Princeton Protein Orthology Database: GO0/ORTHOMCL1063

This family has 22 members: 7 Arabidopsis thaliana, 4 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Escherichia coli, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Notung Tree [Applet]OrganismProteinAmiGO

D = Duplication Event		Arabidopsis thalianaTAIR:gene:1005715645 (AT1G80030.3) AmiGO
Arabidopsis thalianaTAIR:gene:1005715646 (AT1G80030.2) AmiGO
Arabidopsis thalianaTAIR:gene:2016233 (AT1G80030.1) AmiGO
Arabidopsis thalianaTAIR:gene:2041257 (AT2G22360.1) AmiGO
Arabidopsis thalianaTAIR:gene:2088584 (AT3G17830.1) AmiGO
Arabidopsis thalianaTAIR:gene:2140034 (AT4G39960.1) AmiGO
Arabidopsis thalianaTAIR:gene:2162691 (AT5G48030.1) AmiGO
Caenorhabditis elegansUniProtKB:Q8TA83 (DNJ10_CAEEL) AmiGO
Caenorhabditis elegansWB:WBGene00001028 (dnj-10) AmiGO
Caenorhabditis elegansWP:WB:CE24911
Caenorhabditis elegansWP:WB:CE27991
Danio rerioZFIN:ZDB-GENE-030131-7837 (dnaja3a)
Danio rerioZFIN:ZDB-GENE-040115-3 (dnaja3b)
Dictyostelium discoideumdictyBase:DDB0233610 (geneDDB0233610) AmiGO
Drosophila melanogasterFB:FBgn0002174 (l(2)tid) AmiGO
Escherichia coliP08622
Gallus gallusRefSeq:XP_414967 (XP_414967)
Homo sapiensUniProtKB:Q96EY1 (DNJA3_HUMAN) AmiGO
Mus musculusMGI:1933786 (Dnaja3) AmiGO
Rattus norvegicusRGD:1306527 (Dnaja3) AmiGO
Saccharomyces cerevisiaeSGD:S000001878 (MDJ1) AmiGO
Schizosaccharomyces pombeSPCC4G3.14 (mdj1) AmiGO
ProteinPublicationCurator Notes
SGD:S000001878[PubMed]9324254: Deloche O, et al. Structure-function analyses of the Ssc1p, Mdj1p, and Mge1p Saccharomyces cerevisiae mitochondrial proteins in Escherichia coli. J Bacteriol. 1997 Oct;179(19):6066-75.The S. cerevisiae protein MDJ1 complements the orthologous mutation in E. coli. This paper describes a biochemical and genetic analysis of yeast Mdj1p, Ssc1p, and Mge1p in E. coli.
SGD:S000001878[PubMed]10821188: Lisse T, et al. Functional specificity of the mitochondrial DnaJ protein, Mdj1p, in Saccharomyces cerevisiae. Mol Gen Genet. 2000 Apr;263(3):527-34.The E. coli protein DnaJ complements the orthologous mutation in S. cerevisiae.
SGD:S000001878[PubMed]12215516: Christensen CA, et al. Mitochondrial GFA2 is required for synergid cell death in Arabidopsis. Plant Cell. 2002 Sep;14(9):2215-32.The A. thaliana protein AT5G48030.1 complements the orthologous mutation in S. cerevisiae. 
CLUSTAL W (1.83.1) multiple sequence alignment # P-POD


S.cerevisiae|SGD:S000001878       -----------MAFQQGVLSRCSGVFRHHVGHSRHINNILYRHAIAFAS---------IA
S.pombe|SPCC4G3.14                -MFSKYLQSRVCGLHSFTNSSAQQLFSKSIAHSSRRNFVISSSCTKFRN---------VA
D.discoideum|dictyBase:DDB0233610 --MNIEIGNKSKVLLTR----------LLSQHVNKQHILRYSTTNKKP------IPSYKS
A.thaliana|TAIR:gene:2162691      --MVPSNGAKVLRLLSRRCLSSSLIQDLANQKLRGVCIGSYRRLNTSVGNHANVIGDYAS
A.thaliana|TAIR:gene:2016233      ---MAALASPSLIPSSLC---FAAAADGPRSLSS--------NFSAFSD-------GGSN
A.thaliana|TAIR:gene:1005715645   ---MAALASPSLIPSSLC---FAAAADGPRSLSS--------NFSAFSD-------GGSN
