ZDB-GENE-030828-1 ------------------------------------------------------------
D.melanogaster|FB:FBgn0001098 ------------------------------------------------------------
C.elegans|WP:WB:CE06652 ------------------------------------------------------------
C.elegans|WB:WBGene00014095 ------------------------------------------------------------
C.elegans|UniProtKB:Q23621 ------------------------------------------------------------
D.discoideum|dictyBase:DDB0231438 ------------------------------------------------------------
A.thaliana|TAIR:gene:1944559 ------------------------------------------------------------
A.thaliana|TAIR:gene:2172308 ------------------------------------------------------------
A.thaliana|TAIR:gene:2183378 ------------------------------------------------------------
A.thaliana|TAIR:gene:3355773 ------------------------------------------------------------
S.cerevisiae|SGD:S000005902 ------------------------------------------------------------
S.cerevisiae|SGD:S000000058 ------------------------------------------------------------
S.pombe|SPCC622.12c ------------------------------------------------------------
E.coli|P00370 ------------------------------------------------------------
A.thaliana|TAIR:gene:2017541 REPSTGEHDETKHMVLVSDLPSEDQDISKGTPAKRKKKVVKRWREEWADTYKWAYVDMKD
H.sapiens|UniProtKB:P00367 ----------------------MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPA
H.sapiens|UniProtKB:P49448 ----------------------MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPA
R.norvegicus|RGD:2708 ----------------------MYRRLGEVLLLSRAGPAALGSAAADSAALLGWARGQPS
M.musculus|MGI:95753 ----------------------MYRRLGEALLLSRAGPAALGSAAADSAALLGWARGQPS
G.gallus|UniProtKB:P00368 ------------------------------------------------------------
D.rerio|ZFIN:ZDB-GENE-030114-2 ----------------------MYRYLGELVTR-AAANSALASVCVDSALPAS-------
D.rerio|ZFIN:ZDB-GENE-030828-1 ----------------------MYRYFGELLTR-GAG-SALASGCVESALPAS-------
D.melanogaster|FB:FBgn0001098 --------------------MYHLKSLARQGARRQQELATLAKALPTAVMQSSR------
C.elegans|WP:WB:CE06652 -----------------------------MLSTLSRGARSVAVRSYSAAT----------
C.elegans|WB:WBGene00014095 -----------------------------MLSTLSRGARSVAVRSYSAAT----------
C.elegans|UniProtKB:Q23621 -----------------------------MLSTLSRGARSVAVRSYSAAT----------
D.discoideum|dictyBase:DDB0231438 -------------------------------------MQSLARLSRTSLVQKG-------
A.thaliana|TAIR:gene:1944559 ------------------------------------------------------------
A.thaliana|TAIR:gene:2172308 ------------------------------------------------------------
A.thaliana|TAIR:gene:2183378 ------------------------------------------------------------
