Princeton Protein Orthology Database: GO0/ORTHOMCL1110

This family has 22 members: 4 Arabidopsis thaliana, 6 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Escherichia coli, 1 Gallus gallus, 2 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Notung Tree [Applet]	Organism	Protein	AmiGO
D = Duplication Event	Arabidopsis thaliana	TAIR:gene:2033801 (AT1G32470.1)	AmiGO
	Arabidopsis thaliana	TAIR:gene:2062434
	Arabidopsis thaliana	TAIR:gene:2063463 (AT2G35120.1)	AmiGO
	Arabidopsis thaliana	TAIR:gene:4370575 (GDCH)	AmiGO
	Caenorhabditis elegans	UniProtKB:O62122
	Caenorhabditis elegans	UniProtKB:Q20634
	Caenorhabditis elegans	WB:WBGene00008354 (D1025.2)
	Caenorhabditis elegans	WB:WBGene00009918 (F52A8.5)	AmiGO
	Caenorhabditis elegans	WP:WB:CE05912
	Caenorhabditis elegans	WP:WB:CE17610
	Danio rerio	ZFIN:ZDB-GENE-040718-319 (zgc:92732)
	Danio rerio	ZFIN:ZDB-GENE-050320-18 (zgc:112535)
	Dictyostelium discoideum	dictyBase:DDB0231211 (gcvH1)	AmiGO
	Drosophila melanogaster	FB:FBgn0027945 (ppl)	AmiGO
	Escherichia coli	P0A6T9
	Gallus gallus	UniProtKB:P11183 (GCSH_CHICK)
	Homo sapiens	RefSeq:XP_950829
	Homo sapiens	UniProtKB:P23434 (GCSH_HUMAN)	AmiGO
	Mus musculus	MGI:1915383 (Gcsh)
	Rattus norvegicus	RGD:619946 (Gcsh)	AmiGO
	Saccharomyces cerevisiae	SGD:S000000042 (GCV3)	AmiGO
	Schizosaccharomyces pombe	SPBP19A11.01 (SPBP19A11.01)	AmiGO