A.thaliana|TAIR:gene:1005715646   ---MAALASPSLIPSSLC---FAAAADGPRSLSS--------NFSAFSD-------GGSN
A.thaliana|TAIR:gene:2041257      -MAIIQLGSTCVAQWSIR-PQFAVRAYYPSRIESTRHQNSSSQVNCLGA-------SKSS
A.thaliana|TAIR:gene:2140034      -MALIQFGSSCVAQWGILRPRFAVKAFYPSRLES-HQDNCISQINCLGA-------SRSS
A.thaliana|TAIR:gene:2088584      ---MAAMARCALIP-SIN----------PAHSFR----------HQFPQ-------PNAS
E.coli|P08622                     ------------------------------------------------------------
R.norvegicus|RGD:1306527          ---MAAWCSPRWLRVAVGTPRLPAAAGRGVQQPQGGVVAASLCRKLCVSAFGLSMGAHGP
M.musculus|MGI:1933786            ---MAAWCSPRWLRVAVGTPRLPAAAGRGVQQPQGGVVATSLCRKLCVSAFGLSMGAHGP
H.sapiens|UniProtKB:Q96EY1        ---MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFASSLTSCGP
G.gallus|RefSeq:XP_414967         -----MRSTARPLPVRP--------AARGYR-----------------------------
D.rerio|ZFIN:ZDB-GENE-030131-7837 MACSAARSSARWISAAVSSSHSRACSPFIPRADGAYRGFKSLSGRQMWTTRGGLSGGAGA
D.rerio|ZFIN:ZDB-GENE-040115-3    ----MAASSARWLSGAFPGLHSNCALLKSSRNGDVTALRICWSRSYVTEKSLSCWRHRGG
D.melanogaster|FB:FBgn0002174     ----MMISCKKLFVFRQLPAVRRCLAAAAFSTPRATSYRILSSAG---------------
C.elegans|WP:WB:CE24911           ----------MFVLNRSSGLIHRSVPLLAQVS----------------------------
C.elegans|WP:WB:CE27991           ----------MFVLNRSSGLIHRSVPLLAQVS----------------------------
C.elegans|WB:WBGene00001028       ----------MFVLNRSSGLIHRSVPLLAQVS----------------------------
C.elegans|UniProtKB:Q8TA83        ----------MFVLNRSSGLIHRSVPLLAQVS----------------------------
                                                                                              

S.cerevisiae|SGD:S000001878       PR------------IPKSSFHT---SAIRNNEAFKDPYDTLGLKKSATGAEIKKAYYKLA
S.pombe|SPCC4G3.14                IQRNAKREFSRCAALKNFSYHARCFHATRAVWEMTDPYKTLGVSKSASASEIKSAYYKLA
D.discoideum|dictyBase:DDB0233610 KTFLN----NNNNNHNNENNKRYFRSTSPILSEKRDLYEVLGVSRDASKQDIKKAFYALA
A.thaliana|TAIR:gene:2162691      KSGHDRKWINFGGFNTNFGSTRSFHGTGSSFMSAKDYYSVLGVSKNAQEGEIKKAYYGLA
A.thaliana|TAIR:gene:2016233      FRYHKSFLSLSSSSSSSTPYRNRRGRSLVVFATSGDYYATLGVSKSANNKEIKAAYRRLA
A.thaliana|TAIR:gene:1005715645   FRYHKSFLSLSSSSSSSTPYRNRRGRSLVVFATSGDYYATLGVSKSANNKEIKAAYRRLA
A.thaliana|TAIR:gene:1005715646   FRYHKSFLSLSSSSSSSTPYRNRRGRSLVVFATSGDYYATLGVSKSANNKEIKAAYRRLA
A.thaliana|TAIR:gene:2041257      MFSHGSLPFLSMTGMSRNMHPPRRGSRFTVRADA-DYYSVLGVSKNATKAEIKSAYRKLA
A.thaliana|TAIR:gene:2140034      MFAQGSLPFLSLTGVSPNTHS-RRGARFTVRADT-DFYSVLGVSKNATKAEIKSAYRKLA
A.thaliana|TAIR:gene:2088584      FYLPPTLPIFSR--VRRFGISGGYRRRVITMAAGTDHYSTLNVNRNATLQEIKSSYRKLA
E.coli|P08622                     -------------------------------MAKQDYYEILGVSKTAEEREIRKAYKRLA
R.norvegicus|RGD:1306527          RALLTLRPGVRLTGTKSFPFVCTASFHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLA
M.musculus|MGI:1933786            RALLTLRPGVRLTGTKSFPFVCTTSFHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLA
H.sapiens|UniProtKB:Q96EY1        RALLTLRPGVSLTGTKHYPFICTASFHTSAPLAKEDYYQILGVPRNASQKEIKKAYYQLA
G.gallus|RefSeq:XP_414967         ------------AGTKRVP---AASFHSSAARAKEDYYEVLGVPRSASQKEIKKAYYQLA