A.thaliana|TAIR:gene:3355773 ------------------------------------------------------------
S.cerevisiae|SGD:S000005902 ------------------------------------------------------------
S.cerevisiae|SGD:S000000058 ------------------------------------------------------------
S.pombe|SPCC622.12c ------------------------------------------------------------
E.coli|P00370 ------------------------------------------------------------
A.thaliana|TAIR:gene:2017541 GTARIFCSICREYGRKHRRNPYGNEGSRNMQMSALEEHNNSLLHKEALRLQTASKDKIVV
H.sapiens|UniProtKB:P00367 AAPQPGLALAARRHYSEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTR-ESEEQ
H.sapiens|UniProtKB:P49448 AASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQ-ESEEQ
R.norvegicus|RGD:2708 AVPQPGLTPVARRHYSEAATDREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTR-ENEEQ
M.musculus|MGI:95753 AAPQPGLTPVARRHYSEAAADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTR-ESEEQ
G.gallus|UniProtKB:P00368 ----------------CZAADKEDDPNFFKMVEGFFDRGASIVEDKLVEGLRTR-QSMEQ
D.rerio|ZFIN:ZDB-GENE-030114-2 ------ATLLRVRRYSEAVGEKDDDPNFFRMVEGFFDRGASIVEDKLVHDLKTR-ETPEQ
D.rerio|ZFIN:ZDB-GENE-030828-1 ------SSLLRVRHYSDAAD-KEDDPNFFRMVEGFFDRGATIVENKLVEDLKTR-ETPEQ
D.melanogaster|FB:FBgn0001098 -----GYATEHQIPDRLKDVPTAKDPRFFDMVEYFFHRGCQIAEESLVDDMKGK-LTRDE
C.elegans|WP:WB:CE06652 ------LDAHSQVLDEQKPMEEQVNPSFYKMVDFYFNKGAEVIAPKLAEELKSNSLSQKD
C.elegans|WB:WBGene00014095 ------LDAHSQVLDEQKPMEEQVNPSFYKMVDFYFNKGAEVIAPKLAEELKSNSLSQKD
C.elegans|UniProtKB:Q23621 ------LDAHSQVLDEQKPMEEQVNPSFYKMVDFYFNKGAEVIAPKLAEELKSNSLSQKD
D.discoideum|dictyBase:DDB0231438 -----LVPQTIKNYSSVSQAEIDNEPRFLECFKTFFDKAAGLTN----------------
A.thaliana|TAIR:gene:1944559 -------------------------MNALAATNRNFKLAARLLG----------------
A.thaliana|TAIR:gene:2172308 -------------------------MNALAATNRNFKLAARLLG----------------
A.thaliana|TAIR:gene:2183378 -------------------------MNALAATNRNFRHASRILG----------------
A.thaliana|TAIR:gene:3355773 -------------------------MNALAATNRNFRHASRILG----------------
S.cerevisiae|SGD:S000005902 -----------------------MS--EPEFQQAYEEVVSSLEDSTLFEQHPEY------
S.cerevisiae|SGD:S000000058 ----------------------MTS--EPEFQQAYDEIVSSVEDSKIFEKFPQY------
S.pombe|SPCC622.12c ----------------------MSTPYEPEFQQAYKEIVGSIESSKLFEVHPEL------
E.coli|P00370 -------MDQTYSLESFLNHVQKRDPNQTEFAQAVREVMTTLWP--FLEQNPKY------
A.thaliana|TAIR:gene:2017541 DKPIYVKTVMSKSAGSIVEGALKRDPNEIEFVQSVQESVHALER--VIAKNSHY------
. :
H.sapiens|UniProtKB:P00367 KRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVS
H.sapiens|UniProtKB:P49448 KRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVS
R.norvegicus|RGD:2708 KRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVS
M.musculus|MGI:95753 KRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVS
G.gallus|UniProtKB:P00368 RRHRVRGILRIIKPCNHVLSVSFPIKRDDGZWEVIEGYRAQHSHQRTPCKGGIRYSLDVS
D.rerio|ZFIN:ZDB-GENE-030114-2 KRHRVRGILKIIKPCNHVLSVSFPIKRDNGEWEMIEGYRAQHSQHRTPCKGGIRYSTEVS
D.rerio|ZFIN:ZDB-GENE-030828-1 KRSRVRGILKIIKPCNHVLSVSFPIKRDNGEWEVIEGYRAQHSQHRTPCKGGIRYSMDVS
D.melanogaster|FB:FBgn0001098 KKQKVKGILMLMQPCDHIIEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKGGIRFSLDVS
C.elegans|WP:WB:CE06652 KKNLVSGILGAIKPVNKVLYITFPIRRDNGEFEVIEAWRAQHSEHRTPTKGGIRYSLDVC
C.elegans|WB:WBGene00014095 KKNLVSGILGAIKPVNKVLYITFPIRRDNGEFEVIEAWRAQHSEHRTPTKGGIRYSLDVC
C.elegans|UniProtKB:Q23621 KKNLVSGILGAIKPVNKVLYITFPIRRDNGEFEVIEAWRAQHSEHRTPTKGGIRYSLDVC
D.discoideum|dictyBase:DDB0231438 ---LKPGVLNNMKECNVALRVEFPIKNEHGDVDIIAGYRAQHSHHRLPCKGGIRFSEEVD
A.thaliana|TAIR:gene:1944559 ---LDSKLEKSLLIPFREIKVECTIPKDDGTLASFVGFRVQHDNARGPMKGGIRYHPEVD
A.thaliana|TAIR:gene:2172308 ---LDSKLEKSLLIPFREIKVECTIPKDDGTLASFVGFRVQHDNARGPMKGGIRYHPEVD
A.thaliana|TAIR:gene:2183378 ---LDSKIERSLMIPFREIKVECTIPKDDGTLVSYIGFRVQHDNARGPMKGGIRYHPEVD
A.thaliana|TAIR:gene:3355773 ---LDSKIERSLMIPFREIKVECTIPKDDGTLVSYIGFRVQHDNARGPMKGGIRYHPEVD
S.cerevisiae|SGD:S000005902 ---RKV--LPIVSVPERIIQFRVTWENDKGEQEVAQGYRVQYNSAKGPYKGGLRFHPSVN
S.cerevisiae|SGD:S000000058 ---KKV--LPIVSVPERIIQFRVTWENDNGEQEVAQGYRVQFNSAKGPYKGGLRFHPSVN
S.pombe|SPCC622.12c ---KRV--LPIISIPERVLEFRVTWEDDKGNCRVNTGYRVQFNSALGPYKGGLRFHPSVN
E.coli|P00370 ---RQMSLLERLVEPERVIQFRVVWVDDRNQIQVNRAWRVQFSSAIGPYKGGMRFHPSVN
A.thaliana|TAIR:gene:2017541 ---VNI--MERLLEPERMIVFRVPWIDDRGETHVNRGFRVQFNQALGPCRGGIRFHPSMN
: : . : . .:*.*.. * :**:*: .:
H.sapiens|UniProtKB:P00367 VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGP
H.sapiens|UniProtKB:P49448 VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGP
R.norvegicus|RGD:2708 VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGP
M.musculus|MGI:95753 VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGP
G.gallus|UniProtKB:P00368 VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDEDLEKITRRFTMELAKKGFIGP
D.rerio|ZFIN:ZDB-GENE-030114-2 VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYSDTELEKITRRFTIELAKKGFIGP
D.rerio|ZFIN:ZDB-GENE-030828-1 VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPRNYSDNELEKITRRFTIELAKKGFIGP
D.melanogaster|FB:FBgn0001098 RDEVKALSALMTFKCACVDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGP
C.elegans|WP:WB:CE06652 EDEVKALSALMTYKCAVVDVPFGGAKGGVKIDPKQYTDYEIEKITRRIAIEFAKKGFLGP
C.elegans|WB:WBGene00014095 EDEVKALSALMTYKCAVVDVPFGGAKGGVKIDPKQYTDYEIEKITRRIAIEFAKKGFLGP
C.elegans|UniProtKB:Q23621 EDEVKALSALMTYKCAVVDVPFGGAKGGVKIDPKQYTDYEIEKITRRIAIEFAKKGFLGP
D.discoideum|dictyBase:DDB0231438 LQEVMALASLMTYKCAVVDVPFGGAKGGVRIDPKKYTVAQREKITRAYTLLLCQKNFIGP
