This family has 23 members: 5 Arabidopsis thaliana, 3 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Escherichia coli, 1 Gallus gallus, 3 Homo sapiens, 1 Mus musculus, 3 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
| Protein | Publication | Curator Notes |
|---|
| SGD:S000002457 | ![[PubMed]](http://yfgdb.princeton.edu/PubMed.gif) 3521890: McKnight GL, et al. Nucleotide sequence of the triosephosphate isomerase gene from Aspergillus nidulans: implications for a differential loss of introns. Cell. 1986 Jul 4;46(1):143-7. | The A. nidulans protein tpiA complements the orthologous mutation in S. cerevisiae. |
CLUSTAL W (1.83.1) multiple sequence alignment # P-POD
S.cerevisiae|SGD:S000002457 ----------------------------MARTFFVGGN----------------------
S.pombe|SPCC24B10.21 ----------------------------MARKFFVGGN----------------------
R.norvegicus|RGD:1563601 --------------------------MAPSRKFFVGGN----------------------
R.norvegicus|RGD:1560534 --------------------------MAPSRKFFVGGN----------------------
R.norvegicus|RGD:3896 --------------------------MAPSRKFFVGGN----------------------
M.musculus|MGI:98797 --------------------------MAPTRKFFVGGN----------------------
H.sapiens|UniProtKB:Q2QD09 --------------------------MAPSRKFFVGGN----------------------
H.sapiens|RefSeq:XP_001134259 --------------------------MAPSRKFFVVGN----------------------
H.sapiens|UniProtKB:P60174 --------------------------MAPSRKFFVGGN----------------------
G.gallus|UniProtKB:P00940 --------------------------MAP-RKFFVGGN----------------------
D.rerio|ZFIN:ZDB-GENE-020416-4 ---------------------------MSGRKFFVGGN----------------------
D.rerio|ZFIN:ZDB-GENE-020416-3 ---------------------------MSSRKFFVGGN----------------------
D.melanogaster|FB:FBgn0086355 ----------------------------MSRKFCVGGN----------------------
C.elegans|WP:WB:CE19040 ----------------------------MTRKFFVGGN----------------------
C.elegans|WB:WBGene00006601 ----------------------------MTRKFFVGGN----------------------
C.elegans|UniProtKB:Q10657 ----------------------------MTRKFFVGGN----------------------
A.thaliana|TAIR:gene:2047071 MAATSLTAPPSFSGLRRISPKLDAAAVSSHQSFFHRVNSSTRLVSSSSSSHRSPRGVVAM
A.thaliana|TAIR:gene:4010712259 MAATSLTAPPSFSGLRRISPKLDAAAVSSHQSFFHRVNSSTRLVSSSSSSHRSPRGVVAM
A.thaliana|TAIR:gene:3354057 MAATSLTAPPSFSGLRRISPKLDAAAVSSHQSFFHRVNSSTRLVSSSSSSHRSPRGVVAM
A.thaliana|TAIR:gene:2099905 ----------------------------MARKFFVGGN----------------------
A.thaliana|TAIR:gene:3354984 ----------------------------MARKFFVGGN----------------------