CLUSTAL W (1.83.1) multiple sequence alignment # P-POD


A.thaliana|TAIR:gene:2062434      -MALR-MWASSTANALK---------LSSSVSKSHLSP-FSFSRCFSTVLEGLKYANSHE
A.thaliana|TAIR:gene:4370575      -MALR-MWASSTANALK---------LSSSVSKSHLSP-FSFSRCFSTVLEGLKYANSHE
A.thaliana|TAIR:gene:2033801      -MALR-MWASSTANALK---------LSSSASKSHLLPAFSISRCFSSVLEGLKYANSHE
A.thaliana|TAIR:gene:2063463      -MACRLFWASRVASHLR---------ISVAQRG--------FS---SVVLKDLKYADSHE
E.coli|P0A6T9                     ---------------------------------------------MSNVPAELKYSKEHE
R.norvegicus|RGD:619946           -MSLR-VVRSVRAVACSLRIA---LASCPPRPWAPSAAAVRSLRTGSALLSVRKFTEKHE
M.musculus|MGI:1915383            -MSLQ-VSRSLRVVAYSLRTA---LAFCSPRPCVPSAAAVRSLRTGSALLSVRKFTEKHE
H.sapiens|UniProtKB:P23434        -MALR-VVRSVRALLCTLRAVPLPAAPCPPRPWQLGVGAVRTLRTGPALLSVRKFTEKHE
H.sapiens|RefSeq:XP_950829        -MALR-VVRSVRALLCTLRAVPSPAAPCPPRPWQLGVGAVRTLRTGPALLSVRKFTEKHE
G.gallus|UniProtKB:P11183         -MAWL-VLRRLGPVLA---------PRCPRLSLRPQVPAVRRLGTGSLLLSARKFTDKHE
D.rerio|ZFIN:ZDB-GENE-040718-319  -MAMCAALRCVSANFSAALPLLARPPHIWTCQNSLKPNVFRTLSTSSRLSGALKFTDKHE
D.rerio|ZFIN:ZDB-GENE-050320-18   -MAMCTVLRCVSVSLTSSLPRLSNINAHAPARLLARTCYRRSLSTNTPFCAALKFTDKHE
D.melanogaster|FB:FBgn0027945     -MVFITKFARIGLQAAR-----------QLSVTPLGAVQARAIHLTSLLAKERRYTNKHE
C.elegans|WP:WB:CE17610           ----MSFLSRFIPTV----------TARTAIRFASNG---------------RLYTKKHE
C.elegans|WB:WBGene00008354       ----MSFLSRFIPTV----------TARTAIRFASNG---------------RLYTKKHE
C.elegans|UniProtKB:O62122        ----MSFLSRFIPTV----------TARTAIRFASNG---------------RLYTKKHE
C.elegans|WP:WB:CE05912           ----MNQLCRAVP------------SLRSAVRLASSG---------------RLYTKKHE
C.elegans|WB:WBGene00009918       ----MNQLCRAVP------------SLRSAVRLASSG---------------RLYTKKHE
C.elegans|UniProtKB:Q20634        ----MNQLCRAVP------------SLRSAVRLASSG---------------RLYTKKHE
S.pombe|SPBP19A11.01              MLARSALRSGFLPSLTS--------SVKTGFCLKAAAPTLSMKWSAVKYYSTKHFTKEHE
D.discoideum|dictyBase:DDB0231211 ----------------------------MLKTLRFGTRAFGQNLNIAKRNFCTRYTNDHE
S.cerevisiae|SGD:S000000042       MLRTTRLWTTRMPAVSK--------LFLRNSSGNALNKNKLPFLYSSQGPQAVRYTSQHE
                                                                                        ::..**