D.rerio|ZFIN:ZDB-GENE-030131-7837 AVTLS-----GMTAIGSSHVVCKMSFHTSAPSRKQDFYQILGVPRSATQKEIKKAYYQMA
D.rerio|ZFIN:ZDB-GENE-040115-3    VTLRR------IPALRPHSVFSSHFFHTSSGFRQQDFYEVLGVPRTASQKEIKKAYYQLA
D.melanogaster|FB:FBgn0002174     ------------SGSTRADAPQVRRLHTTRDLLAKDYYATLGVAKNANGKDIKKAYYQLA
C.elegans|WP:WB:CE24911           --------------TPTTSTTKLAQLHTTHALSKEDYYKTLGVDKKSDAKAIKKAYFQLA
C.elegans|WP:WB:CE27991           --------------TPTTSTTKLAQLHTTHALSKEDYYKTLGVDKKSDAKAIKKAYFQLA
C.elegans|WB:WBGene00001028       --------------TPTTSTTKLAQLHTTHALSKEDYYKTLGVDKKSDAKAIKKAYFQLA
C.elegans|UniProtKB:Q8TA83        --------------TPTTSTTKLAQLHTTHALSKEDYYKTLGVDKKSDAKAIKKAYFQLA
                                                                     * *  *.: : :    *: ::  :*

S.cerevisiae|SGD:S000001878       KKYHPDINK-EPDAEKKFHDLQNAYEILSDETKRQQYDQFGPAAFGGGGAAGGAG-----
S.pombe|SPCC4G3.14                KQYHPDANP-DKAAQDKFVEIKQAYEVLQDPKKKKAFDTYGAGAFKNGEFTGGDF-----
D.discoideum|dictyBase:DDB0233610 KKYHPDTNRDDPNAHKTFAEISNAYDVLYDDKKRSVYDTAGHQGATQENMEHGGF-----
A.thaliana|TAIR:gene:2162691      KKLHPDMNKDDPEAETKFQEVSKAYEILKDKEKRDLYDQVGHEAFEQN--ASGGF-----
A.thaliana|TAIR:gene:2016233      RQYHPDVNK-EPGATEKFKEISAAYEVLSDEQKRALYDQYGEAGVKST-VGGAS------
A.thaliana|TAIR:gene:1005715645   RQYHPDVNK-EPGATEKFKEISAAYEVLSDEQKRALYDQYGEAGVKST-VGGAS------
A.thaliana|TAIR:gene:1005715646   RQYHPDVNK-EPGATEKFKEISAAYEVLSDEQKRALYDQYGEAGVKST-VGGAS------
A.thaliana|TAIR:gene:2041257      RNYHPDVNK-DPGAEEKFKEISNAYEVLSDDEKKSLYDRYGEAGLKGA-AGFGN------
A.thaliana|TAIR:gene:2140034      RSYHPDVNK-DAGAEDKFKEISNAYEILSDDEKRSLYDRYGEAGVKGA-GMGGM------
A.thaliana|TAIR:gene:2088584      RKYHPDMNK-NPGAEDKFKQISAAYEVLSDEEKRSAYDRFGEAGLEGD-FNGSQD-----
E.coli|P08622                     MKYHPDRNQGDKEAEAKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQG-GMGGGG-----
R.norvegicus|RGD:1306527          KKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASSSGQG-----
M.musculus|MGI:1933786            KKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGTSSSGQG-----
H.sapiens|UniProtKB:Q96EY1        KKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASGSQHS-----
G.gallus|RefSeq:XP_414967         KKYHPDTNKDDPKAKEKFAQLAEAYEVLSDEVKRKQYDAYGTASFDPGATGAGAGR----
D.rerio|ZFIN:ZDB-GENE-030131-7837 KKYHPDTNKEDPQAKEKFAQLAEAYEVLSDEVKRKQYDTYGSAGFDAGRAGAGHQ-----
D.rerio|ZFIN:ZDB-GENE-040115-3    KKYHPDTNPDDPDAKEKFAKLAEAYETLSDELKRKQYDTYGSAG--PSASGTGQQ-----
D.melanogaster|FB:FBgn0002174     KKYHPDTNKEDPDAGRKFQEVSEAYEVLSDEQKRREYDTYGQTAENIGRQGGGFPGGGAG
C.elegans|WP:WB:CE24911           KKYHPDVNKTK-EAQTKFQEISEAYEVLSDDTKRQEYDAYGSGGGPAGGRGGAGG-----
C.elegans|WP:WB:CE27991           KKYHPDVNKTK-EAQTKFQEISEAYEVLSDDTKRQEYDAYGSGGGPAGGRGGAGG-----
C.elegans|WB:WBGene00001028       KKYHPDVNKTK-EAQTKFQEISEAYEVLSDDTKRQEYDAYGSGGGPAGGRGGAGG-----
C.elegans|UniProtKB:Q8TA83        KKYHPDVNKTK-EAQTKFQEISEAYEVLSDDTKRQEYDAYGSGGGPAGGRGGAGG-----
                                   . *** *  .  *  .* .:  **: * *  *:  :*  *  .                