D.discoideum|dictyBase:DDB0231425 --------------------------MTGTRTFFVGGN----------------------
E.coli|P0A858 -----------------------------MRHPLVMGN----------------------
: *
S.cerevisiae|SGD:S000002457 -----------FKLNGSKQSIKEIVERLNTASIPEN--VEVVICPPATYLDYSVSLVKKP
S.pombe|SPCC24B10.21 -----------FKMNGSLESMKTIIEGLNTTKLNVGD-VETVIFPQNMYLITTRQQVKK-
R.norvegicus|RGD:1563601 -----------WKMNGRKKCLGELICTLNAAKMPAD--TEVVCAPPTAYIDFARQKLDP-
R.norvegicus|RGD:1560534 -----------WKMNGKKKCLGELICTLNAAKMPAD--TEVVCAPPTAYIDFARQKLDP-
R.norvegicus|RGD:3896 -----------WKMNGRKKCLGELICTLNAAKLPAD--TEVVCAPPTAYIDFARQKLDP-
M.musculus|MGI:98797 -----------WKMNGRKKCLGELICTLNAANVPAG--TEVVCAPPTAYIDFARQKLDP-
H.sapiens|UniProtKB:Q2QD09 -----------WKMNGRKQSLRELVRTLNAAKVPAD--TEVVCTPPTAYIDFARQKLDP-
H.sapiens|RefSeq:XP_001134259 -----------WKMNGRKQSLRELVRTLNAAKVPAD--TEVVCTPPTAYIDFARQKLDP-
H.sapiens|UniProtKB:P60174 -----------WKMNGRKQSLGELIGTLNAAKVPAD--TEVVCAPPTAYIDFARQKLDP-
G.gallus|UniProtKB:P00940 -----------WKMNGDKKSLGELIHTLNGAKLSAD--TEVVCGAPSIYLDFARQKLDA-
D.rerio|ZFIN:ZDB-GENE-020416-4 -----------WKMNGDKKSIEELANTLNSAKLNPD--TEVVCGAPTIYLDYARSKLDP-
D.rerio|ZFIN:ZDB-GENE-020416-3 -----------WKMNGDKESLGELIMTLNTASLNDK--TDVVCGAPSIYLDYARSKLDQ-
D.melanogaster|FB:FBgn0086355 -----------WKMNGDQKSIAEIAKTLSSAALDPN--TEVVIGCPAIYLMYARNLLPC-
C.elegans|WP:WB:CE19040 -----------WKMNGDYASVDGIVTFLNASADNSS--VDVVVAPPAPYLAYAKSKLKA-
C.elegans|WB:WBGene00006601 -----------WKMNGDYASVDGIVTFLNASADNSS--VDVVVAPPAPYLAYAKSKLKA-
C.elegans|UniProtKB:Q10657 -----------WKMNGDYASVDGIVTFLNASADNSS--VDVVVAPPAPYLAYAKSKLKA-
A.thaliana|TAIR:gene:2047071 AGSGKFFVGGNWKCNGTKDSIAKLISDLNSATLEAD--VDVVVSPPFVYIDQVKSSLTD-
A.thaliana|TAIR:gene:4010712259 AGSGK---------NGTKDSIAKLISDLNSATLEAD--VDVVVSPPFVYIDQVKSSLTD-
A.thaliana|TAIR:gene:3354057 AGSGKFFVGGNWKCNGTKDSIAKLISDLNSATLEAD--VDVVVSPPFVYIDQVKSSLTD-
A.thaliana|TAIR:gene:2099905 -----------WKCNGTAEEVKKIVNTLNEAQVPSQDVVEVVVSPPYVFLPLVKSTLRS-
A.thaliana|TAIR:gene:3354984 -----------WKCNGTAEEVKKIVNTLNEAQVPSQDVVEVVVSPPYVFLPLVKSTLRS-
D.discoideum|dictyBase:DDB0231425 -----------HKMNGSKSMLESLSKGMNESVENKEN-VDIFIAPSYPYLEFLSNKLDNK
E.coli|P0A858 -----------WKLNGSRHMVHELVSNLRKELAGVAG-CAVAIAPPEMYIDMAKREAEGS
** : : : ::
S.cerevisiae|SGD:S000002457 QVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFAL
S.pombe|SPCC24B10.21 DIGVGAQNVFDKKNGAYTGENSAQSLIDAGITYTLTGHSERRTIFKESDEFVADKTKFAL
R.norvegicus|RGD:1563601 KIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHIFGESDELIGQKVNHAL
R.norvegicus|RGD:1560534 KIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHVFGESDELIGQKVNHAL
R.norvegicus|RGD:3896 KIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHIFGESDELIGQKVNHAL
M.musculus|MGI:98797 KIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHVFGESDELIGQKVSHAL
H.sapiens|UniProtKB:Q2QD09 KIAVAAQNCYKVTNGAFTGEISPGMIKDCRATWVVLGHSERRHVFGESDELIGQKVAHAL
H.sapiens|RefSeq:XP_001134259 KIAVAAQNCYKVTNGAFTGEISPGMIKDCRATWVVLGHSERRHVFGESDELIGQKVAHAL
H.sapiens|UniProtKB:P60174 KIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHAL
G.gallus|UniProtKB:P00940 KIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHVFGESDELIGQKVAHAL
D.rerio|ZFIN:ZDB-GENE-020416-4 NIDVAAQNCYKVAKGAFTGEISPAMIKDCGVKWVILGHSERRHVFGESDELIGQKVAHAL
D.rerio|ZFIN:ZDB-GENE-020416-3 RIGVAAQNCYKVPKGAFTGEISPAMIKDCGIDWVILGHSERRHVFGESDELIGQKVAHCL
D.melanogaster|FB:FBgn0086355 ELGLAGQNAYKVAKGAFTGEISPAMLKDIGADWVILGHSERRAIFGESDALIAEKAEHAL
C.elegans|WP:WB:CE19040 GVLVAAQNCYKVPKGAFTGEISPAMIKDLGLEWVILGHSERRHVFGESDALIAEKTVHAL
C.elegans|WB:WBGene00006601 GVLVAAQNCYKVPKGAFTGEISPAMIKDLGLEWVILGHSERRHVFGESDALIAEKTVHAL
C.elegans|UniProtKB:Q10657 GVLVAAQNCYKVPKGAFTGEISPAMIKDLGLEWVILGHSERRHVFGESDALIAEKTVHAL
A.thaliana|TAIR:gene:2047071 RIDISGQNSWVGKGGAFTGEISVEQLKDLGCKWVILGHSERRHVIGEKDEFIGKKAAYAL
A.thaliana|TAIR:gene:4010712259 RIDISGQNSWVGKGGAFTGEISVEQLKDLGCKWVILGHSERRHVIGEKDEFIGKKAAYAL
A.thaliana|TAIR:gene:3354057 RIDISGQNSWVGKGGAFTGEISVEQLKDLGCKWVILGHSERRHVIGEKDEFIGKKAAYAL
A.thaliana|TAIR:gene:2099905 DFFVAAQNCWVKKGGAFTGEVSAEMLVNLDIPWVILGHSERRAILNESSEFVGDKVAYAL
A.thaliana|TAIR:gene:3354984 DFFVAAQNCWVKKGGAFTGEVSAEMLVNLDIPWVILGHSERRAILNESSEFVGDKVAYAL
D.discoideum|dictyBase:DDB0231425 KFKVCSQNCYSVAKGAFTGEISANMLVDLGIPYVIIGHSERRNVFSESSELITKKTKYAI
E.coli|P0A858 HIMLGAQNVDLNLSGAFTGETSAAMLKDIGAQYIIIGHSERRTYHKESDELIAKKFAVLK
. : .** **:*** * : : : : ****** *.. :: .*
S.cerevisiae|SGD:S000002457 GQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEV--KDWTNVVVAYEPVWAIGTGLA
S.pombe|SPCC24B10.21 EQGLTVVACIGETLAEREANETINVVVRQLNAIADKV--QNWSKIVIAYEPVWAIGTGKT
R.norvegicus|RGD:1563601 SEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNV--KDWSKVVLAYEPVWAIGTGKT
R.norvegicus|RGD:1560534 SEGLGVIACIGEKLDEREAGITDKVVFEQTKAIADNV--KDWSKVVLAYEPVWAIGTGKT
R.norvegicus|RGD:3896 SEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNV--KDWCKVVLAYEPVWAIGTGKT
M.musculus|MGI:98797 AEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNV--KDWSKVVLAYEPVWAIGTGKT
H.sapiens|UniProtKB:Q2QD09 AEGLGVIACTGEKLDEREAGITEKVVFEQTKVIADNV--KDWSKVVLAYEPVWAIGTGKT