A.thaliana|TAIR:gene:2062434      WVKHEGS-VATIGITAHAQDHLGEVVFVELPEDNTSVSKEKSFGAVESVKATSEILSPIS
A.thaliana|TAIR:gene:4370575      WVKHEGS-VATIGITAHAQDHLGEVVFVELPEDNTSVSKEKSFGAVESVKATSEILSPIS
A.thaliana|TAIR:gene:2033801      WVKHEGS-VATIGITDHAQDHLGEVVFVELPEANSSVSKEKSFGAVESVKATSEILSPIS
A.thaliana|TAIR:gene:2063463      WVKIDGN-KATFGITDHAQDHLGDVVYVELPDVGHSVSQGKSFGAVESVKATSDINSPVS
E.coli|P0A6T9                     WLRKEADGTYTVGITEHAQELLGDMVFVDLPEVGATVSAGDDCAVAESVKAASDIYAPVS
R.norvegicus|RGD:619946           WVTAKDG-IGTVGISNFAQEALGDVVYCSLPEVGTKLKKQEEFGALESVKAASELYSPLS
M.musculus|MGI:1915383            WITTEEG-IGTVGISNFAQEALGDVVYCSLPEVGTKLKKQEEFGALESVKAASELYSPLS
H.sapiens|UniProtKB:P23434        WVTTENG-IGTVGISNFAQEALGDVVYCSLPEVGTKLNKQDEFGALESVKAASELYSPLS
H.sapiens|RefSeq:XP_950829        WVTTENG-IGTVGISNFAQEALGDVVYCSLPEVGTKLNKQDEFGALESVKAASELYSPLS
G.gallus|UniProtKB:P11183         WISVENG-IGTVGISNFAQEALGDVVYCSLPEIGTKLNKDDEFGALESVKAASELYSPLT
D.rerio|ZFIN:ZDB-GENE-040718-319  WVRVEGS-VGTVGISNFAQEALGDVVYCGLPEVGTKLDQMEEFGALESVKAASELYSPLT
D.rerio|ZFIN:ZDB-GENE-050320-18   WVRVDGG-VATVGISNFAQEALGDVVYCGLPEIGAKLSQTDGFGALESVKAASELYSPLT
D.melanogaster|FB:FBgn0027945     WVEVVSGSNAIVGISSYAQEALGDVVFAQLPEPGTELKQDDECGALESVKAASEVYSPVS
C.elegans|WP:WB:CE17610           WIVVNQS-VGTVGITDFATEQLGDVVFIELPEAGVEIEKGDSTGAVESVKAASDIYAPVS
C.elegans|WB:WBGene00008354       WIVVNQS-VGTVGITDFATEQLGDVVFIELPEAGVEIEKGDSTGAVESVKAASDIYAPVS
C.elegans|UniProtKB:O62122        WIVVNQS-VGTVGITDFATEQLGDVVFIELPEAGVEIEKGDSTGAVESVKAASDIYAPVS
C.elegans|WP:WB:CE05912           WVLVENG-VGTVGITDFATEQLGDVVFIELPDEGTEISKGDSTGAVESVKAASDIYAPIS
C.elegans|WB:WBGene00009918       WVLVENG-VGTVGITDFATEQLGDVVFIELPDEGTEISKGDSTGAVESVKAASDIYAPIS
C.elegans|UniProtKB:Q20634        WVLVENG-VGTVGITDFATEQLGDVVFIELPDEGTEISKGDSTGAVESVKAASDIYAPIS
S.pombe|SPBP19A11.01              WVKVDGD-VGTVGITSYAANALGEVVFVELPEPETTVSVGDGIGAVESVKSASDVYSPVS
D.discoideum|dictyBase:DDB0231211 WVTSLGSQNYRLGITDFAQKQLGDIVFVEIPQIGATLSQGQPITVVESVKAASDIYIPMD
S.cerevisiae|SGD:S000000042       WIAVHQDKTAFVGITKYATDSLGDATYVELPEVGTEISQGESLGSIESVKSASEIYQPAD
                                  *:    .    .**: .* . **: .:  :*:    :.  .     ****::*::  *  