A.thaliana|TAIR:gene:1944559 PDEVNALAQLMTWKTAVAKIPYGGAKGGIGCDPSKLSISELERLTRVFTQKIHD--LIGI
A.thaliana|TAIR:gene:2172308 PDEVNALAQLMTWKTAVAKIPYGGAKGGIGCDPSKLSISELERLTRVFTQKIHD--LIGI
A.thaliana|TAIR:gene:2183378 PDEVNALAQLMTWKTAVADIPYGGAKGGIGCSPRDLSLSELERLTRVFTQKIHD--LIGI
A.thaliana|TAIR:gene:3355773 PDEVNALAQLMTWKTAVADIPYGGAKGGIGCSPRDLSLSELERLTRVFTQKIHD--LIGI
S.cerevisiae|SGD:S000005902 LSILKFLGFEQIFKNSLTGLDMGGGKGGLCVDLKGRSNNEIRRICYAFMRELSR--HIGQ
S.cerevisiae|SGD:S000000058 LSILKFLGFEQIFKNALTGLDMGGGKGGLCVDLKGKSDNEIRRICYAFMRELSR--HIGK
S.pombe|SPCC622.12c LSILKFLGFEQIFKNALTGLPMGGGKGGSDFDPKGKSDNEIRRFSQAFMRQLFR--YIGP
E.coli|P00370 LSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSEGEVMRFCQALMTELYR--HLGA
A.thaliana|TAIR:gene:2017541 LSIAKFLGFQQTLKNALSPYKLGGASGGSDFDPKGKSDNEIMRFCQSFMNEMYR--YMGP
. *. * : **...* . : : :: : :*
H.sapiens|UniProtKB:P00367 GIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVF
H.sapiens|UniProtKB:P49448 GVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVF
R.norvegicus|RGD:2708 GIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVF
M.musculus|MGI:95753 GIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVF
G.gallus|UniProtKB:P00368 GVDVPAPNMSTGEREMSWIADTYASTIGHYDINAHACVTKPGISQGGIHGRISATGRGLF
D.rerio|ZFIN:ZDB-GENE-030114-2 GIDVPAPDMSTGEREMSWIADTYANTMGHHDINAHACVTGKPISQGGIHGRISATGRGVF
D.rerio|ZFIN:ZDB-GENE-030828-1 GIDVPAPDMSTGEREMSWIADTHANTIAHTDINAHACVTGKPISQGGIHGRISATGRGVF
D.melanogaster|FB:FBgn0001098 GVDVPAPDMGTGEREMSWIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVF
C.elegans|WP:WB:CE06652 GVDVPAPDMGTGEREMGWIADTYAQTIGHLDRDASACITGKPIVSGGIHGRVSATGRGVW
C.elegans|WB:WBGene00014095 GVDVPAPDMGTGEREMGWIADTYAQTIGHLDRDASACITGKPIVSGGIHGRVSATGRGVW
C.elegans|UniProtKB:Q23621 GVDVPAPDMGTGEREMGWIADTYAQTIGHLDRDASACITGKPIVSGGIHGRVSATGRGVW
D.discoideum|dictyBase:DDB0231438 GVDVPAPDMGTGEQEMAWIRDTY-QAFNTNDVDSMACVTGKPISSGGIRGRTEATGLGVF
A.thaliana|TAIR:gene:1944559 HTDVPAPDMGTGPQTMAWILDEYSKFHG----YSPAVVTGKPIDLGGSLGRDAATGRGVM
A.thaliana|TAIR:gene:2172308 HTDVPAPDMGTGPQTMAWILDEYSKFHG----YSPAVVTGKPIDLGGSLGRDAATGRGVM
A.thaliana|TAIR:gene:2183378 HTDVPAPDMGTNAQTMAWILDEYSKFHG----HSPAVVTGKPIDLGGSLGREAATGRGVV
A.thaliana|TAIR:gene:3355773 HTDVPAPDMGTNAQTMAWILDEYSKFHG----HSPAVVTGKPIDLGGSLGREAATGRGVV
S.cerevisiae|SGD:S000005902 DTDVPAGDIGVGGREIGYLFGAYRSYKN----SWEGVLTGKGLNWGGSLIRPEATGYGLV
S.cerevisiae|SGD:S000000058 DTDVPAGDIGVGGREIGYLFGAYRSYKN----SWEGVLTGKGLNWGGSLIRPEATGFGLV
S.pombe|SPCC622.12c QTDVPAGDIGVTGFVVMHMFGEYKRLRN----EYSGVVTGKHMLTGGSNIRPEATGYGVV
E.coli|P00370 DTDVPAGDIGVGGREVGFMAGMMKKLSN----NTACVFTGKGLSFGGSLIRPEATGYGLV
A.thaliana|TAIR:gene:2017541 DKDLPSEEVGVGTREMGYLFGQYRRLAG----QFQGSFTGPRIYWAASSLRTEASGYGVV
*:*: ::.. : : . .* : .. * *:* *:
H.sapiens|UniProtKB:P00367 HGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSI
H.sapiens|UniProtKB:P49448 HGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSI
R.norvegicus|RGD:2708 HGIENFINEASYMSILGMTPGLGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSI
M.musculus|MGI:95753 HGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSI
G.gallus|UniProtKB:P00368 GHIENFIENASYMSILGMTPGFGDKTFAVQGFGNVGLHSMRYLHRFGAKCVAVGEFDGSI
D.rerio|ZFIN:ZDB-GENE-030114-2 HGIENFVNEAAYMSQLGLTPGFGDKTFVIQGFGNVGLHSMRYLHRYGAKCVGIGELDGSI
D.rerio|ZFIN:ZDB-GENE-030828-1 HGIENFINEASYMSKLGLTPGFADKTFIIQGFGNVGLHPMRYLHRYGAKCVGIAEIDGSI
D.melanogaster|FB:FBgn0001098 HGLENFINEANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGATCIGVIEHDGTL
C.elegans|WP:WB:CE06652 KGLEVFTNDADYMKMVGLDTGLAGKTAIIQGFGNVGLHTHRYLHRAGSKVIGIQEYDCAV
C.elegans|WB:WBGene00014095 KGLEVFTNDADYMKMVGLDTGLAGKTAIIQGFGNVGLHTHRYLHRAGSKVIGIQEYDCAV
C.elegans|UniProtKB:Q23621 KGLEVFTNDADYMKMVGLDTGLAGKTAIIQGFGNVGLHTHRYLHRAGSKVIGIQEYDCAV
D.discoideum|dictyBase:DDB0231438 YGIREFLSYEEVLKKTGLTPGIKGKSIVIQGFGNVGYFAAKFFEQAGAKVIAVAEHNGAV
A.thaliana|TAIR:gene:1944559 FGTEALLNEHG--------KTISGQRFVIQGFGNVGSWAAKLISEKGGKIVAVSDITGAI
A.thaliana|TAIR:gene:2172308 FGTEALLNEHG--------KTISGQRFVIQGFGNVGSWAAKLISEKGGKIVAVSDITGAI
A.thaliana|TAIR:gene:2183378 FATEALLAEYG--------KSIQGLTFVIQGFGNVGTWAAKLIHEKGGKVVAVSDITGAI
A.thaliana|TAIR:gene:3355773 FATEALLAEYG--------KSIQGLTFVIQGFGNVGTWAAKLIHEKGGKVVAVSDITGAI
S.cerevisiae|SGD:S000005902 YYTQAMIDYATNGK-----ESFEGKRVTISGSGNVAQYAALKVIELGGTVVSLSDSKGCI
S.cerevisiae|SGD:S000000058 YYTQAMIDYATNGK-----ESFEGKRVTISGSGNVAQYAALKVIELGGIVVSLSDSKGCI
S.pombe|SPCC622.12c YYVKHMIEHRTKGA-----ETLKGKRVAISGSGNVAQYAALKCIQEGAIVKSISDSKGVL
E.coli|P00370 YFTEAMLKRHGMG--------FEGMRVSVSGSGNVAQYAIEKAMEFGARVITASDSSGTV
A.thaliana|TAIR:gene:2017541 YFARLILADMNKE--------IKGLRCVVSGCGKIAMHVVEKLIACGAHPVTVSDSKGYL
. : . :.* *::. *. : :
H.sapiens|UniProtKB:P00367 WNPD--GIDPKELEDFKLQHGSILGFPKAKPYEG----------------SILEADCDIL
H.sapiens|UniProtKB:P49448 WNPD--GIDPKELEDFKLQHGSILGFPKAKPYEG----------------SILEVDCDIL
R.norvegicus|RGD:2708 WNPD--GIDPKELEDFKLQHGSILGFPKAKVYEG----------------SILEADCDIL
M.musculus|MGI:95753 WNPD--GIDPKELEDFKLQHGSILGFPKAKVYEG----------------SILEADCDIL
G.gallus|UniProtKB:P00368 WNPD--GIDPKELEDYKLQHGTIMGFPKAQKLEG----------------SILETDCDIL
D.rerio|ZFIN:ZDB-GENE-030114-2 WNPS--GIDPKELEDYKLANGTIVGYPGATAYEG----------------NILEAECDIL
D.rerio|ZFIN:ZDB-GENE-030828-1 WNPN--GMDPKELEDYKLQHGTIVGFPNSQPYEG----------------NILEAQCDIL
D.melanogaster|FB:FBgn0001098 YNPE--GIDPKLLEDYKNEHGTIVGYQNAKPYEGE---------------NLMFEKCDIF
C.elegans|WP:WB:CE06652 YNPD--GIHPKELEDWKDANGTIKNFPGAKNFDPFT--------------ELMYEKCDIF
C.elegans|WB:WBGene00014095 YNPD--GIHPKELEDWKDANGTIKNFPGAKNFDPFT--------------ELMYEKCDIF