H.sapiens|RefSeq:XP_001134259 AEALGVIACTGEKLDEREAGITEKVVFEQTKVIADNV--KDWSKVVLAYEPVWAIGTGKT
H.sapiens|UniProtKB:P60174 AEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNV--KDWSKVVLAYEPVWAIGTGKT
G.gallus|UniProtKB:P00940 AEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNV--KDWSKVVLAYEPVWAIGTGKT
D.rerio|ZFIN:ZDB-GENE-020416-4 ENGLGVIACIGEKLDEREAGITEKVVFAQTKFIADNV--KDWSKVVLAYEPVWAIGTGKT
D.rerio|ZFIN:ZDB-GENE-020416-3 ESDLGVIACIGEKLEEREAGTTEDVVFEQTKVIADNV--KDWTRVVLAYEPVWAIGTGKT
D.melanogaster|FB:FBgn0086355 AEGLKVIACIGETLEEREAGKTNEVVARQMCAYAQKI--KDWKNVVVAYEPVWAIGTGQT
C.elegans|WP:WB:CE19040 EAGIKVVFCIGEKLEEREAGHTKDVNFRQLQAIVDKG--VSWENIVIAYEPVWAIGTGKT
C.elegans|WB:WBGene00006601 EAGIKVVFCIGEKLEEREAGHTKDVNFRQLQAIVDKG--VSWENIVIAYEPVWAIGTGKT
C.elegans|UniProtKB:Q10657 EAGIKVVFCIGEKLEEREAGHTKDVNFRQLQAIVDKG--VSWENIVIAYEPVWAIGTGKT
A.thaliana|TAIR:gene:2047071 SEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAV--PSWDNIVVAYEPVWAIGTGKV
A.thaliana|TAIR:gene:4010712259 SEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAV--PSWDNIVVAYEPVWAIGTGKV
A.thaliana|TAIR:gene:3354057 SEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAV--PSWDNIVVAYEPVWAIGTGKV
A.thaliana|TAIR:gene:2099905 AQGLKVIACVGETLEEREAGSTMDVVAAQTKAIADRV--TNWSNVVIAYEPVWAIGTGKV
A.thaliana|TAIR:gene:3354984 AQGLKVIACVGETLEEREAGSTMDVVAAQTKAIADRV--TNWSNVVIAYEPVWAIGTGKV
D.discoideum|dictyBase:DDB0231425 SLGLTVILCLGELLADRKSNNTEHILSEQLKDFASFTP-EEWSKIVIAYEPVWAIGTGAV
E.coli|P0A858 EQGLTPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKS
: : * ** :.::. * .: * . : *:***********
S.cerevisiae|SGD:S000002457 ATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGAS
S.pombe|SPCC24B10.21 ATPEQAQEVHAEIRKWATNKLGASVAEGLRVIYGGSVNGGNCKEFLKFHDIDGFLVGGAS
R.norvegicus|RGD:1563601 ATPQQAQEVHEKLRGWLKCNVSEEVAQCTRIIYGGSVTGATCKELASQPDVDGFLVGGAS
R.norvegicus|RGD:1560534 ATPQQAQEVHEKLRGWLKCNVSEEVAQCTRIIYGGSVTGATCKELASQPDVDGFLVGGAS
R.norvegicus|RGD:3896 ATPQQAQEVHEKLRGWLKCNVSEGVAQCTRIIYGGSVTGATCKELASQPDVDGFLVGGAS
M.musculus|MGI:98797 ATPQQAQEVHEKLRGWLKSNVNDGVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGAS
H.sapiens|UniProtKB:Q2QD09 ATPQQDQEVHDKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPGVDGFLVGGAS
H.sapiens|RefSeq:XP_001134259 ATPQQDQEVHDKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPGVDGFLVGGAS
H.sapiens|UniProtKB:P60174 ATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGAS
G.gallus|UniProtKB:P00940 ATPQQAQEVHEKLRGWLKSHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGAS
D.rerio|ZFIN:ZDB-GENE-020416-4 ASPQQAQEVHDKLRQWLKTNVSEAVANSVRIIYGGSVTGGTCKELASQKDLDGFLVGGAS