A.thaliana|TAIR:gene:2062434      GEIIEVNKKLTESPGLINSSPYEDGWMIKVKP---SSPAELESLMGPKEYTKFCEEEDAA
A.thaliana|TAIR:gene:4370575      GEIIEVNKKLTESPGLINSSPYEDGWMIKVKP---SSPAELESLMGPKEYTKFCEEEDAA
A.thaliana|TAIR:gene:2033801      GEVIEVNTKLTESPGLINSSPYEDGWMIKVKP---SSPAELEALMGPKEYTKFCEEEDAA
A.thaliana|TAIR:gene:2063463      GKVVEVNEELTESPGLVNSSPYEQGWIIKVEL---SDAGEAEKLMDSDKYSKFCEEEDAK
E.coli|P0A6T9                     GEIVAVNDALSDSPELVNSEPYAGGWIFKIKA---SDESELESLLDATAYEALLEDE---
R.norvegicus|RGD:619946           GEVTEVNEALAENPGLVNKSCYEDGWLIKMTL---SDPSELDELMSEEAYEKYVKSIEE-
M.musculus|MGI:1915383            GEVTEVNEALAENPGLVNKSCYEDGWLIKMTL---SDPSELDELMSEEAYEKYVKSIEE-
H.sapiens|UniProtKB:P23434        GEVTEINEALAENPGLVNKSCYEDGWLIKMTL---SNPSELDELMSEEAYEKYIKSIEE-
H.sapiens|RefSeq:XP_950829        GEVTEINEALAENPGLVNKSCCEDGWLIKMTL---SNPSELDELMSEEAYEKYIKSIEE-
G.gallus|UniProtKB:P11183         GEVTDINAALADNPGLVNKSCYQDGWLIKMTV---EKPAELDELMSEDAYEKYIKSIED-
D.rerio|ZFIN:ZDB-GENE-040718-319  GEVTAINTELTENPALVNKACYEGGWLIKMTI---EKPAELDELMDEAAYEKFIKSLDS-
D.rerio|ZFIN:ZDB-GENE-050320-18   GEVTDANDALADNPGLVNKSCYNDGWLMKMTV---SIPEELDGLMDEAAYERYIKSIED-
D.melanogaster|FB:FBgn0027945     GKVIEKNAEVEDTPALVNSSCYEKGWLFKVDL---KNPKELEALMTEDQYKAFLSSSGDH
C.elegans|WP:WB:CE17610           GKILEKNTKLEDEPGIINKSPLEKGWLYRLEI---TSNEQLNELLTEEQYNKFKSEEEAE
C.elegans|WB:WBGene00008354       GKILEKNTKLEDEPGIINKSPLEKGWLYRLEI---TSNEQLNELLTEEQYNKFKSEEEAE
C.elegans|UniProtKB:O62122        GKILEKNTKLEDEPGIINKSPLEKGWLYRLEI---TSNEQLNELLTEEQYNKFKSEEEAE
C.elegans|WP:WB:CE05912           GTVTQKNVKLEEEAGLINKSPFEKGWLYKLKV---KSADELEKLLNEEQYAKFKKDEEAA
C.elegans|WB:WBGene00009918       GTVTQKNVKLEEEAGLINKSPFEKGWLYKLKV---KSADELEKLLNEEQYAKFKKDEEAA
C.elegans|UniProtKB:Q20634        GTVTQKNVKLEEEAGLINKSPFEKGWLYKLKV---KSADELEKLLNEEQYAKFKKDEEAA
S.pombe|SPBP19A11.01              GTVTSINESLGDSPDKVSSSPEEEGWICKIKL---SSPDELKSLLNDESYAQFCKEEDAS
D.discoideum|dictyBase:DDB0231211 GSITTVNQELESSPELVNEEPMGDGWIVEYKS---SKTDQFQSLMNKAQYDEYIKEH---
S.cerevisiae|SGD:S000000042       GTVEEINTNLEENPGVVNEDPMGDGWLVKMKLGEGVNVEQVEGLMSLEQYEKTLVHDD--
                                  * :   *  : . .  :..     **: .          : . *:    *          

A.thaliana|TAIR:gene:2062434      H
A.thaliana|TAIR:gene:4370575      H
A.thaliana|TAIR:gene:2033801      H
A.thaliana|TAIR:gene:2063463      H
E.coli|P0A6T9                     -
R.norvegicus|RGD:619946           -
M.musculus|MGI:1915383            -
H.sapiens|UniProtKB:P23434        -
H.sapiens|RefSeq:XP_950829        -
G.gallus|UniProtKB:P11183         -
D.rerio|ZFIN:ZDB-GENE-040718-319  -
D.rerio|ZFIN:ZDB-GENE-050320-18   -
D.melanogaster|FB:FBgn0027945     -
C.elegans|WP:WB:CE17610           H
C.elegans|WB:WBGene00008354       H
C.elegans|UniProtKB:O62122        H
C.elegans|WP:WB:CE05912           H
C.elegans|WB:WBGene00009918       H
C.elegans|UniProtKB:Q20634        H
S.pombe|SPBP19A11.01              H
D.discoideum|dictyBase:DDB0231211 -
S.cerevisiae|SGD:S000000042       -

Program	Link
ClustalW alignment file	.alnp
ClustalW dendrogram file	.dnd
Notung tree file: rearranged	.jtt.rooting.0.rearrange.0
Phylip amino acid sequence Maximum Likelihood method	.jtt
Sequences in this family (FASTA)	ORTHOMCL1110.fa

Protein	OMIM Phenotype Information
UniProtKB:P23434	#605899 GLYCINE ENCEPHALOPATHY; GCE
Protein	Disease-related papers from SGD
SGD:S000000042	12134146: Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4