S.cerevisiae|SGD:S000001878       --------GGSGSPFGSQFHDFSGFTSAGGSPFGGINFEDLFGAAFGGGGRGSGGASRSS
S.pombe|SPCC4G3.14                --------EG----FQNGFAGASSFSSG----FPGFNFEDLFGFSS------RGPQARRN
D.discoideum|dictyBase:DDB0233610 --------PGGMGGQNVNLEDLFGGGFDLNDLFGGG------------------GGGGG-
A.thaliana|TAIR:gene:2162691      --------PNDQG-----FGGGGGGGFNPFDIFGSF------------------NGDIFN
A.thaliana|TAIR:gene:2016233      --------GPYTSNPFDLFETFFGASMGGFPGMDQ-------------------ADFGRT
A.thaliana|TAIR:gene:1005715645   --------GPYTSNPFDLFETFFGASMGGFPGMDQ-------------------ADFGRT
A.thaliana|TAIR:gene:1005715646   --------GPYTSNPFDLFETFFGASMGGFPGMDQ-------------------ADFGRT
A.thaliana|TAIR:gene:2041257      --------GDFS-NPFDLFDSLF-EGFG--GGMG------------------------RG
A.thaliana|TAIR:gene:2140034      --------GDYS-NPFDLFESLF-EGMGGMGGMGG-------------------GMGSRG
A.thaliana|TAIR:gene:2088584      --------TSPGVDPFDLYSAFFGGSDGFFGGMGES------------------GGMGFD
E.coli|P08622                     --------FGGGADFSDIFGDVFGDIFG--GGRGR-------------------------
R.norvegicus|RGD:1306527          ---------YWRGGPSVDPEELFRKIFG--EFSSSP--------------------FGDF
M.musculus|MGI:1933786            ---------YWRGGPSVDPEELFRKIFG--EFSSSP--------------------FGDF
H.sapiens|UniProtKB:Q96EY1        ---------YWKGGPTVDPEELFRKIFG--EFSSSS--------------------FGDF
G.gallus|RefSeq:XP_414967         --------QYWSSGPSIDPEELFRKIFG--EFSGSS--------------------FGDF
D.rerio|ZFIN:ZDB-GENE-030131-7837 --------QYWGGGTSIDPEELFRKIFG--EFSGAQG-------------------FGDF
D.rerio|ZFIN:ZDB-GENE-040115-3    --------QYWRGSANVDPEELFRKIFG--EFAGGRG-------------------FGDI
D.melanogaster|FB:FBgn0002174     GFGPEGFSQSWQFRSSIDPEELFRKIFGEGNFRTNS--------------------FDDF
C.elegans|WP:WB:CE24911           ----------FHHHGNVDVNEIFRRAFGGGGGMGGFN-------------------FDNF
C.elegans|WP:WB:CE27991           ----------FHHHGNVDVNEIFRRAFGGGGGMGGFN-------------------FDNF
C.elegans|WB:WBGene00001028       ----------FHHHGNVDVNEIFRRAFGGGGGMGGFN-------------------FDNF
C.elegans|UniProtKB:Q8TA83        ----------FHHHGNVDVNEIFRRAFGGGGGMGGFN-------------------FDNF
                                                                                              

S.cerevisiae|SGD:S000001878       SMFRQYRGDPIEIVHKVSFKDAVFGSKNVQLRFSALDPCSTCSGTGMKPNTHKVSCSTCH
S.pombe|SPCC4G3.14                TSFDVFVGEDIEASITIDFMEAVRGAK-KDLSYSVSSTCSSCHGSGLQPGSHKSTCFACK
D.discoideum|dictyBase:DDB0233610 -GKKSSVGADMEVNLHLDFMEAVNGAE-KDISFYGGTKCTPCDGSGAKPGTKPQTCKQCG
A.thaliana|TAIR:gene:2162691      MYRQDIGGQDVKVLLDLSFMEAVQGCS-KTVTFQTEMACNTCGGQGVPPGTKREKCKACN
A.thaliana|TAIR:gene:2016233      RRSRVTKGEDLRYDITLELSEAIFGSE-KEFDLTHLETCEACAGTGAKAGSKMRICSTCG
A.thaliana|TAIR:gene:1005715645   RRSRVTKGEDLRYDITLELSEAIFGSE-KEFDLTHLETCEACAGTGAKAGSKMRICSTCG
A.thaliana|TAIR:gene:1005715646   RRSRVTKGEDLRYDITLELSEAIFGSE-KEFDLTHLETCEACAGTGAKAGSKMRICSTCG
A.thaliana|TAIR:gene:2041257      SRSRAVDGQDEYYTLILNFKEAVFGME-KEIEISRLESCGTCEGSGAKPGTKPTKCTTCG
A.thaliana|TAIR:gene:2140034      SRSRAIDGEDEYYSLILNFKEAVFGIE-KEIEISRLESCGTCNGSGAKAGTKPTKCKTCG
A.thaliana|TAIR:gene:2088584      FMNKRSLDLDIRYDLRLSFEEAVFGVK-REIEVSYLETCDGCGGTGAKSSNSIKQCSSCD
E.coli|P08622                     --QRAARGADLRYNMELTLEEAVRGVT-KEIRIPTLEECDVCHGSGAKPGTQPQTCPTCH
R.norvegicus|RGD:1306527          QN---VFDQPQE------------------------------------------------