D.rerio|ZFIN:ZDB-GENE-020416-3 ASPEQAQEVHEKLREWLRANVSDAVADSVRIIYGGSVTGGNCKELAAQADVDGFLVGGAS
D.melanogaster|FB:FBgn0086355 ATPDQAQEVHAFLRQWLSDNISKEVSASLRIQYGGSVTAANAKELAKKPDIDGFLVGGAS
C.elegans|WP:WB:CE19040 ASGEQAQEVHEWIRAFLKEKVSPAVADATRIIYGGSVTADNAAELGKKPDIDGFLVGGAS
C.elegans|WB:WBGene00006601 ASGEQAQEVHEWIRAFLKEKVSPAVADATRIIYGGSVTADNAAELGKKPDIDGFLVGGAS
C.elegans|UniProtKB:Q10657 ASGEQAQEVHEWIRAFLKEKVSPAVADATRIIYGGSVTADNAAELGKKPDIDGFLVGGAS
A.thaliana|TAIR:gene:2047071 ASPQQAQEVHVAVRGWLKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGAS
A.thaliana|TAIR:gene:4010712259 ASPQQAQEVHVAVRGWLKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGAS
A.thaliana|TAIR:gene:3354057 ASPQQAQEVHVAVRGWLKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGAS
A.thaliana|TAIR:gene:2099905 ASPAQAQEVHDELRKWLAKNVSADVAATTRIIYGGSVNGGNCKELGGQADVDGFLVGGAS
A.thaliana|TAIR:gene:3354984 ASPAQAQEVHDELRKWLAKNVSADVAATTRIIYGGSVNGGNCKELGGQADVDGFLVGGAS
D.discoideum|dictyBase:DDB0231425 ATPQEAQDTHVFIRKWISEKVSEDVAKKTSIMYGGSVNADNCHNLSKQSDIDGFLVGGAS
E.coli|P0A858 ATPAQAQAVHKFIRDHIAK-VDANIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGAS
*: : * * :* :. : : ****... .. : .:** ******
S.cerevisiae|SGD:S000002457 LK-PEFVDIINSRN------
S.pombe|SPCC24B10.21 LK-PEFHNIVNVHSL-----
R.norvegicus|RGD:1563601 LK-PEFLDIINAKQ------
R.norvegicus|RGD:1560534 LK-PEFVDIINAKQ------
R.norvegicus|RGD:3896 LK-PEFVDIINAKQ------
M.musculus|MGI:98797 LK-PEFVDIINAKQ------
H.sapiens|UniProtKB:Q2QD09 LK-PEFVDIINAKQ------
H.sapiens|RefSeq:XP_001134259 LK-PEFVDIINAKQ------
H.sapiens|UniProtKB:P60174 LK-PEFVDIINAKQ------
G.gallus|UniProtKB:P00940 LK-PEFVDIINAKH------
D.rerio|ZFIN:ZDB-GENE-020416-4 LK-PEFIDIINAKA------
D.rerio|ZFIN:ZDB-GENE-020416-3 LK-PEFVDIINARS------
D.melanogaster|FB:FBgn0086355 LK-PEFVDIINARQ------
C.elegans|WP:WB:CE19040 LK-PDFVKIINARS------
C.elegans|WB:WBGene00006601 LK-PDFVKIINARS------
C.elegans|UniProtKB:Q10657 LK-PDFVKIINARS------
A.thaliana|TAIR:gene:2047071 LKGPEFATIVNSVTSKKVAA
A.thaliana|TAIR:gene:4010712259 LKGPEFATIVNSVTSKKVAA
A.thaliana|TAIR:gene:3354057 LKGPEFATIVNSVTSKKVAA
A.thaliana|TAIR:gene:2099905 LK-PEFIDIIKAAEVKKSA-
A.thaliana|TAIR:gene:3354984 LK-PEFIDIIKAAEVKKSA-
D.discoideum|dictyBase:DDB0231425 LVASDFIAIIKSAVPKKY--
E.coli|P0A858 LKADAFAVIVKAAEAAKQA-
* * *::
| Protein | Disease-related papers from SGD |
|---|
| SGD:S000002457 | 12023819: Olah J, et al. (2002) Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease. Biochem Soc Trans 30(2):30-8 |