C.elegans|UniProtKB:Q23621 YNPD--GIHPKELEDWKDANGTIKNFPGAKNFDPFT--------------ELMYEKCDIF
D.discoideum|dictyBase:DDB0231438 YNAD--GLNIDALNKYKLQHGTFIDFPGATNIVDSV--------------KALEIPCDIL
A.thaliana|TAIR:gene:1944559 KNKD--GIDIPALLKHTKEHRGVKGFDGADPIDPN---------------SILVEDCDIL
A.thaliana|TAIR:gene:2172308 KNKD--GIDIPALLKHTKEHRGVKGFDGADPIDPN---------------SILVEDCDIL
A.thaliana|TAIR:gene:2183378 RNPE--GIDINALIKHKDATGSLNDFNGGDAMNSD---------------ELLIHECDVL
A.thaliana|TAIR:gene:3355773 RNPE--GIDINALIKHKDATGSLNDFNGGDAMNSD---------------ELLIHECDVL
S.cerevisiae|SGD:S000005902 ISET--GITSEQVADISSAKVNFKS-LEQIVNEYSTFSENKVQYIAGARPWTHVQKVDIA
S.cerevisiae|SGD:S000000058 ISET--GITSEQIHDIASAKIRFKS-LEEIVDEYSTFSESKMKYVAGARPWTHVSNVDIA
S.pombe|SPCC622.12c IAKTAEGLVPEEIHEIMALKEKRAS-IADSASLC-----KKHHYIAGARPWTNVGEIDIA
E.coli|P00370 VDES--GFTKEKLARLIEIKASRDGRVADYAKEFG------LVYLEGQQPWSLP--VDIA
A.thaliana|TAIR:gene:2017541 VDDD--GFDYMKLAFLRDIKSQQRS-LRDYSKTYAR-----AKYFDELKPWNER--CDVA
*: : . *:
H.sapiens|UniProtKB:P00367 IPAASEKQLTKSNAPRVKAK---IIAEGANGPTTPEADKIFLER---------NIMVIPD
H.sapiens|UniProtKB:P49448 IPAATEKQLTKSNAPRVKAK---IIAEGANGPTTPEADKIFLER---------NILVIPD
R.norvegicus|RGD:2708 IPAASEKQLTKSNAPRVKAK---IIAEGANGPTTPEADKIFLER---------NIMVIPD
M.musculus|MGI:95753 IPAASEKQLTKSNAPRVKAK---IIAEGANGPTTPEADKIFLER---------NIMVIPD
G.gallus|UniProtKB:P00368 IPAASEKQLTKANAHKVKAK---IIAEGANGPTTPQADKIFLER---------NIMVIPD
D.rerio|ZFIN:ZDB-GENE-030114-2 IPAASEKQLTKKNANNIKAK---IIAEGANGPTTPEADKIFLER---------NIMVIPD
D.rerio|ZFIN:ZDB-GENE-030828-1 IPAAGEKQLTRKNAHNIKAK---IIAEGANGPTTPDADKIFIER---------NVMVIPD
D.melanogaster|FB:FBgn0001098 IPAAVEKVITSENANRIQAK---IIAEAANGPTTPAADKILIDR---------NILVIPD
C.elegans|WP:WB:CE06652 VPAACEKSIHKENASRIQAK---IIAEAANGPTTPAADRILLARG--------DCLIIPD
C.elegans|WB:WBGene00014095 VPAACEKSIHKENASRIQAK---IIAEAANGPTTPAADRILLARG--------DCLIIPD
C.elegans|UniProtKB:Q23621 VPAACEKSIHKENASRIQAK---IIAEAANGPTTPAADRILLARG--------DCLIIPD
D.discoideum|dictyBase:DDB0231438 IPAALEKQIHIGNVADIQAK---LIGEAANGPMTPRADQILLNR---------GHVIIPD
A.thaliana|TAIR:gene:1944559 VPAALGGVINRENANEIKAK---FIIEAANHPTDPDADEILSKK---------GVVILPD
A.thaliana|TAIR:gene:2172308 VPAALGGVINRENANEIKAK---FIIEAANHPTDPDADEILSKK---------GVVILPD
A.thaliana|TAIR:gene:2183378 IPCALGGVLNKENAGDVKAK---FIVEAANHPTDPDADEILSKK---------GVIILPD
A.thaliana|TAIR:gene:3355773 IPCALGGVLNKENAGDVKAK---FIVEAANHPTDPDADEILSKK---------GVIILPD
S.cerevisiae|SGD:S000005902 LPCATQNEVSGEEAKALVAQGVKFIAEGSNMGSTPEAIAVFETARSTATGPSEAVWYGPP
S.cerevisiae|SGD:S000000058 LPCATQNEVSGDEAKALVASGVKFVAEGANMGSTPEAISVFETARSTATNAKDAVWFGPP
S.pombe|SPCC622.12c LPCATQNEVSGEEAAALIKQGCRYVAEGSNMGSSAEAVEVFEKSRASG----EGCWLAPG