M.musculus|MGI:1933786            QN---VFDQPQEYIMELTFNQAAKGVN-KEFTVNIMDTCERCDGKGNEPGTKVQHCHYCG
H.sapiens|UniProtKB:Q96EY1        QT---VFDQPQEYFMELTFNQAAKGVN-KEFTVNIMDTCERCNGKGNEPGTKVQHCHYCG
G.gallus|RefSeq:XP_414967         QN---VFDQPQEYIMDLTFTQAAKGVN-KEIVVNINDACERCNGKGNEPGTKVQRCHYCN
D.rerio|ZFIN:ZDB-GENE-030131-7837 NA---IFNQPQEYVMELTFAQAAKGVN-KEITVNIEGTCQRCDGRGHEPGSKVQHCGNCN
D.rerio|ZFIN:ZDB-GENE-040115-3    NS---MFDQAPEFVMELSFMQAAKGVN-KEITVNIDDDCPRCDGKAFEPGTKVSHCHYCN
D.melanogaster|FB:FBgn0002174     ADSKFGFGQAQEMVMDLTFAQAARGVN-KDVNVNVVDQCPKCAGTKCEPGTKPGRCQYCN
C.elegans|WP:WB:CE24911           AQSAFGHSAAQEMVMDISFEEAVRGAT-KNVSVNVVEDCLKCHGTQVEPGHKKTSCPYCN
C.elegans|WP:WB:CE27991           AQSAFGHSAAQEMVMDISFEEAVRGAT-KNVSVNVVEDCLKCHGTQVEPGHKKTSCPYCN
C.elegans|WB:WBGene00001028       AQSAFGHSAAQEMVMDISFEEAVRGAT-KNVSVNVVEDCLKCHGTQVEPGHKKTSCPYCN
C.elegans|UniProtKB:Q8TA83        AQSAFGHSAAQEMVMDISFEEAVRGAT-KNVSVNVVEDCLKCHGTQVEPGHKKTSCPYCN
                                         .                                                    

S.cerevisiae|SGD:S000001878       GTGTTVHIRG----GFQMMSTCPTCNGEGTMKRPQDNCTKCHGEGVQVNRAKTITVDLPH
S.pombe|SPCC4G3.14                GTGQRLHFIPP---SFHMQTTCDSCGGTGTTIPPNSACRSCMGSG-TVRERKTVSIDIPP
D.discoideum|dictyBase:DDB0233610 GTGSQTRSN----GFFHMATNCRACKGTGKVIKEP--CSSCKGKG-ITQGERTVNIKVPA
A.thaliana|TAIR:gene:2162691      GSGMTSLRR----GMLSIQTTCQKCGGAGQTFSSI--CKSCRGAR-VVRGQKSVKVTIDP
A.thaliana|TAIR:gene:2016233      GRGQVMRTEQTPFGMFSQVSICPNCGGDGEVISEN--CRKCSGEG-RVRIKKSIKVKIPP
A.thaliana|TAIR:gene:1005715645   GRGQVMRTEQTPFGMFSQVSICPNCGGDGEVISEN--CRKCSGEG-RVRIKKSIKVKIPP
A.thaliana|TAIR:gene:1005715646   GRGQVMRTEQTPFGMFSQVSICPNCGGDGEVISEN--CRKCSGEG-RVRIKKSIKVKIPP
A.thaliana|TAIR:gene:2041257      GQGQVVSAARTPLGVFQQVMTCSSCNGTG-EISTP--CGTCSGDG-RVRKTKRISLKVPA
A.thaliana|TAIR:gene:2140034      GQGQVVASTRTPLGVFQQVMTCSPCNGTG-EISKP--CGACSGDG-RVRRTKRISLKVPA
A.thaliana|TAIR:gene:2088584      GKGRVMNSQRTPFGIMSQVSTCSKCGGEGKTITDK--CRKCIGNG-RLRARKKMDVVVPP
E.coli|P08622                     GSGQVQMRQ----GFFAVQQTCPHCQGRGTLIKDP--CNKCHGHG-RVERSKTLSVKIPA
R.norvegicus|RGD:1306527          ----ETINT----GPFVMRSTCRRCGGRGSIITNP--CVVCRGAG-QAKQKKRVTVPVPA
M.musculus|MGI:1933786            GSGMETINT----GPFVMRSTCRRCGGRGSIITNP--CVVCRGAG-QAKQKKRVTIPVPA
H.sapiens|UniProtKB:Q96EY1        GSGMETINT----GPFVMRSTCRRCGGRGSIIISP--CVVCRGAG-QAKQKKRVMIPVPA
G.gallus|RefSeq:XP_414967         GTGMETINT----GPFVMRSTCRRCGGRASIITTP--CVVCRGTG-QTKQKKTVIVPVPA
D.rerio|ZFIN:ZDB-GENE-030131-7837 GTGMETVNT----GPFVMRSTCRRCGGRGSVITSP--CIACRGTG-QTKQRKTVTVPVPA
D.rerio|ZFIN:ZDB-GENE-040115-3    GTGMESINT----GPFMMRSACRRCSGRGFIIITP--CIMCRGSG-QTKQKQTVMVPVPA
D.melanogaster|FB:FBgn0002174     GTGFETVST----GPFVMRSTCRYCQGTRQHIKYP--CSECEGKG-RTVQRRKVTVPVPA
C.elegans|WP:WB:CE24911           GTGAVSQRLQ---GGFFYQTTCNRCRGSGHYNKNP--CQECEGEG-QTVQRRQVSFNVPA
C.elegans|WP:WB:CE27991           GTGAVSQRLQ---GGFFYQTTCNRCRGSGHYNKNP--CQECEGEG-QTVQRRQVSFNVPA
C.elegans|WB:WBGene00001028       GTGAVSQRLQ---GGFFYQTTCNRCRGSGHYNKNP--CQECEGEG-QTVQRRQVSFNVPA
C.elegans|UniProtKB:Q8TA83        GTGAVSQRLQ---GGFFYQTTCNRCRGSGHYNKNP--CQECEGEG-QTVQRRQVSFNVPA
                                                 :     *  * *          *  * *        : : . :  

S.cerevisiae|SGD:S000001878       GLQDGDVVRIPGQGSYPDIAVEADLKDSVKLSRGDILVRIRVDKDPNFSIKNKYDIWYDK