E.coli|P00370 LPCATQNELDVDAAHQLIANGVKAVAEGANMPTTIEATELFQQA---------GVLFAPG
A.thaliana|TAIR:gene:2017541 FPCASQNEVDQADAINLVNAGCRLLVEGSNMPCTAEAVDVFRKAN---------VLIAPA
.*.* : . : : *.:* * :: *
H.sapiens|UniProtKB:P00367 LYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMS-------------VQESL
H.sapiens|UniProtKB:P49448 LYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLS-------------VQESL
R.norvegicus|RGD:2708 LYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMS-------------VQESL
M.musculus|MGI:95753 LYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMS-------------VQESL
G.gallus|UniProtKB:P00368 LYLNAGGVTVSAFZZ-KNLNHVSYGRLTFKYERDSNYHLLMS-------------VQESL
D.rerio|ZFIN:ZDB-GENE-030114-2 MYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMS-------------VQESL
D.rerio|ZFIN:ZDB-GENE-030828-1 MYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMS-------------VQESL
D.melanogaster|FB:FBgn0001098 LYINAGGVTVSFFEWLKNLNHVSYGRLTFKYERESNYHLLASVQQSIERIINDESVQESL
C.elegans|WP:WB:CE06652 MYVNSGGVTVSYFEWLKNLNHVSYGRLTFKYDEEANKMLLAS-------------VQESL
C.elegans|WB:WBGene00014095 MYVNSGGVTVSYFEWLKNLNHVSYGRLTFKYDEEANKMLLAS-------------VQESL
C.elegans|UniProtKB:Q23621 MYVNSGGVTVSYFEWLKNLNHVSYGRLTFKYDEEANKMLLAS-------------VQESL
D.discoideum|dictyBase:DDB0231438 LLLNAGGVTVSYFEWLKNLSHVRFGRLNKKWEESSKKLLLEF-------------VESTV
A.thaliana|TAIR:gene:1944559 IYANSGGVTVSYFEWVQNIQG-------FMWEEEK-------------------------
A.thaliana|TAIR:gene:2172308 IYANSGGVTVSYFEWVQNIQG-------FMWEEEK-------------------------
A.thaliana|TAIR:gene:2183378 IYANAGGVTVSYFEWVQNIQG-------FMWEEEK-------------------------
A.thaliana|TAIR:gene:3355773 IYANAGGVTVSYFEWVQNIQG-------FMWEEEK-------------------------
S.cerevisiae|SGD:S000005902 KAANLGGVAVSGLEMAQNSQR-------ITWTSER-------------------------
S.cerevisiae|SGD:S000000058 KAANLGGVAVSGLEMAQNSQK-------VTWTAER-------------------------
S.pombe|SPCC622.12c KAANAGGVAVSGLEMAQNAQF-------STWTHAE-------------------------
E.coli|P00370 KAANAGGVATSGLEMAQNAAR-------LGWKAEK-------------------------
A.thaliana|TAIR:gene:2017541 IAAGAGGVAAGEIEVLRESNS-------MQWSAED-------------------------
. ***:.. : :: :
H.sapiens|UniProtKB:P00367 ERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMK------Y
H.sapiens|UniProtKB:P49448 ERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMK------Y
R.norvegicus|RGD:2708 ERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMK------Y
M.musculus|MGI:95753 ERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMK------Y
G.gallus|UniProtKB:P00368 ERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMK------Y
D.rerio|ZFIN:ZDB-GENE-030114-2 ERKFGKHGGAIPIVPTSDFQERISGASEKDIVHSGLAYTMERSARQIMRTANR------Y
D.rerio|ZFIN:ZDB-GENE-030828-1 ERKFGKQGGPIPIVPTADFQARVAGASEKDIVHSGLAYTMERSARQIMRTANK------Y