S.pombe|SPCC4G3.14                GIDDNTVLRVMGAG---NDASTAKGGPNAKSRPGDLFATIHVRKHP-FFVREGTNVTYNA
D.discoideum|dictyBase:DDB0233610 GINNGTTIKLAGEG----------EPSKTGRR-GNLFVHITVSEHE-LFRRQGNDIHLDV
A.thaliana|TAIR:gene:2162691      GVDNSDTLKVARVG----------GADPEGDQPGDLYVTLKVREDP-VFRREGSDIHVDA
A.thaliana|TAIR:gene:2016233      GVSAGSILRVAGEG----------DSGPRGGPPGDLYVYLDVEDVR-GIERDGINLLSTL
A.thaliana|TAIR:gene:1005715645   GVSAGSILRVAGEG----------DSGPRGGPPGDLYVYLDVEDVR-GIERDGINLLSTL
A.thaliana|TAIR:gene:1005715646   GVSAGSILRVAGEG----------DSGPRGGPPGDLYVYLDVEDVR-GIERDGINLLSTL
A.thaliana|TAIR:gene:2041257      GVDSGSRLRVRGEG----------NAGKRGGSPGDLFVVIEVIPDP-ILKRDDTNILYTC
A.thaliana|TAIR:gene:2140034      GVDSGSRLRVRGEG----------NAGKRGGSPGDLFAVIEVIPDP-VLKRDDTNILYTC
A.thaliana|TAIR:gene:2088584      GVSDRATMRIQGEG----------NMDKRSGRAGDLFIVLQVDEKR-GIRREGLNLYSNI
E.coli|P08622                     GVDTGDRIRLAGEG----------EAGEHGAPAGDLYVQVQVKQHP-IFEREGNNLYCEV
R.norvegicus|RGD:1306527          GVEDGQTVRMPVGK-------------------REIFVTFRVQKSP-VFRRDGADIHSDL
M.musculus|MGI:1933786            GVEDGQTVRMPVGK-------------------REIFVTFRVQKSP-VFRRDGADIHSDL
H.sapiens|UniProtKB:Q96EY1        GVEDGQTVRMPVGK-------------------REIFITFRVQKSP-VFRRDGADIHSDL
G.gallus|RefSeq:XP_414967         GVEDGQTVRMPVGK-------------------KEIFITFRVQKSS-VFRRNGADIHSDL
D.rerio|ZFIN:ZDB-GENE-030131-7837 GIEDGQTVRMPVGK-------------------KEIFITFKVQKSP-IFRRDGADIHSDV
D.rerio|ZFIN:ZDB-GENE-040115-3    GIADGQTVKVPVGK-------------------KHMYITFRVQKSP-VFRRDGADIHSDV
D.melanogaster|FB:FBgn0002174     GIENGQTVRMQVGS-------------------KELFVTFRVERSD-YFRREGADVHTDA
C.elegans|WP:WB:CE24911           GTNNGDSLKFQVGK-------------------NQLFVRFNVAPSL-KFRREKDDIHCDV
C.elegans|WP:WB:CE27991           GTNNGDSLKFQVGK-------------------NQLFVRFNVAPSL-KFRREKDDIHCDV
C.elegans|WB:WBGene00001028       GTNNGDSLKFQVGK-------------------NQLFVRFNVAPSL-KFRREKDDIHCDV
C.elegans|UniProtKB:Q8TA83        GTNNGDSLKFQVGK-------------------NQLFVRFNVAPSL-KFRREKDDIHCDV
                                  *      ::.                        .:   . *        ::  ::    

S.cerevisiae|SGD:S000001878       EIPITTAALGGTVTIPTVEGQKIRIKVAPGTQYNQVISIPNMGVP-KTSTIR-GDMKVQY
S.pombe|SPCC4G3.14                KIPMTTAALGGTLRVPTLTG-NVDLRVSPGTSTGDRITMAGKGIR-KVNTSRYGNFYVNF
D.discoideum|dictyBase:DDB0233610 PITISQAILGDTVSIPTLSG-EVELKVPKGTQPNEKRVLKGKGVR-FVNSTEFGSQFVHF
A.thaliana|TAIR:gene:2162691      VLSVTQAILGGTIQVPTLTG-DVVVKVRPGTQPGHKVVLRNKGIR-ARKSTKFGDQYVHF
A.thaliana|TAIR:gene:2016233      SISYLDAILGAVVKVKTVEG-DTELQIPPGTQPGDVLVLAKKGVPKLNRPSIRGDHLFTV
A.thaliana|TAIR:gene:1005715645   SISYLDAILGAVVKVKTVEG-DTELQIPPGTQPGDVLVLAKKGVPKLNRPSIRGDHLFTV
A.thaliana|TAIR:gene:1005715646   SISYLDAILGAVVKVKTVEG-DTELQIPPGTQPGDVLVLAKKGVPKLNRPSIRGDHLFTV
A.thaliana|TAIR:gene:2041257      KISYIDAILGTTLKVPTVDG-TVDLKVPAGTQPSTTLVMAKKGVPVLNKSNMRGDQLVRV
A.thaliana|TAIR:gene:2140034      KISYVDAILGTTLKVPTVDG-EVDLKVPAGTQPSTTLVMAKKGVPVLNKSKMRGDQLVRV
A.thaliana|TAIR:gene:2088584      NIDFTDAILGATTKVETVEG-SMDLRIPPGTQPGDTVKLPRKGVPDTDRPSIRGDHCFVV
E.coli|P08622                     PINFAMAALGGEIEVPTLDG-RVKLKVPGETQTGKLFRMRGKGVKSVRG-GAQGDLLCRV
R.norvegicus|RGD:1306527          FISIAQAILGGTAKAQGLYE-TINVTIPAGIQTDQKIRLTGKGIP-RINSYGYGDHYIHI
M.musculus|MGI:1933786            FISIAQAILGGTAKAQGLYE-TINVTIPAGIQTDQKIRLTGKGIP-RINSYGYGDHYIHI
H.sapiens|UniProtKB:Q96EY1        FISIAQALLGGTARAQGLYE-TINVTIPPGTQTDQKIRMGGKGIP-RINSYGYGDHYIHI
G.gallus|RefSeq:XP_414967         LISVAQAVLGGTARCQGLYE-TINITIPPGIQPDQRIRMSGKGIP-KVNSYGYGDHYIHI
D.rerio|ZFIN:ZDB-GENE-030131-7837 MISVAQAILGGTIRAQGLYE-TINLSIPVGTQTDQRIRLSGKGIP-RVSGYGYGDHYVHI
D.rerio|ZFIN:ZDB-GENE-040115-3    LISIAQAILGGTARAQGLYS-TIDIAIPPGIQTDHKIKLEGKGIP-RMNSFGYGDHYVYI
D.melanogaster|FB:FBgn0002174     AISLAQAVLGGTVRVQGVYE-DQWINVEPGTSSHHKIMLRGKGLK-RVNAHGHGDHYVHV
C.elegans|WP:WB:CE24911           DISLAQAVLGGTVKVPGING-DTYVHIPAGTGSHTKMRLTGKGVK-RLHSYGNGDQYMHI
C.elegans|WP:WB:CE27991           DISLAQAVLGGTVKVPGING-DTYVHIPAGTGSHTKMRLTGKGVK-RLHSYGNGDQYMHI
C.elegans|WB:WBGene00001028       DISLAQAVLGGTVKVPGING-DTYVHIPAGTGSHTKMRLTGKGVK-RLHSYGNGDQYMHI
C.elegans|UniProtKB:Q8TA83        DISLAQAVLGGTVKVPGING-DTYVHIPAGTGSHTKMRLTGKGVK-RLHSYGNGDQYMHI
                                   :    * **       :      : :           :   *:         *.     

S.cerevisiae|SGD:S000001878       KIVVK--KPQSLAEKCLWEALADVTNDDMAKKTMQP--GTAAGTAINEEILKK-------
S.pombe|SPCC4G3.14                EVTIP--KILSPHERSLLEQLADALNDSTARRTQSSPSGTNSSTSTSSTSSKH-------
D.discoideum|dictyBase:DDB0233610 IVSIP--KNINQKQQELIKEFDQEEKKNNGPLDSLSHPVLSFWNKAMKRWRDY-------
A.thaliana|TAIR:gene:2162691      NVSIP--ANITQRQRELLEEFSKAEQGEYEQRTATGSSQ---------------------
A.thaliana|TAIR:gene:2016233      KVSVP--NQISAGERELLEELASLKDTSSNRSRTRAKPQQPSTLS---TAPSG-------
A.thaliana|TAIR:gene:1005715645   KVSVP--NQISAGERELLEELASLKDTSSNRSRTRAKPQQPSTLS---TAPSG-------
A.thaliana|TAIR:gene:1005715646   KVSVP--NQISAGERELLEELASLKDTSSNRSRTRAKPQQPSTLS---TAPSG-------
A.thaliana|TAIR:gene:2041257      QVEIP--KRLSKEEKKLIEELADMSKNKTANSTSR-------------------------
A.thaliana|TAIR:gene:2140034      QVEIP--KRLSKEEKMLVEELADMSKNKVANSRR--------------------------
A.thaliana|TAIR:gene:2088584      KISIP--KKLSERERKLVEEFSSLRRSSSSTGPTETRQEEQSFGSEPRKEPSL-------
E.coli|P08622                     VVETP--VGLNERQKQLLQELQESFGGPTGEHNSP-------------RSKSF-------
R.norvegicus|RGD:1306527          KIRVP--KRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGGRTMDS-------------
M.musculus|MGI:1933786            KIRVP--KRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGGRTMDS-------------
H.sapiens|UniProtKB:Q96EY1        KIRVP--KRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSGGSTMDS-------------
G.gallus|RefSeq:XP_414967         KIKVP--QRLTDRQRALMMSYAEDETDVDGTVNGVTNTASG-------------------
D.rerio|ZFIN:ZDB-GENE-030131-7837 KIKIP--KMLTDRQRALMMSYAEDESDVEGTVNGVTSTTAG-------------------
D.rerio|ZFIN:ZDB-GENE-040115-3    KIKIP--KKLTRRQKMLLLSFAEDEEDVEGTVNGVTKPAPGRSQAGQ-------------
D.melanogaster|FB:FBgn0002174     KITVPSAKKLDKKRLALIEAYAELEEDTPGQIHGIANRKDGSKQATAGASEEPGAGAAAK
C.elegans|WP:WB:CE24911           KVTVP--KYLTAEQKQIMLAWAATEQLKDGTIKGLEKNQKTEEKETKKNEE--------K
C.elegans|WP:WB:CE27991           KVTVP--KYLTAEQKQIMLAWAATEQLKDGTIKGLEKNQKTEEKETKKNEE--------K
C.elegans|WB:WBGene00001028       KVTVP--KYLTAEQKQIMLAWAATEQLKDGTIKGLEKNQKTEEKETKKNEE--------K
C.elegans|UniProtKB:Q8TA83        KVTVP--KYLTAEQKQIMLAWAATEQLKDGTIKGLEKNQKTEEKETKKNEE--------K
                                   :           .  :                                           

S.cerevisiae|SGD:S000001878       ----QKQEEEKHAKKDDDNTLKRLENFITNTFRKIKGDKKN-------------------
S.pombe|SPCC4G3.14                ----STGISTEPTTGEENKQDGSVGGFFKRAFRRLHPDEDQNPKKDESSS----------