D.melanogaster|FB:FBgn0001098 ERRFGRVGGRIPVTPSESFQKRISGASEKDIVHSGLDYTMERSARAIMKTAMK------Y
C.elegans|WP:WB:CE06652 SKAVGK---DCPVEPNAAFAAKIAGASEKDIVHSGLEYTMQRSGEAIIRTAHK------Y
C.elegans|WB:WBGene00014095 SKAVGK---DCPVEPNAAFAAKIAGASEKDIVHSGLEYTMQRSGEAIIRTAHK------Y
C.elegans|UniProtKB:Q23621 SKAVGK---DCPVEPNAAFAAKIAGASEKDIVHSGLEYTMQRSGEAIIRTAHK------Y
D.discoideum|dictyBase:DDB0231438 NKKLSE----------AERSLIIHGADEIDIVRSGLEDTMQNACAETRKTANE------K
A.thaliana|TAIR:gene:1944559 -------------------------------VNDELKTYMTRSFKDLKEMCKT------H
A.thaliana|TAIR:gene:2172308 -------------------------------VNDELKTYMTRSFKDLKEMCKT------H
A.thaliana|TAIR:gene:2183378 -------------------------------VNLELQKYMTRAFHNIKTMCHT------H
A.thaliana|TAIR:gene:3355773 -------------------------------VNLELQKYMTRAFHNIKTMCHT------H
S.cerevisiae|SGD:S000005902 -------------------------------VDQELKRIMINCFNECIDYAKKYT--KDG
S.cerevisiae|SGD:S000000058 -------------------------------VDQELKKIMINCFNDCIQAAQEYSTEKNT
S.pombe|SPCC622.12c -------------------------------VDAKLAGIMQNIFEQSTDVASKYCD-SGS
E.coli|P00370 -------------------------------VDARLHHIMLDIHHACVEHG-------GE
A.thaliana|TAIR:gene:2017541 -------------------------------FESRLQEALKQTYEKALKAANDFG--YQK
. * :
H.sapiens|UniProtKB:P00367 NLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
H.sapiens|UniProtKB:P49448 NLGLDLRTAAYVNAIEKVFKVYSEAGVTFT
R.norvegicus|RGD:2708 NLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
M.musculus|MGI:95753 NLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
G.gallus|UniProtKB:P00368 NLGLDLRTAAYVNAIEKVFKVYNEAGLTFT
D.rerio|ZFIN:ZDB-GENE-030114-2 NLGLDLRTAAYVNAIEKVFKVYHEAGLTFT
D.rerio|ZFIN:ZDB-GENE-030828-1 NLGLDLRTAAYVNAIEKVFKVYNEAGLTFT
D.melanogaster|FB:FBgn0001098 NLGLDLRTAAYVNSIEKIFTTYRDAGLAF-
C.elegans|WP:WB:CE06652 NLGLDIRTAAYANSIEKVYNTYRTAGFTFT
C.elegans|WB:WBGene00014095 NLGLDIRTAAYANSIEKVYNTYRTAGFTFT
C.elegans|UniProtKB:Q23621 NLGLDIRTAAYANSIEKVYNTYRTAGFTFT
D.discoideum|dictyBase:DDB0231438 NT--DYRSAALYNAIMKIKAVYESSGNVFS
A.thaliana|TAIR:gene:1944559 SC--DLRMGAFTLGVNRVAQATILRGWGA-
A.thaliana|TAIR:gene:2172308 SC--DLRMGAFTLGVNRVAQATILRGWGA-
A.thaliana|TAIR:gene:2183378 SC--NLRMGAFTLGVNRVARATQLRGWEA-
A.thaliana|TAIR:gene:3355773 SC--NLRMGAFTLGVNRVARATQLRGWEA-
S.cerevisiae|SGD:S000005902 KVLPSLVKGANIASFIKVSDAMFDQGDVF-
S.cerevisiae|SGD:S000000058 NTLPSLVKGANIASFVMVADAMLDQGDVF-
S.pombe|SPCC622.12c NNIPSLVDGANIAGFLKVATAMQAVGDWW-
E.coli|P00370 GEQTNYVQGANIAGFVKVADAMLAQGVI--
A.thaliana|TAIR:gene:2017541 ESPEALLHGATIAAFLNIAQAMTDQGCV--
.* .. : . *
| Protein | OMIM Phenotype Information |
|---|
| UniProtKB:P00367 | #606762 HYPERINSULINEMIC HYPOGLYCEMIA, FAMILIAL, 6; HHF6 |