D.discoideum|dictyBase:DDB0233610 ----SNKFKK--------------------------------------------------
A.thaliana|TAIR:gene:2162691      ------------------------------------------------------------
A.thaliana|TAIR:gene:2016233      ----SENKKDEVKEENEEPEQENYLWN---------------NIKEFAGSVANGALKWLR
A.thaliana|TAIR:gene:1005715645   ----SENKKDEVKEENEEPEQENYLWN---------------NIKEFAGSVANGALKWLR
A.thaliana|TAIR:gene:1005715646   ----SENKKDEVKEENEEPEQENYLWN---------------NIKEFAGSVANGALKWLR
A.thaliana|TAIR:gene:2041257      ------------------------------------------------------------
A.thaliana|TAIR:gene:2140034      ------------------------------------------------------------
A.thaliana|TAIR:gene:2088584      ----WHKMKNFIRPEDSRTKFGTMSLNPSLPLRRMKVSETSIAFSVLALCVITSAVALVQ
E.coli|P08622                     ----FDGVKKFFDDLTR-------------------------------------------
R.norvegicus|RGD:1306527          ----STGSKDRREAG--EDNEG-----------------------------FLSKLKKIF
M.musculus|MGI:1933786            ----SAGSKDRREAG--EDNEG-----------------------------FLSKLKKIF
H.sapiens|UniProtKB:Q96EY1        ----SAGSKARREAG--EDEEG-----------------------------FLSKLKKMF
G.gallus|RefSeq:XP_414967         ----------KRSTG--N------------------------------------------
D.rerio|ZFIN:ZDB-GENE-030131-7837 ----------KRSAG--N------------------------------------------
D.rerio|ZFIN:ZDB-GENE-040115-3    ----TSTSGQSREEEPEKEEEG-----------------------------FFSKLKKMF
D.melanogaster|FB:FBgn0002174     ASAAAAGSGASKPGPGAEESEGKDQWTDNKKTKAKEGGGSGSGQGDGGGGGFISKIKSMF
C.elegans|WP:WB:CE24911           KSEGASESQKRRSEPVAENAETIDENQENE--------------------GFFEKIKRKI
C.elegans|WP:WB:CE27991           KSEGASESQKRRSEPVAENAETIDENQENE--------------------GFFEKIKRKI
C.elegans|WB:WBGene00001028       KSEGASESQKRRSEPVAENAETIDENQENE--------------------GFFEKIKRKI
C.elegans|UniProtKB:Q8TA83        KSEGASESQKRRSEPVAENAETIDENQENE--------------------GFFEKIKRKI
                                                                                              

S.cerevisiae|SGD:S000001878       ------------
S.pombe|SPCC4G3.14                ------------
D.discoideum|dictyBase:DDB0233610 ------------
A.thaliana|TAIR:gene:2162691      ------------
A.thaliana|TAIR:gene:2016233      DNL---------
A.thaliana|TAIR:gene:1005715645   DNL---------
A.thaliana|TAIR:gene:1005715646   DNL---------
A.thaliana|TAIR:gene:2041257      ------------
A.thaliana|TAIR:gene:2140034      ------------
A.thaliana|TAIR:gene:2088584      KKGNRLKQKKET
E.coli|P08622                     ------------
R.norvegicus|RGD:1306527          TS----------
M.musculus|MGI:1933786            TS----------
H.sapiens|UniProtKB:Q96EY1        TS----------
G.gallus|RefSeq:XP_414967         ------------
D.rerio|ZFIN:ZDB-GENE-030131-7837 ------------
D.rerio|ZFIN:ZDB-GENE-040115-3    T-----------
D.melanogaster|FB:FBgn0002174     N-----------
C.elegans|WP:WB:CE24911           FG----------
C.elegans|WP:WB:CE27991           FG----------
C.elegans|WB:WBGene00001028       FG----------
C.elegans|UniProtKB:Q8TA83        FG----------
ProgramLink
ClustalW alignment file.alnp
ClustalW dendrogram file.dnd
Notung tree file: rearranged.jtt.rooting.0.rearrange.0
Phylip amino acid sequence Maximum Likelihood method.jtt
Sequences in this family (FASTA)ORTHOMCL1063.fa
No disease information
Send questions, suggestions, and comments to: yfgdb@genomics.princeton.edu